xt o 573 ' (On shh > a8 pe 4 Gag) ELSE ~~ Toxicology 102 (1995) 322-324 Volume contents Volume 102 (1995) Numbers 1,2 Special Issue: BIOLOGICAL MECHANISMS AND QUANTITATIVE RISK ASSESSMENT Proceedings of a symposium sponsored by the Health Effects Research Laboratory of the U.S. Environmental Protection Agency (November 1—4, 1993) Preface — R. Woodrow Setzer, Jr., L. Earl Gray, Jr INTRODUCTION Research to strengthen the scientific basis for health risk assessment: a survey of the context and rationale for mechanistically based methods and models K. Sexton, L.W. Reiter, H. Zenick (USA) Part 1. RISK ASSESSMENT AND RESEARCH: SETTING THE STAGE Assessing the risk assessment paradigm G.S. Omenn (USA) Historical perspective on risk assessment in the federal government J.D. Graham (USA) The future of mechanistic research in risk assessment: Where are we going and can we get there from here? M.J. Goddard, D. Krewski (Canada) Part 2, APPLYING MECHANISTIC RESEARCH TO RISK ASSESSMENT Hepatic and pulmonary carcinogenicity of methylene chloride in mice: a search for mecha- nisms R.R. Maronpot, T.R. Devereux, M. Hegi, J.F. Foley, J. Kanno, R. Wiseman, M.W. Anderson (USA, Switzerland, Japan) Incorporating biological information in quantitative risk assessment: an example with methylene chloride H.J. Clewell Ill (USA) 0300-483X/95/$09.50 © 1995 Elsevier Science Ireland Ltd. All rights reserved xt o 573 ' (On shh > a8 pe 4 Gag) ELSE ~~ Toxicology 102 (1995) 322-324 Volume contents Volume 102 (1995) Numbers 1,2 Special Issue: BIOLOGICAL MECHANISMS AND QUANTITATIVE RISK ASSESSMENT Proceedings of a symposium sponsored by the Health Effects Research Laboratory of the U.S. Environmental Protection Agency (November 1—4, 1993) Preface — R. Woodrow Setzer, Jr., L. Earl Gray, Jr INTRODUCTION Research to strengthen the scientific basis for health risk assessment: a survey of the context and rationale for mechanistically based methods and models K. Sexton, L.W. Reiter, H. Zenick (USA) Part 1. RISK ASSESSMENT AND RESEARCH: SETTING THE STAGE Assessing the risk assessment paradigm G.S. Omenn (USA) Historical perspective on risk assessment in the federal government J.D. Graham (USA) The future of mechanistic research in risk assessment: Where are we going and can we get there from here? M.J. Goddard, D. Krewski (Canada) Part 2, APPLYING MECHANISTIC RESEARCH TO RISK ASSESSMENT Hepatic and pulmonary carcinogenicity of methylene chloride in mice: a search for mecha- nisms R.R. Maronpot, T.R. Devereux, M. Hegi, J.F. Foley, J. Kanno, R. Wiseman, M.W. Anderson (USA, Switzerland, Japan) Incorporating biological information in quantitative risk assessment: an example with methylene chloride H.J. Clewell Ill (USA) 0300-483X/95/$09.50 © 1995 Elsevier Science Ireland Ltd. All rights reserved Volume contents 102 (1995) 322-324 Use of quantitative modelling in methylene chloride risk assessment L. Rhomberg (USA) Dioxins: model chemicals for assessing receptor-mediated toxicity M.J. DeVito, L.S. Birnbaum (USA) Biologically-based models of dioxin pharmacokinetics L.A. Buckley (USA) Biochemical mechanisms and cancer risk assessment models for dioxin M.C. Kohn (USA) Part 3. BIOLOGICAL MECHANISMS AND THEIR APPLICATION TO CANCER RISK ASSESSMENT Incorporating cell proliferation kinetics into models for cancer risk assessment S.H. Moolgavkar, E.G Luebeck (USA) Cell proliferation in the bladder and implications for cancer risk assessment S.M. Cohen (USA) Comparison of experimental and theoretical parameters of the Moolgavkar—Venzon—Knud- son incidence function for the stages of initiation and promotion in rat hepatocarcinogenesis Y.P. Dragan, J. Hully, K. Baker, R. Crow, M.J. Mass, H.C. Pitot (USA) Part 4. BIOLOGICAL MECHANISMS AND THEIR APPLICATION TO NON-CANCER RISK ASSESSMENT Cancer and non-cancer risk assessment: not so different if you consider mechanisms R.B. Conolly (USA) Pharmacokinetics and receptor-mediated pharmacodynamics of corticosteroids W.J. Jusko (USA) Toxicity prediction from metabolic pathway modelling R.C. Jackson (USA) Biological modeling of 5-fluorouracil developmental toxicity D.L. Shuey, R.W. Setzer, C. Lau, R.M. Zucker, K.H. Elstein, M.G. Narotsky, R.J. Kavlock, J.M. Rogers (USA) Regulatory and research issues related to cholinesterase inhibition S. Padilla (USA) Part 5. EMERGING RESEARCH AREAS IN HEALTH EFFECTS RISK ASSESSMENT. Negative selection in hepatic tumor promotion in relation to cancer risk assessment M.E. Andersen, J.J. Mills, R.L. Jirtle, W.F. Greenlee (USA) Risk assessment and biological mechanisms: lessons learned, future opportunities R.O. McClellan (USA) Number 3 In vitro murine embryotoxicity of cyclophosphamide in embryos co-cultured with maternal hepatocytes: development and application of a murine embryo-hepatocyte co-culture model (Maternal bioactivation is required for murine cyclophosphamide embryopathy) T.R.S. Ozolins, L.A. Oglesby, M.J. Wiley, P.G. Wells (Toronto, Canada; Research Triangle Park, 259-274 324 Volume contents Toxicology 102 (1995) 322-324 Porphyrin production and excretion by long-term cultures of adult rat hepatocytes and effect of lead exposure (Porphyrin excretion appears to be a sensitive indicator of Pb toxicity) B. Quintanilla-Vega, A. Hernandez, Ma.L. Lopez, G. Garcia-Vargas, M.E. Cebrian, T. Mendoza- Figueroa (Mexico City, Mexico) 275-283 Cadmium and mercury toxicity in a human fetal hepatic cell line (WRL-68 cells) (The system responds differently to the two metals) L. Bucio, V. Souza, A. Albores, A. Sierra, E. Chavez, A. Carabez, M.C. Gutiérrez-Ruiz (Mexico City, Mexico) 285-299 Immunotoxicity Role of interferon-y in contact hypersensitivity assessed in interferon-y receptor-deficient mice (Ear swel- ling to oxazolone or TNCB is not reduced in IFN-y knock-out mice, but dermal mononuclear infiltrates and epidermal microabscesses are diminished suggesting that contact hypersensitivity is partially depen- dent on a functional IFN-y system) M. Saulnier, S. Huang, M. Aguet, B. Ryffel (Schwerzenbach, Ziirich, Switzerland) 301-312 Contents of journals relating to toxicology 313-316 Author index 317 Subject index 318-321 Volume contents 322-324