Find out about cutting-edge research being conducted in: » Biopharmaceuticals and Bio processing » Medical Device Technologies >> Nano/Biosensors » Nanomanufacturing Technology for Biomedical Applications Register Early and Take $50 off the $350 Conference Fee! •H ~ University of • ~ueen's University DCLJ ~ Massachusetts ~elfast UMASS Lowell Dublin City University US/Ireland Emerging Technologies Conf ere nee CONFERENCE SESSIONS Monday, October 19, 2009 Tuesday, October 20, 2009 Check-in & Registration 8:ooam-8:3oam Morning Session 8:3oam-Noon Morning Session 8:3oam-Noon BIO PHARMACEUTICALS NANO/BIOSENSORS AND BIOPROCESSING These sessions will present novel, innovative nano- and micro-technology-based sensors aimed at point-of-care medical diagnostics, environmental monitoring, and chemical detection A changing regulatory environment and the introduction of biosimilars has put pressure on (including explosives). A variety of sensor platforms will be discussed, including antibody biopharmaceutical manufacturers to lower production costs and refocus on product quality. based, living-cell-based, and electrical and optical property-based devices. These Biopharmaceuticals and Bioprocessing sessions will cover innovative production, purification, and analytical technologies that will help biomanufacturers solve these Sensors for Chemical and Biological Threats challenging industry conditions. James E. Whitten, University of Massachusetts Lowell Innovative Technologies in the Manufacture of Biopharmaceuticals Advanced Polymer Micro-and Nanofabrication for Next Generation Diagnostic Lab-on-a-Chip Carl W. Lawton, Director, Massachusetts Biomanufacturing Center, University of Massachusetts Platforms Lowell Jens Ducree, Pl Microfluidic Platforms, Biomedical Diagnostics Institute, Dublin City University Developing lmmunoassays for Bioprocess Analysis and Diagnostics Novel Biosensor Platforms for Medical Diagnostics Richard O'Kennedy, Professor of Biotechnology and Vice President for Learning Innovation, Professor Brian D. MacCraith, School of Physical Sciences and Biomedical Diagnostics Dublin City University Institute, Dublin City University Ireland's Center for BioAnalytical Sciences: A Biopharmaceutical Perspective In-Vivo Multi-Biomarker Nano-Biosensor Speaker from the Center for BioAnalytical Sciences Ahmed Busnaina, W.L. Smith Professor and Director of the NSF Nanoscale Science and Engineering Center for High-rate Nanomanufacturing, Northeastern University Better Enzymes for Biosensors Dr. Ciar6n Fagan, School of Biotechnology and National Centre for Sensor Research, Dublin City The Nanocanary: A Living Cell Biosensor for Environmental Monitoring University Professor Susan Braunhut, Biological Sciences, University of Massachusetts Lowell Covalent Aggregation of Protein Therapeutics - A Case Study Optical Fiber Sensors for Bioapplications Jiu Xu, Director of Protein Sciences, Massachusetts Biomanufacturing Center, University of Xingwei Wang, Electrical and Computer Engineering, University of Massachusetts Lowell Massachusetts Lowell Panel Discussion Physical-Chemical Sensors: Application to Bioreactor Monitoring and Control Richard Baggio, Senior Research Scientist, Millipore Afternoon Session 1:oopm-4:oopm Panel Discussion NANOMANUFACTURING TECHNOLOGY Afternoon Session 1:oopm-4:3opm FOR BIOMEDICAL APPLICATIONS MEDICAL DEVICE TECHNOLOGIES The transfer of nanoscience accomplishments into useful technology is severely hindered by a lack of understanding of the barriers to nanoscale manufacturing. Nanotechnology-based Medical devices have emerged as an innovative and profitable area of research and commercial products cannot be realized without first understanding how one can assemble development. The key to commercialization of novel medical devices is transitioning from a and connect trillions of nanoelements, how to prevent failures and avoid defects, and how to research lab through design, manufacturing, business formation and FDNclinical approval. develop responsible manufacturing processes. Speakers will present on recent micro and These Medical Device Technologies sessions will cover novel devices, MedTech start-ups, nanomanufacturing developments with focus on biological and medical applications. novel processing and tissue engineering, as well as clinical trials for medical devices. Directed Assembly of Polymer Blends as Platforms for Bio/Medical Devices Novel Medical Devices from Massachusetts Start-Ups Dr. Joey L. Mead, Deputy Director, NSF Center for High-Rate Nanomanufacturing and Co Stephen McCarthy, Co-Director M2D2, University of Massachusetts Lowell Director Nanomanufacturing Center, University of Massachusetts Lowell