CONTENTS VOLUME 122 NUMBER 1 JULY 2003 OLarF S. ANDERSEN, DAvipC . GapsBy, and MICHAELJ .H ELD. In Memoriam: Paul F. Cranefield, M.D., Ph.D. O.arF S. ANDERSEN. Editorial MARTA LOPEZ-FONTANALS, SILVIA RODRIGUEZ-MULERO, F. JAVIER CASADO, BEeNorr DéRIJARD, and MARCAL PAsTOR-ANGLADA. The osmoregulatory and the amino acid-regulated responses of system A are mediated by different signal transduction pathways NrkirA GAMPER and Mark S. SHAPIRO. Calmodulin mediates Ca**-dependent modulation of M-type K* channels ANDREI SKORINKIN, ANDREA NISTRI, and RASHID GINIATULLIN. Bimodal action of protons on ATP cur- rents of rat PC12 cells SuJUNG Ryu, BEtyING Liu, and FENG QIN. Low pH potentiates both capsaicin binding and channel gat- ing of VRI receptors KwokyIN Hul, DEANE MCINTYRE, and ROBERTJ .F RENCH. Conotoxins as sensors of local pH and electro- static potential in the outer vestibule of the sodium channel KONSTANTIN GusEV, LyUBA GLOUCHANKOVA, ALEXANDER ZUBOV, ELENA KAZNACHEYEVA, ZHENGNAN WANG, ILYA BEZPROZVANNY, and GALINA N. MoZHAYEva. The store-operated calcium entry pathways in human carcinoma A431 cells: Functional properties and activation mechanisms J. ZHou, G. Brum, A. GONZALEZ, B.S. LAUNIKONIS, M.D. STERN, and E. Rios. Ca** sparks and embers of mammalian muscle. Properties of the sources GUNTHER WENNEMUTH, DONNER F. BABCOCK, and BERTIL HILLE. Calcium clearance mechanisms of mouse sperm ABSTRACTS OF PAPERS AT THE FIFTY-SEVENTH ANNUAL MEETING OF THE SOCIETY OF GENERAL PHYSIOLO- GISTS INDEX TO AUTHORS OF ABSTRACTS VOLUME 122 NUMBER 2 AUGUST 2003 CHRISTOPHER MILLER. Commentary: CIC channels: reading eukaryotic function through prokaryotic spec- tacles MEI-FANG CHEN and TsuNG-Yu CHEN. Side-chain charge effects and conductance determinants in the pore of CIC-0 chloride channels CuiA-Wet! LIN and TsuNG-Yu CHEN. Probing the pore of CIC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents PauL K. KiENKER, KAREN S. JAKES, ROBERT O. BLAUSTEIN, CHRISTOPHER MILLER, and ALAN FINKEL- STEIN. Sizing the protein translocation pathway of colicin Ia channels HERVE BARRIERE, RADIA BELFODIL, ISABELLE RUBERA, MICHEL TAUC, FLORIAN LESAGE, CHANTAL PoujEOL, NicoLas Guy, JACQUES BARHANIN, and PHILIPPE POUJEOL. Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules MIKKO JUUSOLA and GONZALO G. DE PoOLAvirjA. The rate of information transfer of naturalistic stimula- tion by graded potentials THE JOURNAL OF GENERAL PHYSIOLOGY + VOLUME 122 - 2003. PAGES iii-vi 207. Ana Y. Estevez, RANDOLPH K. RoBERTS, and KEVIN STRANGE. Identification of store-independent and store-operated Ca** conductances in Caenorhabditis elegans intestinal epithelial cells Yu-WEN Lin, TarpinG JIA, ANNE M. Wernsort, and SHOW-LING SHYNG. Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits 239 Jit THOMPSON and TED BrGeENIsIcu. External TEA block of Shaker K* channels is coupled to the move- ment of K* ions within the selectivity filter VOLUME 122 NUMBER 3 SEPTEMBER 2003 PeTeR H. BARRY. Commentary: The relative contributions of cAMP and InsP; pathways to olfactory re- sponses in vertebrate olfactory receptor neurons and the specificity of odorants for both pathways MANFRED LINDAU. Commentary: Synaptotagmin function illuminated Hiroko TAKEUCHI, YUKIE IMANAKA, JUNZO HIRONO, and TAKASHI KURAHASHI. Cross-adaptation between olfactory responses induced by two subgroups of odorant molecules JaAkos B. SORENSEN, RAFAEL FERNANDEZ-CHACON, THOMAS C, SUDHOF, and ERWIN NEHER. Examining synaptotagmin | function in dense core vesicle exocytosis under direct control of Ca?