The American Journal of PATHOLOGY CONTENTS FOR VOLUME 158 January 2001 Commentary Do Neurons Have a Choice in Death? George Perry, Xiongwei Zhu, and Mark A. Smith Short Communications Selectivity of Recombinant Human Leukotriene D,, Leukotriene B,, and Lipoxin A, Receptors with Aspirin-Triggered 15-epi-LXA, and Regulation of Vascular and Inflammatory Responses Karsten Gronert, Titti Martinsson-Niskanen, Saula Ravasi, Nan Chiang, and Charles N. Serhan Cyclic Stretching of Mesangial Cells Up-Regulates Intercellular Adhesion \Molecule-1 and Leukocyte Adherence: A Possible New Mechanism for Glomerulosclerosis \ Bruce L. Riser, James Varani, Pedro Cortes, Jerry Yee, Michael Dame, and Abdul K. Sharba Identification of a Novel Gene with Increasing Rate of Suppression in High Grade Prostate Cancers Yan Ping Yu, Fan Lin, Michelle Bisceglia, Diane Krill, Rajiv Dbir, Michael Becich, and Jian-Hua Luo Increased Expression of the Interleukin-11 Receptor and Evidence of STAT3 Activation in Prostate Carcinoma Cara L. Campbell, Zhong Jiang, Diane M. F. Savarese, and Todd M. Savarese Molecular and Clinical Differences Between Adenocarcinomas of the Esophagus and of the Gastric Cardia Philippe Taniére, Ghislaine Martel-Planche, Daniela Maurici, Catherine Lombard-Bobas, Jean-Yves Scoazec, Ruggero Montesano, Francoise Berger, and Pierre Hainaut Technical Advances Leukocytes Expressing Green Fluorescent Protein as Novel Reagents for Adoptive Cell Transfer and Bone Marrow Transplantation Studies Denise J.M anfra, Shu-Cheng Chen, Tong-Yuan Yang, Lee Sullivan, Maria T. Wiekowski, Susan Abbondanzo, Galya Vassileva, Petronio Zalamea, Donald N. Cook, and Sergio A. Lira Three-Dimensional Imaging of Embryonic Mouse Kidney by Two-Photon Microscopy Carrie L. Phillips, Lois J.A rend, AdeleJ . Filson, DougJ . Kojetin, Jeffrey L. Clendenon, Shiaofen Fang, and Kenneth W. Dunn Regular Articles NHE-RFF, a Merlin-Interacting Protein, Is Primarily Expressed in Luminal Epithelia, Proliferative Endometrium, and Estrogen Receptor-Positive Breast Carcinomas Anat O. Stemmer-Rachamimov, Thorsten Wiederhold, G. Petur Nielsen, Marianne James, Denise Pinney-Michalowski, Jennifer E. Roy, Wendy A. Coben, Vijaya Ramesh, and David N. Louis AB-Induced Inflammatory Processes in Microglia Cells of APP23 Transgenic Mice Klaus D. Bornemann, Karl-Heinz Wiederhold, Chantal Pauli, Florian Ermini, Martina Stalder, Lisa Schnell, Bernd Sommer, Mathias Jucker, and Matthias Staufenbiel Role of Atrophic Tubules in Development of Interstitial Fibrosis in Microembolism-Induced Renal Failure in Rat Takayuki Suzuki, Masato Kimura, Mitsuko Asano, Yoshibide Fujigaki, and Akira Hishida Protective Function of p27*'*' against Apoptosis in Small Cell Lung Cancer Cells in Unfavorable Microenvironments Akira Masuda, Hirotaka Osada, Yasushi Yatabe, Ken-ichi Kozaki, Yoshio Tatematsu, Takao Takahashi, Toyoaki Hida, Toshitada Takahashi, and Takashi Takahashi Size-Dependent in Vivo Growth Potential of Adult Rat Hepatocytes Shigeru Katayama, Chise Tateno, Toshimasa Asabara, and Katsutoshi Yoshizato Remodeling of the Vessel Wall after Copper-induced Injury Is Highly Attenuated in Mice with a Total Deficiency of Plasminogen Activator Inhibitor-1 Victoria A. Ploplis, leo Cornelissen, Mayra J. Sandoval-Cooper, Lisa Weeks, Francisco A. Noria, and FrancisJ . Castellino Production of Interferon-y by Influenza Hemagglutinin-Specific CD8 Effector T Cells Influences the Development of Pulmonary Immunopathology James A. Wiley, Adelheid Cerwenka, Jack R. Harkema, Richard W. Dutton, and Allen G. Harmsen Role of Granulocyte/Macrophage Colony-Stimulating Factor in Zymocel-Induced Hepatic Granuloma Formation Aye Aye Wynn, Kazubisa Miyakawa, Emi Miyata, Glenn Dranoff, Motobiro Takeya, and Kiyoshi Takahashi Leukocyte-Mediated Endothelial Cell Injury and Death in the Diabetic Retina Antonia M. Joussen, Toshinori Murata, Akitaka Tsujikawa, Bernd Kirchbof, Sven-Erik Bursell, and Anthony P. Adamis Fas (CD95) Induces Alveolar Epithelial Cell Apoptosis in Vivo: Implications for Acute Pulmonary Inflammation Gustavo Matute-Bello, Robert K. Winn, Mechthild Jonas, Emil Y. Chi, Thomas R. Martin, and W. Conrad Liles Cerebral Malaria in Mice: Interleukin-2 Treatment Induces Accumulation of yé