Bone Substitute Materials Processing and Performance of Polymer-Clay Nanocomposites: Implications for Processability Dr. Nicholas Dunne, School of Mechanical and Aerospace Engineering, Queen's University and Performance in Medical Devices and Packaging A Flexible Method for the Preparation of Tissue Engineering Scaffolds Dr. Eileen Harkin-Jones, School of Mechanical and Aerospace Engineering, Queen's University Daniel Schmidt, Assistant Professor of Plastics Engineering, University of Massachusetts Lowell BioModular Multi-Scale Systems Tailoring Resorption Rates of Biodegradable Polymers Dr. David Kazmer, Professor, University of Massachusetts Lowell Dr. Fraser Buchanan, Reader, School of Mechanical and Aerospace Engineering, Queen's Molding Microstructures for Medical Applications University Dr. Carol Barry, Associate Director, NSF Center for High-Rate Nanomanufacturing and Co Overcoming the Challenges of Clinical Trials for Medical Devices Director Nanomanufacturing Center, University of Massachusetts Lowell Sheila Noone, Associate Vice Provost for Clinical Research, University of Massachusetts On-Line Monitoring of Nanocomposite/Biomaterial Compounding for Process Optimization Worcester Dr. Marion McAfee, School of Mechanical and Aerospace Engineering, Queen's University Supercritical Fluid Assisted Processing of Polymers for Medical Use Panel Discussion Peter Hornsby, Queen's University Multifunctional Additives for Medical Polymers Tony McNally, Ph.D., Queen's University Panel Discussion Continental breakfast, lunch and refreshments will be provided at the conference. Poster Sessions 4:3opm-6:oopm v=. . )P,. >, US/Ireland Emerging Technologies Conference CONFERENCE SESSIONS I 11 Monday, October 19, 2009 II Check-in & Registration 8:ooam-8:3oam Morning Session 8:3oam-Noon Afternoon Session 1:oopm-4:3opm BIO PHARMACEUTICALS MEDICAL DEVICE TECHNOLOGIES AND BIOPROCESSING Novel Medical Devices from Massachusetts Start-Ups Innovative Technologies in the Manufacture of Stephen McCarthy, Co-Director M2D2, University of Massachusetts Lowell An overview of M2D2 (Massachusetts Medical Device Development Center) and Biopharmaceuticals the current medical devices being developed will be presented. These novel Carl W. Lawton, Director, Massachusetts Biomanufacturing Center, University of devices include biodegradable drug eluting stents, nanosphere-antibiotic corneal Massachusetts Lowell contact lenses, photochemical tissue bonding, and RF bone welding. Recent advances in innovative technologies address critical issues in the manufacture of biopharmaceuticals. This presentation will discuss work About the Speaker performed at the Massachusetts Biomanufacturing Center to evaluate UCOE Stephen McCarthy is a Professor of Plastics Engineering at the University of (ubiquitous chromatin opening elements) for stabilizing gene expression, single Massachusetts Lowell and Co-Director of the Massachusetts Medical Device use membrane chromatography, and ozone CIP (clean in place). Development Center at UMass Lowell and UMass Worcester. He is also Director of the Biodegradable Polymer Research Center where he is conducting research into About the Speaker Biodegradable Polymers and Blends. He currently serves as editor for the Journal Dr. Carl W. Lawton is an Associate Professor in the Department of Chemical of Polymer and the Environment. He received his B.S. from Southeastern Engineering and Director of the Massachusetts Biomanufacturing Center where he Massachusetts University, a Master's in Chemical Engineering from Princeton directs a staff that helps biotechnology companies with process development, University, and a Ph.D. in Macromolecular Science from Case Western University evaluates innovative technologies, and develops training programs for industry. in Cleveland, Ohio. He worked as an Advanced Engineer in R&D for Owens Corning Fiberglas in Granville, Ohio. Developing lmmunoassays for Bioprocess Analysis and Diagnostics Bone Substitute Materials Richard O'Kennedy, Professor of Biotechnology and Vice President for Learning Dr. Nicholas Dunne, School of Mechanical and Aerospace Engineering, Queen's Innovation, Dublin City University University Antibodies are ideal reagents for use in assay development and genetic Calcium phosphate cements have attracted a great deal of interest as possible engineering facilitates optimization of their performance characteristics in terms bone substitute materials due to their ability to produce hydroxyapatite of specificity, sensitivity, structural format, stability and immobilization. Their demonstrating chemical and crystallographic structures similar to that naturally generation and potential applications