* ALEssio ACCARDI and MICHAEL PuscH. Conformational changes in the pore of CLC-0 SONIA TRAVERSO, LAURA ELIA, and MICHAEL PuscH. Gating competence of constitutively open CLC-0 mutants revealed by the interaction with a small organic inhibitor RUDOLF KARCH, FRIEDERIKE NEUMANN, BRUNO K. PODESSER, MARTIN NEUMANN, PAUL SZAWLOWSKI, and WOLFGANG SCHREINER. Fractal properties of perfusion heterogeneity in optimized arterial trees: a model study WEI XIONG, RONALD A. LI, YANLI TIAN, and GORDON F. TOMASELLI. Molecular motions of the outer ring of charge of the sodium channel: do they couple to slow inactivation? CLAUDIA Basso, PAOLA VERGANI, ANGUS C. NAIRN, and Davip C. GapsBy. Prolonged nonhydrolytic in- teraction of nucleotide with CFTR’s NHg,-terminal nucleotide binding domain and its role in channel gating JOHANNES REISERT, PAULJ .B AUER, KING-WalI YAU, and STEPHAN FRINGs. The Ca-activated Cl channel and its control in rat olfactory receptor neurons GING Kuo WANG, CoRINNA RUSSELL, and SHO-YA WANG. State-dependent block of wild-type and inactiva- tion-deficient Na* channels by flecainide CORRECTION VOLUME 122 NUMBER 4 OCTOBER 2003 CARLA M. PEDROSA RIBEIRO, ANTHONY M. PARADISO, ALESSANDRA LIVRAGHI, and RICHARD C. Bovu- CHER. The mitochondrial barriers segregate agonist-induced calcium-dependent functions in human air- way epithelia J. KRONENGOLD, E.B. TREXLER, F.F. BUKAUsSKAS, T.A. BARGIELLO, and V.K. VERSELIS. Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels CLAUDIA KeTTLUN, ADOM GONZALEZ, EDUARDO Rios, and MICHAEL FILL. Unitary Ca?* current through mammalian cardiac and amphibian skeletal muscle ryanodine receptor channels under near-physiologi- cal ionic conditions R.D. Hamer, S.C. NicHo.as, D. TRANCHINA, P.A. LIEBMAN, and T.D. Las. Multiple steps of phosphory- lation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses THE JOURNAL OF GENERAL PHYSIOLOGY + VOLUME 122 - 2003 Kay Dyupsunb, TETsuo FURUKAWA, SyYOZO YASUI, and MASAHIRO YAMADA. Asymmetric temporal proper- ties in the receptive field of retinal transient amacrine cells RAMON LATORRE, RICCARDO OLCESE, CLAUDIA Basso, CARLOS GONZALEZ, FABIAN MuNOoz, D1EGo Cos- MELLI, and OsvALDO ALVAREZ. Molecular coupling between voltage sensor and pore opening in the Ara- bidopsis inward rectifier Ky channel KAT] VOLUME 122 NUMBER 5 NOVEMBER 2003 D. ENKVETCHAKUL and C.G. NICHOLS. Brief Review: Gating mechanism of Ky;p channels: function fits form PETER R. STANFIELD and MICHAELJ . SUTCLIFFE. Commentary: Spermine is fit to block inward rectifier (Kir) channels DONGLIN Guo and ZHE Lv. Interaction mechanisms between polyamines and IRKI inward rectifier K* channels BRAD S. ROTHBERG, Ki SOON SHIN, and GARY YELLEN. Movements near the gate of a hyperpolarization- activated cation channel YUANLIN SONG, JAY THIAGARAJAH, and A.S. VERKMAN. Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways SUDHA CHAKRAPANI, TrMoTny D. BAILEY, and ANTHONY AUERBACH. The role of Loop 5 in acetylcholine receptor channel gating MANANA SUKHAREVA, Davip H. HAckos, and KENTONJ . SWARTZ. Constitutive activation of the Shaker Kv channel HriRoKO TAKEUCHI and TAKASHI KuRAHASHI. Identification of second messenger mediating Signal trans- duction in the olfactory receptor cell Don-ON DANIEL Mak, SEAN M.J. MCBRIDE, NATALIYA B. PETRENKO, andJ . KEVIN FosKETT. Novel regu- lation of calcium inhibition of the inositol 1,4,5-trisphosphate receptor calcium-release channel Don-ON DANIEL Mak, SEAN M.J. MCBrIDE, andJ . Kevin Fosketr. Spontaneous channel activity of the inositol 1,4,5-trisphosphate (InsP;) receptor (InsP3R). Application of allosteric modeling to calcium and InsP, regulation of InsP3R single-channel gating ZHIWEI Cal, Tosy S. ScorTt-WArRD, and DAviD N. SHEPPARD. Voltage-dependent gating of the cystic fi- brosis transmembrane conductance regulator Cl” channel JOHN P. Reeves and MADALINA ConpbRESCU. Allosteric activation of sodium—calcium exchange activity by calcium: persistence at low calcium concentrations TsuNG-Yu CHEN, MEI-FANG CHEN, and Cu1A-WEI LIN. Electrostatic control and chloride regulation of the fast gating of CIC-0 chloride channels VOLUME 122 NUMBER 6 DECEMBER 2003 STEVEN BARNES. Commentary: Center-surround antagonism mediated by proton signaling at the cone photoreceptor synapse Hajime Hirasawa and AKIMICHI KANEKO. pH changes in the invaginating synaptic cleft mediate feed- back from horizontal cells to cone photoreceptors by modulating Ca** channels XIANDI GonG and PAuL LINSDELL. Mutation-induced blocker permeability and multiion block of the CFTR chloride channel pore Davin M. BroweE and CLive M. BAUMGARTEN. Stretch of B1 integrin activates an outwardly rectifying chloride current via FAK and Src in rabbit ventricular myocytes THE JOURNAL OF GENERAL PHYSIOLOGY + VOLUME 122 - 2003 CLAUDIA M. KrisPEL, CHING-KANG CHEN, MELVIN I. Simon, and Marie E. Burns. Novel form of adapta- tion in mouse retinal rods speeds recovery of phototransduction GABoR L. PETHEO, ANDRES MATURANA, ANDRAS SPAT, and NICOLAS DEMAUREX. Interactions between elec- tron and proton currents in excised patches from human eosinophils ANJA MULLER, DOROTHEE GUNZEL, and WOLF-RUDIGER SCHLUE. Activation of AMPA/kainate receptors but not acetylcholine receptors causes Mg** influx into Retzius neurones of the leech Hirudo medicinalis AMIR BROOMAND, ROOPE MANNIKKO, H. PETER LARSSON, and FREDRIK ELINDER. Molecular movement of the voltage sensor in a K channel R. LANE Brown, LEATHA L. LYNCH, TAMMIE L. HALEY, and REZA ARSANJANI. Pseudechetoxin binds to the pore turret of cyclic nucleotide—gated ion channels IRINA KULIKOVSKAYA, GEORGE MCCLELLAN, JEANNE FLAVIGNY, LUCIE CARRIER, and SAUL WINEGRAD. Ef- fect of MyBP-C binding to actin on contractility in heart muscle Davip L. PROLE, PEDRO A. Lima, and NEIL V. MARRION. Mechanisms underlying modulation of neuronal KCNQ2/KCNQ3 potassium channels by extracellular protons L. REVELL PHILLIPS and COLIN G. NicHOLs. Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the pore THE JOURNAL OF GENERAL PHYSIOLOGY * VOLUME 122 - 2003