THE JOURNAL OF IMMUNOLOGY VOLUME 167 NuMBERS I TO 12 CopyriGut © 2001 By THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS VOLUME 167/ N° 1 / JULY 1, 2001 (UTTIDG hut Cutting Edge: The Common y-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex Hironobu Asao, Chikara Okuyama, Satoru Kumaki, Naoto Ishii, Shigeru Tsuchiya, Don Foster, and Kazuo Sugamura Cutting Edge: Ly49A Inhibits TCR/CD3-Induced Apoptosis and IL-2 Secretion Joanne Roger, Anick Chalifour, Suzanne Lemieux, and Pascale Duplay Cutting Edge: Antibody-Mediated Cessation of Hemotropic Infection by the Intraerythrocytic Mouse Pathogen Bartonella grahamii Jan Koesling, Toni Aebischer, Christine Falch, Ralf Schiilein, and Christoph Dehio 15 Cutting Edge: Germinal Centers Can Be Induced in the Absence of T Cells Vicky M. Lentz and Tim Manser CELLULAR IMMUNOLOGY AND IMMUNE REGULATION 21 Molecular Characterization of B Cell Clonal Expansions in the Liver of Chronically Hepatitis C Virus-Infected Patients Vito Racanelli, Domenico Sansonno, Claudia Piccoli, Francesca Paola D'Amore, Felicia Anna Tucci, and Franco Dammacco 118-Hydroxysteroid Dehydrogenase Type 1 Is Induced in Human Monocytes upon Differentiation to Macrophages Rolf Thieringer, Cheryl B. Le Grand, Linda Carbin, Tian-Quan Cai, Birming Wong, Samuel D. Wright, and Anne Hermanowski-Vosatka Structural Features of Nonpeptide Prenyl Pyrophosphates That Determine Their Antigenicity for Human yé T Cells Craig T. Morita, Hoi K. Lee, Hong Wang, Hongmin Li, Roy A. Mariuzza, and Yoshimasa Tanaka Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation Michael J. Parsons, Russell G. Jones, Ming-Sound Tsao, Bernard Odermatt, Pamela S. Ohashi, and James R. Woodgett The Distinct Roles of T Cell-Derived Cytokines and a Novel Follicular Dendritic Cell-Signaling Molecule 8D6 in Germinal Center-B Cell Differentiation Xin Zhang, Li Li, Jaeho Jung, Shulin Xiang, Christiane Hollmann, and Yong Sung Choi Lymphotactin Expression by Engineered Myeloma Cells Drives Tumor Regression: Mediation by CD4* and CD8* T Cells and Neutrophils Expressing XCR1 Receptor Chantelle M. Cairns, John R. Gordon, Fang Li, Maria E. Baca-Estrada, Terence Moyana, and Jim Xiang Novel Roles of CpG Oligodeoxynucleotides as a Leader for the Sampling and Presentation of CpG-Tagged Antigen by Dendritic Cells Hidekazu Shirota, Kunio Sano, Noriyasu Hirasawa, Tadashi Terui, Kazuo Ohuchi, Toshio Hattori, Kunio Shirato, and Gen Tamura Nitric Oxide Inhibits the Transcription Repressor Yin-Yang | Binding Activity at the Silencer Region of the Fas Promoter: A Pivotal Role for Nitric Oxide in the Up-Regulation of Fas Gene Expression in Human Tumor Cells Hermes J. Garban and Benjamin Bonavida Fas Aggregation Does Not Correlate with Fas-Mediated Apoptosis Yang-ja Lee and Emily Shacter IL-1 Enhances T Cell-Dependent Antibody Production Through Induction of CD40 Ligand and OX40 on T Cells Susumu Nakae, Masahide Asano, Reiko Horai, Nobuo Sakaguchi, and Yoichiro Iwakura Constitutive Expression of MHC Class II Genes in Melanoma Cell Lines Results from the Transcription of Class II Transactivator Abnormally Initiated from Its B Cell-Specific Promoter Virginie Deffrennes, Jocelyn Vedrenne, Marie-Claude Stolzenberg, Janet Piskurich, Giovanna Barbieri, Jenny P. Ting, Dominique Charron, and Catherine Alcaide-Loridan Oral Exposure to Alloantigen Generates Intragraft CD8* Regulatory Cells Juan Zhou, Ronald I. Carr, Robert S. Liwski, Andrew W. Stadnyk, and Timothy D. G. Lee Signal Thresholds and Modular Synergy During Expression of Costimulatory Molecules in B Lymphocytes Krishnamurthy Natarajan, Naresh C. Sahoo, and Kanury V. S. Rao Antibody-Induced Shedding of CD44 from Adherent Cells Is Linked to the Assembly of the Cytoskeleton Mei Shi, Kathryn Dennis, Jacques J. Peschon, Raman Chandrasekaran, and Katalin Mikecz Enhancement of CD8~* T Cell Responses by ICOS/B7h Costimulation Jeffrey J. Wallin, Linda Liang, Anastasia Bakardjiev, and William C. Sha CD28-independent’ Costimulation of T Cells in Alloimmune Responses Akira Yamada, Koji Kishimoto, Victor M. Dong, Masayuki Sho, Alan D. Salama, Natalie G. Anosova, Gilles Benichou, Didier A. Mandelbrot, Arlene H. Sharpe, Laurence A. Turka, Hugh Auchincloss, Jr., and Mohamed H. Sayegh An Immunodominant MHC Class II-Restricted Tumor Antigen Is Conformation Dependent and Binds to the Endoplasmic Reticulum Chaperone, Calreticulin Denise Golgher, Firouzeh Korangy, Bin Gao, Kevin Gorski, Elizabeth Jaffee, Michael Edidin, Drew M. Pardoll, and Tim Elliott IL-12 Augments CD8~ T Cell Development for Contact Hypersensitivity Responses and Circumvents Anti-CD154 Antibody- Mediated Inhibition Anton V. Gorbachev, Nancy A. Dilulio, and