Volume Contents Volume 197, Number | May 2002 Editorials The glomerulo-tubular junction: a target in renal diseases: G. M. Lindop, |. W. Gibson, T. T. Downie, D. Vass and P. ( ohen Radiotherapy and rectal cancer: N. Scott Review Article Does MSI-low exist? |. Tomlinson, S. Halford, L. Aaltonen, N. Hawkins and R. Ward...... Original Papers Glomerulo-tubular junction stenosis as a factor contributing to glomerular obsolescence in IgA nephropathy: M. Sato, O. Hotta and Y. Taguma Short-term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer: I. D. Nagtegaal, C. A. M. Marijnen, E. K. Kranenbarg, A. Mulder-Stapel, J. Hermans, C. J. H. van de Velde and J. H. J. M. van Krieken and the Pathology Review Committee Mucin expression in the ileoanal reservoir reflects incomplete mucosal adaptation: P. A. Sylvester, N. A. C. S. Wong, N. Myerscough, B. F. Warren, A. P. Corfield, M. G. Thomas and P. Durdey....... Expression of mucins (MUCI, MUC2, MUCSAC and MUC6) and type 1 Lewis antigens in cases with and without Helicobacter pylori colonization in metaplastic glands of the human stomach: A. Teixeira, L. David, C. A. Reis, J. Costa and M. Sobrinho-Simées Loss of heterozygosity at 18q21 region in gastric cancer involves a number of cancer-related genes and correlates with stage and histology, but lacks independent prognostic value: M. E. Candusso, O. Luinetti, L. Villani, P. Alberizzi, C. Klersy, R. Fiocca, G. N. Ranzani and E. Solcia BAG-1! expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data: P. A. Townsend, E. Dublin, |. R. Hart, R.-H. Kao, A. M. Hanby, R. I. Cutress, R. Poulsom, K. Ryder, D. M. Barnes and G. Packham Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases: A. Hague, G. Packham, S. Huntley, K. Shefford and J. W. Eveson Expression and regulation of collagenase-2 (M/MP-8) in head and neck squamous cell carcinomas: M. Moilanen, E. Piriléa, R. Grénman, T. Sorsa and T. Salo Frequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract: M. Furihata, A. Kurabayashl, M. Matsumoto, H. Sonobe, Y. Ohtsuki, N. Terao. M. Kuwahara ind T. Shuin Expression of CXC chemokine IP-10 in testicular germ cell tumours: S. Schweyer, A. Soruri, D. Baumhoer, J. Peters. M. Cattaruzza, H. J. Radzun and A. Fayyazi Frequent genomic imbalances in chromosomes 17, 19 and 22q in peripheral nerve sheath tumours detected by comparative genomic hybridization analysis: T. Koga, H. Iwasaki, M. Ishiguro, A. Matsuzaki and M. Kikuchi Expression of the Duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium: A. M. Patterson, H. Siddall, G. Chamberlain, L. Gardner and J. Middleton Skin flap-induced regression of granulation tissue correlates with reduced growth factor and increased metalloproteinase expression: |. A. Darby, T. Bisucci, B. Pittet, S.G arbin, G. Gabbiani and A. Desmouliére Cyclin D1 overexpression in colorectal carcinoma in vivo is dependent on f-catenin protein dysregulation, but not k-ras mutation: N. A. C. S. Wong, R. G. Morris, A. McCondochie, S. Bader, D. I. Jodrell and D. J. Harrison Book Revi Volume Contents Volume 197, Number | May 2002 Editorials The glomerulo-tubular junction: a target in renal diseases: G. M. Lindop, |. W. Gibson, T. T. Downie, D. Vass and P. ( ohen Radiotherapy and rectal cancer: N. Scott Review Article Does MSI-low exist? |. Tomlinson, S. Halford, L. Aaltonen, N. Hawkins and R. Ward...... Original Papers Glomerulo-tubular junction stenosis as a factor contributing to glomerular obsolescence in IgA nephropathy: M. Sato, O. Hotta and Y. Taguma Short-term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer: I. D. Nagtegaal, C. A. M. Marijnen, E. K. Kranenbarg, A. Mulder-Stapel, J. Hermans, C. J. H. van de Velde and J. H. J. M. van Krieken and the Pathology Review Committee Mucin expression in the ileoanal reservoir reflects incomplete mucosal adaptation: P. A. Sylvester, N. A. C. S. Wong, N. Myerscough, B. F. Warren, A. P. Corfield, M. G. Thomas and P. Durdey....... Expression of mucins (MUCI, MUC2, MUCSAC and MUC6) and type 1 Lewis antigens in cases with and without Helicobacter pylori colonization in metaplastic glands of the human stomach: A. Teixeira, L. David, C. A. Reis, J. Costa and M. Sobrinho-Simées Loss of heterozygosity at 18q21 region in gastric cancer involves a number of cancer-related genes and correlates with stage and histology, but lacks independent prognostic value: M. E. Candusso, O. Luinetti, L. Villani, P. Alberizzi, C. Klersy, R. Fiocca, G. N. Ranzani and E. Solcia BAG-1! expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data: P. A. Townsend, E. Dublin, |. R. Hart, R.-H. Kao, A. M. Hanby, R. I. Cutress, R. Poulsom, K. Ryder, D. M. Barnes and G. Packham Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases: A. Hague, G. Packham, S. Huntley, K. Shefford and J. W. Eveson Expression and regulation of collagenase-2 (M/MP-8) in head and neck squamous cell carcinomas: M. Moilanen, E. Piriléa, R. Grénman, T. Sorsa and T. Salo Frequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract: M. Furihata, A. Kurabayashl, M. Matsumoto, H. Sonobe, Y. Ohtsuki, N. Terao. M. Kuwahara ind T. Shuin Expression of CXC chemokine IP-10 in testicular germ cell tumours: S. Schweyer, A. Soruri, D. Baumhoer, J. Peters. M. Cattaruzza, H. J. Radzun and A. Fayyazi Frequent genomic imbalances in chromosomes 17, 19 and 22q in peripheral nerve sheath tumours detected by comparative genomic hybridization analysis: T. Koga, H. Iwasaki, M. Ishiguro, A. Matsuzaki and M. Kikuchi Expression of the Duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium: A. M. Patterson, H. Siddall, G. Chamberlain, L. Gardner and J. Middleton Skin flap-induced regression of granulation tissue correlates with reduced growth factor and increased metalloproteinase expression: |. A. Darby, T. Bisucci, B. Pittet, S.G arbin, G. Gabbiani and A. Desmouliére Cyclin D1 overexpression in colorectal carcinoma in vivo is dependent on f-catenin protein dysregulation, but not k-ras mutation: N. A. C. S. Wong, R. G. Morris, A. McCondochie, S. Bader, D. I. Jodrell and D. J. Harrison Book Revi Volume Contents Volume 197, Number 2 June 2002 Editorial Screening for prostatic cancer and its evolution within Britain: M. C. Parkinson, S. R. J. Bott, R. Montironi and J. Melia Review Article Oestrogen receptor # in breast cancer: good, bad or still too early to tell? V. Speirs Original Papers Value of tissue markers p27“"', MIB-1 and CD44s for the pre-operative prediction of tumour features in screen-detected prostate cancer: A. N. Vis, B. W. G. van Rhijn, M. A. Noordzij, F. H. Schréder and Th. H. van der Kwast.... Evaluation of seven oestrogen receptor # antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue: G. P. Skliris, A. T. Parkes, J. L. Limer, S. E. Burdall, P. J. Carder and V. Speirs Short-term rhythmic proliferation of human breast cancer cell lines: surface effects and fractal growth patterns: R. Sedivy, S. Thurner, A. C. Budinsky, W. J. Késtler and C. C. Zielinski. Allelic imbalance in the diagnosis of benign, atypical and malignant Spitz tumours: M. C. R. F. van Dijk, P. D. M. Rombout, W. J. Mooi, F. J. J.M . van de