T Cells in the Brain and Alters Resistant Mice to Susceptible-Like Phenotype Azizul Haque, Hakim Echchannaoui, Rosanne Seguin, Joseph Schwartzman, Lloyd H. Kasper, and Sakbina Haque B-Site APP Cleaving Enzyme mRNA Expression in APP Transgenic Mice: Anatomical Overlap with Transgene Expression and Static Levels with Aging Michael C. Irizarry, Joseph J. Locascio, and Bradley T. Hyman Role of Macrophage Scavenger Receptors in Response to Listeria monocytogenes Infection in Mice Takuro Ishiguro, Makoto Naito, Takashi Yamamoto, Go Hasegawa, Fumitake Gejyo, Masao Mitsuyama, Hiroshi Suzuki, and Tatsubiko Kodama Correlation between Caspase Activation and Neurofibrillary Tangle Formation in Alzheimer’s Disease Troy T. Rohn, Elizabeth Head, Joseph H. Su, AileenJ .A nderson, Ben A. Babr, Carl W. Cotman, and David H. Cribbs Abnormal Nuclear Shape in Solid Tumors Reflects Mitotic Instability David Gisselsson, Jonas Bj6rk, Mattias Héglund, Fredrik Mertens, Paola Dal Cin, Mans Akerman, and Nils Mandabl Molecular Cytogenetic Comparison of Apocrine Hyperplasia and Apocrine Carcinoma of the Breast Chris Jones, Stefania Damiani, Dagan Wells, Ranbir Chaggar, Sunil R. Lakhani, and Vincenzo Eusebi Interferon-y Acts Directly on Rejecting Renal Allografts to Prevent Graft Necrosis Philip F. Halloran, Marjan Afrouzian, Vido Ramassar, Joan Urmson, Lin-Fu Zhu, Lisa M. H. Helms, Kim Solez, and Norman M. Kneteman Biochemical Characterization of a Neuroserpin Variant Associated with Hereditary Dementia Masahide Yazaki, Juris J.L iepnieks, Jill R. Murrell, Masaki Takao, Brian Guenther, Pedro Piccardo, Martin R. Farlow, Bernardino Ghetti, and Merrill D. Benson Staging of Neurofibrillary Degeneration Caused by Human Tau Overexpression in a Unique Cellular Model of Human Tauopathy Garth F. Hall. Virginia M.-Y. Lee, Gloria Lee, and Jun Yao Endothelial Nitric Oxide Synthase Gene-Deficient Mice Demonstrate Marked Retardation in Postnatal Bone Formation, Reduced Bone Volume, and Defects in Osteoblast Maturation and Activity José Aguirre, Lee Buttery, Meg O'Shaughnessy, Faiza Afzal, Inigo Fernandez de Marticorena, Mika Hukkanen, Paul Huang, lain MacIntyre, and Julia Polak In Situ Detection of Hepatitis C Virus RNA in Salivary Glands Juan José Arrieta, Elena Rodriguez-Inigo, Nuria Ortiz-Movilla, Javier Bartolomé, Margarita Pardo, Félix Manzarbeitia, Horacio Oliva, David Mariscal Macias, and Vicente Carreno Vascular Endothelial Growth Factor Receptor-2-Mediated Mitogenesis Is Negatively Regulated by Vascular Endothelial Growth Factor Receptor-1 in Tumor Epithelial Cells Caroline Dunk and Asif Abmed Hepatocyte Growth Factor, but Not Insulin-Like Growth Factor |, Protects Podocytes against Cyclosporin A-Induced Apoptosis Alessia Fornoni, Hong Li, Annalisa Foschi, Gary E. Striker, and LilianeJ . Striker Independent Influence of Strain Difference and mi Transcription Factor on the Expression of Mouse Mast Cell Chymases Yi Ge, Tomoko Jippo, Young-Mi Lee, Shiro Adachi, and Yukibiko Kitamura i Regional! Quantification of F-Ring and D-/E-Ring lsoprostanes and Neuroprostanes in Alzheimer's isease Erin E. Reich, William R. Markesbery, L. Jackson Roberts, II, Larry L. Swift, Jason D. Morrow, and ThomasJ . Montine Biallelic Inactivation of Retinoic Acid Receptor B2 Gene by Epigenetic Change in Breast Cancer Qifeng Yang, Ichiro Mori, Liang Shan, Misa Nakamura, Yasushi Nakamura, Hirotoshi Utsunomiya, Goro Yoshimura, Takaomi Suzuma, Takeshi Tamaki, Teiji Umemura, Takeo Sakurai, and Kennichi Kakudo Evidence that Furin Is an Authentic Transforming Growth Factor-B1-Converting Enzyme Claire M. Dubois, Francois Blanchette, Marie-Heélene Laprise, Richard Leduc, Francine Grondin, and Nabil G. Seidah Molecular Characterization of Pancreatic Serous Microcystic Adenomas: Evidence for a Tumor Suppressor Gene on Chromosome 10q Patrick S. Moore, Giuseppe Zamboni, Antonietta Brighenti, Daniele Lissandrini, Davide Antonello, Paola Capelli, Gildas Rigaud, Massimo Falconi, and Aldo Scarpa Animal Models Hyalinosis and Ym1/Ym2 Gene Expression in the Stomach and Respiratory Tract of 129S4/SvJae and Wild-Type and CYP1A2-Null B6,129 Mice Jerrold M. Ward, Michung Yoon, Miriam R. Anver, Diana C. Haines, Gen Kudo, Frank J].G onzalez, and Shioko Kimura Allergic