in a range of diagnostic and process present in bone. Calcium phosphate cements can be delivered through a related analyses using sensors and other platforms will be described. cannulated needle to an anatomical site or molded to a desired shape to fill a bone defect. However, calcium phosphate cements are recognized for their low About the Speaker compressive strength and susceptibility to brittle fracture, which significantly Richard O'Kennedy is internationally recognized for his contributions in relation limits their use in load-bearing orthopaedic applications. This presentation will to antibody production and applications including antibody-based sensors and explore different strategies for augmenting the load-bearing capabilities of immunoanalysis, and has developed novel strategies for antibody generation calcium phosphate bone cements. including the use of antibody-derived fragments produced by genetic methods. He is an acknowledged world expert in the analysis, mode of action and effects About the Speaker of coumarins and coumarin-derived molecules including aflatoxins and warfarins. Dr. Nicholas Dunne is a Senior Lecturer of Biomaterials and Medical Devices at Queen's University. He has developed a strong, interdisciplinary research program Ireland's Center for BioAnalytical Sciences: complimented with over-arching institutional and industrial collaborations. His field of expertise focuses on two main areas: 1) development and understanding A Biopharmaceutical Perspective of cement-based materials for hard tissue replacement and 2) development of Speaker from the Center for BioAnalytical Sciences hierarchical constructs for tissue engineering. Ireland's Center for Bio Analytical Sciences is an industry-academia collaboration utilizing the best academic research skills to resolve shared problems associated A Flexible Method for the Preparation of Tissue with research-intensive bioindustries. Based on the experience gained from the Engineering Scaffolds initial partnership, the concept is now expanding and is being utilized to bring novel and advanced bioanalytical solutions to the biopharmaceutical and life Daniel Schmidt, Assistant Professor of Plastics Engineering, University of science industry sectors, including novel diagnostic and nanotechnologies. Massachusetts Lowell One of the major barriers to successful regenerative medicine is the availability Better Enzymes for Biosensors of appropriate scaffolds on which living tissue is able to form. Here, organic sol gel chemistry is presented as a novel approach to the creation of such Dr. Ciar6n Fagan, School of Biotechnology and National Centre for Sensor scaffolds. This flexibility of this method comes from its general applicability to a Research, Dublin City University wide range of polymeric materials, as well as the possibility to alter structure Enzymes have many uses but their scope is limited by protein instability. We independent of composition or vice-versa. Additional examples of the ability to have performed chemical modification (CM) and genetic manipulation (GM) on achieve multifunctionality include the replication of biologically relevant porous the widely-used horseradish peroxidase (HRP). The lecture will show how these bodies, the preparation of materials with shape-memory characteristics and the have led to more stable forms HRP. Biosensor-relevant improvements to HRP and selection of materials designed to produce potentially therapeutic degradation another peroxidase will also be described. products. About the Speaker About the Speaker Ciaran Fagan is a senior lecturer at Dublin City University, where he is deputy Prior to joining UMass Lowell in 2005, Daniel Schmidt performed undergraduate head of the School of Biotechnology and a member of the National Centre for studies in Chemistry and Materials Science at Carnegie Mellon University, doctoral Sensors Research. work in Materials Science at Cornell University, and a two-year stint with BASF in Strasbourg, France. His research interests include polymer/ layered nanofiller Covalent Aggregation of Protein Therapeutics - A Case nanocomposites, porous and non-porous sol-gel derived materials, new polymer Study and hybrid synthesis (primarily networks) via step-growth / polycondensation reactions, as well as preceramic polymers and materials analysis. Jiu Xu, Director of Protein Sciences, Massachusetts Biomanufacturing Center, University of Massachusetts Lowell Tailoring Resorption Rates of Biodegradable Polymers Protein aggregation is a major concern of biomanufacturing. In this study, various biochemical, biophysical and molecular biology techniques were Dr. Fraser Buchanan, Reader, School of