THE JOURNAL OF 2006 Volume 208 Pathology JPTLAS 207 (1-5) 1-738 (2006) ISSN 0022-3417 The Journal of The Pathological Society — ‘Understanding disease’ Editor-in-Chief Professor C Simon Herrington: Bute Medical School, Bute Medical Buildings, University of St Andrews, St Andrews, Fife KY16 9TS, UK Associate Editors Professor Andrew M Hanby: Academic Unit of Pathology, St James’s University Hospital, Beckett Street, Leeds LS9 7TF, UK Professor Pancras CW Hogendoorn: Department of Pathology, Leiden University Medical Centre, L-1-Q PO Box 9600, The Netherlands, 2300 RC Professor C James Kirkpatrick: Institute of Pathology, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany Professor Graeme | Murray: Department of Pathology, University of Aberdeen, University Medical Buildings, Foresterhill, Aberdeen AB25 2ZD, UK Professor Richard Poulsom: Histopathology Unit, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK Professor Rosemary A Walker: Department of Pathology, University of Leicester, Clinical Sciences Building, PO Box 65, Leicester Royal Infirmary, Leicester LE2 7LX, UK Reviews Editor Professor Fred T Bosman: University Institute of Pathology, Rue du Bugnon 25, 1011 Lausanne, Switzerland Advisory Board Professor AD Burt Professor JR Jass Professor M Sobrinho-Simoes Professor AH Wyllie Newcastle, UK Montreal, Canada Porto, Portugal Cambridge, UK Professor CDM Fletcher Professor G Kloppel Professor H Stein Professor RM Zinkernagel Boston, USA Kiel, Germany Berlin, Germany Zurich, Switzerland Professor PA Hall Professor DA Levison Professor PG Toner Belfast, UK Dundee, UK Cheltenham, UK Professor KJ Hillan Professor CULM Meijer Professor DH Wright San Francisco, USA Amsterdam, The Netherlands Winchester, UK Professor PG Isaacson Professor M Pignatelli Professor NA Wright London, UK Bristol, UK London, UK Editorial Board Professor M Alison Professor MQ Du Professor M Ilyas Professor MG Papotti London, UK Cambridge, UK Leeds, UK Turin, Italy Dr MJ Arends Professor S Fleming Professor SR Lakhani Dr D Rimm Cambridge, UK Dundee, UK Brisbane, Australia Yale, USA Professor P Bedossa Professor AJ Freemont Professor JE Martin Dr SEH Russell Paris, France Manchester, UK London, UK Belfast, Northern Ireland Dr PJ Coates Professor P Furness Professor U Moll Professor W Timens Dundee, UK Leicester, UK Stony Brook, USA Groningen, The Netherlands Professor C Cuvelier Dr J Going Professor G Niedobitek Professor KF To Ghent, Belgium Glasgow, UK Erlangen, Germany Hong Kong Professor MJAP Daemen Dr P Harnden Dr K Oien Professor IPM Tomlinson Maastricht, The Netherlands Leeds, UK Glasgow, UK London, UK Dr DC Douek Professor F Hofstadter Professor ST Pals Professor P Waring Bethesda, USA Regensburg, Germany Amsterdam, The Netherlands San Francisco, USA Aims and Scope The main interests of The Journal of Pathology lie in the pathophysiological and pathogenetic mechanisms of human disease and in the application of such knowledge to diagnosis and prognosis. In determining content, the primary considerations are excellence, relevance and novelty The Journal welcomes investigative studies on human tissues, experimental studies in vitro and in vivo, and investigations based on animal models with a clear relevance to human disease, including transgenic systems. Methodological improvements in investigative and diagnostic pathology are also of interest. Correlative studies of pathological data and clinical outcomes are considered but purely descriptive papers on diagnostic