Robert L. Fairchild CONTENTS [voL. 167 The Role of the CD19/CD21 Complex in B Cell Processing and Presentation of Complement-Tagged Antigens Anu Cherukuri, Paul C. Cheng, and Susan K. Pierce TNF-a-Induced Sphingosine 1-Phosphate Inhibits Apoptosis Through a Phosphatidylinositol 3-Kinase/Akt Pathway in Human Hepatocytes Yosuke Osawa, Yoshiko Banno, Masahito Nagaki, David A. Brenner, Takafumi Naiki, Yoshinori Nozawa, Shigeru Nakashima, and Hisataka Moriwaki Functional Heterogeneity of Cytokines and Cytolytic Effector Molecules in Human CD8* T Lymphocytes Johan K. Sandberg, Noam M. Fast, and Douglas F. Nixon Generation of Anergic and Potentially Immunoregulatory CD25*CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen Kristen M. Thorstenson and Alexander Khoruts Rapid Induction of Naive T Cell Apoptosis by Ecto-Nicotinamide Adenine Dinucleotide: Requirement for Mono(ADP- Ribosyl)Transferase 2 and a Downstream Effector Sahil Adriouch, Wiebke Ohlrogge, Friedrich Haag, Friedrich Koch-Nolte, and Michel Seman Partially Distinct Molecular Mechanisms Mediate Inhibitory Fc yRIIB Signaling in Resting and Activated B Cells Anne Brauweiler, Idan Tamir, Susanne Marschner, Cheryl D. Helgason, and John C. Cambier Memory T Cells Constitute a Subset of the Human CD8*CD45RA~ Pool with Distinct Phenotypic and Migratory Characteristics Jeffery M. Faint, Nicola E. Annels, S. John Curnow, Philip Shields, Darreli Pilling, Andrew D. Hislop, Lijun Wu, Arne N. Akbar, Christopher D. Buckley, Paul A. H. Moss, David H. Adams, Alan B. Rickinson, and Mike Salmon Positive Regulatory Role of IL-12 in Macrophages and Modulation by IFN-y Ursula Grohmann, Maria L. Belladonna, Carmine Vacca, Roberta Bianchi, Francesca Fallarino, Ciriana Orabona, Maria C. Fioretti, and Paolo Puccetti Regulation of Dendritic Cell Recruitment into Resting and Inflamed Airway Epithelium: Use of Alternative Chemokine Receptors as a Function of Inducing Stimulus Philip A. Stumbles, Deborah H. Strickland, Carolyn L. Pimm, Stephen F. Proksch, Amanda M. Marsh, Andrew S. McWilliam, Anthony Bosco, Iriani Tobagus, Jennifer A. Thomas, Sylvia Napoli, Amanda E. I. Proudfoot, Timothy N. C. Wells, and Patrick G. Holt Down-Regulation of IL-12 p40 Gene in Plasmodium berghei-Infected Mice Xin Xu, Kohsuke Sumita, Chiguang Feng, Xiaozhong Xiong, Hua Shen, Saho Maruyama, Makoto Kanoh, and Yoshihiro Asano B-Myb Overexpression Results in Activation and Increased Fas/Fas Ligand-Mediated Cytotoxicity of T and NK Cells Mark A. Powzaniuk, Rossana Trotta, Matthew J. Loza, Amy Harth, Renato V. Iozzo, Lawrence C. Eisenlohr, Bice Perussia, and Bruno Calabretta Pertussis Toxin Inhibits Induction of Tissue-Specific Autoimmune Disease by Disrupting G Protein-Coupled Signals Shao Bo Su, Phyllis B. Silver, Meifen Zhang, Chi-Chao Chan, and Rachel R. Caspi MOLECULAR AND STRUCTURAL IMMUNOLOGY Unequal V,, Gene Rearrangement Frequency Within the Large V,,7183 Gene Family Is Not Due to Recombination Signal Sequence 257 Variation, and Mapping of the Genes Shows a Bias of Rearrangement Based on Chromosomal Location G. Stuart Williams, Alan Martinez, Alina Montalbano, Alan Tang, America Mauhar, Kisani M. Ogwaro, Denise Merz, Christophe Chevillard, Roy Riblet, and Ann J. Feeney Transcription Factor NF-«B Regulates IgA Light Chain Gene Rearrangement Heather H. Bendall, Michael L. Sikes, and Eugene M. Oltz Critical Role for CD8 in Binding of MHC Tetramers to TCR: CD8 Antibodies Block Specific Binding of Human Tumor-Specific MHC-Peptide Tetramers to TCR Galit Denkberg, Cyril J. Cohen, and Yoram Reiter The Sushi Domain of Soluble IL-15 Receptor a Is Essential for Binding IL-15 and Inhibiting Inflammatory and Allogenic Responses In Vitro and In Vivo Xiao-qing Wei, Michael Orchardson, J. Alastair Gracie, Bernard P. Leung, Bao-mei Gao, Hui Guan, Wanda Niedbala, Gavin K. Paterson, lain B. McInnes, and Foo Y. Liew IL-1 Induced Chemokine Production Through the Association of Syk with TNF Receptor-Associated Factor-6 in Nasal Fibroblast Lines Takechiyo Yamada, Shigeharu Fujieda, Shigeru Yanagi, Hirohei Yamamura, Ryoko Inatome, Hideyuki Yamamoto, Hideki Igawa, and Hitoshi Saito Human Notch-1 Inhibits NF-«B Activity in the Nucleus Through a Direct Interaction Involving a Novel Domain Jinhai Wang, Lesile Shelly, Lucio Miele, Robert Boykins, Michael A. Norcross, and Ennan Guan Structural Effects of Framework Mutations on a Humanized Anti-Lysozyme Antibody MargaretA . Holmes, Timothy N. Buss, and Jefferson Foote A NF-«B/Sp1 Region Is Essential for Chromatin Remodeling and Correct Transcription of a Human Granulocyte- Macrophage Colony-Stimulating Factor Transgene Dimitrios Cakouros, Peter N. Cockerill, Andrew G. Bert, Renu