Mechanical and Aerospace Engineering, employed to elucidate the disulfide bond-related mechanism of protein Queen's University aggregation. Bioresorbable polymers such as polylactic acid (PLA), polyglycolic acid (PGA) and copolymers are widely used in medical devices, however their degradation About the Speaker behavior is not ideal as they tend to lose strength well before any significant Dr. Jin Xu is the director of the Massachusetts Biomanufacturing Center (MBMC) loss in mass. This presentation will cover methods to evaluate bioresorbable Protein Analysis and Characterization laboratory and an assistant professor in the polymers, including accelerated aging, as well as approaches to tailor the Chemistry Department at UMass Lowell. Dr. Xu currently oversees and actively degradation rate. participates in protein structural/functional studies, protein product characterization and analytical development at MBMC. With his expertise in About the Speaker protein chemistry and biophysics, Dr. Xu also designs and conducts studies on Dr. Fraser Buchanan is a member of the Polymer Research Cluster at Queen's the relationship between protein folding and protein productivity/quality. Before University, where he coordinates a number of medical device related research joining UMass Lowell, Dr. Xu received his Ph.D. in Biochemistry from the activities in bioresorbable polymers, calcium phosphate ceramics and marine University of North Texas. Afterwards he worked as senior research scientist and derived biomaterials. principal scientist at Wyeth Pharmaceuticals for over five years, before most recently establishing and leading the protein chemistry group at Percivia, LLC. Overcoming the Challenges of Clinical Trials for Medical Devices Physical-Chemical Sensors: Application to Bioreactor Sheila Noone, Associate Vice Provost for Clinical Research, University of Monitoring and Control Massachusetts Worcester Richard Baggio, Senior Research Scientist, Millipore All clinical trials, including medical device studies, rely on an efficient and reliable Real-time bioprocess monitoring is fundamental to maximize yield, improve infrastructure to ensure success. This is a particular challenge in a highly efficiency and process reproducibility, minimize costs, optimize product quality, matrixed academic health center. This presentation will highlight the shared and fully understand how a system works. These results offer insight into how responsibilities of sponsor, institution and research staff over the life cycle of the the application of new optical probes and both NIR and dielectric spectroscopy clinical trial to achieve study success. can more fully integrate the PAT initiative in a bioreactor workflow to improve product quality. About the Speaker Sheila B. Noone, Ph.D., is Assistant Vice Provost for Clinical Research at Panel Discussion University of Massachusetts Worcester. She has responsibility for the oversight of clinical research practice, clinical study agreements, training and education, and the Institutional Review Board (IRB). Along with Professor Stephen McCarthy, she is Co-Director of the Massachusetts Medical Device Development Center (M2D2). About UMass Lowell Supercritical Fluid Assisted Processing of Polymers for Medical Use UMass Lowell is a comprehensive university with a Peter Hornsby, Queen's University national reputation in science, engineering and Supercritical carbon dioxide can exert a strong transient plasticizing effect to technology, and committed to educating students for many polymers during melt processing resulting in decreased viscosity, thereby providing an opportunity to reduce processing temperatures or limit mechanical lifelong success in a diverse world and conducting damage to the material. The application of this approach will be discussed with research and outreach activities that sustain the economic, reference to extrusion technology and the processing benefits achievable, including its use with inherently thermally unstable polymers and modifying environmental and social health of the region. Located in additives used for medical purposes. the historic industrial city of Lowell, 25 miles northwest of About the Speaker Boston, the campus spans more than 125 acres along the Peter Hornsby is Professor of Polymer Engineering at Queen's University and Merrimack River. More than 12,000 resident and commuter Director of the Polymers Research Cluster in the School of Mechanical and Aerospace Engineering. His current research interests relate to the development students of all backgrounds pursue bachelor's, master's, of novel polymer processing technologies and the formulation and processing of polymers containing