Molengraft, J. H. J. M. van Krieken, D. J. Ruiter and M. J. L. Ligtenberg. Identification of activated matrix metalloproteinase-2 (MMP-2) as the main gelatinolytic enzyme in malignant melanoma by in situ zymography: P. Kurschat, C. Wickenhauser, W. Groth, T. Krieg and C. Mauch Identification of histological features associated with metastatic potential in thin (< 1.0 mm) cutaneous melanoma with metastases. A study on behalf of the EORTC Melanoma Group: M. G. Cook, A. Spatz, E-B. Brécker and D. J. Ruiter Transient P-cadherin expression in radiation proctitis; a model of mucosal injury and repair: R. G. Hardy, R. M. Brown, S. J. Miller, C. Tselepis, D. G. Morton, J. A. Z. Jankowski and D. S. A. Sanders New classification of pancreatic intraductal papillary—mucinous tumour by mucin expression: its relationship with potential for malignancy: A. Nakamura, M. Horinouchi, M. Goto, K. Nagata, K. Sakoda, S. Takao, K. Imai, Y. S. Kim, E. Sato and S. Yonezawa Robotic telepathology: efficacy and usability in pulmonary pathology: F. J. W.-M. Leong, A. G. Nicholson and 1. OD. McGee.. Expression of glycoprotein 90K in human malignant pleural mesothelioma: correlation with patient survival: L. Strizzi. R. Muraro, G. Vianale, C. Natoli, L. Talone, A. Catalano, L. Mutti, G. Tassi and A. Procopio A possible role for complement in the pathogenesis of chronic chagasic cardiomyopathy: V. D. Aiello, M. M. Reis, L. A. Benvenuti, M. de Lourdes Higuchi, J. A. F. Ramires and J. A. Halperin Reduction of hypoxia-inducible heme oxygenase-! in the myocardium after left ventricular mechanical support: F. Grabellus, C. Schmid, B. Levkau, D. Breukelmann, P. F. Halloran, C. August, N. Takeda, A. Takeda, M. Wilhelm, M. C. Deng and H. A. Baba Correlation between localization, age, and chromosomal imbalances in ependymal tumours as detected by CGH: J. W. M. Jeuken, S. H. E. Sprenger, J. Gilhuis, H. L. J. M. Teepen, A. J. Grotenhuis and P. Wesseling Cellular pathology changes in rat skin following intradermal injection of nerve growth factor: neutrophil-dependent and -independent events: P. A. Foster, S. Wicks, M. Foster and S. D. Brain A novel bel-1/JH breakpoint from a patient affected by mantle cell lymphoma extends the major translocation cluster: M. Degan, R. Doliana, A. Gloghini, R. Di Francia, D. Aldinucci, L. Mazzocut-Zecchin, A. Colombatti, V. Attadia, A. Carbone and V. Gattei Secretion of interleukin-6 and vascular endothelial growth factor by spindle cell sarcoma complicating Castleman’s disease (so-called ‘vascular neoplasia’): C. Kakiuchi, T. Ishida, H. Sato, H. Katano, T. Ishiko, H. Mukai, M. Kogi, N. Kasuga, K. Takeuchi, K. Yamane, M. Fukayama and S. Mori Letters to the Editor {nnouncements Volume Contents Volume 197, Number 3 July 2002 Editorial Development and pathology: The Pax gene: C. Berry ; — sapiennaaananaiaeaia wiaduaio 279 Original Papers Mast cells in the pathogenesis of chronic back pain: a hypothesis: A. J. Freemont, M. Jeziorska, J. A. Hoyland, P. Rooney and S. Kumar Nerve growth factor expression and innervation of the painful intervertebral disc: A. J. Freemont, A. Watkins, C. Le Maitre, P. Baird, M. Jeziorska, M. T. N. Knight, E. R. S. Ross, J. P.O ’Brien and J. A. Hoyland Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus: J.