th Program 8th International Conference on THROMBOSIS AND HEMOSTASIS ISSUES IN CANCER Seminario Vescovile “Giovanni XXIII” www.icthic.com April 8-10, 2016 • Bergamo, Italy AUSPICES The meeting is held under the auspices of Società Italiana per lo Studio dell'Emostasi e della Trombosi Società Italiana di Ematologia Società Italiana di Medicina Trasfusionale e Immunoematologia 2 AUSPICES CONFERENCE ORGANIZATION CONFERENCE CHAIRMEN Anna Falanga Benjamin Brenner Frederick R. Rickles Department of Immunohematology Department of Hematology The George Washington University and Transfusion Medicine and Bone Marrow Transplantation Katzen Cancer Center & Hemostasis and Thrombosis Center & Thrombosis and Hemostasis Unit 2150 Pennsylvania Ave NW Hospital Papa Giovanni XXIII Rambam Health Care Campus Washington, DC 20037, USA Piazza OMS, 1 Technion, Israel Institute of Technology & Division of Hematology 24127 Bergamo, Italy POB 9602 Haifa, Israel Department of Medicine e-mail: [email protected] e-mail: [email protected] Veterans Affairs Medical Center 50 Irving St NW Washington, DC 20422, USA e-mail: [email protected] ORGANIZING COMMITTEE Anna FALANGA Benjamin BRENNER Frederick R. RICKLES Bergamo, Italy Haifa, Israel Washington, DC, USA Marina MARCHETTI Alfonso VIGNOLI Laura RUSSO Bergamo, Italy Bergamo, Italy Bergamo, Italy SCIENTIFIC SECRETARIAT Anna Falanga | Marina Marchetti | Alfonso Vignoli | Laura Russo Department of Immunohematology and Transfusion Medicine Hospital Papa Giovanni XXIII Piazza OMS, 1 - 24127 Bergamo - Italy [email protected] ORGANIZING SECRETARIAT Servizi C.E.C. Srl Via G. Verdi, 18 - 24121 Bergamo - Italy Phone +39.035.249899 - Fax +39.035.237852 - [email protected] 3 SPONSORS Platinum Gold Silver Bronze 4 SPONSORS FACULTY Walter Ageno Italy Nigel S. Key USA Giancarlo Agnelli Italy Alok A. Khorana USA Tiziano Barbui Italy Stavros Kostantinides Germany Rupert Bauersachs Germany Nicole Kuderer USA Suzanne M. Bleker The Netherlands Agnes Y.Y. Lee Canada Benjamin Brenner Israel Frank W.G. Leebeek The Netherlands Harry Büller The Netherlands Marcel M. Levi The Netherlands Marc Carrier Canada Howard A. Liebman USA Marina Camera Italy Giancarlo Liumbruno Italy Giancarlo Castaman Italy Gary H. Lyman USA Elisabetta Castoldi The Netherlands Anthony Maraveyas UK Marco Cattaneo Italy Patrick Mismetti France Erica De Candia Italy Yona Nadir Israel Maria Benedetta Donati Italy Simon Noble UK Christophe Dubois France Ingrid Pabinger Austria Sabine Eichinger Austria Marina Panova-Noeva Germany Ismail Elalamy France Janusz Rak Canada Anna Falanga Italy Pieter H. Reitsma The Netherlands Augusto Federici Italy Frederick R. Rickles USA Brunilde H. Felding USA Wolfram Ruf USA Charles W. Francis USA Per Morten Sandset Norway Raffaella Giavazzi Italy Sam Schulman Canada Job Harenberg Germany Hugo ten Cate The Netherlands Licia Iacoviello Italy Henry H. Versteeg The Netherlands Davide Imberti Italy Ted Wun USA Aiay K. Kakkar UK Jeffrey Zwicker USA Pieter W. Kamphuisen The Netherlands 5 PROGRAM OVERVIEW Friday April 8th, 2016 Saturday April 9th, 2016 Sunday April 10th, 2016 09:00 08:00 Secretariat Opening 08:00 Secretariat Opening 08:30 08:30 Plenary Session 4 Plenary Session 7 Secretariat Hematological Treatment of Opening malignancies and cancer-associated hemostatic thrombosis complications Auditorium Auditorium 11:00 Congress Opening 10:45 Coffee Break 10:45 Coffee Break 11:15 11:15 11:15 Plenary Session 1 Plenary Session 5 Plenary Session 8 Epidemiology of Risk factors for Open questions in thrombosis in cancer thrombosis in cancer cancer and thrombosis Auditorium Auditorium Auditorium 13:30 13:30 13:30 Concluding Lunch Sessions Lunch Sessions 13:45 Remarks 14:30 14:30 Special Session Plenary Session 2 History of ICTHIC Role of hemostatic Auditorium pathways in cancer progression 15:00 Poster Sessions Auditorium with refreshments Poster Area 16:45 Coffee Break 17:15 Plenary Session 3 17:00 Plenary Session 6 Old and emerging Prophylaxis of biomarkers for thrombosis