pathology are not central to the Journal’s purpose. In general, studies that appropriately employ multiple investigative techniques are preferred over those that rely on a single methodology. Illustrations must be of the highest quality to be acceptable for publication. As well as original research papers, the Journal seeks to provide rapid publication in a variety of other formats, including editorials, review articles and other features, both contributed and solicited. Papers covering significant developments in teaching methods and in the practice of pathology may be acceptable ift hey are of international scope and relevance. Correspondence from readers will be published if it is of general interest. In summary, the Journal aims to serve as a bridge between basic biomedical science and clinical medicine with particular emphasis on morphologically based studies. As the journal of The Pathological Society, it seeks to reflect the broad scientific interests of the Society’s membership but its ethos, authorship, content and purpose are those expected of a leading publication in the international scientific literature. Volume Contents Volume 208, Number | January 2006 Perspective Assessing p53 in clinical contexts: unlearned lessons and new perspectives PA Hall and WG McCluggage Review Article Human breast epithelial stem cells and their regulation H Kalirai and RB Clarke Or gina Papers Dereauiation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development U Tostar, CU Malm, JM Meis-Kindblom, L-G Kindblom, R Toftgard and AB Unden TGF-1 drives partial myofibroblastic differentiation in amen fibroma of bone S Romeo, B Eyden, FA Prins, IH Briaire-de Bruijn, AHM Taminiau and PCW Hogendoorn Synovial fluid macrophages are capable of osteoclast formation and resorption IE Adamopoulos, A Sabokbar, BP Wordsworth, A Carr, DJ Ferguson and NA Athanasou Autocrine motility factor/glucose-6-phosphate isomerase is a senitelie predictor of metastasis in bone and soft tissue tumours Y Dobashi, H Watanabe, M Matsubara, T Yanagawa, A Raz, T Shimamiya and A Ooi.. Oxidative stress in fibroblasts from patients with pseudoxanthoma elasticum: possible role in the osteiniaieatn of clinical manifestations I Pasquali-Ronchetti, MI Garcia-Fernandez, F Boraldi, D Quaglino, D Gheduzzi, C De Vincenzi Paolinelli, R Tiozzo, S Bergamini, D Ceccarelli and U Muscatello How ischaemic preconditioning protects small liver grafts R Franco-Gou, J Rosellé-Catafau, A Casillas-Ramirez, M Massip-Salcedo, A Rimola, N Calvo, R Bartrons and C Peralta Amelioration of non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice vmo ral immune omens towards liver-extracted proteins is associated with elevated intrahepatic NKT lymphocytes and serum IL-10 levels E Elinav, O Pappo, M Sklair-Levy, M Margalit, O Shibolet, M Gomori, R Alper, B Thalenfeld, D Engelhardt, E Rabbani and Y Ilan lron-free neoplastic nodules and hepatocellular carcinoma without cirrhosis in Wistar rats fed a diet high in iron GA Asare, AC Paterson, MC Kew, S Khan and KS Mossanda iLK over-expression in human colon cancer progression correlates with activation of p-catenin, Seneneantiaien of E-cadherin and activation of the Akt-FKHR pathway V Bravou, G Klironomos, E Papadaki, S Taraviras and J Varakis . Methylation of APC, TIMP3 and TERT: a new predictive marker to distinguish Barrett’s oesophagus patients at risk for malignant transformation G Clément, R Braunschweig, N Pasquier, FT Bosman and J Benhattar.......... Role of metalloproteinases