VOLUME 160/ N° 1 / JANUARY 1, 1998 EDITORIAL More Changes in The Journal of Immunology CUTTING Hut Cutting Edge: Lymphocyte Inhibitor of TRAIL (TNF-Related Apoptosis-Inducing Ligand): A New Receptor Protecting Lymphocytes from the Death Ligand TRAIL Juthathip Mongkolsapaya, Alison E. Cowper, Xiao-Ning Xu, Gwilym Morris, Andrew J. McMichael, John I. Bell, and Gavin R. Screaton Cutting Edge: p21-Activated Kinase (PAK) Is Required for Fas-Induced JNK Activation in Jurkat Cells Thomas Rudel, Frank T. Zenke, Tsung-Hsien Chuang, and Gary M. Bokoch Cutting Edge: CTLA-4 Ligation Delivers a Unique Signal to Resting Human CD4 T Cells That Inhibits Interleukin-2 Secretion but Allows Bcl-X; Induction Patrick J. Blair, James L. Riley, Bruce L. Levine, Kelvin P. Lee, Nancy Craighead, Tara Francomano, Steven J. Perfetto, Gary S. Gray, Beatriz M. Carreno, and Carl H. June Cutting Edge: Critical Role of NK1* T Cells in IL-12-Induced Immune Responses In Vivo Toshihiko Kawamura, Kazuyoshi Takeda, Sanjeev K. Mendiratta, Hiroki Kawamura, Luc Van Kaer, Hideo Yagita, Toru Abo, and Ko Okumura Cutting Edge: Identification of the Mouse IgG3 Receptor: Implications for Antibody Effector Function at the Interface Between Innate and Adaptive Immunity Amanda L. Gavin, Nadine Barnes, Hilde M. Dijstelbloem, and P. Mark Hogarth Cutting Edge: Stimulation of CD28 with B7-2 Promotes Focal Adhesion-Like Cell Contacts Where Rho Family Small G Proteins Accumulate in T Cells Shuji Kaga, Scott Ragg, Kem A. Rogers, and Atsuo Ochi Cutting Edge: HIV-1 Infection Induces a Selective Reduction in STAT5 Protein Expression Federica Pericle, Ligia A. Pinto, Stuart Hicks, Robert A. Kirken, Giuseppe Sconocchia, Janice Rusnak, Matthew J. Dolan, Gene M. Shearer, and David M. Segal CELLULAR IMMUNOLOGY AND IMMUNE REGULATION 33 Differences Between Responses of Naive and Activated T Cells to Anergy Induction Robert J. Hayashi, Dennis Y. Loh, Osami Kanagawa, and Fanping Wang An Alternative Translational Reading Frame Encodes an Immunodominant Retroviral CTL Determinant Expressed by an Immunodeficiency-Causing Retrovirus Shawn-Marie Mayrand, David A. Schwarz, and William R. Green A New Role for B Cells in Systemic Autoimmunity: B Cells Promote Spontaneous T Cell Activation in MRL-lpr/pr Mice Owen Chan and Mark J. Shlomchik IL-4 Induces Eotaxin: A Possible Mechanism of Selective Eosinophil Recruitment in Helminth Infection and Atopy Mitsuru Mochizuki, Joachim Bartels, Antony I. Mallet, Enno Christophers, and Jens-M. Schroder CONTENTS [voL. 160 In SCID-hu Mice, Passive Transfer of a Humanized Antibody Prevents Infection and Atrophic Change of Medulla in Human Thymic Implant due to Intravenous Inoculation of Primary HIV-1 Isolate Yukari Okamoto, Yasuyuki Eda, Atsuo Ogura, Shinwa Shibata, Takashi Amagai, Yoshimoto Katsura, Toshihiko Asano, Kazuhiko Kimachi, Keiichi Makizumi, and Mitsuo Honda Naturally Occurring Low Affinity Peptide/MHC Class I Ligands Can Mediate Negative Selection and T Cell Activation Bruce Motyka and Hung-Sia Teh Differential Effects of the Rejection of Bone Marrow Allografts by the Depletion of Activating Versus Inhibiting Ly-49 Natural Killer Cell Subsets Arati Raziuddin, Dan L. Longo, Llewellyn Mason, John R. Ortaldo, Michael Bennett, and William J. Murphy Normal Responsiveness of CTLA-4-Deficient Anti-Viral Cytotoxic T Cells Martin F. Bachmann, Paul