Volume Contents Volume 194, Number | May 2001 Editorial How well does the CSF inform upon pathology in the brain in Creutzfeldt-Jakob and Alzheimer’s diseases?: R. O. Weller Review Article Met protein and hepatocyte growth factor (HGF) in papillary carcinoma of the thyroid: evidence for a pathogenetic role in tumourigenesis: L. P. Ruco, A. Stoppacciaro, F. Ballarini, M. Prat and S. Scarpino Original Papers Absence of protease-resistant prion protein in the cerebrospinal fluid of Creutzfeldt-Jakob disease: B.-S. Wong. A. J. E. Green, R. Li, Z. Xie, T. Pan, T. Liu, 8. G. Chen, P. Gambetti and M.-S. Sy Increased expression of cFLIP, in colonic adenocarcinoma: B.-K. Ryu, M.-G. Lee, $.-G. Chi, Y.-W. Kim and J.-H. Park Expression of the E-cadherin—catenin complex in lung neuroendocrine tumours: C. E. Clavel, F. Nollet, G. Berx, S. Tejpar, B. Nawrocki-Raby, H. H. Kaplan, F. M. van Roy and P. L. Birembaut Altered intracellular localization of fibroblast growth factor receptor 3 in human breast cancer: C. Zammit. R. Barnard, J. Gomm, R. Coope, S. Shousha, C. Coombes and C. Johnston Differential expression of p16/p21/p27 and cyclin D1/D3, and their relationships to cell proliferation, apoptosis, and tumour progression in invasive ductal carcinoma of the breast: S.C. C. Wong, J. K. C. Chan, K. C. Lee and W. L. W. Hsiao The Ets-1 transcription factor is up-regulated together with MMP 1 and MMP 9 in the stroma of pre-invasive breast cancer: P. Behrens, M. Rothe, A. Wellmann, J. Krischler and N. Wernert Comparative analysis of human papillomavirus infections in cervical scrapes and biopsy specimens by general SPF,, PCR and HPV genotyping: W. G. V. Quint, G. Scholte, L. J. van Doorn, B. Kleter, P. H. M. Smits and J. Lindeman Frequent nuclear f-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation: M. Saegusa and |. Okayasu p53 mutation does not affect prognosis in ovarian epithelial malignancies: S. Fallows, J. Price, R. J. Atkinson, P. G. Johnston, |. Hickey and S. E. H. Russell The chromosome 9q genes TGFBR/, TSCI, and ZNF189 are rarely mutated in bladder cancer: A. A. G. van Tilborg, A. de Vries and E. C. Zwarthoff Subtyping of oligo-astrocytic tumours by comparative genomic hybridization: J. W. M. Jeuken, S. H. E. Sprenger, R. H. Boerman, A. von Deimling, H. L. J. M. Teepen, J. J. van Overbeeke and P. Wesseling Expression of COLIA1-PDGFB fusion transcripts in superficial adult fibrosarcoma suggests a close relationship to dermatofibrosarcoma protuberans: W.-Q. Sheng, H. Hashimoto, S. Okamoto, T. Ishida, J. M. Meis-Kindblom, L.-G. Kindblom and M. Hisaoka Expression of neurotrophins and their receptors in pigment cell lesions of the skin: P. F. Innominato, L. Libbrecht and J. J. van den Oord The angiogenic pathway ‘vascular endothelial growth factor/fik-1( KDR)-receptor’ in rheumatoid arthritis and osteoarthritis: A. Giatromanolaki, E. Sivridis, N. Athanassou, E. Zois, P. E. Thorpe, R. A. Brekken, K. C. Gatter, ee a, Pe INTIS SII SUE; i." CIN csc csccicncawpacetinndsasounancacusssneiotnacesedanmennse vaabeimsadcasceceseuresentsones Targeted disruption of the nitric oxide synthase 2 gene protects against ischaemia/reperfusion injury to skeletal muscle: J. E. Barker, K. R. Knight, R. Romeo, J. V. Hurley, W. A. Morrison and A. G. Stewart Histopathological findings in skeletal muscle used in human dynamic cardiomyoplasty: P. S. Gutierrez, W. O. Pires Jr. S. K. N. Marie, L. F. P. Moreira, C. Mady, M. L. Higuchi, N. A. G. Stolf and J. A. F. Ramires Chronic blockade of angiotensin II action prevents glomerulosclerosis, but