in cancer thrombosis and disease patients progression in cancer Auditorium Auditorium 19:10 19:30 4th Simon Karpatkin Memorial Lecture Auditorium Presidential Dinner 20:30 Welcome Reception 20:30 (by invitation only) 6 PROGRAM OVERVIEW PROGRAM Friday April 8th, 2016 CONGRESS OPENING 11.00 | 11.15 Opening remarks from the Conference Chairmen A. Falanga, F.R. Rickles, B. Brenner and representatives of Institutional Authorities SCIENTIFIC SESSIONS (Auditorium) 11.15 | 13.25 PLENARY SESSION 1: EPIDEMIOLOGY OF THROMBOSIS IN CANCER Chairs: N.S. Key (USA); M.B. Donati (Italy) 11.15 | 11.40 Venous thromboembolism and occult cancer: impact on clinical practice..........................................PL-01 M. Carrier (Canada) 11.40 | 12.05 Cancer associated thrombosis: risk factors and outcomes...............PL-02 S. Eichinger (Austria) 12.05 | 12.30 Update of incidental venous thromboembolism in cancer ................PL-03 H.A. Liebman (USA) 12.30 | 12.55 Thrombosis and anticancer therapies: the contribution of chemotherapy and the specific drugs implicated in cancer associated thrombosis........PL-04 P. Mismetti (France) SELECTED ABSTRACTS 12.55 | 13.10 Clinical hystory of cancer patients with isolated distal deep vein thrombosis: a multicenter cohort study .......................... OC-01 F. Dentali, S. Pegoraro, S. Barco, M.N.D. di Minno, D. Mastroiacovo, F. Pomero, C. Lodigiani, F. Bagna, M. Sartori, G. Barillari, N. Mumoli, M. Napolitano, S. Passamonti, R. Benedetti, W. Ageno, M. di Nisio (Italy) 13.10 | 13.25 Risk of Arterial Thromboembolism in Patients with Breast Cancer........ OC-02 B.B. Navi, A.S. Reiner, H. Kamel, C. Iadecola, M.S.V. Elkind, K.S. Panageas, L.M. DeAngelis (USA) 13.30 | 14.30 Lunch Sessions (see page 20) 14.30 | 16.40 PLENARY SESSION 2: ROLE OF HEMOSTATIC PATHWAYS IN CANCER PROGRESSION Chairs: R. Giavazzi (Italy); B. Brenner (Israel) 14.30 | 14.55 Microparticles and cancer thrombosis in animal models.................PL-05 C. Dubois (France) 14.55 | 15.20 Inhibition of platelet function as a target for cancer progression control....PL-06 B.H. Felding (USA) 7 15.20 | 15.45 Biological basis of personalised anticoagulation in cancer: oncomir networks as regulators of coagulopathy.......................PL-07 J. Rak (Canada) 15.45 | 16.10 Heparanase procoagulant activity in cancer progression.................PL-08 Y. Nadir (Israel) SELECTED ABSTRACTS 16.10 | 16.25 Modelisation of the procoagulant properties of cancer cells and their capacity to alter the antithrombotic efficiency of LMWHs and specific inhibitors of factor Xa .. OC-03 G.T. Gerotziafas, A. Rousseau, P. van Dreden, E. Mbemba, V. Gkalea, A. Khaterchi, A. Larsen, I. Elalamy (France) 16.25 | 16.40 Tissue factor positive microvesicles activate platelets in vitro and in vivo and enhance thrombosis in mice.................... OC-04 Y. Hisada, J.E. Geddings, Y. Boulaftali, T.M. Getz, M. Whelihan, R. Fuentes, R. Dee, B.C. Cooley, N.S. Key, A.S. Wolberg, W. Bergmeier, N. Mackman (USA) 16.45 | 17.15 Coffee break 17.15 | 19.25 PLENARY SESSION 3: OLD AND EMERGING BIOMARKERS FOR THROMBOSIS AND DISEASE PROGRESSION IN CANCER Chairs: S. Kostantinides (Germany); P. Reitsma (The Netherlands) 17.15 | 17.40 Cancer-associated thrombosis novel biomarker discovery ...............PL-09 N. Kuderer (USA) 17.40 | 18.05 Venous thromboembolism risk assessment models in cancer ............PL-10 I. Pabinger (Austria) 18.05 | 18.30 Polymorphisms of clotting factors and cancer risk......................PL-11 P.M. Sandset (Norway) 18.30 | 18.55 Hypercoagulation markers in early diagnosis and prognosis in cancer: The Hypercoagulation Screening in Cancer (HYPERCAN) prospective study .................................................PL-12 A. Falanga (Italy) SELECTED ABSTRACTS 18.55 | 19.10 D-Dimer, fibrinogen and TEG-MA predict thromboembolism in Non-Small Cell Lung Cancer – Interim results from a prospective cohort study....... OC-05 M. Alexander, R. Wolfe, D. Ball, R. Manser, M. McManus, B. Riedel, B. Solomon, D. Westerman and K. Burbury (Australia) 8 PROGRAM 19.10 | 19.25 Pro-thrombotic biomarkers in pancreatic diseases: are they specific of cancer?........................................ OC-06 D. Faille, N. Ajzenberg, L. de Chaisemartin, V. Granger, S. Chollet-Martin, E. de Raucourt, P. Hammel, P. Lévy, P. Ruszniewski, V. Rebours (France) 19.30 | 20.30 PLENARY LECTURE: 4TH SIMON KARPATKIN MEMORIAL LECTURE Chairs: A. Falanga (Italy); B. Brenner (Israel); F.R. Rickles (USA) Introduction to Lecture F.R. Rickles (USA) Targeting-clotting proteins in cancer therapy: progress and challenges W. Ruf (USA) Saturday April 9th, 2016 8.30 | 10.40 PLENARY SESSION 4: HEMATOLOGICAL MALIGNANCIES AND HEMOSTATIC COMPLICATIONS Joint symposium of the European Hematology Association (EHA) in collaboration with the Scientific Working Group (SWG) on Bleeding and Thrombosis Chairs: On behalf of the EHA: A. Falanga (Italy); On behalf of the SWG: T. Barbui (Italy) 8.30 | 8.55 Intracranial hemorrhage in cancer patients on anticoagulation............PL-13 On behalf of the SWG: J. Zwicker (USA)....................................... 8.55 | 9.20 Management of cancer-associated disseminated intravascular coagulation PL-14 On behalf of the EHA: M. Levi (The Netherlands)................................. 9.20 | 9.45 New insights into the biology and management of thrombosis in myeloproliferative neoplasms .......................................PL-15 On behalf of the SWG: T. Barbui (Italy) 9.45 | 10.10 Update of thrombosis in multiple myeloma ............................PL-16 On behalf of the EHA: F.W.G. Leebeek (The Netherlands) SELECTED ABSTRACTS 10.10 | 10.25 Decoding risk for thromboembolic events in lymphoma patients ......... OC-07 D. Antic, N. Milic, M. Todorovic, J. Bila, B. Andjelic, V. Djurasinovic, A. Sretenovic, V. Vukovic, J. Jelicic, S. Nikolovski, B. Mihaljevic (Serbia) 10.25 | 10.40 Multiple functional defects in platelets from thrombocytopenic cancer patients undergoing chemotherapy ........................... OC-08 C. Baaten, F.C.J.I. Moenen, Y.M.C. Henskens, F. Swieringa, R. Wetzels, R. van Oerle, H. ten Cate, E.A.M. Beckers, J.W.M. Heemskerk and P.E.J. van der Meijden (The Netherlands) 10.45 | 11.15 Coffee Break 9 11.15 | 13.25 PLENARY SESSION 5: RISK FACTORS FOR THROMBOSIS IN CANCER Chairs: I. Elalamy (France); G. Liumbruno (Italy) 11.15 | 11.40 Upper extremity deep vein thrombosis: comparison between cancer and non-cancer patients............................................PL-17 S.M. Bleker (The Netherlands) 11.40 | 12.05 Risk of thrombosis and supportive care (transfusion, catheters, growth factors) ...............................PL-18 G. Castaman (Italy) 12.05 | 12.30 New findings from global registries of cancer-associated thrombosis......PL-19 A.K. Kakkar (UK) 12.30 | 12.55 Predictors of recurrent venous thromboembolism and bleeding on anticoagulation .....................................PL-20 A.A. Khorana (USA) SELECTED ABSTRACTS 12.55 | 13.10 Microparticle-mediated transfer of TF hypercoagulability between cancer cells ............................................. OC-09 H. Shaker, C. Kirwan, A. Rothmeier, W. Ruf (UK) 13.10 | 13.25 Disseminated intravascular coagulation at diagnosis strongly predicts both arterial and venous thrombosis in acute myeloid leukemia patients....... OC-10 E.J. Libourel, C. Klerk, Y. van Norden, M.P.M. de Maat, M.J. Kruip, P. Sonneveld, B. Löwenberg, F.W.G. Leebeek (The Netherlands) 13.30 | 14.30 Lunch Sessions (see page 21) 14.30 | 15.00 SPECIAL SESSION Chairs: H. Liebman (USA); A. Falanga (Italy); B. Brenner (Israel) History of ICTHIC - How has the field progressed since our first meeting in 2001? ...................................... SPL F.R. Rickles (USA) 15.00 | 17.00 POSTER SESSIONS WITH REFRESHMENTS POSTER WALK DISCUSSION SESSIONS WITH CHAIR (NOT CME ACCREDITED) 15.00 | 16.00 Poster Discussion Sessions 1, 2 and 3 (Poster Area, see pages 13-16) 16.00 | 17.00 Poster Discussion Sessions 4, 5 and 6 (Poster Area, see pages 16-19) 10