Waterhouse, Daniel E. Speiser, Kim McKall-Faienza, Tak W. Mak, and Pamela S. Ohashi Spontaneous Inflammatory Disease in HLA-B27 Transgenic Mice Is Independent of MHC Class II Molecules: A Direct Role for B27 Heavy Chains and Not B27-Derived Peptides Sanjay D. Khare, Michael J. Bull, Julie Hanson, Harvinder S. Luthra, and Chella S. David Long-Lived B Cells Are Distinguished by Elevated Expression of Al Mary M. Tomayko and Michael P. Cancro Post-Thymic Maturation of Migrating Human Thymic Single-Positive T Cells: Thymic CDla CD4* T Cells Are More Susceptible to Anergy Induction by Toxic Shock Syndrome Toxin-1 than Cord Blood CD4* T Cells Kenichi Imanishi, Kazuhiro Seo, Hidehito Kato, Tohru Miyoshi-Akiyama, Rui-Hua Zhang, Yoshinori Takanashi, Yasuharu Imai, and Takehiko Uchiyama TNF Receptor-Deficient Mice Reveal Striking Differences Between Several Models of Thymocyte Negative Selection Dawne M. Page, Edda M. Roberts, Jacques J. Peschon, and Stephen M. Hedrick The c-Jun N-Terminal Kinase Cascade Plays a Role in Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression Mary Faris, Niels Kokot, Kevin Latinis, Shailaja Kasibhatla, Douglas R. Green, Gary A. Koretzky, and Andre Nel Harnessing Syk Family Tyrosine Kinases as Signaling Domains for Chimeric Single Chain of the Variable Domain Receptors: Optimal Design for T Cell Activation Cheryl J. Fitzer-Attas, Daniel G. Schindler, Tova Waks, and Zelig Eshhar Induction of Granulomatous Experimental Autoimmune Thyroiditis in IL-4 Gene-Disrupted Mice Haiwen Tang, Gordon C. Sharp, Karin E. Peterson, and Helen Braley-Mullen Regulation of TCR Signal Transduction in Murine Thymocytes by Multiple TCR ¢-Chain Signaling Motifs Nicolai S. C. van Oers, Paul E. Love, Elizabeth W. Shores, and Arthur Weiss MOLECULAR AND STRUCTURAL IMMUNOLOGY 171 Reduced Cell Surface Expression of HLA-C Molecules Correlates with Restricted Peptide Binding and Stable TAP Interaction Anne Neisig, Cornelis J. M. Melief, and Jacques Neefjes CONTENTS Detection and Delineation of CXCR4 (Fusin) as an Entry and Fusion Cofactor for T Cell- Tropic HIV-1 by Three Different Monoclonal Antibodies Toshiyuki Hori, Hitoshi Sakaida, Akihiko Sato, Toshihiro Nakajima, Hisatoshi Shida, Osamu Yoshie, and Takashi Uchiyama The MHC-E Locus Is the Most Well Conserved of All Known Primate Class I Histocompatibility Genes Leslie A. Knapp, Luis F. Cadavid, and David I. Watkins Characterization and Mapping to Human Chromosome 8q24.3 of Ly-6-Related Gene 9804 Encoding an Apparent Homologue of Mouse TSA-1 Xiaochuan Shan, Annie Bourdeau, Angela Rhoton, Dan E. Wells, Edward H. Cohen, Bryan E. Landgraf, and Roger G. E. Palfree Nuclear Factor of Activated T Cells (NFAT) as a Molecular Target for la,25- Dihydroxyvitamin D.-Mediated Effects Atsuko Takeuchi, G. Satyanarayana Reddy, Tadashi Kobayashi, Toshio Okano, Jungchan Park, and Surendra Sharma Identification of an Inhibitory MHC Receptor on Alloreactive Rat Natural Killer Cells Christian Naper, James C. Ryan, Mary C. Nakamura, Doris Lambracht, Bent Rolstad, and John T. Vaage Staphylococcal Enterotoxin D Is a Promiscuous Superantigen Offering Multiple Modes of Interactions With the MHC Class II Receptors Reem Al-Daccak, Khalil Mehindate, Farida Damdoumi, Pierre Etongué-Mayer, Helen Nilsson, Per Antonsson, Michael Sundstrém, Mikael Dohlsten, Rafick-Pierre Sékaly, and Walid Mourad Identification of Distinct Regions of 5’ Flanking DNA That Mediate Constitutive, IFN-y, STATI, and TGF-6-Regulated Expression of the Class II Transactivator Gene Janet F. Piskurich, Ying Wang, Michael W. Linhoff, Leigh C. White, and Jenny P.