Asthma Induced in Rhesus Monkeys by House Dust Mite (Dermatophagoides farinae) Edward S. Schelegle, Laurel J. Gershwin, Lisa A. Miller, Michelle V. Fanucchi, Laura S. Van Winkle, Joan P. Gerriets, William F. Walby, Amanda M. Omlor, Alan R. Buckpitt, Brian K. Tarkington, Viviana J. Wong, Jesse P. Joad, Kent B. Pinkerton, Reen Wu, Michael J. Evans, Dallas M. Hyde, and Charles G. Plopper February 2001 In Memoriam Ramzi Suliman Cotran, M.D.: 1933-2000 James L. Madara and Michael A. Gimbrone, Jr. Short Communications Decorin Is Produced by Capillary Endothelial Cells in Inflammation-Associated Angiogenesis Lassi Nelimarkka, Heli Salminen, Teijo Kuopio, Seppo Nikkari, Tauno Ekfors, Jukka Laine, Lauri Pelliniemi, and Hannu Jdrveldinen X-Linked Vacuolated Myopathy: TNF-a and IFN-y Expression in Muscle Fibers with MHC Class | on Sarcolemma Karl Rouger, Jean-Pierre Louboutin, Marcello Villanova, Yan Cherel, and Michel Fardeau Disruption of Nuclear Factor-Interleukin-6, a Transcription Factor, Results in Severe Mycobacterial Infection Isamu Sugawara, Satoru Mizuno, Hiroyuki Yamada, Makoto Matsumoto, and Shizuo Akira Suprabasa! Overexpression of the hsRPB7 Gene in Psoriatic Epidermis as Identified by a Reverse Transcriptase-Polymerase Chain Reaction Differential Display Model Comparing Psoriasis Plaque Tissue with Peritonsillar Mucosa Raik Bockelmann, Peter Neugebauer, Nuschin Djahan Paseban, Martin Htittemann, Harald Gollnick, and Bernd Bonnekoh Molecular Analysis of Mutant and Wild-Type Tau Deposited in the Brain Affected by the FTDP-17 R406W Mutation Tomobiro Miyasaka, Maho Morishima-Kawashima, Rivka Ravid, Peter Heutink, Jobn C. van Swieten, Kazuo Nagashima, and Yasuo Ihara Role of PTCH and p53 Genes in Early-Onset Basal Cell Carcinoma Hong Zhang, Xiao Li Ping, Patricia K. Lee, Xiu Li Wu, Ya Juan Yao, Ming Jian Zhang, David N. Silvers, Désirée Ratner, Rajwant Malhotra, Monica Peacocke, and Hui C. Tsou Identification of Fas-L-Expressing Apoptotic T Lymphocytes in Normal Human Peripheral Blood: /n Vivo Suicide Giuseppe De Panfilis, Arnaldo Caruso, Paolo Sansoni, Giorgio Pasolini, Diego Semenza, and Claudio Torresani Gain of 1q Is Associated with Adverse Outcome in Favorable Histology Wilms’ Tumors Sandra Hing, Yong-Jie Lu, Brenda Summersgill, Linda King-Underwood, James Nicholson, Paul Grundy, Richard Grundy, Manfred Gessler, Janet Shipley, and Kathy Pritchard-Jones Molecular Cytogenetic Analysis of Prostatic Adenocarcinomas from Screening Studies: Early Cancers May Contain Aggressive Genetic Features Janneke C. Alers, Pieter-Jaap Krijtenburg, André N. Vis, Robert F. Hoedemaeker, Mark F. Wildhagen, Wim C. J. Hop, Theodorus H. van der Kwast, Fritz H. Schréder, Hans J. Tanke, and Herman van Dekken Technical Advances Comparison of Different Detection Methods in Quantitative Microdensitometry Leander Ermert, Andreas Christian Hocke, Hans-Rainer Duncker, Werner Seeger. and Monika Ermert Quantitative Gene Expression Analysis in Microdissected Archival Formalin-Fixed and Paraffin- Embedded Tumor Tissue Katja Specht, Thomas Richter, Ulrike Miiller, Axel Walch, Martin Werner, and Heinz Hofler Regular Articles Differential and Sequential Expression of Multiple Chemokines during Elicitation of Allergic Contact Hypersensitivity Matthias Goebeler, Axel Trautmann, Ariane Voss, Eva-Bettina Brécker, Atiye Toksoy, and Reinhard Gillitzer In Vivo Modulation of FGF Biological Activity Alters Cranial Suture Fate Joshua A. Greenwald, Babak J.M ebrara, Jason A. Spector, Stephen M. Warren, Peter J.F agenholz, Lee P. Smith, PierreJ .B ouletreau, Francesca E. Crisera. Hikaru Leno, and Michael T. Longaker Hippocampal Apoptosis in Major Depression Is a Minor Event and Absent from Subareas at Risk for Glucocorticoid Overexposure Paul J. Lucassen, Marianne B. Miiller, Florian Holsboer, Jan Bauer, Anne Holtrop, Jose Wouda, WitteJ .G . Hoogendijk, E. Ron De Kloet, and Dick F. Swaab The Characterization of Mice with a Targeted Combined Deficiency of Protein C and Factor XI Joyce C. Y. Chan, Jorge G. Ganopolsky, Ivo Cornelissen, Mark A. Suckow, MayraJ . Sandoval-Cooper, Erica C. Brown, Francisco Noria, David Gailani, Elliot D. Rosen, Victoria A. Ploplis, and FrancisJ . Castellino Decreased Expression of the Decoy