nano-fillers. and doctoral degrees as well as professional certificates in the arts, humanities and sciences; education; Multifunctional Additives for Medical Polymers engineering; health and environment; and management. Tony McNally, Ph.D., Queen's University This presentation will be divided into two parts: 1) the role of ionic liquids as UMass Lowell is a nationally ranked research university both plasticisers and antimicrobial agents for use with PVC, and 2) the use of with more than $50 million in funded research being nanoparticles to retard drug release from biopolymers will be described. conducted each year. About the Speaker Tony McNally is a faculty member in the School of Mechanical and Aerospace Engineering at Queen's University. His current research interests include polymer layered silicate nanocomposites for drug delivery; ionic liquid modification of nanoclays; composites of polymers with carbon nanotubes, MoSl nanowires, POSS and graphene; multifunctional ionic liquids as additives for medical polymers. Panel Discussion Poster Sessions 4:3opm-6:oopm Tuesday, October 20, 2009 Morning Session 8:3oam-Noon Afternoon Session 1:oopm-4:oopm NANO/BIOSENSORS NANOMANUFACTURING TECHNOLOGY FOR BIOMEDICAL APPLICATIONS Sensors for Chemical and Biological Threats James E. Whitten, University of Massachusetts Lowell Directed Assembly of Polymer Blends as Platforms for A variety of nanotechnology-based sensors are being developed at Bio/Medical Devices the University of Massachusetts Lowell to address chemical and biological threats of relevance to the United States Army. These sensors lend themselves to high Dr. Joey L. Mead, Deputy Director, NSF Center for High-Rate Nanomanufacturing rate nanomanufacturing methods that will make possible their cost-effective and Co-Director Nanomanufacturing Center, University of Massachusetts Lowell mass production. An overview of the UMass Lowell research efforts will be Nanoscale templates have been used to direct the assembly polymer blends into presented, with emphasis on chemiresistive, functionalized gold nanoparticle uniform and nonuniform patterns. Chemically functionalized templates have films useful for the detection of chemical vapors, including explosives. assembled two polymers in 30 seconds directly from a solution of the two polymers. The approach can be used to generate a variety of complex geometries About the Speaker including 900 bends, T-junctions, square and circle arrays, which have potential James E. Whitten is a Professor of Chemistry at the University of Massachusetts applications in fabrication of biosensors and platforms for other biomedical Lowell and member of the Center for High-Rate Nanomanufacturing (CHN). His applications. Electrophoretic assembly processes have been used to assemble research group has expertise in chemical sensors, organic electronic interfaces, conducting polymers followed by transfer to a secondary substrate to produce metal oxide surface chemistry, conjugated polymer films, and self-assembled patterned polymer structures. These structures have application for electrically monolayers. based biosensors. Advanced Polymer Micro- and Nanofabrication for Next About the Speaker Dr. Joey Mead is a Professor in the Department of Plastics Engineering at UMass Generation Diagnostic Lab-on-a-Chip Platforms Lowell and Deputy Director of the NSF funded Center for High-Rate Jens Ducree, Pl Microfluidic Platforms, Biomedical Diagnostics Institute, Dublin Nanomanufacturing (a collaboration between Northeastern University, UMass City University Lowell, and the University of New Hampshire). She is Co-Director of UMass The translation of leading-edge research in biomedical diagnostics into patient Lowell's Nanomanufacturing Center. Her research interests include Elastomers, friendly point-of-care devices based on smart micro- and nanofluidic operating thermoplastic elastomers, nanomanufacturing, electrospinning, mechanical principles will require sophisticated polymer fabrication technologies. This behavior of elastomers and polymers, recycling of rubber and elastomeric barrier presentation will cover important aspects of the emerging program on multi-scale materials. polymer micro- and nanomachining and highlight recent developments on novel lab-on-a-chip platforms for application in the life sciences at the Biomedical Processing and Performance of Polymer-Clay Diagnostics Institute. Nanocomposites: Implications for Processability and Performance in Medical Devices and Packaging About the Speaker Jens Ducree is an Associate Professor for Microsystems at Dublin City University, a Dr. Eileen Harkin-Jones, School of Mechanical and Aerospace Engineering, Pl