-Y. Ting A Two-Step Mechanism for Recruitment of Pip by PU.1 Jeffrey M. Perkel and Michael L. Atchison Monoclonal Anti-Cardiolipin Antibodies from New Zealand Black x New Zealand White F, Mice React to Thrombomodulin Kazuhiko Haruta, Shigeto Kobayashi, Sachiko Hirose, Aiko Horiai, Mutsuko Ohyanagi, Mitsuhiko Tanaka, Terunaga Kawano, Toshikazu Shirai, Yoshinari Takasaki, and Hiroshi Hashimoto V,, Repertoire of a Marsupial (Monodelphis domestica) Robert D. Miller, Hilary Grabe, and George H. Rosenberg Molecular Analysis of the Major MHC Recombinational Hot Spot Located Within the G7c Gene of the Murine Class III Region That Is Involved in Disease Susceptibility Margriet Snoek, Cory Teuscher, and Huub van Vugt HosT DEFENSE 273 Common and Distinct Signaling Pathways Mediate the Induction of TNF-a and IL-5 in IgE Plus Antigen-Stimulated Mast Cells R. Csonga, E. E. Prieschl, D. Jaksche, V. Novotny, and T. Baumruker The Role of Recombinant Murine IL-12 and IFN-y in the Pathogenesis of a Murine Systemic Candida albicans Infection Liz M. Lavigne, Lisa R. Schopf, Charles L. Chung, Rich Maylor, and Joseph P. Sypek CONTENTS [voL. 160 Peptides That Mimic the Group B Streptococcal Type III Capsular Polysaccharide Antigen Seth H. Pincus, Michael J. Smith, Harold J. Jennings, James B. Burritt, and Pati M. Glee IL-18 (IFN-y-Inducing Factor) Regulates Early Cytokine Production in, and Promotes Resolution of, Bacterial Infection in Mice Erwin Bohn, Andreas Sing, Robert Zumbihl, Claudia Bielfeldt, Haruki Okamura, Masashi Kurimoto, Jiirgen Heesemann, and Ingo B. Autenrieth Septic Arthritis Following Staphylococcus aureus Infection in Mice Lacking Inducible Nitric Oxide Synthase Iain B. McInnes, Bernard Leung, Xiao-Qing Wei, Curtis C. Gemmell, and Foo Y. Liew Legionella pneumophila Infection in Intratracheally Inoculated T Cell-Depleted or -Nondepleted A/J Mice Milorad Susa, Brigita Ticac, Tomislav Rukavina, Miljenko Doric, and Reinhard Marre Mechanism of Protective Immunity Against Influenza Virus Infection in Mice Without Antibodies Suzanne L. Epstein, Chia-Yun Lo, Julia A. Misplon, and Jack R. Bennink Accumulation of the p53 Protein Allows Recognition by Human CTL of a Wild-Type p53 Epitope Presented by Breast Carcinomas and Melanomas Sacha Gnjatic, Zhenzi Cai, Mireille Viguier, Salem Chouaib, Jean-Gérard Guillet, and Jeannine Choppin Successful Adoptive Cellular Immunotherapy Is Dependent on Induction of a Host Immune Response Triggered by Cytokine (IFN-y and Granulocyte/Macrophage Colony-Stimulating Factor) Producing Donor Tumor-Infiltrating Lymphocytes Makoto Nagoshi, Peter S. Goedegebuure, Ulrike L. Burger, Noriaki Sadanaga, Maximilian P. Chang, and Timothy J. Eberlein Neutrophils but Not Eosinophils Are Involved in Growth Suppression of IL-4-Secreting Tumors Gabriele Noffz, Zhihai Qin, Manfred Kopf, and Thomas Blankenstein Helminth Antigens Selectively Differentiate Unsensitized CD45RA*CD4* Human T Cells in Vitro Cathy Steel and Thomas B. Nutman Macrophages Kill T9 Glioma Tumor Cells Bearing the Membrane Isoform of Macrophage Colony Stimulating Factor Through a Phagecytosis-Dependent Pathway Martin R. Jadus, Christopher