-K. Gerber, T. Richter, E. Kremmer, J. Adamski, H. H6fler, R. Balling and H. Peters...... Loss of heterozygosity in the clonal evolution of flat colorectal neoplasms: H. Fujii, Y. Ajioka, S. Kazami, T. Takagaki, X. G. Zhu, S. Hirose, H. Watanabe and T. Shirai Enhanced mRNA expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in breast carcinomas is correlated with adverse prognosis: L. Nakopoulou, |. Giannopoulou, K. Stefanaki, E. Panayotopoulou, I. Tsirmpa, P. Alexandrou, J. Mavrommatis, S. Katsarou and P. Davaris Expression of carbonic anhydrase [X in breast is associated with malignant tissues and is related to overexpression of c-erbB2: M. BartoSova, S. Parkkila, K. Pohlodek, T. J. Karttunen, $.G albavy, V. Mucha, A. L. Harris, J. Pastorek and S. Pastorekova Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection: C.-C. Loong, H.-G. Hsieh, W.-Y. Lui, A. Chen and C.-Y. Lin Extranodal marginal zone B cell lymphomas of the uvea: an analysis of 13 cases: S. E. Coupland, H.-D. Foss, A. A. Hidayat. G. C. Cockerham, M. Hummel and H. Stein Immunohistochemical detection of CD79a expression in precursor T cell lymphoblastic lymphoma/ leukaemias: M. Hashimoto, Y. Yamashita and N. Mori Clonal T cell receptor y-chain gene rearrangement by PCR-based GeneScan analysis in the skin and blood of patients with parapsoriasis and early-stage mycosis fungoides: C.-D. Klemke, E. Dippel, A. Dembinski, N. Pénitz. C. Assaf, M. Hummel, H. Stein and S. Goerdt Vascularization of cutaneous melanoma involves vessel co-option and has clinical significance: B. Dome, S. Paku, B. Somlai and J. Timar Molecular cytogenetic differences between histological subtypes of malignant mesotheliomas: DNA cytometry and comparative genomic hybridization of 90 cases: M. Krismann, K.-M. Miller, M. Jaworska and G. Johnen. iNOS gene upregulation is associated with the early proliferative response of human lung fibroblasts to cytokine stimulation: H. M. Romanska, J. M. Polak, R. A. Coleman, R. S. James, D. W. Harmer, J. C. Allen and \. E. Bishop Changes in myosin heavy chain and its localization in rat heart in association with hypobaric hypoxia-induced pulmonary hypertension: K. Nakanishi, Y. Nakata, F. Kanazawa, S. Imamura, R. Matsuoka, H. Osada, T. Kawai, M. Uenoyama, T. Aurues and T. Ikeda Tenascin-C is a useful marker for disease activity in myocarditis: K. Imanaka-Yoshida, M. Hiroe, Y. Yasutomi, l. Toyozaki, T. Tsuchiya, N. Noda, T. Maki, T. Nishikawa, T. Sakakura and T. Yoshida Herpesviruses in brain and Alzheimer’s disease: W.-R. Lin, M. A. Wozniak, R. J. Cooper, G. K. Wilcock and R. F. Itzhaki Expert system support using a Bayesian belief network for the classification of endometrial hyperplasia: M. L. Morrison, W. G. McCluggage, G. J. Price, J.D iamond, M. R. M. Sheeran, K. M. Mulholland, M. Y. Walsh, R. Montironi, P. H. Bartels, D. Thompson and P. W. Hamilton Book Revie {nnouncements Volume Contents Volume 197, Number 4 July 2002 Editorial Preface to stem cells: M. R. Alison, R. Poulsom and N. A. Wright... 417 Review Articles An introduction to stem cells: M. R. Alison, R. Poulsom, S. Forbes and N. A. Wright.. Embryonic stem cells: A. E. Bishop, L. D. K. Buttery and J. M. Polak Haematopoietic stem cells: D. Bonnet Adult stem cell plasticity: R. Poulsom, M. R. Alison, S. J. Forbes and N. A. Wright Muscle stem cells: K. Goldring, T. Partridge and D. Watt Cardiac stem cells: S. Hughes.. Epidermal stem cells: S. M. Janes, S. Lowell and C. Hutter . Gastrointestinal stem cells: M. Brittan and N. A. Wright. Hepatic stem cells: S. Forbes, P. Vig, R. Poulsom, H. Thomas and M. Alison Pancreatic stem cells: S. Bonner-Weir and A. Sharma ..... Lung epithelial stem cells: W. R. Otto Neural stem cells: N. L. Kennea and H. Mehmet.. Prostatic stem cells: C. S. Foster, A. Dodson, V. Karavana, P. H. Smith and Y. Ke.... viii Volume Contents Volume 197, Number 5 August 2002 Original Papers Functional allelic loss detected at the protein level in archival human tumours using allele-specific E-cadherin monoclonal antibodies: K.