Interleukin-1 Receptor Type II in Human Endometriosis Ali Akoum, Christine Jolicoeur, Abdelaziz Kharfi, and Marie Aubé Dynamics of Early Synovial Cytokine Expression in Rodent Collagen-Induced Arthritis: A Therapeutic Study Using a Macrophage-Deactivating Compound Karin Palmblad, Helena Erlandsson-Harris, KevinJ . Tracey, and Ulf Andersson Tumorigenic Properties of Neurofibromin-Deficient Neurofibroma Schwann Cells David Muir, Debbie Neubauer, Ingrid T. Lim, Anthony T. Yachnis, and Margaret R. Wallace Regional Distribution of Amyloid-Bri Deposition and Its Association with Neurofibrillary Degeneration in Familial British Dementia Janice L. Holton, Jorge Ghiso, Tammaryn Lashley, Agueda Rostagno, Christopher J.G uerin, Grabam Gibb, Henry Houlden, Hilary Ayling. Lillian Martinian, Brian H. Anderton, Nicholas W. Wood, Ruben Vidal, Gordon Plant, Blas Frangione, and Tamas Revesz Histopathological Identification of Colon Cancer with Microsatellite Instability Julian Alexander, Toshiaki Watanabe, Tsung-Teb Wu, Asif Rashid, Shuan Li, and Stanley R. Hamilton Nuclear Localization of Doc4 (Madh4, Smad4) in Colorectal Carcinomas and Relation to Mismatch Repair/Transforming Growth Factor-B Receptor Defects Elizabeth Montgomery, Michael Goggins, Shibin Zhou, Pedram Argani, Robb E. Wilentz, Manju Kaushal, Susan Booker, Katharine Romans, Parul Bhargava, Ralph H. Hruban, and Scott E. Kern PC-1 Nucleoside Triphosphate Pyrophosphohydrolase Deficiency in Idiopathic Infantile Arterial Calcification Frank Rutsch, Sucheta Vaingankar, Kristen Johnson, Ira Goldfine, Betty Maddux, Petra Schauerte, Hermann Kalhoff,. Kimibiko Sano, William A. Boisvert, Andrea Superti-Furga, and Robert Terkeltaub Age-Dependent Induction of Congophilic Neurofibrillary Tau Inclusions in Tau Transgenic Mice Takeshi Ishibara, Bin Zhang, Makoto Higuchi, Yasumasa Yoshiyama, John Q. Trojanowski, and Virginia M.-Y. Lee Angiopoietin-2 Is Implicated in the Regulation of Tumor Angiogenesis Qin Yu and Ivan Stamenkovic Liver Repopulation and Correction of Metabolic Liver Disease by Transplanted Adult Mouse Pancreatic Cells Xin Wang. Mubsen Al-Dhalimy, Eric Lagasse, Milton Finegold, and Markus Grompe Internalization of Proteinase 3 Is Concomitant with Endothelial Cell Apoptosis and Internalization of Myeloperoxidase with Generation of Intracellular Oxidants Jia Jin Yang, Gloria A. Preston, William F. Pendergraft, Marten Segelmark, Peter Heeringa, Susan L. Hogan, J. Charles Jennette, and RonaldJ . Falk CDKN2A Mutation Analysis, Protein Expression, and Deletion Mapping of Chromosome Qp in Conventional Clear-Cell Renal Carcinomas: Evidence for a Second Tumor Suppressor Gene Proximal to CDOKN2A Peter Schrami, Kirsten Struckmann, Rudolf Bednar, Wenting Fu, Thomas Gasser, Kim Wilber, Juba Kononen, Guido Sauter, Michael J].M ibatsch, and Holger Moch Neutrophil Interaction with Inflamed Postcapillary Venule Endothelium Alters Annexin 1 Expression Sonia M. Oliani, Mark J. Paul-Clark, Helen C. Christian, Roderick J.F lower, and Mauro Perretti A Compound Heterozygous One Amino-Acid Insertion/Nonsense Mutation in the Plectin Gene Causes Epidermolysis Bullosa Simplex with Plectin Deficiency Jobann W. Bauer, Fatima Rouan, Barbara Kofler, Gtinther A. Rezniczek, Iris Kornacker, Wolfgang Muss, Rudolf Hametner, Alfred Klausegger, Ariana Huber, Gabriele Pobla-Gubo, Gerhard Wiche, Jouni Uitto, and Helmut Hintner Immune Complex Formation after Xenotransplantation: Evidence of Type III as well as Type II Immune Reactions Provide Clues to Pathophysiology Zoie E. Holzknecht, Sarah Coombes, Brian A. Blocher, Timothy B. Plummer, Matilde Bustos, Christine L. Lau, R. Duane Davis, and Jeffrey L. Platt A Potential Role for Interleukin-8 in the Metastatic Phenotype of Breast Carcinoma Cells Joseph E. De Larco, Beverly R. K. Wuertz, Karen A. Rosner, Steven A. Erickson, David E. Gamache, J. Carlos Manivel, and Leo T. Furcht Helicobacter pylori Genotypes May Determine Gastric Histopathology Cristina Nogueira, Céu Figueiredo, Fatima Carneiro, Antonio Taveira Gomes, Raul Barreira, Paulo Figueira, Céu Saigado, Luis Belo, Antonio Peixoto, Juan C. Bravo, Luis E. Bravo, Jose L. Realpe, Anton P. Plaisier, Wim G. V. Quint, Bernardo Ruiz, Pelayo Correa, and Leen-Jan van Doorn Chromosomal