C. Williams, Maria D. Avina, Mann Ly, Suzanna Kim, Ying Liu, Ryan Narasaki, Clifford A. Lowell, and H. Terry Wepsic Accommodation and T-Independent B Cell Tolerance in Rats With Long Term Surviving Hamster Heart Xenografts Yuan Lin, Michel Vandeputte, and Mark Waer Chronic Listeria Infection in SCID Mice: Requirements for the Carrier State and the Dual Role of T Cells in Transferring Protection or Suppression Vatsala Bhardwaj, Osami Kanagawa, Paul E. Swanson, and Emil R. Unanue Lymphoid Hyperplasia, Autoimmunity, and Compromised Intestinal Intraepithelial Lymphocyte Development in Colitis-Free Gnotobiotic IL-2-Deficient Mice Nikhat V. Contractor, Hamid Bassiri, Tannishtha Reya, Audrey Y. Park, Daniel C. Baumgart, Mariusz A. Wasik, Stephen G. Emerson, and Simon R. Carding 1998} CONTENTS INFLAMMATION 395 Human CD38 (ADP-Ribosyl Cyclase) Is a Counter-Receptor of CD31, an Ig Superfamily Member Silvia Deaglio, Massimo Morra, Roberto Mallone, Clara M. Ausiello, Elisabeth Prager, Giovanni Garbarino, Umberto Dianzani, Hannes Stockinger, and Fabio Malavasi IL-1 and TNF Antagonists Inhibit the Inflammatory Response and Bone Loss in Experimental Periodontitis R. Assuma, T. Oates, D. Cochran, S. Amar, and D. T. Graves Inhibition of Proinflammatory Molecule Production by Adenovirus-Mediated Expression of a Nuclear Factor xB Super-Repressor in Human Intestinal Epithelial Cells Christian Jobin, Asit Panja, Claus Hellerbrand, Yuji Iimuro, Joseph Didonato, David A. Brenner, R. Balfour Sartor Regulated Production of Type I Collagen and Inflammatory Cytokines by Peripheral Blood Fibrocytes Jason Chesney, Christine Metz, Abram B. Stavitsky, Michael Bacher, and Richard Bucala RANTES-Induced T Cell Activation Correlates with CD3 Expression Daniel J. Dairaghi, Kenneth S. Soo, Elizabeth R. Oldham, Brett A. Premack, Toshio Kitamura, Kevin B. Bacon, and Thomas J. Schall Importance of MEK in Neutrophil Microbicidal Responsiveness Gregory P. Downey, Jeffrey R. Butler, Hans Tapper, Lea Fialkow, Alan R. Saltiel, Barry B. Rubin, and Sergio Grinstein CD8* Myelin Peptide-Specific T Cells Can Chemoattract CD4* Myelin Peptide-Specific T Cells: Importance of IFN-Inducible Protein 10 William E. Biddison, William W. Cruikshank, David M. Center, Clara M. Pelfrey, Dennis D. Taub, and Richard V. Turner Regulation of Chemokine Gene Expression in Human Peripheral Blood Neutrophils Phagocytosing Microbial Pathogens Mohamed Hachicha, Palaniswami Rathanaswami, Paul H. Naccache, and Shaun R. McColl Apical Secretion of a Pathogen-Elicited Epithelial Chemoattractant Activity in Response to Surface Colonization of Intestinal Epithelia by Salmonella typhimurium Beth A. McCormick, Charles A. Parkos, Sean P. Colgan, Denice K. Carnes, and James L. Madara Adhesion Molecule Mechanisms Mediating Monocyte Migration Through Synovial Fibroblast and Endothelium Barriers: Role for CD11/CD18, Very Late Antigen-4 (CD49d/ CD29), Very Late Antigen-5 (CD49e/CD29), and Vascular Cell Adhesion Molecule-1 (CD106) Xiao-zhou Shang, Bianca J. Lang, and Andrew C. Issekutz Effect of Cl Inhibitor on Inflammatory and Physiologic Response Patterns in Primates Suffering from Lethal Septic Shock Patty M. Jansen, Bernd Eisele, Irma W. de Jong, Alvin Chang, Ulrich Delvos, Fletcher B. Taylor, Jr., and C. Erik Hack Differential Activities of Secreted Lymphotoxin-a, and Membrane Lymphotoxin-a, 8, in