Mital, Donna C. Roberts, and M. Frances Shannon The Smad3 Protein Is Involved in TGF-8 Inhibition of Class II Transactivator and Class II MHC Expression Yuanshu Dong, Liping Tang, John J. Letterio, and Etty N. Benveniste Induction of Germline Transcription in the Human TCRy Locus by STATS Hai-Chon Lee, Sang-Kyu Ye, Tasuku Honjo, and Koichi Ikuta CONTENTS Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase { Marilyn Diaz, Laurent K. Verkoczy, Martin F. Flajnik, and Norman R. Klinman Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells Pedro A. Reche, Vassili Soumelis, Daniel M. Gorman, Teresa Clifford, Man-ru Liu, Marilyn Travis, Sandra M. Zurawski, Jim Johnston, Yong-Jun Liu, Hergen Spits, Rene de Waal Malefyt, Robert A. Kastelein, and J. Fernando Bazan Unstimulated Human CD4 Lymphocytes Express a Cytoplasmic Immature Form of the Common Cytokine Receptor y-Chain Lynda Bani, Virginie Pasquier, Marko Kryworuchko, Jean Salamero, and Jacques Théze HOST DEFENSE 350 A Distinct Pathway of Cell-Mediated Apoptosis Initiated by Granulysin Allan A. Kaspar, Satoshi Okada, Jayant Kumar, Francis R. Poulain, Katerina A. Drouvalakis, Ameeta Kelekar, Dennis A. Hanson, Ruth M. Kluck, Yasumichi Hitoshi, Daniel E. Johnson, Christopher J. Froelich, Craig B. Thompson, Donald D. Newmeyer, Alberto Anel, Carol Clayberger, and Alan M. Krensky Protection Against Murine Listeriesis by Oral Vaccination with Recombinant Salmonella Expressing Hybrid Yersinia Type III Proteins Holger Riissmann, Emeka I. Igwe, Jeannette Sauer, Wolf-Dietrich Hardt, Andreas Bubert, and Gernot Geginat IL-8 Production in Human Lung Fibroblasts and Epithelial Cells Activated by the Pseudomonas Autoinducer N-3-Oxododecanoy! Homoserine Lactone Is Transcriptionally Regulated by NF-«B and Activator Protein-2 Roger S. Smith, Eric R. Fedyk, T. A. Springer, N. Mukaida, Barbara H. Iglewski, and Richard P. Phipps Enhanced Protection Against Fatal Mycobacterial Infection in SCID Beige Mice by Reshaping Innate Immunity with IFN-y Transgene Zhou Xing, Anna Zganiacz, Jun Wang, and Sudhir K. Sharma Dendritic Cells Recruitment and In Vivo Priming of CD8~ CTL Induced by a Single Topical or Transepithelial Immunization Via the Buccal Mucosa with Measles Virus Nucleoprotein Nathalie Etchart, Pierre-Olivier Desmoulins, Karine Chemin, Charles Maliszewski, Bertrand Dubois, Fabian Wild, and Dominique Kaiserlian IFN-y-Independent Autocrine Cytokine Regulatory Mechanism in Reprogramming of Macrophage Responses to Bacterial Lipopolysaccharide Ryan Brewington, Manjil Chatterji, Mikhail Zoubine, Roberto N. Miranda, Mari Norimatsu, and Alex Shnyra Cytokine-Responsive Gene-2/IFN-Inducible Protein-10 Expression in Multiple Models of Liver and Bile Duct Injury Suggests a Role in Tissue Regeneration Leonidas G. Koniaris, Teresa Zimmers-Koniaris, Edward C. Hsiao, Kenneth Chavin, James V. Sitzemann, and Joshua M. Farber Impaired Mucosal Immunity in L-Selectin-Deficient Mice Orally Immunized with a Salmonella Vaccine Vector David W. Pascual, Michelle D. White, Trina Larson, and Nancy Walters Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite Marco A. S. Campos, Igor C. Almeida, Osamu Takeuchi, Shizuo Akira, Eneida P. Valente, Daniela O. Procépio, Luiz R. Travassos, Jason A. Smith, Douglas T. Golenbock, and Ricardo T. Gazzinelli Role of Effector Cell-Derived IL-4, IL-5, and Perforin in Early and Late Stages of Type 2 CD8 Effector Cell-Mediated Tumor Rejection Mark J. Dobrzanski, Jouce B. Reome, and Richard W. Dutton Induction of Apoptosis in Human T Cells by Actinobacillus actinomycetemcomitans Cytolethal Distending Toxin Is a Consequence of G» Arrest of the Cell Cycle Bruce J. Shenker, Roselle H. Hoffmaster, Ali Zekavat, Noboru Yamaguchi, Edward T. Lally, and Donald R. Demuth Lacto-N-fucopentaose III Found on Schitosoma mansoni Egg Antigens Functions as Adjuvant for Proteins by Inducing Th2-Type Response Mitsuhiro Okano, Abhay R. Satoskar, Kazunori Nishizaki, and Donald A. Harn, Jr. INFLAMMATION 481 Serum Proteins Modified by Neutrophil-Derived Oxidants as Mediators of Neutrophil Stimulation GiintherF . Kérméczi, Ulrike M. Wolfel, Alexander R. Rosenkranz, Walter H. Hérl, Rainer Oberbauer, and Gerhard J. Zlabinger Role of Mitogen-Activated Protein Kinase-Mediated Cytosolic Phospholipase A, Activation in Arachidonic Acid Metabolism in Human Eosinophils Xiangdong Zhu, Hiroyuki Sano, Kwang Pyo Kim, Akiko Sano, Evan Boetticher, Nilda M. Mufioz, Wonhwa Cho, and Alan R. Leff Microsomal Prostaglandin E Synthase Is Regulated by Proinflammatory Cytokines and Glucocorticoids in Primary Rheumatoid Synovial Cells Dirk O. Stichtenoth, Staffan Thorén, Huimin Bian, Marc Peters-Golden, Per-Johan Jakobsson, and