induces graft vasculopathy in experimental kidney transplantation: A. Smit-van Oosten, G. Navis, C. A. Stegeman, J. A. Joles, P. A. Klok. F. Kuipers, A. T. M. G. Tiebosch and H. van Goor A novel method for detecting HIV-1 by non-radioactive in situ hybridization: application of a peptide nucleic acid probe and catalysed signal amplification: T.M urakami, T. Hagiwara, K. Yamamoto, J. Hattori, M. Kasami, M. Utsumi and T. Kaneda Book Reviews Volume Contents Volume 194, Number | May 2001 Editorial How well does the CSF inform upon pathology in the brain in Creutzfeldt-Jakob and Alzheimer’s diseases?: R. O. Weller Review Article Met protein and hepatocyte growth factor (HGF) in papillary carcinoma of the thyroid: evidence for a pathogenetic role in tumourigenesis: L. P. Ruco, A. Stoppacciaro, F. Ballarini, M. Prat and S. Scarpino Original Papers Absence of protease-resistant prion protein in the cerebrospinal fluid of Creutzfeldt-Jakob disease: B.-S. Wong. A. J. E. Green, R. Li, Z. Xie, T. Pan, T. Liu, 8. G. Chen, P. Gambetti and M.-S. Sy Increased expression of cFLIP, in colonic adenocarcinoma: B.-K. Ryu, M.-G. Lee, $.-G. Chi, Y.-W. Kim and J.-H. Park Expression of the E-cadherin—catenin complex in lung neuroendocrine tumours: C. E. Clavel, F. Nollet, G. Berx, S. Tejpar, B. Nawrocki-Raby, H. H. Kaplan, F. M. van Roy and P. L. Birembaut Altered intracellular localization of fibroblast growth factor receptor 3 in human breast cancer: C. Zammit. R. Barnard, J. Gomm, R. Coope, S. Shousha, C. Coombes and C. Johnston Differential expression of p16/p21/p27 and cyclin D1/D3, and their relationships to cell proliferation, apoptosis, and tumour progression in invasive ductal carcinoma of the breast: S.C. C. Wong, J. K. C. Chan, K. C. Lee and W. L. W. Hsiao The Ets-1 transcription factor is up-regulated together with MMP 1 and MMP 9 in the stroma of pre-invasive breast cancer: P. Behrens, M. Rothe, A. Wellmann, J. Krischler and N. Wernert Comparative analysis of human papillomavirus infections in cervical scrapes and biopsy specimens by general SPF,, PCR and HPV genotyping: W. G. V. Quint, G. Scholte, L. J. van Doorn, B. Kleter, P. H. M. Smits and J. Lindeman Frequent nuclear f-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation: M. Saegusa and |. Okayasu p53 mutation does not affect prognosis in ovarian epithelial malignancies: S. Fallows, J. Price, R. J. Atkinson, P. G. Johnston, |. Hickey and S. E. H. Russell The chromosome 9q genes TGFBR/, TSCI, and ZNF189 are rarely mutated in bladder cancer: A. A. G. van Tilborg, A. de Vries and E. C. Zwarthoff Subtyping of oligo-astrocytic tumours by comparative genomic hybridization: J. W. M. Jeuken, S. H. E. Sprenger, R. H. Boerman, A. von Deimling, H. L. J. M. Teepen, J. J. van Overbeeke and P. Wesseling Expression of COLIA1-PDGFB fusion transcripts in superficial adult fibrosarcoma suggests a close relationship to dermatofibrosarcoma protuberans: W.-Q. Sheng, H. Hashimoto, S. Okamoto, T. Ishida, J. M. Meis-Kindblom, L.-G. Kindblom and M. Hisaoka Expression of neurotrophins and their receptors in pigment cell lesions of the skin: P. F. Innominato, L. Libbrecht and J. J. van den Oord The angiogenic pathway ‘vascular endothelial growth factor/fik-1( KDR)-receptor’ in rheumatoid arthritis and osteoarthritis: A. Giatromanolaki, E. Sivridis, N. Athanassou, E. Zois, P. E. Thorpe, R. A. Brekken, K. C. Gatter, ee a, Pe INTIS SII SUE; i." CIN csc csccicncawpacetinndsasounancacusssneiotnacesedanmennse vaabeimsadcasceceseuresentsones Targeted disruption of the