Lymphotoxin-Induced Inflammation: Critical Role of TNF Receptor 1 Signaling Rosalba Sacca, Carolyn A. Cuff, Werner Lesslauer, and Nancy H. Ruddle CLINICAL IMMUNOLOGY 494 Distinct Classes of Chaperoned IL-6 in Human Blood: Differential Immunological and Biological Availability MacKevin I. Ndubuisi, Kirit Patel, Ravi J. Rayanade, Abraham Mittelman, Lester T. May, and Pravin B. Sehgal CONTENTS [voL. 160 A Model of Peptide-Induced Lupus Autoimmune B Cell Epitope Spreading Is Strain Specific and Is Not H-2 Restricted in Mice Judith A. James and John B. Harley CDR3 Size Spectratyping and Sequencing of Spectratype-Derived TCR of Spinal Cord T Cells in Autoimmune Encephalomyelitis Giok Kim, Naoyuki Tanuma, Takashi Kojima, Kuniko Kohyama, Yoko Suzuki, Yoko Kawazoe, and Yoh Matsumoto Author Index Information for Authors Editorial Policies and Practices Submission From: Full Length Articles AAI Membership Application Submission Form: Cutting Edge AAI Trainee Membership Application CIS Membership Application VOLUME 160/ N° 2/ JANUARY 15, 1998 CUTTING Out 535 Cutting Edge Commentary: Differential TCR Signaling and the Generation of Memory T Cells Donna L. Farber Cutting Edge: A Critical, Invariant Chain-Independent Role for H2-M in Antigen Presentation Kevin Swier, Daniel R. Brown, Jennifer J. Bird, W. David Martin, Luc Van Kaer, and Steven L. Reiner Cutting Edge: Cytokine-Dependent Abortion in CBA x DBA/2 Mice Is Mediated by the Procoagulant fgl2 Prothombinase David A. Clark, Gerard Chaouat, Petra C. Arck, Hans Willi Mittruecker, and Gary A. Levy Cutting Edge: T Helper 1 and T Helper 2 Cells Respond Differentially to Chemokines Jens T. Siveke and Alf Hamann Cutting Edge: Detection of MCP-4 in Dermal Fibroblasts and Its Activation of the Respiratory Burst in Human Eosinophils Holger Petering, Renate Héchstetter, Daniela Kimmig, Regina Smolarski, Alexander Kapp, and Jorn Elsner CELLULAR IMMUNOLOGY AND IMMUNE REGULATION 559 Suppression of Immune Responses by CD8 Cells: Superantigen-Activated CD8 Cells Induce Unidirectional Fas-Mediated Apoptosis of Antigen-Activated CD4 Cells Alistair Noble, Gary A. Pestano, and Harvey Cantor CONTENTS Suppression of Immune Responses by CD8 Cells: Qa-1 on Activated B Cells Stimulates CD8 Cell Suppression of T Helper 2 Responses Alistair Noble, Zi-Shan Zhao, and Harvey Cantor Rejection of Allogeneic and Syngeneic But Not MHC Class I-Deficient Tumor Grafts by MHC Class I-Deficient Mice Sofia Freland, Benedict J. Chambers, Malena Andersson, Luc Van Kaer, and Hans-Gustaf Ljunggren Ovalbumin-Specific, MHC Class I-Restricted, aB-Positive, Tcl and Tc0 CD8" T Cell Clones Mediate the In Vivo Inhibition of Rat IgE Paul A. MacAry, Beverly J. Holmes, and David M. Kemeny Reduced T Helper 1 Responses in IL-12 p40 Transgenic Mice Takayuki Yoshimoto, Chrong-Reen Wang, Toshihiko Yoneto, Seiji Waki, Shinji Sunaga, Yoshinori Komagata, Masao Mitsuyama, Jun-ichi Miyazaki, and Hideo Nariuchi CD40 Ligand Exerts Differential Effects on the Expression of Iy Transcripts in Subclones of an IgM* Human B Cell Lymphoma Line Gregory S. Ford, Chun Hui Yin, Bryan Barnhart, Kevin Sztam, and Lori R. Covey MHC Class II Expression in Double Mutant Mice Lacking Invariant Chain and DM Functions George Kenty, W. David Martin, Luc Van Kaer, and Elizabeth K. Bikoff Intercellular Adhesion Molecule-1 and Leukocyte Function-Associated Antigen-3 