for Microfluidic Platforms at the Biomedical Diagnostics Institute and the Queen's University Director of the Polymer MicroNanoFab at the National Centre for Sensor Research. The processability of polymers can be significantly altered by the presence of Before moving to Ireland in May 2008, he initiated and headed the group "Lab nanoclay while the complex deformation and thermal regimes in industrial on-a-Chip Systems" and the "Lab-on-a-Chip Foundry Service" at the Institute of processes have an important influence on polymer-clay structuring and Microsystems Engineering (IMTEK) and the HSG-IMIT in Freiburg, Germany. performance. In this presentation these aspects of polymer-clay nanocomposites processing will be examined and possibilities for tailored structuring in devices Novel Biosensor Platforms for Medical Diagnostics and packaging will be examined. Professor Brian D. MacCraith, School of Physical Sciences and Biomedical About the Speaker Diagnostics Institute, Dublin City University Dr. Eileen Harkin-Jones is a Professor in the School of Mechanical and Aerospace In the coming decades, innovative biosensors will play an increasingly important role in the area of healthcare in both the developed and developing world. These Engineering at Queen's University. Her research is focused on polymer processing devices will often be disposable and will rely on the integration of recent including rotational molding, thermoforming and blow molding. She is a member developments in a range of sciences and technologies, such as nanotechnology, of the Institute of Materials, Polymer Processing and Engineering National microfluidics (lab-on-a-chip) and photonics. This presentation will discuss Committee. emerging strategies that will yield substantial enhancements in the analytical BioModular Multi-Scale Systems performance of optical biochip platforms, especially for point-of-care (POC) diagnostic applications. Dr. David Kazmer, Professor, University of Massachusetts Lowell The design, modeling, fabrication, testing and manufacturing of a low-cost, About the Speaker mixed-scale system is described. The Molecular Processing System under Brian D. MacCraith is Professor of Physics and Director of the BDI (www.bdi.ie) at development will possess the ability to analyze different inputs in near real time Dublin City University. The BDI is an Industry-Academic-Clinical partnership for a variety of molecular signatures in applications such as homeland security, involving over 120 researchers. Brian's research interests are in nanobiophotonics, biological discovery, forensics and diagnostics. The technologies are focused on optical biosensor platforms and fluorescence enhancement strategies. multi-scale and bio-modular design approaches that utilize paradigm-shifting molecular assays to offer near real-time readout at the single-molecule level. In-Vivo Multi-Biomarker Nano-Biosensor Some of the current challenges regarding high-performance materials and high production rate manufacturing of the bio-modules are discussed. Ahmed Busnoina, W.L. Smith Professor and Director of the NSF Nanoscale Science and Engineering Center for High-rate NanomanufactL:.-ing, Northeastern About the Speaker University Dr. David Kazmer is a Professor in the Department of Plastics Engineering at the There is a need for multifunctional nanosystems for the simultaneous monitoring University of Massachusetts Lowell. Dr. Kazmer is researching advanced of a variety of biomarkers in biological fluids to assess the progress of disease, capabilities in design of manufacturing processes, focusing on molding process toxicity, stress, etc. Further, the use of such devices for multidrug release in real time disease treatment is an important goal. The detection of biomarkers in simulation and development as well as product and machine design towards combination with controlled drug release represents an exciting long term integrated product and process engineering. He teaches courses pertaining to application of multifunctional nanosystems. Northeastern University's NSF process engineering, mold design, process control, and process simulation. Nanoscale Science and Engineering Center for High-rate Nanomanufacturing (CHN) Molding Microstructures for Medical Applications developed a new process for selective assembly of nanoparticles into designated nanotrenches to yield structures for such multipurpose devices. Dr. Carol Barry, Associate Director, NSF Center for High-Rate Nanomanufacturing and Co-Director Nanomanufacturing Center, University of Massachusetts Lowell About the Speaker Use of polymers offer opportunities for cost-effective, high-rate manufacturing of Ahmed A. Busnaina, Ph.D., is