Alterations in Paired Gastric Adenomas and Carcinomas Yun Hee Kim, Nam-Gyun Kim, Jong Gun Lim, Chanil Park, and Hoguen Kim Expression of SMARCF1, a Truncated Form of SWI1, in Neuroblastoma Tamotsu Takeuchi, Sophie Nicole, Akiko Misaki, Mutsuo Furibata, Jun lwata, Hiroshi Sonobe, and Yuji Obtsuki Basement Membrane Pores in Human Bronchial Epithelium: A Conduit for Infiltrating Cells? WilliamJ .H owat, James A. Holmes, Stephen T. Holgate, and Peter M. Lackie Mucosal Pathophysiology and Inflammatory Changes in the Late Phase of the Intestinal Allergic Reaction in the Rat Ping-Chang Yang, M. Cecilia Berin, Linda Yu, and Mary H. Perdue Loss of Heterozygosity on Chromosome 11q22-23 in Melanoma Is Associated with Retention of the Insertion Polymorphism in the Matrix Metalloproteinase-1 Promoter Walter W. Noll, Dorothy R. Belloni, Joni L. Rutter, Craig A. Storm, Alan R. Schned, Linda Titus-Ernstoff, Marc S. Ernstoff, and Constance E. Brinckerhoff API2-MALT1 Fusion Transcripts Involved in Mucosa-Associated Lymphoid Tissue Lymphoma: Multiplex RT-PCR Detection Using Formalin-Fixed Paraffin-Embedded Specimens Hiroshi Inagaki, Mitsukuni Okabe, Masaru Seto, Shigeo Nakamura, Ryuzo Ueda, and Tadaaki Eimoto Localization of the Peptide Transporter PEPT2 in the Lung: Implications for Pulmonary Oligopeptide Uptake David A. Groneberg, Monika Nickolaus, Jochen Springer, Frank Déring, Hannelore Daniel, and Axel Fischer Ratio of Local to Systemic Chemokine Concentrations Regulates Neutrophil Recruitment Douglas Ruben Call, Jean Ann Nemzek, Samuel John Ebong, Gerald Lee Bolgos, David Eric Newcomb, and Daniel George Remick Overexpression of Matrix Metalloproteinase-10 and Matrix Metalloproteinase-3 in Human Diabetic Corneas: A Possible Mechanism of Basement Membrane and Integrin Alterations Mebrnoosh Saghizadeb, Donald J. Brown, Raquel Castellon, Marilyn Chwa, Gang H. Huang, Julia Y. Ljubimova, Shari Rosenberg, Konstantin S. Spirin, Raisa B. Stolitenko, Wakako Adachi, Shigeru Kinoshita, Gillian Murphy, L. Jack Windsor, M. Cristina Kenney, and Alexander V. Ljubimov Expression Levels of Genes that Regulate Metastasis and Angiogenesis Correlate with Advanced Pathological Stage of Renal Cell Carcinoma Joel W. Slaton, Keiji Inoue, Paul Perrotte, Adel K. El-Naggar, David A. Swanson, Isaiah J. Fidler, and Colin P. N. Dinney Animal Models A Transplantable Human Carcinoid as Model for Somatostatin Receptor-Mediated and Amine Transporter-Mediated Radionuclide Uptake Lars Kélby, Peter Bernhardt, Hakan Ablman, Bo Wéngberg, Viktor Jobanson, Annelie Wigander, Eva Forssell-Aronsson, Sven Karlsson, Bo Abrén, Goran Stenman, and Ola Nilsson Animal Model of Fatal Human Monocytotropic Ehrlichiosis Edgar A. Sotomayor, Vsevolod L. Popov, Hui-Min Feng, David H. Walker, and Juan P. Olano Massive Liver Replacement by Transplanted Hepatocytes in the Absence of Exogenous Growth Stimuli in Rats Treated with Retrorsine Sergio Laconi, Sara Pillai, Pietro Paolo Porcu, David A. Shafritz, Paolo Pani, and Ezio Laconi Biological Significance at Microsatellite Instability-Low (MSI-L) Status in Colorectal Tumors J. R. Jass, J. Young, and B.A. Leggett Authors’ Reply Nicholas Hawkins, lan Tomlinson, and Robyn Ward Is Singlet Oxygen Antiatherosclerotic? Thomas W. Stief Reclamation March 2001 This Month in AJP Editorial Frances A. Pitlick, Ph.D.: Commemorating 12 Years of Distinguished Service Priscilla Smith Markwood Commentaries one at Microvascular Proliferation Orchestrated by VPF/VEGF: A New World of Angiogenesis esearch Daniel J].B rat and Erwin G. Van Meir Alzheimer’s Disease in Man and Transgenic Mice: Females at Higher Risk R. Scott Turner Short Communications A Comparative Study of the Expression of Cytotoxic Proteins in Allergic Contact Dermatitis and Psoriasis: Spongiotic Skin Lesions in Allergic Contact Dermatitis Are Highly Infiltrated by T Cells Expressing Perforin and Granzyme B Nikhil Yawalkar, Robert E. Hunger, Caroline Buri, Simone Schmid, Fabienne Egli, Christoph U. Brand, Christoph Mueller, WernerJ . Pichler, and Lasse R. Braathen Selective Expression of Murine Prostate Stem Cell Antigen in Fetal and Adult Tissues and the Transgenic Adenocarcinoma of the Mouse Prostate Model of Prostate Carcinogenesis Sarajane Ross, Susan