Provide Costimulation for Superantigen-Induced T Lymphocyte Proliferation in the Absence of a Specific Presenting Molecule James G. Lamphear, Kristin Reda Stevens, and Robert R. Rich Blockade of Chemokine Activity by a Soluble Chemokine Binding Protein From Vaccinia Virus Antonio Alcami, Julian A. Symons, Paul D. Collins, Timothy J. Williams, and Geoffrey L. Smith The Level of CD4 Surface Protein Influences T Cell Selection in the Thymus Gregory D. Frank and Jane R. Parnes Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity David J. Morgan, Huub T. C. Kreuwel, Shonna Fleck, Hyam I. Levitsky, Drew M. Pardoll, and Linda A. Sherman Perforin Protects Against Autoimmunity in Lupus-Prone Mice Stanford L. Peng, Javid Moslehi, Marie E. Robert, and Joe Craft MHC Class II-Transfected Tumor Cells Directly Present Antigen to Tumor-Specific CD4° T Lymphocytes Todd D. Armstrong, Virginia K. Clements, and Suzanne Ostrand-Rosenberg Induction of Tyrosine Phosphorylation in Human MHC Class II-Positive Antigen-Presenting Cells by Stimulation with Contact Sensitizers Ulrich Kiihn, Pia Brand, Judith Willemsen, Helmut Jonuleit, Alexander H. Enk, Renate van Brandwijk-Petershans, Joachim Saloga, Jiirgen Knop, and Detlef Becker NK Cells from Human MHC Class I (HLA-B) Transgenic Mice Do Not Mediate Hybrid Resistance Killing Against Parental Nontransgenic cells Sam K. P. Kung, Ruey-Chyi Su, Jeremy J. K. Graham, John W. Chamberlain, and Richard G. Miller CONTENTS {voL. 160 Molecular and Genetic Requirements for Preferential Recruitment of TCRBV8S2* T Cells in Lewis Rat Experimental Autoimmune Encephalomyelitis Robert Weissert, Anders Svenningsson, Anna Lobell, Katrien L. de Graaf, Roland Andersson, and Tomas Olsson Adenovector-Mediated Expression of Human Thrombopoietin cDNA in Immune- Compromised Mice: Insights into the Pathophysiology of Osteomyelofibrosis Beat M. Frey, Shahin Rafii, Michael Teterson, Dan Eaton, Ronald G. Crystal, and Malcolm A.S. Moore Opposite CD4/CD8 Lineage Decisions of CD4*8* Mouse and Rat Thymocytes to Equivalent Triggering Signals: Correlation with Thymic Expression of a Truncated CD8a Chain in Mice But Not Rats Rita Mitnacht, Astrid Bischof, Nora Torres-Nagel, and Thomas Hiinig Three Populations of Mouse Lymph Node Dendritic Cells with Different Origins and Dynamics Benoit Salomon, José L. Cohen, Carole Masurier, and David Klatzmann Positive Selection of Thymocytes Expressing the Same TCR by Different MHC Ligands Results in the Production of Functionally Distinct Thymocytes Distinguished by Differential Expression of the Heat Stable Antigen Hung-Sia Teh, Bruce Motyka, and Soo-Jeet Teh A Periarteriolar Lymphoid Sheath-Associated B Cell Focus Response Is Not Observed During the Development of the Anti-Arsonate Germinal Center Reaction Kalpit A. Vora, Kathleen M. Tumas-Brundage, and Tim Manser Aberrant Intermolecular Disulfide Bonding in a Mutant HLA-DM Molecule: Implications for Assembly, Maturation, and Function Robert Busch, Robert C. Doebele, Emily von Scheven, Jimothy Fahrni, and Elizabeth D. Mellins Natural Killer Cell Development and Function Precede af T Cell Differentiation in Mouse Fetal Thymic Ontogeny James R. Carlyle, Alison M. Michie, Sarah K. Cho, and Juan Carlos Ziiniga-Pfliicker Lack of Local Suppression in Orally Tolerant CD8-Deficient Mice Reveals a Critical Regulatory Role of CD8* T Cells in the