MMP-9 and MT1-MMP in CXCL12-promoted myeloma cell invasion across basement membranes M Parmo-Cabanas, I Molina-Ortiz, S Martias-Roman, D Garcia-Bernal, X Carvajal-Vergara, I Valle, A Pandiella, AG Arroyo and J Teixido Contiguous spread of Mycobacterium ulcerans in Buruli ulcer lesions ines byp inataten and real-time PCR quantification of mycobacterial DNA S Rondini, C Horsfield, E Mensah-Quainoo, T Junghanss, S Lucas and G Pluschke Announcements Volume Contents Volume 208, Number 2 January 2006 Introductory Article infection and disease: cause and cure CS Herrington and DC Douek 131 Review Articles Pathogenesis and prevalence of variant Creutzfeldt-Jakob disease DA Hilton 134 How the SARS coronavirus causes disease: host or organism? AWI Lo, NLS Tang and K-F To 142 HPV-mediated cervical carcinogenesis: concepts and clinical implications PJF Snijders, RDM Steenbergen, DAM Heideman and CJLM Meijer 152 HPV-associated skin disease B Akgiil, JC Cooke and A Storey Viruses and lymphoma/leukaemia RF Jarrett 176 a The pleiotropic effects of Kaposi’s sarcoma herpesvirus TF Schulz Morbilliviruses and human disease BK Rima and WP Duprex Subversion of cellular functions by Listeria monocytogenes J Pizarro-Cerda and P Cossart The pathogenesis of syphilis: the Great Mimicker, revisited RW Peeling and EW Hook, III Helicobacter infection and gastric neoplasia RM Peek Jr and JE Crabtree Innate defences against methicillin-resistant Staphylococcus aureus (MRSA) infection H Komatsuzawa, K Ouhara, S Yamada, T Fujiwara, K Sayama, K Hashimoto and M Sugai New insights into the function of granulomas in human tuberculosis T Ulrichs and SHE Kaufmann The function of immunoglobulin A in immunity JM Woof and MA Kerr Rational design of gene-based vaccines DH Barouch Bacterial gene therapy strategies G Vassaux, J Nitcheu, S Jezzard and NR Lemoine Viral gene therapy strategies: from basic science to clinical application LS Young, PF Searle, D Onion and V Mautner Volume Contents Volume 208, Number 3 February 2006 Review Articles Regulation and interplay of apoptotic and non-apoptotic cell death R Kim, M Emi, K Tanabe, S Murakami, Y Uchida and K Arihiro ae atk al - Tissue factor pathway inhibitor: structure, biology and involvement in disease BA Lwaleed and PS Bass . Original Papers Expression and functional analysis of Bax inhibitor-1 in human breast cancer cells M Grzmil, S Kaulfuss, P Thelen, B Hemmerlein, S Schweyer, S Obenauer, TW Kang and P Burfeind PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma F Buttitta, L Felicioni, F Barassi, C Martella, D Paolizzi, G Fresu, S Salvatore, F Cuccurullo, A Mezzetti, D Campani and A Marchetti Microsomal prostaglandin E, synthase-1 in breast cancer: a potential target for therapy S Mehrotra, A Morimiya, B Agarwal, R Konger and S Badve The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis HY Lau and M Bhatia Knock-down of hepatitis B virus X protein reduces the tumorigenicity of hepatocellular carcinoma cells DW Chan and IO Ng Characterization of tumour-infiltrating lymphocytes and apoptosis in colitis-associated neoplasia: comparison with sporadic colorectal cancer JM Michael-Robinson, N Pandeya, MD Walsh, A-E Biemer-Huttmann, RD Eri, RL Buttenshaw, D Lincoln, AD Clouston, JR Jass and GL Radford-Smith Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with seabieesenie morphology P Brandal, B Bjerkehagen and S Heim Germ cell lineage differentiation in non-seminomatuus germ cell tumours F Honecker, H Stoop, F Meyer, C