nitric oxide synthase 2 gene protects against ischaemia/reperfusion injury to skeletal muscle: J. E. Barker, K. R. Knight, R. Romeo, J. V. Hurley, W. A. Morrison and A. G. Stewart Histopathological findings in skeletal muscle used in human dynamic cardiomyoplasty: P. S. Gutierrez, W. O. Pires Jr. S. K. N. Marie, L. F. P. Moreira, C. Mady, M. L. Higuchi, N. A. G. Stolf and J. A. F. Ramires Chronic blockade of angiotensin II action prevents glomerulosclerosis, but induces graft vasculopathy in experimental kidney transplantation: A. Smit-van Oosten, G. Navis, C. A. Stegeman, J. A. Joles, P. A. Klok. F. Kuipers, A. T. M. G. Tiebosch and H. van Goor A novel method for detecting HIV-1 by non-radioactive in situ hybridization: application of a peptide nucleic acid probe and catalysed signal amplification: T.M urakami, T. Hagiwara, K. Yamamoto, J. Hattori, M. Kasami, M. Utsumi and T. Kaneda Book Reviews Volume Contents Volume 194, Number 2 June 2001 Dysplasia classification: pathology in disgrace?: F. T. Bosman Expression of cytokine and chemokine genes in Epstein-Barr virus-associated nasopharyngeal carcinoma: comparison with Hodgkin’s disease: A. Beck, D. Pazolt, G. G. Grabenbauer, J. M. Nicholls, H. Herbst, L. S. Young and G. Niedobitek Inter-observer variation between general and specialist gastrointestinal pathologists when grading dysplasia in ulcerative colitis: J. Eaden, K. Abrams, H. McKay, H. Denley and J. Mayberry Expression of the tumour necrosis factor receptor-associated factors 1 and 2 in Hodgkin’s disease: P. G. Murray, J. R. Flavell, K. N. Baumforth, S. M. Toomey, C. W. Dawson, D. Lowe, J. Crocker, R. F. Ambinder and L. S. Young Ductal invasive G2 and G3 carcinomas of the breast are the end stages of at least two different lines of genetic evolution: H. Buerger, E. C. Mommers, R. Littmann, R. Simon, R. Diallo, C. Poremba, B. Dockhorn-Dworniczak, P. J. van Diest and W. Boecker DNA image cytometry and human papillomavirus (HPV ) detection help to select smears at high risk of high-grade cervical lesions: M. Lorenzato, C. Clavel, M. Masure, J.-M. Nou, D. Bouttens, G. Evrard, J.-P. Bory, B. Maugard, C. Quereux and P. Birembaut New chromosomal regions with high-level amplifications in squamous cell carcinomas of larynx and pharynx identified by comparative genomic hybridization: M. Hermsen, M. A. Guervos, G. Meijer, J. Baak, P. van Diest, C. A. Marcos and A. Sampedro Telomerase activity and telomere length in thyroid neoplasia: biological and clinical implications: P. Matthews, C. J. Jones, J. Skinner, M. Haughton, C. de Micco and D. Wynford-Thomias .................:ccccseeececeeeeseeseseeseeeeeeeeceeesseceees Inducible nitric oxide synthase expression in benign and malignant cutaneous melanocytic lesions: D. Massi, A. Franchi, I. Sardi, L. Magnelli, M. Paglierani, L. Borgognoni, U. M. Reali and M. Santucci MMP-9 is predominantly expressed in epitheloid and not spindle cell uveal melanoma: Y. El-Shabrawi, N. Ardjomand, H. Radner and N. Ardjomand Keratinocyte derived growth factors play a role in the formation of hypertrophic scars: F. B. Niessen, AG. TF; FSO, F. Te Thc, RUM GUN WE .,U NIIII pocincicrscescsnsesecenacesccscecocnsuxanssbivecendnesesthestaienakousanatickabecseugeassos Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions: J. Wahlgren, P. Maisi, T. Sorsa, M. Sutinen, T. Tervahartiala, E. Pirila, O. Teronen, J. Hietanen, L. Tjéderhane and T. Salo Expression of MMP2, MMP9, MT1-MMP, TIMP1 and TIMP2 mRNA in valvular lesions of the heart: Y. Soini, J. Satta, M. Maattaé and H. Autio-Harmainen