Normal Gut Mucosa Dubravka Grdic, Elisabeth Hérnquist, Martin Kjerrulf, and Nils Y. Lycke T Cell Growth Cytokines Cause the Superinduction of Molecules Mediating Antigen- Induced T Lymphocyte Death Lixin Zheng, Carol L. Trageser, Dennis M. Willerford, and Michael J. Lenardo TGF-B, Induces the Cyclin-Dependent Kinase Inhibitor p27”? mRNA and Protein in Murine B Cells Hiroshi Kamesaki, Kimiko Nishizawa, Ginette Y. Michaud, Jeffrey Cossman, and Tohru Kiyono Presence of Activated Antigen-Binding B Cells During Immunization Enhances Relative Levels of IFN-y in T Cell Responses Chandrashekhar Pasare, Vivian Morafo, Maureen Entringer, Pratima Bansal, Anna George, Vineeta Bal, Satyajit Rath, and Jeannine M. Durdik 788 Role of Proteasomes in T Cell Activation and Proliferation Xin Wang, Hongyu Luo, Huifang Chen, William Duguid, and Jiangping Wu MOLECULAR AND STRUCTURAL IMMUNOLOGY 802 Degenerate Recognition of Alloantigenic Peptides on a Positive-Selecting Class I Molecule Michelle D. Taliquist, Arthur J. Weaver, and Larry R. Pease CONTENTS Nuclear Targeted Suppression of NF-«B Activity by the Novel Quinone Derivative E3330 Masaki Hiramoto, Noriaki Shimizu, Kotaro Sugimoto, Jianwei Tang, Yutaka Kawakami, Masaharu Ito, Shin Aizawa, Hirotoshi Tanaka, Isao Makino, and Hiroshi Handa Lack of Intraclonal Diversification in Ig Heavy and Light Chain V Region Genes Expressed by CD5*IgM* Chronic Lymphocytic Leukemia B Cells: A Multiple Time Point Analysis Edward W. Schettino, Andrea Cerutti, Nicholas Chiorazzi, and Paolo Casali Distinct Patterns of Folding and Interactions with Calnexin and Calreticulin in Human Class I MHC Proteins with Altered N-Glycosylation Qing Zhang and Russell D. Salter Activation of STAT5 by Lipopolysaccharide Through Granulocyte-Macrophage Colony- Stimulating Factor Production in Human Monocytes Kunihiro Yamaoka, Takeshi Otsuka, Hiroaki Niiro, Yojiro Arinobu, Yoshiyuki Niho, Naotaka Hamasaki, and Kenji Izuhara In Vitro and In Vivo Mechanisms of Action of the Antiproliferative and Immunosuppressive Agent, Brequinar Sodium Xiulong Xu, James W. Williams, Jikun Shen, Haihua Gong, Deng-Ping Yin, Leonard Blinder, Robert T. Elder, Howard Sankary, Alison Finnegan, and Anita S.-F. Chong Separation of Function Between the Domains of Toxic Shock Syndrome Toxin-1 Jennifer L. Wahlsten and S. Ramakrishnan HOST DEFENSE 860 Expression of Two Different Antiphagocytic M Proteins by Streptococcus pyogenes of the OF” Lineage Anette Thern, Maria Wastfelt, and Gunnar Lindahl CpG DNA is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen Heather L. Davis, Risini Weeranta, Thomas J. Waldschmidt, Lorraine Tygrett, Joachim Schorr, and Arthur M. Krieg Identification and Characterization of the CXCR4 Chemokine Receptor in Human T Cell Lines: Ligand Binding, Biological Activity, and HIV-1 Infectivity Joseph Hesselgesser, Meina Liang, James Hoxie, Michael Greenberg, Lawrence F. Brass, Michael J. Orsini, Dennis Taub, and Richard Horuk Control of Leishmania major by a Monoclonal af T Cell Repertoire Steven L. Reiner, Deborah J. Fowell, Naomi H. Moskowitz, Kevin Swier, Daniel R. Brown, Charles R. Brown, Christoph W. Turck, Phillip A. Scott, Nigel Killeen, and Richard M. Locksley Recognition of an Antigenic Peptide Derived from Tyrosinase-Related Protein-2 by CTL in the Context of HLA-A31 and -A33 Rong-Fu Wang, Samuel L. Johnston, Scott