Abhay Rané · Ranan Dasgupta Editors Urinary Tract Infection Clinical Perspectives on Urinary Tract Infection Urinary Tract Infection Abhay Rané (cid:129) Ranan Dasgupta Editors Urinary Tract Infection Clinical Perspectives on Urinary Tract Infection Editors Abhay Rané, MS, FRCS, FRCS (Urol) Ranan Dasgupta, MBBChir, MA, MD, Department of Urology FRCS (Urol) Surrey and Sussex Healthcare NHS Trust Department of Urology East Surrey Hospital Imperial College Healthcare NHS Trust Redhill St Mary’s Hospital UK London UK ISBN 978-1-4471-4708-4 ISBN 978-1-4471-4709-1 (eBook) DOI 10.1007/978-1-4471-4709-1 Springer London Heidelberg New York Dordrecht Library of Congress Control Number: 2013942668 © Springer-Verlag London 2013 This work is subject to copyright. 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Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Foreword Urinary tract infections (UTIs) constitute a signifi cant health-care burden, affecting over 13 % of adult women yearly and comprising a lifetime prevalence of over 50 %. As such, the economic consequences and effect on quality of life of even routine UTIs are substantial. Add to that the impact of complicated UTIs – those infections occurring in patients with underlying anatomic abnormalities or those with urosepsis – and the effect on our health-care system is staggering. The care of UTIs crosses medical disciplinary lines, falling to family practice doctors, obstetrician-gynecologists, internists, and urologists to diagnose and man- age these problems. Thus, it behooves these clinicians to understand the underlying pathophysiology behind UTIs, to be able to differentiate simple from complicated UTIs, to be familiar with the diagnostic work-up, and fi nally to be comfortable with the treatment algorithm. Patients experiencing UTIs require acute diagnosis and management as well as potentially more detailed investigation and long-term care for those with recurrent UTIs. It is imperative that those patients at risk of or expe- riencing recurrent infections undergo appropriate evaluation to identify behavioral, genetic, or anatomic factors that contribute to their risk of UTIs. In their book, U rinary Tract Infection , Abhay Rané and Ranan Dasgupta have assembled a group of well-known experts to author chapters addressing all aspects of UTI, including routine UTI; UTI complicated by diabetes, pregnancy, anatomic abnormalities, or indwelling catheters; UTI in children; and UTI associated with unusual organisms. Written in an easy-to-read question-answer format, this book addresses all aspects of clinical UTI, from pathogenesis to evaluation and treatment. Useful tables of antibiotic choices and dosages and signs and symptoms of UTI provide quick reference sources to which the busy practitioner can refer on the go. Applicable to practitioners in any specialty, this book provides a current, concise, yet comprehensive practical guide to the diagnosis and management of UTIs. I rec- ommend this valuable publication be kept readily available on the shelf of any prac- titioner who cares for patients with UTIs. Dallas, TX, USA Margaret S. Pearle, MD, PhD v Preface The causative organisms of urinary tract infection are dynamic in terms of their virulence and resistance patterns, leading to challenges in the prevention and treat- ment of urinary infection. This is of relevance in both primary and secondary care, and many of the challenges are similar in both developed and developing countries alike. UTI is also associated with considerable cost in terms of morbidity, economic, and research expenditure. Written by an exceptional and well-known team of clinical experts, the purpose of Clinical Perspectives on Urinary Tract Infections is to address some key ques- tions facing physicians about this condition. The book is written primarily for gen- eral physicians who wish to have a broad understanding of a number of important issues concerning infection in parts of the urinary tract. Specialists may also fi nd the book useful as a quick reference guide. We approach the subject from an organ-by-organ perspective, aware that patients may be affected systemically. By focusing on specifi c organs, it may help physi- cians to target investigation and management of underlying pathologies, as well as treating the infection by conventional antimicrobial measures. Chapter 1 helps to defi ne what is meant by “urinary tract infection” and describes the classifi cation systems of common organisms. This leads on to Chap. 2 , which discusses the main antibiotics used in treating these infections and includes discus- sion of antibiotic resistance, a growing problem on a global level. Two very important areas of clinical dilemmas in UTI are comprehensively dis- cussed next: pregnancy and children. These are followed by chapters on urinary tract infections and diabetes, less common infections, and a focus on UTI in AIDS and tuberculosis. Our fi nal chapter discusses complementary therapies, such as plant-based supplements, nutritional formulas, and beverages. In Urinary Tract Infection , we have utilized a question and answer style, which characterizes a clear and easy approach to learning and understanding, and which readers have found stimulating and helpful for information retention. The attractive vii viii Preface handbook format makes the publication simple to carry and access and provides quick reference to those points that are of most interest. We hope you fi nd the book informative and useful to your needs. Redhill, UK Abhay Rané, MS, FRCS, FRCS (Urol) Acknowledgments We wish to thank the team of extremely talented authors that have helped us put this book together. We also formally wish to acknowledge the support from Melissa Morton at Springer, and the dedication and hard work put in by our developmental editor, Portia Wong. Finally, such an effort would not be complete without acknowledging our better halves: for their patience, understanding and words of encouragement, Ruta and Nina, we thank you. Abhay Rané, MS, FRCS, FRCS (Urol) Ranan Dasgupta, MBBChir, MA, MD, FRCS (Urol) ix