Bokemeyer, DH Castrillon, Y-FC Lau, LHJ Looijenga and JW Oosterhuis The p38 transduction pathway in prostatic neoplasia M Ricote, I Garcia-Tunhon, F Bethencourt, B Fraile, P Onsurbe, R Paniagua and M Royuela Differential expression of oestrogen receptors in human aauaiions lymphoid tissues G-J Shim, D Gherman, H-J Kim, Y Omoto, H Iwase, D Bouton, LL Kis, C Thulin Andersson, M Warner and J-A Gustafsson Immunoglobulin V, genes in thymic MALT lymphoma are biased toward a restricted repertoire and ome unmutated M Yoshida, M Okabe, T Eimoto, S Shimizu, K Ueda-Otsuka, M Okamoto, G Ishii, R Ueda, JKC Chan, S Nakamura and H Inagaki Cytokine gene expression profile distinguishes CD4+/CD57* T cells of the nodular enatiniini osetia type of Hodgkin’s lymphoma from their tonsillar counterparts C Atayar, S Poppema, L Visser and A van den Berg The expression of fibroblast growth factors and their receptors in Hodgkin’s lymphoma D Khnykin, G Troen, J-M Berner and J Delabie Inducible nitric oxide synthase activity correlates with lymphangiogenesis and vascular endothelial growth factor-C expression in head and neck squamous cell carcinoma A Franchi, D Massi, M Santucci, E Masini, DR Degl’Innocenti, L Magnelli, E Fanti, A Naldini, C Ardinghi, F Carraro and O Gallo Career choices for pathology: national surveys of graduates of 1974-2002 from UK medical schools TW Lambert, MJ Goldacre, G Turner, P Domizio and C du Boulay Volume Contents Volume 208. Number 4 March 2006 Role of the ephrin and Eph receptor tyrosine kinase families in angiogenesis and development of the cardiovascular 453 system J Zhang and SE Hughes Centrosome-, chromosomal-passenger- and cell-cycle-associated mRNAs are differentially regulated in the development of sporadic colorectal cancer U Gerlach, G Kayser, Al Walch, U Hopt, J Schulte-Monting, M Werner and S Lassmant Higher neutrophil infiltration mediated by osteopontin is a likely contributing factor to the increased susceptibility of females to alcoholic liver disease A Banerjee, UM Apte, R Smith and SK Ramaiah Comparative expressed Sequence biotnrrecser eveals differential gene expression in morphological breast cancer subtypes I Vanden Bempt, V Vanhentenrijk, M Drijke gen and C De Wolf-Peeters my and immunophenotypic — of breast carcinomas with basal and myoepithelial differentiation EA Rakha, TC Putti, DM Abd El-Rehim, C Paish, AR Green, DG Powe, AH Lee, JF Robertson and IO Ellis The absence of CCL2 expression in cervical carcinoma is associated with increased survival and loss of heterozygosity at 17q11.2 HJMAA Zijlmans, GJ Fleuren, HJ Baelde, PHC Eilers, GG Kenter and A Gorter Testicular development in the complete androgen insensitivity syndrome SE Hannema, IS Scott, E Rajpert-De Meyts NE Skakkebaek, N Coleman and IA Hughes Early embryonic demise: no evidence of abnormal spiral artery transformation or trophoblast invasion E Ball, SC Robsor S Ay . a Lyall af i1JNB Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion E Ba JN Bulmer S Ayis F Lyall and SUC Robso A gene expression een that distinguishes desmoid tumours from nodular fascilitis M Bacac, E Migliavacca J-C Stehie vicKee. M Delorenzi, J-M Coindre, L Guillou and I Stamenkovic Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and Pr evaluation of the different histological components A Ehrbrecht, U Miller, M Wolter, A Hoischen, A Koch BR; mmoer, B ActorA, Mincheva, T Pietsch, P Lichter, G Reifenbergearn d RG Weber Lack of ones and 7 ee in meningiomas without NF2 loss AAG van Tilborg, B Morolli, M Giphart-Gassler. A de Vries, DAN v nen, I Lurkis A Kros and EC Zwarthoff Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis J-H Martens, J Kzhyshkowska, M Falkowski-Hansen, K Schledzewski, A Gratchev, U Mansmann, C Schmuttermaier, E Dippel, W Koenen, F Riedel, M Sankala, K Tryggvason, L Kobzik G Moldent juer, BArnold and S Goerat Re: Ward et a/. Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified. J Pathol 2005; 207: 377-384 JR Jass Authors’ reply: Response to Jass RL Ward, J Turner and NJ Hawkins Volume Contents Volume 208, Number 5 April 2006 Review Article Array based proteomics: mapping of protein circuitries for diagnostics, prognostics and therapy guidance in cancer C Gulmann, KM Sheehan, EW Kay, La Liotta and EF Petricoin III pam Sieiscabanbioey oeiaiaceiein 595 Original Papers A new approach to the validation of tissue microarrays L Goethals, C Perneel, A Debucquoy, H De Schutter, D Borghys, N Ectors, K Geboes, WH McBride and KM Haustermans PDGFRa, PDGFR® and KIT expression/activation in conventional chondrosarcoma MS Lagonigro, E Tamborini, T Negri, S Staurengo, GP Dagrada, F Miselli, E Gabanti, A Greco, PG Casali, A Carbone, MA Pierotti and S Pilotti ..........000000..... STAT3 is activated in a subset of the Ewing sarcoma family of tumors R Lai, F Navid, C Rodriguez-Galindo, T Liu, CE Fuller, R Ganti, J Dien, J Dalton, C Billups and JD Khoury. . Down-regulation of the claudin-18 gene, identified through serial ores of gene expression data analysis, in gastric cancer with an intestinal phenotype Y Sanada, N Que, Y Mitani, K Yoshida, H Nakayama and WY asui ........ Primary tumour genetic alterations and intra-tumoral heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability D Guenot, E Guérin, S Aguillon-Romain, E Pencreach, A Schneider, A Neuville, M-P Chenard, I Duluc, S Du Manoir, C Brigand, P Oudet, M Kedinger and M-P Gaub Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic nei related? H Denk, C Stumptner, A Fuchsbichler, T Muller, GH Farr, W Muller, LM Terracciano and K Zatloukal Dysregulated expression of Pl and P2 promoter-driven hepatocyte nuclear factor-4a in the pathcgenesis of human cancer T Tanaka, S Jiang, H Hotta, K Takano, H Iwanari, K Sumi, K Daigo, R Ohashi, M Sugai, C Ikegame, H Umezu, Y Hirayama, Y Midorikawa, Y Hippo, A Watanabe, Y Uchiyama, G Hasegawa, PC Reid, H Aburatani, T Hamakubo, J Sakai, M Naito and T Kodama. Tenascin C and annexin Il expression in the process of pancreatic carcinogenesis I Esposito, R Penzel, M Chaib-Harrireche, U Barcena, F Bergmann, S Riedl, H Kayed, N Giese, J Kleeff, H Friess and P Schirmacher ...................cccc0eeeeeee Development of testicular inflammation in the rat involves activation of proteinase-activated receptor-2 R Iosub, J Klug, M Fijak, E Schneider, S Frohlich, K Blumbach, G Wennemuth, C Sommerhoff, M Steinhoff and A Meinhardt The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion PCMS Verhagen, PW van Duijn, KGL Hermans, LHJ Looijenga, RJHLM van Gurp, H Stoop, TH van der Kwast and J Trapman .. High frequency of f-catenin mutations in boderline endometrioid tumours of the ovary E Oliva, D Sarrio, EF Brachtel, C Sanchez-Estévez, RA Soslow, G Moreno-Bueno and J Palacios sain es Immunohistochemical profiling based on Bcl-2, CD10 and MUM1 expression improves risk stratification in patients with primary nodal diffuse large B cell lymphoma JJF Muris, CULM Meijer, W Vos, JHJM van Krieken, NM Jiwa, G Ossenkoppeie and JJ Oudejans The HAUSP gene plays an