the William Lincoln Smith Chair Professor and microfluidic devices and other products with micro and nanoscale structures. This Director of National Science Foundation's Nanoscale Science and Engineering presentation will cover the major technologies emerging for molding Center (NSEC) for High-rate Nanomanufacturing and the NSF Center for Nano and microstructured polymeric devices, (hot embossing, nanoimprint lithography, and Microcontamination Control at Northeastern University, Boston, MA. He is injection molding) and creating the tooling (molds) for these processes. The internationally recognized for his work on nano and micro scale defects capabilities and limitations of each process will be discussed, specifically with (particulate and chemical) mitigation and removal in semiconductor fabrication. respect to replication of feature sizes, shapes, and surfaces. He also involved in the fabrication of nanoscale wires, structures and interconnects. He specializes in directed assembly of nanoelements and in the About the Speaker fabrication of micro and nanoscale structures. Dr. Carol Barry is a Professor in the Department of Plastics Engineering at UMass Lowell, Associate Director of the NSF funded Center for High-Rate The Nanocanary: A Living Cell Biosensor for Nanomanufacturing (a collaboration between Northeastern University, UMass Environmental Monitoring Lowell, and the University of New Hampshire). She is Co-Director of UMass Lowell's Nanomanufacturing Center. Her research areas include extrusion, Professor Susan Braunhut, Biological Sciences, University of Massachusetts injection molding, novel processing techniques and analysis, and nanoscale Lowell plastics processing. The number and variety of engineered nanomaterials (ENMs) being manufactured and in commercial use is increasing rapidly and yet many of these materials have On-Line Monitoring of Nanocomposite / Biomaterial not been evaluated for their environmental safety. We have developed a Compounding for Process Optimization biosensor using live pulmonary cells and quartz crystal nanobalance technology that can detect and distinquish in real time cellular responses to diverse ENMs, Dr. Marion McAfee, School of Mechanical and Aerospace Engineering, Queen's representing different doses and different degrees of cellular toxicity. University Interest in nanocomposites has grown exponentially over the past decade. About the Speaker However, several years and much research effort later, there are few commercial Dr. Susan Braunhut is a Full Professor in the Department of Biological Sciences at applications of nanocomposite polymers worldwide. It is known that processing the University of Massachusetts Lowell. She oversees a team of postdoctoral conditions play a major role in successful nanocomposite production but there is fellows, staff and students working in the areas of radiation biology, cancer little agreement among researchers on the relative effects of various processing therapy and diagnosis and biosensors for counterterrorism and environmental conditions on factors such as clay dispersion. This presentation will cover novel monitoring of aerosolized cytotoxic carbon nanotubes and other nanomaterials. methods for on-line monitoring of nanocomposite compounding, which can be used for better fundamental understanding of the process and ultimately achieve greater optimization and consistency of nanocomposite quality. Applications of such sensors in monitoring processing of degradation-prone biomaterials will also be discussed. Optical Fiber Sensors for Bioapplications Xingwei Wang, Electrical and Computer Engineering, University of Massachusetts Lowell Optical fiber has its unique advantages when applied in biomedical sensing areas About the Speaker due to its small size, low signal loss, high sensitivity, biocompatibility, and Dr. Marion McAfee is a Lecturer in the School of Mechanical and Aerospace immunity to electromagnetic interferences. This presentation will mainly focus on Engineering at Queen's University. Her research interests involve on-line a blood pressure sensor that can be inserted into a standard guidewire for real monitoring, modeling and control of polymer and biomaterial processing and time blood pressure measurement inside the arteries. predictive modeling of biomaterials in-vivo. Current projects include soft-sensor and fault detection techniques for extrusion; ultrasound-assisted recyclate About the Speaker processing; nanocomposite processing; and predictive modeling of CaP and Xingwei Wang is an Assistant Professor at the University of Massachusetts Lowell bioresorbable polymer behavior. in the Department of Electrical and Computer