Leslie J. Crofford G,-Mediated Activation of the Syk Kinase by the Receptor Mimetic Basic Secretagogues of Mast Cells: Role in Mediating Arachidonic Acid/Metabolites Release Trit Shefler and Ronit Sagi-Eisenberg Diphosphoryl Lipid A from Rhodobacter sphaeroides Blocks the Binding and Internalization of Lipopolysaccharide in RAW 264.7 Cells Galina D. Kutuzova, Ralph M. Albrecht, Chris M. Erickson, and Nilofer Qureshi CONTENTS [voL. 167 Gammalinolenic Acid, an Unsaturated Fatty Acid with Anti-Inflammatory Properties, Blocks Amplification of IL-18 Production by Human Monocytes Robert K. Furse, Ronald G. Rossetti, and Robert B. Zurier Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-y Production in Human Peripheral Blood Mononuclear and NK Cells Shin-Je Lee, Young-Sik Cho, Min-Chul Cho, Jung-Hyun Shim, Kyung-Ae Lee, Kwang-Kjune Ko, Yong Kyung Choe, Sue-Nie Park, Tomoaki Hoshino, SooHyun Kim, Charles A. Dinarello, and Do-Young Yoon Kaposi’s Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Constitutively Activates NF-xB and Induces Proinflammatory Cytokine and Chemokine Production Via a C-Terminal Signaling Determinant Mario Schwarz and Philip M. Murphy Dissection of the Intracellular Pathways in Hepatocytes Suggests a Role for Jun Kinase and IFN Regulatory Factor-1 in Con A- Induced Liver Failure Konrad Streetz, Bastian Fregien, Jérg Pliimpe, Kerstin Korber, Stefan Kubicka, G. Sass, Stephan C. Bischoff, Michael P. Manns, Gisa Tiegs. and Christian Trautwein Stem Cell Factor-Induced Leukotriene B, Production Cooperates with Eotaxin to Mediate the Recruitment of Eosinophils During Allergic Pleurisy in Mice André Klein, André Talvani, Patricia M. R. Silva, Marco A. Martins, Tim N. C. Wells, Amanda Proudfoot, Nick W. Luckacs, and Mauro M. Teixeira CLINICAL IMMUNOLOGY Critical Role for IL-4 in the Development of Transplant Arteriosclerosis in the Absence of CD40-CD154 Costimulation Stephan M. Ensminger, Bernd M. Spriewald, Henrik V. Sorensen, Oliver Witzke, Emily G. Flashman, Andrew Bushell, Peter J. Morris, Marlene L. Rose, Amin Rahemtulla, and Kathryn J. Wood Estrogen Treatment Down-Regulates TNF-a Production and Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Cytokine Knockout Mice Atsushi Ito, BruceF . Bebo, Jr., Agata Matejuk, Alex Zamora, Marc Silverman, Amber Fyfe-Johnson, and Halina Offner Suppression of IL-2-Induced T Cell Proliferation and Phosphorylation of STAT3 and STAT5 by Tumor-Derived TGF£ Is Reversed by IL-15 John D. M. Campbell, Gordon Cook, Susan E. Robertson, Alasdair Fraser, Kelly S. Boyd, J. Alastair Gracie, and Ian M. Franklin T Cell Epitope Mapping of the Smith Antigen Reveals That Highly Conserved Smith Antigen Motifs Are the Dominant Target of T Cell Immunity in Systemic Lupus Erythematosus Beth L. Talken, Kim R. Schdfermeyer, Craig W. Bailey, David R. Lee, and Robert W. Hoffman Therapeutic Alteration of Insulin-Dependent Diabetes Mellitus Progression by T Cell Tolerance to Glutamic Acid Decarboxylase 65 Peptides In Vitro and In Vivo Stephen S. Wilson, Todd C. White, and Dominick DeLuca A Retro-Inverso Peptide Mimic of CD28 Encompassing the MYPPPY Motif Adopts a Polyproline Type II Helix and Inhibits Encephalitogenic T Cells In Vitro Mythily Srinivasan, Richard M. Wardrop, Ingrid E. Gienapp, Scott S. Stuckman, Caroline C. Whitacre, and Pravin T. P. Kaumaya Plasmid DNAs Encoding Insulin and Glutamic Acid Decarboxylase 65 Have Distinct Effects on the Progression of Autoimmune Diabetes in Nonobese Diabetic Mice Donald J. Weaver, Jr., Bo Liu, and Roland Tisch Correction Author Index AAI Membership Application AAI Trainee Membership Application VOLUME 167/N° 2/ JULY 15, 2001 PRESIDENTIAL ADDRESS 617 Presidential Address to The American Association of Immunologists: Major Histocompatibility Complex Proteins and TCRs: Do They Really Go Together Like a Horse and Carriage? Philippa Marrack, Jeremy Bender, Michael Jordan, William Rees, Jennifer Robertson, Brian C. Schaefer, and John Kappler CUTTING Out 623 Cutting Edge: IFN-Inducible ELR~ CXC Chemokines Display Defensin-Like Antimicrobial Activity Alexander M. Cole, Tomas Ganz, Amy M. Liese, Marie D. Burdick, Lide Liu, and Robert M. Strieter Cutting Edge: Differential Requirements for Stat4 in Expression of Glycosyltransferases Responsible for Selectin Ligand Formation in Thi Cells Samuel J. White, Gregory H. Underhill, Mark H. Kaplan, and Geoffrey S. Kansas CONTENTS Cutting Edge: Editing of Recycling Class II:Peptide Complexes by HLA-DM Sulabha S. Pathak, John D. Lich, and Janice S. Blum Cutting Edge: Protein Kinase CB Expression Is Critical for Export of IL-2 from T Cells Aideen Long, Dermot Kelleher, Sara Lynch, and Yuri Volkov Cutting Edge: Integration of Human T Lymphocyte Cytoskeleton by the Cytolinker Plectin Martin J. Brown, John A. Hallam, Yin Liu, Kenneth M. Yamada, and Stephen Shaw CELLULAR IMMUNOLOGY AND IMMUNE REGULATION 647 Chromatin-Independent Binding of Serum Amyloid P Component to Apoptotic Cells Atoosa Familian, Bas Zwart, Han G. Huisman, Irma Rensink, Dorina Roem, Peter L. Hordijk, Lucien A. Aarden, and C. Erik Hack Expansion of the Antigenic Repertoire of a Single T Cell Receptor upon T Cell Activation Abdelaziz Amrani, Pau Serra, Jun Yamanouchi, Jacqueline D. Trudeau, Rusung Tan, John F. Elliott, and Pere Santamaria Antigen Presentation by Liver Cells Controls Intrahepatic T Cell Trapping, Whereas Bone Marrow-Derived Cells Preferentially Promote Intrahepatic T Cell Apoptosis Wajahat Z. Mehal, Francesco Azzaroli, and I. Nicholas Crispe Fas Ligand (CD95L) Protects Neurons Against Perforin-Mediated T Lymphocyte Cytotoxicity Isabelle Medana, Zhaoxia Li, Alexander Fliigel, Jiirg Tschopp, Hartmut Wekerle, and Harald Neumann The Peyer’s Patch Microenvironment Suppresses T Cell Responses to Chemokines and Other Stimuli Sirid-Aimée Kellermann and Leslie M. McEvoy A Genetic Model of Stress Displays Decreased Lymphocytes and Impaired Antibody Responses Without Altered Susceptibility to Streptococcus pneumoniae Susan E. Murray, Holly R. Lallman, Amanda D. Heard, Marvin B. Rittenberg, and Mary P. Stenzel-Poore Competitive Inhibition In Vivo and Skewing of the T Cell Repertoire of Antigen-Specific CTL Priming by an Anti-Peptide-MHC Monoclonal Antibody Doo Hyun Chung, Igor M. Belyakov, Michael A. Derby, Jian Wang, Lisa F. Boyd, Jay A. Berzofsky, and David H. Margulies IL-6 Inhibits the Tolerogenic Function of CD8a* Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase Ursula Grohmann, Francesca Falliarino, Roberta Bianchi, Maria Laura Belladonna, Carmine Vacca, Ciriana Orabona, Catherine Uyttenhove, Maria Cristina Fioretti, and Paolo Puccetti Enforced Expression of GATA-3 During T Cell Development Inhibits Maturation of CD8 Single-Positive Cells and Induces Thymic Lymphoma in Transgenic Mice Martijn C. Nawijn, Rita Ferreira, Gemma M. Dingjan, Olev Kahre, Dubravka Drabek, Alar Karis, Frank Grosveld, and Rudolf W. Hendriks Enforced Expression of GATA-3 in Transgenic Mice Inhibits Th1 Differentiation and Induces the Formation of a T1/ST2- Expressing Th2-Committed T Cell Compartment In Vivo Martijn C. Nawijn, Gemma M. Dingjan, Rita Ferreira, Bart N. Lambrecht, Alar Karis, Frank Grosveld, Huub Savelkoul, and Rudolf W. Hendriks B Cell Receptor Cross-Linking Triggers a Caspase-8-Dependent Apoptotic Pathway That Is Independent of the Death Effector Domain of Fas-Associated Death Domain Protein Laurence Besnault, Nicolas Schrantz, Marie Thérése Auffredou, Gérald Leca, Marie Francoise Bourgeade, and Aimé Vazquez The Dendritic Cell Populations of Mouse Lymph Nodes Sandrine Henri, David Vremec, Arun Kamath, Jason Waithman, Stuart Williams, Christophe Benoist, Kim Burnham, Sem Saeland, Emanuela Handman, and Ken Shortman IL-12 Decreases Activation-Induced Cell Death in Human Naive Th Cells Costimulated by Intercellular Adhesion Molecule-t. L. IL- 12 Alters Caspase Processing and Inhibits Enzyme Function Ellen M. Palmer, Lili Farrokh-Siar, Jean Maguire van Seventer, and Gijs A. van Seventer The Binding of Thymus Leukemia (TL) Antigen Tetramers to Normal Intestinal Intraepithelial Lymphocytes and Thymocytes Kunio Tsujimura, Yuichi Obata, Yasue Matsudaira, Satoshi Ozeki, Kazuhiro Yoshikawa, Shinsuke Saga, and Toshitada Takahashi Wnt Signaling Regulates Hemopoiesis Through Stromal Cells Toshiyuki Yamane, Takahiro Kunisada, Hirotake Tsukamoto, Hidetoshi Yamazaki, Hitoshi Niwa, Shinji Takada, and Shin-Ichi Hayashi Regulation of TGF-8 Response During T Cell Activation Is Modulated by IL-10 Francoise Cottrez and Hervé Groux A Role for IL-12 Receptor Expression and Signal Transduction in Host Defense in Leprosy Jenny Kim, Koichi Uyemura, Melissa K. Van Dyke, Annaliza J. Legaspi, Thomas H. Rea, Ke Shuai, and Robert L. Modlin Identification of New Epitopes from Four Different Tumor-Associated Antigens: Recognition of Naturally Processed Epitopes Correlates with HLA-A*0201-Binding Affinity Elissa Keogh, John Fikes, Scott Southwood, Esteban Celis, Robert Chesnut, and Alessandro Sette Engagement of FceRI on Human Monocytes Induces the Production of IL-10 and Prevents Their Differentiation in Dendritic Cells Natalija Novak, Thomas Bieber, and Norito Katoh Peripheral T Cells Become Sensitive to Glucocorticoid- and Stress-Induced Apoptosis in Transgenic Mice Overexpressing SRG3 Sunmi Han, Heonsik Choi, Myung-gon Ko, Young I. Choi, Dong H. Sohn, Joong K. Kim, Dongho Shin, Heekyoung