important role in non-small cell an carcinogenesis through 053-d nniiteis is D Masuya, C-L Huang, D Liu, T Nakashima, H Yokomise, M Ueno, N Nakashima and S Sumitomo .. Journal of Pathology J] Pathol 2006; 208: vii—x. Keyword index acute pancreatitis, 364 comparative genome head and neck squamous cell lymphangiogenesis, 439 adenovirus, 283 hybridization, 643 carcinoma, 439 lymphoma, 176, 408, 431 African dietary iron overload, 82 comparative genomic Helicobacter pylori >2423 Akt, 91 hybridization, 554 hepatitis B virus X protein, 37 alcohol, 473 complete androgen insensitivity hepatocellular carcinoma, 37 M. ulcerans, 119 algorithm, 714 syndrome, 518 653 macrophages, 35 allelotyping, 564, 643 connective tissue, 54 hepatocyte nuclear malignancy of children and altered hepatic foci, 82 conventional central primary factor-4a, 662 young adults, 624 alternative promoter, 662 chondrosarcoma, 615 HHV-8, 176 Mallory bodies, 653 aminosalicylates, 381 copper toxicosis, 653 histopathology, 119 MARCO, 574 angiogenesis, 453 coronavirus, 142 Hodgkin’s lymphoma, 423, 431 mast cells, 686 aannnteixtihnr ombIIo,t i6c7 3 agent, 3 5,5 CcPy9c6l,o3ox4y5g,e na3s6e4, 356 HHSPPV,, 6126 5 mmedams2l,es , 72419 9 APC, 100 HTLV-1, 176 medical education, 446 cytogenetics, 388 apoptosis, 165, 340, 381 human papillomavirus, 152 medulloblastoma, 554 aapssoapyt,o tic| cell death, 319 cytpooklinyem orgpehnies ms, 3322 hyaluronan receptor, 574 mMeEnKi-n6g,i om4a0,1 564 cytokines, 142, 423, 686 ATF-2, 401 metastasis, 44 Aurora-A/STK15, 462 IgA, 270 methylation, 564 autocrine motility factor, 44 defensin, 249 gA deficiency, 270 microarrays, 543 autoimmune disease, 408, 415 desmoid tumour, gA nephropathy, 270 microbiology, 131 autoimmune orchitis, 686 diagnosis, 131 IgA1 proteases, 270 microsatellite instability, 381 differentiation, 395 IL-1, 62 microsomal prostaglandin E > ILK, 91 bbaaccttbeeirrniidaai,ln g 2i8mp3mr,ou tne2oi9gn0sl ,o bu2l70i n ddiirfeficuyts mep hhelopamaragte,o c aBr 7c1ci4enl lo genicity, 82 iimmmmgueunnneoe,g l4or1be5su ploinns e, he2a6v1y, c2h8a3i n mmiisgscryaantrtirhoianas,ge e,, 1035852 68 , 535 Barrett's oesophagus, 100 disease, 199 immunohistochemistry, | model, 152 basal, 495 DNA methylation, 100 immunology, 131 molecular genetics, 554 bax, 724 immunoprofile, 495 molecular targets, 615 Bax inhibitor-1, 340 EBV, 176 immunosuppression, 187 monoclonal antibody, 662 morbillivirus, 199 bBielo-c2h,e mi7s1t4r y, 3 ia eEl-acsatdinh ermiinn,e ra9l1i,z a2t1i5o n, 54 iinnffeercttiiloint,y , 163816, 199 morphology, 495 bbiiooimnafrokremra tidciss cov5e9r5y , 595 eElnkd-o1m,e t4r0i1o id carcinoma, 708 iinnffllaammmmaattioorny, b2o3w3e l disease, 290 mMMRRRPSN6AA,,, 542444 9 bone and soft tissue tumours, 44 endothelial cell, 453 innate immunity, 249 mucosal immunity, 270 bone neoplasm, 26 Eph, 453 internalin, 215 multicentric Castleman’s borderline endometrioid ephrin, 453 international prognostic tumour, 708 epithelial—mesenchymal index, 714 muldtiispelaes e,m ye18l7o ma, 108 breast. 