Charles D. Ericsson, MD, Herbert L. DuPont, MD, Robert Steffen, MD Travelers Diarrhea aims to convey a thorough history, a basic understanding of the discipline, state-of-the-art management recommendations and thoughts for future research. Substantial understanding of the risks of acquiring travelers diarrhea exists and we continue to learn about differences in host susceptibility. Recent research questions the pivotal role of fluid replacement in the treatment of adults with travelers diarrhea. An increasing number of medications are available for symptomatic relief and for specific antimicrobial therapy against causal organisms. Modern molecular and genetic techniques, vaccine development, and new production techniques are discussed, in addition to the improvement of public health services around the world.