Chung, Han W. Lee, Jae-B. Kim, Sang D. Park, and Rho H. Seong Viii CONTENTS [voL. 167 MOLECULAR AND STRUCTURAL IMMUNOLOGY gil A Pivotal Role for DNase I-Sensitive Regions 3b and/or 4 in the Induction of Somatic Hypermutation of IgH Genes Akiko Terauchi, Katsuhiko Hayashi, Daisuke Kitamura, Yuko Kozono, Noboru Motoyama, and Takachika Azuma 821 Monomeric Class I Molecules Mediate TCR/CD3¢/CD8 Interaction on the Surface of T Cells Matthew S. Block, Aaron J. Johnson, Yanice Mendez-Fernandez, and Larry R. Pease CD28 Signaling Augments Elk-1-Dependent Transcription at the c-fos Gene During Antigen Stimulation Wei Li, Carmella D. Whaley, Jody L. Bonnevier, Anna Mondino, Molly E. Martin, Kjersti M. Aagaard-Tillery, and Daniel L. Mueller Functional Evidence That Conserved TCR CDRa3 Loop Docking Governs the Cross-Recognition of Closely Related Peptide:Class I Complexes Ilthem Messaoudi, Joel LeMaoult, Beatrix M. Metzner, Michael J. Miley, Daved H. Fremont, and Janko Nikolich-Zugich Signal Transduction by Human-Restricted Fc yRIla Involves Three Distinct Cytoplasmic Kinase Families Leading to Phagocytosis Damon S. Cooney, Hyewon Phee, Anand Jacob, and K. Mark Coggeshall Unexpected Characteristics of the IFN-y Reporters in Nontransformed T Cells Hong Zhu, Jianfei Yang, Theresa L. Murphy, Wenjun Ouyang, Fred Wagner, Arman Saparov, Casey T. Weaver, and Kenneth M. Murphy Chromatin Remodeling at the Ig Loci Prior to V(D)J Recombination Jéréme Maés, Laura P. O'Neill, Patricia Cavelier, Bryan M. Turner, Francois Rougeon, and Michele Goodhardt Functional CD4 T Cells after Intercellular Molecular Transfer of OX40 Ligand Eishi Baba, Yoshiaki Takahashi, Juliane Lichtenfeld, Reiko Tanaka, Atsushi Yoshida, Kazuo Sugamura, Naoki Yamamoto, and Yuetsu Tanaka Regulation of MHC Class II Antigen Presentation by Sorting of Recycling HLA-DM/DO and Class II within the Multivesicular Body Marcel van Lith, Marieke van Ham, Alexander Griekspoor, Esther Tjin, Desiree Verwoerd, Jero Calafat, Hans Janssen, Eric Reits, Liesbeth Pastoors, and Jacques Neefjes HoOsT DEFENSE 893 Oxidative Responses of Human and Murine Macrophages During Phagocytosis of Leishmania chagasi Kira R. Gantt, Todd L. Goldman, Michael L. McCormick, Melissa A. Miller, Selma M. B. Jeronimo, Eliana T. Nascimento, Bradley E. Britigan, and Mary E. Wilson IFN-y Overproduction and High Level Apoptosis Are Associated with High but Not Low Virulence Toxoplasma gondii Infection L. Cristina Gavrilescu and Eric Y. Toll-Like Receptor 2-Dependent Inhibition of Macrophage Class II MHC Expression and Antigen Processing by 19-kDa Lipoprotein of Mycobacterium tuberculosis Erika H. Noss, Rish K. Pai, Timothy J. Sellati, Justin D. Radolf, John Belisle, Douglas T. Golenbock, W. Henry Boom, and Clifford V. Harding A Dominant Role for Fey Receptors in Antibody-Dependent Corneal Inflammation Laurie R. Hall, Eugenia Diaconu, and Eric Pearlman Negative Selection of T Cells by Helicobacter pylori as a Model for Bacterial Strain Selection by Immune Evasion Jide Wang, Edward G. Brooks, Kathleen B. Bamford, Timothy L. Denning, Jacques Pappo, and Peter B. Ernst Regulation of Complement Classical Pathway by Association of C4b-Binding Protein to the Surfaces of SK-OV-3 and Caov-3 Ovarian Adenocarcinoma Cells Mikko T. Holmberg, Anna M. Blom, and Seppo Meri Modulation of Macrophage Cytokine Production by ES-62, a Secreted Product of the Filarial Nematode Acanthocheilonema viteae Helen S. Goodridge, Emma H. Wilson, William Harnett, Carol C. Campbell, Margaret M. Harnett, and Foo Y. Liew Overexpression of IL-15 In Vivo Enhances Protection Against Mycobacterium bovis Bacillus Calmette-Guérin Infection Via Augmentation of NK and T Cytotoxic 1 Responses Masayuki Umemura, Hitoshi Nishimura, Kenji Hirose, Tetsuya Matsuguchi, and Yasunobu Yoshikai INFLAMMATION 957 IL-12/1L-18-Dependent IFN-y Release by Murine Dendritic Cells Detlef Stober, Reinhold Schirmbeck, and Jérg Reimann 966 Inhibition of Endotoxin-Induced Macrophage Chemokine Production by Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide In Vitro and In Vivo Mario Delgado and Doina Ganea Glucocorticoid Augmentation of Macrophage Capacity for Phagocytosis of Apoptotic Cells Is Associated with Reduced p130Cas Expression, Loss of Paxillin/pyk2 Phosphorylation, and High Levels of Active Rac Katherine M. Giles, Katherine Ross, Adriano G. Rossi, Neil A. Hotchin, Christopher Haslett, and Ian Dransfield Cooperation of Toll-Like Receptor 2 and 6 for Cellular Activation by Soluble Tuberculosis Factor and Borrelia burgdorferi Outer Surface Protein A Lipoprotein: Role of Toll-Interacting Protein and IL-1 Receptor Signaling Molecules in Toll-Like Receptor 2 Signaling Yonca