Southwood, Alessandro Sette, and Steven A. Rosenberg Perforin-Deficient CD8* T Cells Provide Immunity to Listeria monocytogenes by a Mechanism That Is Independent of CD95 and IFN-y but Requires TNF-a Douglas W. White and John T. Harty INFLAMMATION 906 CXC Chemokines Suppress Proliferation of Myeloid Progenitor Cells by Activation of the CXC Chemokine Receptor 2 Ximena Sanchez, Katsutoshi Suetomi, Beth Cousins-Hodges, Julie K. Horton, and Javier Navarro CONTENTS {voL. 160 High Affinity Receptor for IgG (FcyRI/CD64) Gene and STAT Protein Binding to the IFN-y Response Region (GRR) Are Regulated Differentially in Human Neutrophils and Monocytes by IL-10 Chiara Bovolenta, Sara Gasperini, Patrick P. McDonald, and Marco A. Cassatella Regulation of Monocyte IL-10 Synthesis by Endogenous IL-1 and TNF-a: Role of the p38 and p42/44 Mitogen-Activated Protein Kinases Andrew D. Foey, Sarah L. Parry, Lynn M. Williams, Marc Feldmann, Brian M. J. Foxwell, and Fionula M. Brennan Prostaglandin E, Modulation of p59/”" Tyrosine Kinase in T Lymphocytes During Sepsis Mashkoor A. Choudhry, Shahab Uddin, and Mohammed M. Sayeed Translational Efficiency Is Up-Regulated by Alternative Exon in Murine IL-15 mRNA Hitoshi Nishimura, Junji Washizu, Nobuhisa Nakamura, Atsushi Enomoto, and Yasunobu Yoshikai TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation Jacques J. Peschon, Dauphine S. Torrance, Kim L. Stocking, Moira B. Glaccum, Carol Otten, Cynthia R. Willis, Keith Charrier, Philip J. Morrissey, Carol B. Ware, and Kendall M. Mohler Distinct Phospholipases A, Regulate the Release of Arachidonic Acid for Eicosanoid Production and Superoxide Anion Generation in Neutrophils Patricia K. Tithof, Marc Peters-Golden, and Patricia E. Ganey Fever-Range Hyperthermia Enhances L-Selectin-Dependent Adhesion of Lymphocytes to Vascular Endothelium Wan-Chao Wang, Lorin M. Goldman, David M. Schleider, Michelle M. Appenheimer, John R. Subjeck, Elizabeth A. Repasky, and Sharon S. Evans Dynamic Regulation of a- and B-Chemokine Expression in the Central Nervous System During Mouse Hepatitis Virus-Induced Demyelinating Disease Thomas E. Lane, Valérie C. Asensio, Naichen Yu, Alyssa D. Paoletti, lain L. Campbell, and Michael J. Buchmeier IL-4 Is an Endogenous Inhibitor of Neutrophil Influx and Subsequent Pathology in Acute Antibody-Mediated Inflammation Sohail Saleem, Zhenhua Dai, Sandra N. Coelho, Bogumila T. Konieczny, Karel J. M.A ssmann, Fady K. Baddoura, and Fadi G. Lakkis Gene Organization and Promoter Function for CC Chemokine Receptor 5 (CCR5) Florence Guignard, Christophe Combadiere, H. Lee Tiffany, and Philip M. Murphy Neuropeptides, Via Specific Receptors, Regulate T Cell Adhesion to Fibronectin Mia Levite, Liora Cahalon, Rami Hershkoviz, Lawrence Steinman, and Ofer Lider Thymosin a, Stimulates Endothelial Cell Migration, Angiogenesis, and Wound Healing Katherine M. Malinda, Gurmel S. Sidhu, Krishna K. Banaudha, Jaya P. Gaddipati, Radha K. Maheshwari, Allan L. Goldstein, and Hynda K. Kleinman Neutrophils are Major Contributors to Intraparenchymal Lung IL-18 Expression After Hemorrhage and Endotoxemia Merdad V. Parsey, Rubin M. Tuder, and Edward Abraham Requirements for ad in IgG Immune Complex-Induced Rat Lung Injury Thomas P. Shanley, Roscoe L. Warner, Larry D. Crouch, Gregory N. Dietsch, Darcey L. Clark, Maggie M. O’Brien, W. Michael Gallatin, and Peter A. Ward