147918 ULTRA LOW DOSES au 2n Ultra Low Doses Edited by C. Doutremepuich Université Bordeaux France Taylor & Francis London - Washington, DC 1991 UK Taylor & Francis Ltd., 4 John St. London WCIN 2ET USA Taylor & Francis Inc., 1900 Frost Road, Suite 101, Bristol, PA 19007 Copyright © Taylor & Francis Ltd., 1991 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or otherwise, without the prior permission \DERBIL PavERt : ICAL CENTER LIBRARY SHVILLE, TENNESSEE 37232 British Library Cataloguing in Publication Data Available on request Library of Congress Cataloging-in-Publication Data Available on request Printed in Great Britain by Burgess Science Press, Basingstoke on paper which has a specified pH value on final paper manufacture of not less than 7.5 and is therefore ‘acid free’. Contents Preface I EXPERIMENTAL PHARMACOLOGY First experimental arguments in favor of the effect of very weak doses of copper on digestive motricity in mice and rabbits Santini, R., Tessier,M., Belon, P., Pacheco, H. The effects of some regulatory peptides in femtomolar and lower concentrations on the contraction of lymphatic vessels (LVs) Ashmarin,I.P., Levekova, L.Ts., Sanzhieva. 11 Modulation of experimental rat liver carcinogenesis by ultra low doses of the carcinogens De Gerlache, J., Lans, M. 17 Overcoming tumor cell drug resistance by low doses of recombinant tumor necrosis factor and drug Bonavida, B., Safrit, J., Tsuchitani, T., Zighelboim, J. Rs Effect of acetylsalicylic acid at ultra low dose on the interaction platelets/ vessel wall Lalanne, M.C., De Seze, O., Doutremepuich, C. 45 II BIOPHYSICS A quantum chemical study of some model anti-inflammatory compounds: the preferred conformations and their electrostatic similarities Bhattacharjee, Apurka, K. 55 Influence of several physical factors on the activity of ultra low doses Cazin,J.C., Cazin, M., Chaoui,A., Belon,P . 69 vi Contents III BIOCHEMISTRY — TOXICOLOGY Uranyl nitrate induced corpuscular derangement in rat, an early indication of renel dysfunctioning Gojer, M., Sawant, V. 81 Degranulation of mesenteric mast cells as ‘spot test’ in toxicology Rathinam, K., Mohanan, P.V., Lizzy Michael 89 IV CELL BIOLOGY Simultaneous measurement of oxidative metabolism and adhesion of human neutrophils and evaluation of multiple doses of agonists and inhibitors Bellavite, P., Chirumbolo,S., Signorini,A. , Bianchi,I., Dri,P . 93 Non-stimulatory concentrations of concanavalin A can modulate subsequent stimulation by the same mitogen Eskinazi, D.P., Molinaro, G.A. 119 Biological activity of ultra low doses: I/ Effect of ultra low doses of histamine on human basophil degranulation triggered by D. pteronyssinus extract Sainte-Laudy, J., Sambucy, J.L., Belon,P. 127 Biological activity of ultra doses: II/ Effect of ultra low doses of histamine on human basophil degranulation triggered by anti-IgE Sainte-Laudy, J., Belon,P. 139 V CLINICAL PHARMACOLOGY A study of the effectiveness of ultra low doses of copper in the treatment of hemodialysis-related muscle cramps Hariveau, E., Nolen, P., Holtzscherer, A. 145 Action of aspirin after ingestion at ultra low doses in healthy volunteers Lalanne, M.C., De Seze, O., Le Roy,D .,D outremepuich, C., Boiron, J. 151 Index 15