Bulut, Emmanuelle Faure, Lisa Thomas, Ozlem Equils, and Moshe Arditi CONTENTS ix Human Eosinophils and Human High Affinity IgE Receptor Transgenic Mouse Eosinophils Express Low Levels of High Affinity IgE Receptor, but Release IL-10 upon Receptor Activation Hiroyuki Kayaba, David Dombrowicz, Gaetane Woerly, Jean-Paul Papin, Sylvie Loiseau, and Monique Capron IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis Erik Lubberts, Leo A. B. Joosten, Birgitte Oppers, Liduine van den Bersselaar, Christina J. J. Coenen-de Roo, Jay K. Kolls, Paul Schwarzenberger, Fons A. J. van de Loo, and Wim B. van den Berg Interaction of Mite Allergens Der P3 and Der P9 with Protease-Activated Receptor-2 Expressed by Lung Epithelial Cells Guo Sun, Martin A. Stacey, Matthias Schmidt, Luca Mori, and Sabrina Mattoli Distinct Tissue Site-Specific Requirements of Mast Cells and Complement Components C3/C5a Receptor in IgG Immune Complex- Induced Injury of Skin and Lung Ulrich Baumann, Nelli Chouchakova, Britta Gewecke, Jérg Kohl, Michael C. Carroll, Reinhold E. Schmidt, and J. Engelbert Gessner Differential Regulation of Chemokine Production in Human Peritoneal Mesothelial Cells: IFN-y Controls Neutrophil Migration Across the Mesothelium In Vitro and In Vivo Rachel L. Robson, Rachel M. McLoughlin, Janusz Witowski, Pius Loetscher, Thomas S. Wilkinson, Simon A. Jones, and Nicholas Topley Functional Expression of IL-12 Receptor by Human Eosinophils: [L-12 Promotes Eosinophil Apoptosis Esra Nutku, Qianli Zhuang, Abdelillah Soussi-Gounni, Fadi Aris, Bruce D. Mazer, and Qutayba Hamid Tissue-Type Plasminogen Activator Deficiency Exacerbates Arthritis Yuan H. Yang, Peter Carmeliet, and John A. Hamilton Adenoviral Delivery of Human and Viral IL-10 in Murine Sepsis Rebecca M. Minter, Maria A. Ferry, Michelle E. Murday, Cynthia L. Tannahill, Frances R. Bahjat, Caroline Oberholzer, Andreas Oberholzer, Drake LaFace, Beth Hutchins, Shufen Wen, Jeremy Shinoda, Edward M. Copeland III, and Lyle L. Moldawer Respiratory Syncytial Virus Predisposes Mice to Augmented Allergic Airway Responses Via IL-13-Mediated Mechanisms Nicholas W. Lukacs, Kim K. Tekkanat, Aaron Berlin, Cory M. Hogaboam, Allison Miller, Holly Evanoff, Pam Lincoln, and Hussien Maassab CLINICAL IMMUNOLOGY 1066 H-2D End Confers Dominant Protection from IL-1C-Mediated Acceleration of Autoimmune Diabetes in the Nonobese Diabetic Mouse Antonio La Cava, Balaji Balasa, Augusta Good, Kurt van Gunst, Nadja Jung, and Nora Sarvetnick Lymphoid Neogenesis in Rheumatoid Synovitis Seisuke Takemura, Andrea Braun, Cynthia Crowson, Paul J. Kurtin, Robert H. Cofield, William M. O'Fallon, Jérg J. Goronzy, and Cornelia M. Weyand Lipopolysaccharide-Activated B Cells Down-Regulate Thl Immunity and Prevent Autoimmune Diabetes in Nonobese Diabetic Mice Jide Tian, Dan Zekzer, Lorraine Hanssen, Yuxin Lu, Angelica Olcott, and Daniel L. Kaufman CD4* T Cells Engrafted with a Recombinant Immunoreceptor Efficiently Lyse Target Cells in a MHC Antigen- and Fas- Independent Fashion Andreas Hombach, Claudia Heuser, Thomas Marquardt, Anja Wieczarkowiecz, Volker Groneck, Christoph Pohl, and Hinrich Abken Immunofluorescence Detection of 5 Opioid Receptors (DOR) on Human Peripheral Blood CD4* T Cells and DOR-Dependent Suppression of HIV-1 Expression Burt M. Sharp, K. McAllen, Genya Gekker, N. A. Shahabi, and Phillip K. Peterson Costimulation Blockade, Busulfan, and Bone Marrow Promote Titratable Macrochimerism, Induce Transplantation Tolerance, and Correct Genetic Hemoglobinopathies with Minimal Myelosuppression Andrew B. Adams, Megan M. Durham, Leslie Kean, Nozomu Shirasugi, Jongwon Ha, Matthew A. Williams, Phyllis A. Rees, Michael C. Cheung, Stephen Mittelstaedt, Adam W. Bingaman, David R. Archer, Thomas C. Pearson, Edmund K. Waller, and Christian P. Larsen Defective CD8* T Cell Peripheral Tolerance in Nonobese Diabetic Mice Huub T. C. Kreuwel, Judith A. Biggs, Ingrid M. Pilip, Eric G. Pamer, David Lo, and Linda A. Sherman Acetylcholine Receptor Peptide Recognition in HLA DR3-Transgenic Mice: In Vivo Responses Correlate with MHC-Peptide Binding Raghavanpillai Raju, Edward G. Spack, and Chella S. David Failure to Induce Neonatal Tolerance in Mice That Lack Both IL-4 and IL-13 but Not in Those That Lack IL-4 Alone Yoshihiko Inoue, Bogumila T. Konieczny, Maylene E. Wagener, Andrew N. J. McKenzie, and Fadi G. Lakkis Author Index AAI Membership Application AAI Trainee Membership Application VOLUME 167 / N° 3/ AUGUST 1, 2001 CUTTING Hut 1137 Cutting Edge: Control of CD8* T Cell Activation by CD4*CD25~* Immunoregulatory Cells Ciriaco A. Piccirillo and Ethan M. Shevach CONTENTS [voL. 167 Cutting Edge: The Mouse NK Cell-Associated Antigen