7 transition, 9] interplay, 319 MUM1, 714 bbrreeaasstt ccaanncceerr, hi3s40t,o lo3g5y6,, 438506 EEwRiBnBg2 s,a 4r8c6o ma, 624 iinnttersatcienlallu larm etahpylaalsiinae, bo6d6i2e s, 653 mMuytcaotbioanc,t er|i um tuberculosis, 261 bBrSeEa,s t 1c3a4r cinoma, 495 eExWpSr,e ssi6o2n4 profiling, 486 iinnvvaassiiovne, du1c0t8a l carcinoma, 486 mmyyooefpiibtrhoeblliaaslt,, 42965 extracellular matrix, 54, 673 invasive lobular carcinoma, 486 cag pathogenicity island, 233 ischaemia-reperfusion, 62 cancer, 7, 290, 299, 595 Fe receptors, 270 NASH, 74 ccaanncceerr ptrreoagtrmeesnsti,o n, 3199 ] females, 473 Kaposi's sarcoma, 187 NneBoCplCaSs,ia , 171 52 carcinogenesis, 152 ferrocene, 82 Kaposi's sarcoma neurokinin receptors, 364 carcinoma, 507 fibroblast, 54 herpesvirus, 187 neutrophils, 473 carcinoma of unknown fibroblast growth factor, 431 keratinocytes, 249 nitric oxide, 439 primary, 662 fibroblast growth factor keratins, 653 NKT lymphocytes, 74 career choice, 446 receptor, 431 KIT, 615 nodular fasciitis, 543 B-catenin mutation, 708 fibroblasts/myofibroblasts, 543 KRAS , 708 nodular lymphocyte cathelicidin, 249 FKHR, 91 predominance type of CD47 /CD57* T cells, 423 FLI1, 624 Hodgkin's lymphoma, 423 CD10, 714 lectin receptors, 574 non-apoptotic cell death, 319 cell proliferation, 372 gastric cancer, 633 leukaemia, 176 non-melanoma skin cancer, 165 cell transformation, 37 gastric neoplasia, 233 Lieber-DeCarli diet, 473 nude mouse, 643 centrosomes, 462 gene amplification, 554 lipoblastoma, 388 cervix, 152, 507 gene expression, 543 lipomatous tumour, 388 CESH, 486 gene therapy, 290, 299 Listeria, 290 ob/ob mice, 74 chemokines, 142 genetic instability, 462 Listeria monocytogenes, 215 oestrogen receptor, 340, 408 chemokines, germ cell lineage, 395 listeriolysin O, 215 oncolytic, 299 metalloproteinases, 108 germ cell tumour, 395, 518 liver, 574 ongoing mutation, 415 chondromyxoid fibroma, 26 liver regeneration, 62 oral immune regulation, 74 chromosome instability, 643 germinal centre, 408 lobular carcinoma, 350 organism, 283 CIN, 152 granuloma, 261 loss of heterozygosity, 507 osteoarthritis, 35 CJD, 134 granzyme B, 381 lung, 364 osteoclasts, 35 claudin-18, 633 lung cancer, 724 osteopontin, 473 colon cancer, 643 HAUSP, 724 lymph node, 574 ovary, 708 colorectal cancer, 381, 462 HCV, 176 lymph node metastasis, 439 oxidative stress, 54, 62 Copyright 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. J Pathol 2006; 208: vii—x. Author index teon ‘ signal transduction, 453 transformation xantinoma elastic ! Ssignailing pt athway, 7 translational 1 PXE), 54 sinusoidal endothelial cei treatment, 13 PTCH nusoidal macrophage Treponeme PTEN, 699 smooth muscle actin, 2 trophoblast TEN vat vpermuta n tuIbDeErr CUIO| SIS rai artery 1S PDGFR PDGER Pk ( kowski-Hansen, M, 574 GP, 615 inti, E, 439 Daigo, K, 662 arr, GH, 653 Dalton, J, 624 elicioni. L. 350 Debucquoy, A, 60 erguson. DJ. 35 Deg! Innocenti, DR, 439 lig M. 686 Delabie. J, 43] le *n. GJ. 507 Delorenzi, M, 543 raile 401 Denk, H, 653 anchi. A. 439 De Schutter, H, 607 ranco-Gou, R, 62 De Vincenzi Paolinelli, C, 54 le Vries, A, 564 Bac 1S M Badve, S Dien, J, 624 ihlich. S. 686 Baelde, HJ Dippel E. 574 uchsbichler, Ball, E, 52 Dobashi, Y, 44 ujiwara, T Banerjee Domizio, P, 446 uller, CI Barassi, f ; Douek, DC, 131 Barcena, U, 673 aial-Vercara ' Drijkoningen, M, 486 Barouch, DH, 283 asali. PG. 615 d:u Boulay, C, 44a 6 Gabanti, E, 615 Bartrons. R. 6? asStirlilllaosn-.R amDiHr.e z, 395 A DJuu luc,M anoIi, r.64 3 S, 643 GGaaaln:n lttoi ,, OR,, F 64223 49 Bass, PS, 327 astrill . Duprex, WP. 199 Garcia-Bernal, D, 108 ; Benhattar, J, 100 eccarelli, D 4 Garcia-Fernandez, MI, 54 Bergamini, S, 54 haib-Harrireche, M 7 Garcia-Tufién, I, 401 Bergmann, F, 673 han, DW, 372 Ectors, N, 607 Gaub, M-P, 643 Berner, J-M, 431 han, JKC, 415 Ehrbrecht, A, 55 Geboes, K, 607 Bethencourt, F, 401 henard, M-P, 643 Gerlach, U, 462 Bhatia, M, 364 larke, RB, 7 Gheduzzi, D, 54 Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd J Pathol 2006; 208: vii—x