In-vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis: K. Prikk, E. Pirila, R. Sepper, P. Maisi, T. Salo, J. Wahlgren and T. Sorsa Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation: S. J. Chakravorty, A. J. Howie, J. Girdlestone, D. Gentle and C. S. Savage Nerve growth factor and brain-derived neurotrophic factor mRNAs are regulated in distinct cell populations of rat heart after ischaemia and reperfusion: J. O. Hiltunen, A. Laurikainen, A. Vakeva, S. Meri and M. Saarma Expression of CD31 by cells of extensive ductal in situ and invasive carcinomas of the breast: A. Sapino, M. Bongiovanni, P. Cassoni, L. Righi, R. Arisio, S. Deaglio and F. Malavasi Overproduction of perlecan core protein in cultured cells and transgenic mice: M. Hart, L. Li, T. Tokunaga, J. R. Lindsey, J. R. Hassell, A. D. Snow and K. Fukuchi Announcements Volume Contents Volume 194, Number 3 July 2001 Review Article Neuropathology of paediatric chronic intestinal pseudo-obstruction and related animal models: R. P. Kapur 277 Editorials Molecular markers of metastasis in squamous carcinomas: T. R. Helliwell 289 Histological grading of oral epithelial dysplasia: revisited: S. Warnakulasuriya 294 Original Papers Expression of genetic markers in lymph node metastases compared to their primary tumours in head and neck cancer: R. P. Takes, R. J. Baatenberg de Jong, K. Wijffels, E. Schuuring, S. V. Litvinov, J. Hermans and J. M. van Krieken Comparison of histological grading and large scale genomic status (DNA ploidy) as prognostic tools in oral dysplasia: J. Sudbo, M. Bryne, A. C. Johannessen, W. Kildal, H. E. Damielsen and A. Reith ...................:ccccsseccceesseceeeneeeeceeeeees Detailed gene expression analysis but not microsatellite marker analysis of 9p21 reveals differential defects in the INK4a gene locus in the majority of head and neck cancers: A. Griittgen, M. Reichenzeller, M. Jiinger, S. Schlien, A. Affolter and F. X. Bosch Detailed deletion mapping in sporadic breast cancer at chromosomal region 17P13 distal to the TP53 gene: association with clinicopathological parameters: S. Seitz, K. Poppe, J. Fischer, A. Nothnagel, L. Estévez-Schwarz, W. Haensch, P. M. Schlag and S. Scherneck Similarity in expression of cell cycle proteins between in situ and invasive ductal breast lesions of same differentiation grade: E. M. Mommers, A. M. Leonhart, F. Falix, R. Michalides, C. M. Meijer, J. A. Baak and P. J. van Diest Microsatellite alterations and target gene mutations in the early stages of multiple gastric cancer: S. Ogata, G. Tamura, Y. Endoh, K. Sakata, K. Ohmura and T. Motoyama PTEN expression is maintained in sporadic colorectal tumours: K. Taniyama, S$. Goodison, R. Ito, R. Bookstein, N. Miyoshi, E. Tahara, D. Tarin and V. Urquidi Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade: A. Nocito. L. Bubendorf, E. M. Tinner, K. Siess, U. Wagner, T. Forster, J. Kononen, A. Fijan, J. Bruderer, U. Schmid, D. Ackermann, R. Maurer, G. Alund, H. Knénagel, M. Rist, M. Anabitarte, F. Hering, T. Hardmeier, A. Schoenenberger, R. Flary, P. Jager, J.-L. Fehr, P. Schraml, H. Moch, M. J. Mihatsch, T. Gasser and G. Sauter . Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant: A. S. Rocha, P. Soares, R. Seruca, V. Maximo, X. M. Guiu, J. Cameselle-Teijeiro and M. Sobrinho-Simdes NF?2 status of meningiomas is associated with tumour localization and histology: J. Kros, K. de Greve, A. van Tilborg. W. Hop, H. Pieterman, C. Avezaat, R. L. dit Deprez and E. Zwarthoff Human MUCI mucin: a potent glandular morphogen: M. J. Hudson, G. W. Stamp, K. S. Chaudhary, R. Hewitt, A. P. Stubbs, P. D. Abel and E. Lalani Hyaluronan synthases, hyaluronan and its CD44 receptor in tissue around loosened total hip prostheses: Y. T. Konttinen, T. L. Fang, J. Mandelin, M. Ainola, J. Lassus, I. Virtanen, S. Santavirta, M. Tammi and R. Tammi {nnouncements . Volume Contents Volume 194, Number 4 August 2001 Editorials Inflammation in human skin: a model to study chemokine-mediated leukocyte migration in vivo: R. Gillitzer Are some breast carcinomas polyclonal in origin?: S. Heim, M. A. R. Teixeira, N. Pandis .........00.........ccccccceeceeceeeeeeeeeeee Original Papers Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCLI1 in different types of skin inflammation: J. Flier, D.M . Boorsma, P. J. van Beek, C. Nieboer, T. J. Stoof, R. Willemze and C. P. Tensen Clonal origins of human breast cancer: J. J. Going, H. M. Abd El-Monem and J. A. Craft Expression of amphiregulin and epidermal growth factor receptor in human breast cancer: analysis of autocriny and stromal-—epithelial interactions: L. Ma, A. de Roquancourt, P. Bertheau, S. Chevret, G. Millot, X. Sastre-Garau, M. Espié, M. Marty, A. Janin and F. Calvo Loss of alveolar basement membrane type IV collagen a3, a4 and a5 chains in bronchioloalveolar cacinoma of the lung: K. Nakano, K. lyama, T. Mori, M. Yoshioka, T. Hiraoka, Y. Sado and Y. Ninomiya Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma: D. A. M. Heideman, P. J. F. Snijders, E. Bloemena, C. J. L. M. Meijer, G. J. A. Offerhaus, S. G. M. Meuwissen, W. R. Gerritsen and M. E. Craanen Apoptosis and cell cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival: M. A. Elkablawy, P. Maxwell, K. Williamson, N. Anderson and P. W. Hamilton Bcl-2 expression in pancreas development and pancreatic cancer progression: D. Campani, |. Esposito, U. Boggi, D. Cecchetti, M. Menicagli, F. De Negri, L. Colizzi, M. Del Chiaro, F. Mosca, G. Fornaciari and G. Bevilacqua .... Deletion at 3p25.3-p23 is frequently encountered in endocrine pancreatic tumours and is associated with metastatic progression: A. Barghorn, P. Komminoth, D. Bachmann, K. Riitimann, P. Saremaslani, S$. Muletta-Feurer, A. Perren, J. Roth, P. U. Heitz and E. J. M. Speel In situ detection of telomerase enzymatic activity in human hepatocellular carcinogenesis: N. Youssef, V. Paradis, S. Ferlicot and P. Bedossa Expression of Fas and Fas ligand in uveal melanoma: biological implication and prognostic value: G. Anastassiou, S. E. Coupland, A. Stang, R. Boeloeni, H. Schilling and N. Bornfeld Expression of the sonic hedgehog receptor ‘PATCHED?’ in basal cell carcinomas and odontogenic keratocysts: W. Zedan, P. A. Robinson, A. F. Markham and A. S. High Intrahepatic MxA expression is correlated with interferon—alpha expression in chronic and fulminant hepatitis: L. Leifeld, J. Ramakers, A. M. Schneiders, F. L. Dumoulin, M. Sterneck, A. Miller, T. Sauerbruch and U. Spengler Distribution and activation of eosinophils in inflammatory bowel disease using an improved immunohistochemical technique: M. Jeziorska, N. Haboubi, P. Schofield and D. E. Woolley Apoptosis induction by sennoside laxatives in man: escape from a protective mechanism during chronic sennoside use?: B. A. P. van Gorkom, A. Karrenbeld, T. van der Sluis, N. Zwart, E. G. E. de Vries and J. H. Kieibeuker Brain Af amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau: Y. Tomidokoro, Y. Harigaya, E. Matsubara, M. Ikeda, T. Kawarabayashi, T. Shirao, K. Ishiguro, K. Okamoto, S. G. Younkin and M. Shoji Erratum {nnouncements