Recognized by DX5 Moncoclonal Antibody is CD49b (a, Integrin, Very Late Antigen-2) Hisashi Arase, Takashi Saito, Joseph H. Phillips, and Lewis L. Lanier CELLULAR IMMUNOLOGY AND IMMUNE REGULATION 1145 Unexpected Transcriptional Induction of Monocyte Chemoattractant Protein 1 by Proteasome Inhibition: Involvement of the c-Jun N-Terminal Kinase-Activator Protein 1 Pathway Kenji Nakayama, Akira Furusu, Qihe Xu, Tsuneo Konta, and Masanori Kitamura Clonotypic Structure of the Human CD4* Memory T Cell Response to Cytomegalovirus Arlene D. Bitmansour, Shar L. Waldrop, Christine J. Pitcher, Elham Khatamzas, Florian Kern, Vernon C. Maino, and Louis J. Picker CD1d-Restricted NKT Cells: An Interstrain Comparison Kirsten J. L. Hammond, Daniel G. Pellicci, Lynn D. Poulton, Olga V. Naidenko, Anthony A. Scalzo, Alan G. Baxter, and Dale I. Godfrey Rejection of Mouse Cardiac Allografts by Costimulation in trans Didier A. Mandelbrot, Koji Kishimoto, Hugh Auchincloss, Jr., Arlene H. Sharpe, and Mohamed H. Sayegh IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation Fabrizio Mattei, Giovanna Schiavoni, Filippo Belardelli, and David F. Tough Mature Dendritic Cells Prime Functionally Superior Melan-A-Specific CD8* Lymphocytes as Compared with Nonprofessional APC Mariolina Salio, Dawn Shepherd, P. Rod Dunbar, Michael Palmowski, Kristine Murphy, Lijun Wu, and Vincenzo Cerundolo CD44 Is the Physiological Trigger of Fas Up-Regulation on Rheumatoid Synovial Cells Koichi Fujii, Yuko Fujii, Stefan Hubscher, and Yoshiya Tanaka A Novel Autocrine Pathway of Tumor Escape from Immune Recognition: Melanoma Cell Lines Produce a Soluble Protein That Diminishes Expression of the Gene Encoding the Melanocyte Lineae Melan-A/MART-1 Antigen Through Down-Modulation of Its Promoter James T. Kurnick, Teresa Ramirez-Montagut, Lenora A. Boyle, David M. Andrews, Franco Pandolfi, Paul J. Durda, David Butera, Ian S. Dunn, Elizabeth M. Benson, Sam J. P. Gobin, and PeterJ . van den Elsen Differences in the Expression of Human Class I MHC Alleles and Their Associated Peptides in the Presence of Proteasome Inhibitors Chance John Luckey, Jarrod A. Marto, Megan Partridge, Ed Hall, Forest M. White, John D. Lippolis, Jeffrey Shabanowitz, Donald F. Hunt, and Victor H. Engelhard A Role of the Mitochondrial Apoptosis-Inducing Factor in Granulysin-Induced Apoptosis Julian Pardo, Patricia Pérez-Galan, Susana Gamen, Isabel Marzo, Inmaculada Monleon, Allan A. Kaspar, Santos A. Susin, Guido Kroemer, Alan M. Krensky, Javier Naval, and Alberto Anel IL-4 Influences Apoptosis of Mycobacterium-Reactive Lymphocytes in the Presence of TNF-a Geok Teng Seah and Graham A. W. Rook Human IL-18 Receptor and ST2L Are Stable and Selective Markers for the Respective Type 1 and Type 2 Circulating Lymphocytes Woon Ling Chan, Nada Pejnovic, Christine A. Lee, and Nadia A. Al-Ali CD4*CD25"*" Regulatory Cells in Human Peripheral Blood Clare Bazcher-Allan, Julia A. Brown, Gordon J. Freeman, and David A. Hafler A V,,12 Transgenic Mouse Exhibits Defects in Pre-B Cell Development and Is Unable to Make IgM* B Cells Hongsheng Wang, Jian Ye, Larry W. Arnold, Suzanne K. McCray, and Stephen H. Clarke Positive Signaling Through CD72 Induces Mitogen-Activated Protein Kinase Activation and Synergizes with B Cell Receptor Signals to Induce X-Linked Immunodeficiency B Cell Proliferation Hsin-Jung Wu, Chandrasekar Venkataraman, Steven Estus, Chen Dong, RogerJ .D avis, Richard A. Flavell, and Subbarao Bondada Processing of Exogenous Antigens for Presentation by Class I MHC Molecules Involves Post-Golgi Peptide Exchange Influenced by Peptide-MHC Complex Stability and Acidic pH Peter J. Chefalo and Clifford V. Harding Multiple Paths for Activation of Naive CD8* T Cells: CD4-Independent Help Bo Wang, Christopher C. Norbury, Roberta Greenwood, Jack R. Bennink, Jonathan W. Yewdell, and Jeffrey A. Frelinger Minimal Requirements for IgE-Mediated Regulation of Surface FceRI Teresa A. Borkowski, Marie-Héléne Jouvin, Shih-Yao Lin, and Jean-Pierre Kinet Recombinant Adenovirus Coexpressing Covalent Peptide/MHC Class II Complex and B7-1: In Vitro and In Vivo Activation of Myelin Basic Protein-Specific T Cells Jiang Chen, Brigitte T. Huber, Richard J. Grand, and Wei Li An Absolute Requirement for STAT4 and a Role for IFN-y as an Amplifying Factor in IL-12 Induction of the Functional IL-18 Receptor Complex Masakiyo Nakahira, Michio Tomura, Masayuki Iwasaki, Hyun-Jong Ahn, Yang Bian, Toshiyuki Hamaoka, Tsunetaka Ohta, Masashi Kurimoto, and Hiromi Fujiwara 4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Effi Jennifer L. Cannons, Peggy Lau, Birinder Ghumman, Mark A. DeBenedette, Hideo Yagita, Ko Okumura, and Tania H. Watts