-F. Becker, E. Kremmer, M. Eulitz, 8. Schulz, J. Mages, G. Handschuh, M. J. Wheelock, A.-M. Cleton-Jansen, H. Héfler and I. Becker.................... ; Analysis of the progression of fibroepithelial tumours of the breast by PCR-based clonality assay: A. Kuijper, H. Buerger, R. Simon, K.-L. Schaefer, A. Croonen, W. Boecker, E. van der Wall and P. J. van Diest Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues: W. K. Leung, J. Yu, F. K. L. Chan, K. F. To, M. W. Y. Chan, M. P. A. Ebert, E. K. W. Ng, S. C. S. Chung, P. Malfertheiner and J. J. Y. Sung.... Expression of 4C8 antigen, a novel transendothelial migration-associated molecule on activated T lymphocytes, in inflammatory bowel disease: N. Oshitani, F. Hato, S. Kitagawa, J. Masuyama, K. Higuchi, T. Matsumoto and T. Arakawa FK409 inhibits both local and remote organ damage after intestinal ischaemia: N. Kalia, N. J. Brown, K. Hopkinson, lr. J.S tephenson, R. F. M. Wood and A. G. Pockley Genetic progression in sporadic endometrial and gastrointestinal cancers with high microsatellite instability: D. Furlan, B. Casati, R. Cerutti, C. Facco, L. Terracciano, C. Capella and A. M. Chiaravalli Different expression of hepatitis B surface antigen between hepatocellular carcinoma and its surrounding liver tissue, studied using a tissue microarray: Y. Wang, M.-C. Wu, J. S. T. Sham, L.-S. Tai, Y. Fang, W.-Q. Wu, D. Xie and X.-Y. Guan Lack of in vivo blockade of Fas- and TNFR1-mediated hepatocyte apoptosis by the hepatitis C virus: L. Rubbia-Brandt, S. Taylor, P. Gindre, R. Quadri, K. Abid, L. Spahr and F. Negro.......... Genetic and epigenetic alterations of the INK4a-ARF pathway in cholangiocarcinoma: A. Tannapfel, F. Sommerer, M. Benicke, L. Weinans, A. Katalinic, F. Geifler, D. Uhlmann, J. Hauss and C. Wittekind.... Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions: B. Terris, S. Dubois, M.-P. Buisine, A. Sauvanet, P. Ruszniewski, J.-P. Aubert, N. Porchet, A. Couvelard, C. Degott and J.-F. Fléjou Induction of PDX-1-positive cells in the main duct during regeneration after acute necrotizing pancreatitis in rats: M. Taguchi, T. Yamaguchi and M. Otsuki Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma-in-situ or seminoma: R. Brehm, A. Marks, R. Rey, S. Kliesch, M. Bergmann and K. Steger........... Significance of loss of heterozygosity of the RB/ gene during tumour progression in well-differentiated liposarcomas: R. Schneider-Stock, C. Boltze, V. Jaeger, M. Stumm, C. Seiler, J. Rys, K. Schiitze and A. Roessner.. Gene expression of TrkC (NTRK3) in human soft tissue tumours: M. Hisaoka, W.-Q. Sheng, A. Tanaka and H. Hashimoto Multiple complementary transcripts of pCMal, a novel gene located at chromosome 11p15.1—2, and melanocytic cell transformation: C. B. Meije, P. K. Das, M. M. E. Jans, C. Hau, A. C. van der Wal, M. Alders, T. B. M. Hakvoort, U. H. Weidle, W. H. Lamers and G. W. M. Swart Vascular endothelial growth factor (VEGF) is expressed by neoplastic Hodgkin—-Reed—Sternberg cells in Hodgkin’s disease: |. A. Doussis-Anagnostopoulou, K. L. Talks, H. Turley, P.D ebnam, D. C. Tan, G. Mariatos, V. Gorgoulis, C. Kittas and K. C. Gatter Detection of Epstein-Barr virus genome within thymic epithelial tumours in Taiwanese patients by nested PCR, PCR in situ hybridization, and RNA in situ hybridization: P. C.-H. Chen, C.-C. Pan, A.-H. Yang, L.-S. Wang and H. Chiang B 10k Re vic)