D. Spencer, Laurence A. Lasky, and Hartmut Koeppen Expression of the Intermediate Filament Nestin in Gastrointestinal Stromal Tumors and Interstitial Cells of Cajal Tobru Tsujimura, Chiaki Makiishi-Shimobayashi, Joban Lundkvist, Urban Lendabhl. Keiji Nakasho, Ayako Sugibara, Teruo lwasaki, Masayuki Mano, Naoko Yamada, Kunibiro Yamashita, Akihiro Toyosaka, and Nobuyuki Terada Expression of Scavenger Receptor Class B, Type |, by Astrocytes and Vascular Smooth Muscle Cells in Normal Adult Mouse and Human Brain and in Alzheimer’s Disease Brain Jens Husemann and Samuel C. Silverstein Down-Regulation of Caveolin-1, a Candidate Tumor Suppressor Gene, in Sarcomas Kai Wiechen, Christine Sers, Alexander Agoulnik, Katharina Arlt, Manfred Dietel, Peter M. Schlag, and Ulrike Schneider Endothelin Receptor Blockade Inhibits Proliferation of Kaposi's Sarcoma Cells Anna Bagnato, Laura Rosano, Valeriana Di Castro, Adriana Albini, Debora Salani, Marco Varmi, Maria Rita Nicotra, and Pier Giorgio Natali Expression of Cyclooxygenase-2 in Human Transitional Cell Carcinoma of the Urinary Bladder Ari Ristimdki, Outi Nieminen, Kirsi Saukkonen, Kristina Hotakainen, Stig Nordling, and Caj Haglund Regular Articles The Transmembrane Form of the CX3CL1 Chemokine Fractalkine Is Expressed Predominantly by Epithelial Cells in Vivo Andrew D. Lucas, Nicholas Chadwick, Bryan F. Warren, Derek P. Jewell, Siamon Gordon, Fiona Powrie, and David R. Greaves The B-Chemokine Receptor D6 Is Expressed by Lymphatic Endothelium and a Subset of Vascular Tumors RobertJ . B. Nibbs, Ernst Kriehbuber, Paul D. Ponath, David Parent, Shixin Qin, Jobn D. M. Campbell. Alison Henderson, Dontscho Kerjaschki, Dieter Maurer, Gerard J.G rabam, and Antal Rot Macrophage Myeloperoxidase Regulation by Granulocyte Macrophage Colony-Stimulating Factor in Human Atherosclerosis and Implications in Acute Coronary Syndromes Seigo Sugiyama, Yosbikatsu Okada, Galina K. Sukbova, Renu Virmani, Jay W. Heinecke, and Peter Libby Oxidative Stress and Induction of Heme Oxygenase-1 in the Kidney in Sickle Cell Disease Karl A. Nath, Joseph P. Grande, Jill J.H aggard, Anthony J. Croatt, Zvonimir S. Katusic, Anna Solovey, and Robert P. Hebbel Expression of Hypoxia-Inducible Cell-Surface Transmembrane Carbonic Anhydrases in Human Cancer Sergey Ivanov, Shu-Yuan Liao, Alla Ivanova, Alla Danilkovitch-Miagkova, Nadezhda Tarasova, Gregor Weirich, MarshaJ . Merrill, Martin A. Proescholdt, Edward H. Oldfield, Joshua Lee, Jan Zavada, Abdul Waheed, William Sly, Michael I. Lerman, and EricJ . Stanbridge Plasminogen Activators Direct Reorganization of the Liver Lobule after Acute Injury JorgeA . Bezerra, Angela R. Currier, Hector Melin-Aldana, Gregg Sabla, Thomas H. Bugge, Keith W. Kombrinck, and Jay L. Degen Inhibition of Type | Procollagen Synthesis by Damaged Collagen in Photoaged Skin and by Collagenase-Degraded Collagen in Vitro James Varani, Dara Spearman, Patricia Perone, Suzanne E. G. Fligiel, Subhash C. Datta, Zeng Quan Wang, Yuan Shao, Sewon Kang, GaryJ . Fisher, and John J. Voorbees Basic Fibroblast Growth Factor and Ultraviolet B Transform Melanocytes in Human Skin Carola Berking, Richelle Takemoto, Kapaettu Satyamoorthy, Rosalie Elenitsas, and Meenhard Herlyn HOX Genes in Human Lung: Altered Expression in Primary Pulmonary Hypertension and Emphysema Heiko A. Golpon, Mark W. Geraci, Mark D. Moore, Heidi L. Miller, Gary J. Miller, Rubin M. Tuder, and Norbert F. Voelkel NF-«B Is Activated in Cholestasis and Functions to Reduce Liver Injury Hideyuki Miyoshi, Christian Rust, M. Eugenia Guicciardi, and GregoryJ . Gores CD28-B7-Mediated T Cell Costimulation in Chronic Cardiac Allograft Rejection: Differential Role of B7-1 in Initiation versus Progression of Graft Arteriosclerosis Kyung Soo Kim, Mark D. Denton, Anil Chandraker, Andreas Knoflach, Rolando Milord, Anna Maria Waaga, Laurence A. Turka, Mary E. Russell, Robert Peach, and Mohamed H. Sayegh B-Catenin Dysregulation in Thyroid Neoplasms: Down-Regulation, Aberrant Nuclear Expression, and CTNNB1 Exon 3 Mutations Are Markers for Aggressive Tumor Phenotypes and Poor Prognosis Ginesa Garcia-Rostan, Robert L. Camp, Agustin Herrero, Maria Luisa Carcangiu, David L. Rimm, and Giovanni Tallini PG490-88, a Derivative of