Engineering. She has a unique combination of expertise in electrical engineering, optics, and sensor technology. Panel Discussion She has nine years experience in the optical sensor area, and her research in the fields of optical sensors, in biomedical and harsh environment applications, MEMS, and sensor control has been disseminated through many journal and conference publications. Dr. Wang received her Ph.D. and M.S. in Electrical Note: Conference schedule is subject to change. Please refer to the conference Engineering from Virginia Tech. website (www.uml.edu/EmergingTech) for any updates to the schedule. Panel Discussion i ' I A unique opportunity to learn from and interact with researchers and I discover collabQrative opportunities to develop the next generation of i ' innovative prod_ucts. I Register for the Conference Register by phone, fax or mail by Friday, October 16, 2009. Registrations will not be processed unless accompanied by a check, purchase order or credit card information. Cancellations must be made by Friday, October 16, 2009. There will be no refunds for cancellations after that date. By Phone By Fax By Mail Call 978-934-2405 Fax this completed form UMass Lowell to register by phone to 978-934-2028 Continuing Studies Attn: Gwen Picanco Please print clearly or type. Photocopy for additional forms. One University Avenue Lowell, MA 01854-2881 Attendee Information First Name Ml Last Name Title Company Address City State Zip Work Telephone Home Telephone Fax Email Address istration D Total: $350 Save $50 - Pay only $300 if you register by October 1st. Continental breakfast, lunch and refreshments will be provided at the conference. Please note we cannot accept American Express. D Check enclosed, payable to the University of Massachusetts Lowell D Purchase Order#: Company's Federal Tax ID #: Please fax a copy of your PO to 978-934-2028 or mail it to the address above with your registration. A copy of the PO is REQUIRED in order to process your registration. Contact Name for PO: Telephone: ___________ D Bill Credit Card: (cid:143) MasterCard (cid:143) VISA D Discover We cannot accept American Express. Credit Card Number Expiration Date Cardholder Name Cardholder Signature Location and Accommodations The Emerging Technologies Conference will be held at UMass Lowell's new state-of-the-art Inn & Conference Center located at 50 Warren Street, Lowell, MA. Hotels are conveniently located throughout the area. Please visit the conference website (www.uml.edu/EmergingTech) for further information on area accommodations. I Don't miss this unique opportunity to hear about cutting-edge research in biomanufacturing, bioprocessing, medical device devel nt and diagnostics. Researchers from the US and Ireland will come together to present innovative research that may help shape the future of how we use nanotechnology and biological sciences in manufacturing and medical diagnostics. Exhibitors For information on exhibiting at the conference, email [email protected] or call 978-934-2186. Conference Location and Travel The Emerging Technologies Conference will be held at UMass Lowell's new state-of-the-art Inn & Conference Center in Lowell, MA. UMass Lowell Inn & Conference Center 50 Warren Street Lowell, MA 01852 About Lowell Lowell is a city rich in history and culture. Home to the University of Massachusetts Lowell, the city is conveniently located between two major airports: Logan International Airport in Boston, MA and Manchester-Boston Regional Airport in Manchester, NH. From Boston, Lowell is a 30 minute ride by commuter rail or car. America's Industrial Revolution began here and is commemorated at the Lowell National Historical Park, where visitors can tour the canals, textile mills, and "mill girl" boarding houses that tell the story of the transition from farm to factory. With sports events, historical parks, museums, and theaters, Lowell has something for See conference website for directi'ons to everyone. For additional information on UMass Lowell's Inn & Conference Center. Lowell and the surrounding areas, visit www.uml.edu/EmergingTech http://www.merrimackvalley.org. US/Ireland October 19-20, 2009 M Emerging Technologies www.uml.edu/EmergingTech Conference r University of ~ Massachusetts UMASS Lowell University of Massachusetts Lowell Continuing Studies, Corporate & Distance Education One University Avenue Lowell, MA 01854 www.uml.edu/EmergingTech Don't miss this unique opportunity to learn about cutting-edge research in nanotechnology, biomanufacturing, bioprocessing, medical device development, and diagnostics. •H A v) University of ~ueen's University DCU ~ Massachusetts ~elfast UMASS Lowell Dublin City University