Triptolide, Blocks Bleomycin-Induced Lung Fibrosis Ganesh Krishna, Kela Liu, Hidenobu Shigemitsu, Mingxing Gao, Thomas A. Raffin, and Glenn D. Rosen Sporadic Fundic Gland Polyps: Common Gastric Polyps Arising Through Activating Mutations in the B-Catenin Gene Susan C. Abraham, Bunsei Nobukawa, Francis M. Giardiello, Stanley R. Hamilton, and Tsung-Teb Wu Expression of the Hypoxia-Inducible and Tumor-Associated Carbonic Anhydrases in Ductal Carcinoma in Situ of the Breast Charles C. Wykoff, Nigel Beasley, Peter H. Watson, Leticia Campo, Stephen K. Chia, Ruth English, Jaromir Pastorek, William S. Sly, Peter Ratcliffe, and Adrian L. Harris Protection of ATP-Depleted Cells by Impermeant Strychnine Derivatives: Implications for Glycine Cytoprotection Zheng Dong, Manjeri A. Venkatachalam, Joel M. Weinberg, Pothbana Saikumar, and Yogendra Patel A Putative Role for Cathepsin K in Degradation of AA and AL Amyloidosis Christoph Récken, Barbara Stix, Dieter Brémme, Siegfried Ansorge, Albert Roessner, and Frank Btibling Generation of C-Reactive Protein and Complement Components in Atherosclerotic Plaques Koji Yasojima, Claudia Schwab, Edith G. McGeer, and Patrick L. McGeer Chemokine-induced Cutaneous Inflammatory Cell Infiltration in a Model of Hu-PBMC-SCID Mice Grafted with Human Skin Olivier Faby, Henri Porte, Stéphanie Sénéchal, Han Vorng, Alan R. McEuen, Mark G. Buckley, Andrew F. Walls, Benoit Wallaert, André-Bernard Tonnel, and Anne Tsicopoulos Structural and Functional Disruption of Vascular Smooth Muscle Cells in a Transgenic Mouse Model of Amyloid Angiopathy Richard Christie, Masaru Yamada, Michael Moskowitz, and Bradley Hyman Frequent B-Catenin Mutations in Juvenile Nasopharyngeal Angiofibromas Susan C. Abraham, Elizabeth A. Montgomery, Francis M. Giardiello, and Tsung-Teh Wu Disruption of Integrin Function in the Murine Myocardium Leads to Perinatal Lethality, Fibrosis, and Abnormal Cardiac Performance Rebecca S. Keller, Shaw-Yung Shai, ChristopherJ . Babbitt, Can G. Pham, R. John Solaro, Maria L. Valencik, Joseph C. Loftus, and Robert S. Ross High Glucose-induced Hypertrophy of Mesangial Cells Requires p27“'®', an Inhibitor of Cyclin- Dependent Kinases Gunter Wolf, Regine Schroeder, Gunther Zabner, RolfA . K. Stahl, and StuartJ .S hankland Monocyte/Macrophage Activation by Normal Bacteria and Bacterial Products: Implications for Altered Epithelial Function in Crohn’s Disease Mebri Zareie, Paramijit K. Singh, E. Jan Irvine, Philip M. Sherman, Derek M. McKay, and Mary H. Perdue Hepatocyte Growth Factor Enhances Vascular Endothelial Growth Factor-Induced Angiogenesis in Vitro and in Vivo Xiaohua Xin, Suya Yang, Gladys Ingle, Constance Zlot, Linda Rangell, Joe Kowalski, Ralph Schwail. Napoleone Ferrara, and Mary E. Gerritsen Primary Ovarian Carcinomas Display Multiple Methylator Phenotypes Involving Known Tumor Suppressor Genes Gordon Strathdee, Kim Appleton, Maureen Illand, David W. M. Millan, Jean Sargent, Jim Paul, and Robert Brown Investigation into the Mechanism of the Loss of Laminin 5 (a3B3y2) Expression in Prostate Cancer Junshan Hao, Lorren Jackson, Robert Calaluce, Kathy McDaniel, Bruce L. Dalkin, and Ray B. Nagle Chromosomal Abnormalities Subdivide Ependymal Tumors into Clinically Relevant Groups Yuichi Hirose, Kenneth Aldape, Andrew Bollen, C. David James, Daniel Brat, Kathleen Lamborn, Mitchel Berger, and Burt G. Feuerstein Animal Models Glomeruloid Microvascular Proliferation Follows Adenoviral Vascular Permeability Factor/Vascular Endothelial Growth Factor-164 Gene Delivery Christian Sundberg, Janice A. Nagy, Lawrence F. Brown, Dian Feng, Isabelle A. Eckelboefer, EleanorJ .M anseau, Ann M. Dvorak, and Harold F. Dvorak Intrachoroidal Neovascularization in Transgenic Mice Overexpressing Vascular Endothelial Growth Factor in the Retinal Pigment Epithelium Catherine Schwesinger, Charles Yee, Richard M. Rohan, Antonia M. Joussen, Antonio Fernandez, Tobias N. Meyer, Vassiliki Poulaki, Joseph J. K. Ma, T. Michael Redmond, Suyan Liu, Anthony P. Adamis, and RobertJ .D 'Amato Augmented Senile Plaque Load in Aged Female B-Amyloid Precursor Protein-Transgenic Mice Michael J. Callahan, WilliamJ . Lipinski, Feng Bian, Robert A. Durham, Amy Pack, and Lary C. Walker April 2001 This Month in AJP Commentaries Glucose, VEGF-A, and Diabetic Complications Laura E. Benjamin A Case of Tumor Betrayal: Biphasic Effects of TIMP-1 on Burkitt's Lymphoma Li Yan and Marsha A. Moses Short Communications Induction of Megakaryocytic Differentiation in Primary Human Erythroblasts: A Physiological Basis for Leukemic Lineage Plasticity Adam N. Goldfarb, Dongyan Wong, and Frederick K. Racke Hyperglycemia-Induced Vasculopathy in the Murine Conceptus Is Mediated via Reductions of VEGF-A Expression and VEGF Receptor Activation Emese Pinter, Jody Haigh, Andras Nagy, and Joseph A. Madri Tissue Inhibitor of Metalloproteinase-1 Alters the Tumorigenicity of Burkitt's Lymphoma via Divergent Effects on Tumor Growth and Angiogenesis Liliana Guedez, Andrew J.M cMarlin, Douglas W. Kingma, Teresa A. Bennett, Maryalice Stetler-Stevenson, and William G. Stetler-Stevenson Growth Hormone Receptor Is Expressed in Human Breast Cancer Maria Gebre-Medhin, Lars-Gunnar Kindblom, Hakan Wennbo, Jan Térnell, and Jeanne M. Meis-Kindblom The Neurofibromatosis Type 2 Gene Is Mutated in Perineurial Cell Tumors: A Molecular Genetic Study of Eight Cases Jerzy Lasota, Jobn F. Fetsch, Agnieszka Wozniak, Bartek Wasag, Raf Sciot, and Markku Miettinen Comparative Genome-Scale Analysis of Gene Expression Profiles in T Cell Lymphoma Cells during Malignant Progression Using a Complementary DNA Microarray Shiyong Li, Douglas T. Ross, Marshall E. Kadin, Patrick O. Brown, and Mariusz A. Wasik Proliferating Bile Duct Epithelial Cells Are a Major Source of Connective Tissue Growth Factor in Rat Biliary Fibrosis Nicolai Sedlaczek, Ji-Dong Jia, Michael Bauer, Hermann Herbst, Martin Ruebl, Eckhart G. Hahn, and Detlef Schuppan Validation of Tissue Microarrays for Immunohistochemical Profiling of Cancer Specimens Using the Example of Human Fibroblastic Tumors Axel Hoos, Marshall J. Urist, Alexander Stojadinovic, Stephen Mastorides, Maria E. Dudas, Denis H. Y. Leung, David Kuo, Murray F. Brennan, JonathanJ . Lewis, and Carlos Cordon-Cardo Technical Advance Detection of 1p and 19q Loss in Oligodendroglioma by Quantitative Microsatellite Analysis, a Real- Time Quantitative Polymerase Chain Reaction Assay Janice M. Nigro, Michelle A. Takahashi, David G. Ginzinger, Mark Law, Sandra Passe, Robert B. Jenkins, and Ken Aldape Regular Articles Macrophage-Derived Chemokine (MDC/CCL22) and CCR4 Are Involved in the Formation of T Lymphocyte-Dendritic Cell Clusters in Human Inflamed Skin and Secondary Lymphoid Tissue Fuminori Katou, Haruo Obtani, Takashi Nakayama, Katsubiko Ono, Kouji Matsushima, Anne Saaristo, Hiroshi Nagura, Osamu Yoshie, and Katsutoshi Motegi Relocalization of Apoptosis-Inducing Factor in Photoreceptor Apoptosis Induced by Retinal Detachment in Vivo Toshio Hisatomi, Taiji Sakamoto, Toshinori Murata, Ichiro Yamanaka, Yuji Oshima, Yasuaki Hata, Tatsuro Ishibashi, Hajime Inomata, Santos A. Susin, and Guido Kroemer Molecular Determinants of Ovarian Cancer Plasticity Anil K. Sood, Elisabeth A. Seftor, Mavis S. Fletcher, Lynn M. G. Gardner, Paul M. Heidger, Richard E. Buller, Richard E. B. Seftor, and MaryJ . C. Hendrix c-Myb and Bcl-x Overexpression Predicts Poor Prognosis in Colorectal Cancer: Clinical and Experimental Findings Annamaria Biroccio, Barbara Benassi, Igea D'Agnano, Carmen D'Angelo, Simonetta Buglioni, Marcella Mottolese, Andrea Ricciotti, Gennaro Citro, Maurizio Cosimelli, Robert G.R amsay, Bruno Calabretta, and Gabriella Zupi Matriptase and HAI-1 Are Expressed by Normal and Malignant Epithelial Cells in Vitro and in Vivo Michael Oberst, Joanna Anders, Bin Xie, Baljit Singh, Miguel Ossandon, Michael Johnson, Robert B. Dickson, and Chen-Yong Lin Origin and Structural Evolution of the Early Proliferating Oval Cells in Rat Liver Sandor Paku, Janos Schnur, Peter Nagy, and Snorri S. Thorgeirsson Heterogeneous Vascular Dependence of Tumor Cell Populations Joanne L. Yu, Janusz W. Rak, Peter Carmeliet, Andras Nagy, Robert S. Kerbel, and Brenda L. Coomber Expression and Potential Role of Fas-Associated Phosphatase-1 in Ovarian Cancer Ivo Meinhold-Heerlein, Frank Stenner-Liewen, Heike Liewen, Shinichi Kitada, Maryla Krajewska, Stanislaw Krajewski, Juan M. Zapata, Anne Monks, Dominic A. Scudiero, Thomas Bauknecht, and Jobn C. Reed