Index of Subjects Volume 158, 2001 ABCC8 gene, focal CHI, unbalanced H19/IFG2 expres- AB-induced inflammatory processes in microglial cells sion, non-neoplastic cells, 2177 (APP23 transgenic mouse), 63 ABri. see Amyloid-Bri BACE mRNA expression (APP transgenic mouse), 173 ACD. see Allergic contact dermatitis brain quantification of F-ring and D-/E-ring isopros- 2-Acetylaminofluorene, histological changes after, oval tanes and neuroprostanes, 293 cells (rat), 1313 caspase activation and NFT formation, 189 ACID. see Activation-induced cell death FE65 in, 1585 Acquired nephrotic syndrome, nephrin on podocytes gender as risk factor (man and transgenic mouse), 797 and proteinuria in, 1723 inflammatory responses to amyloidosis (transgenic Activation-induced cell death, Fas-l-expressing T mouse), 1345 cells, identification in human peripheral blood, 387 PS-1-linked, variability in AB deposition, PS-7 gene Activator protein |, systemic infusion, and activation of mutations, 2165 NF-«B and AP-1, 1743 senile plaque load, aged female-BAPP transgenic Acute myeloid leukemias, megakaryocytic differentia- mouse (mouse), 1173 tion in primary human erythroblasts, 1191 SR-B, type |, brain astrocytes and VSMCs (mouse and ADCC. see Adenocarcinoma of the cardia man), 825 ADCE. see Adenocarcinoma of the esophagus Amine transporters, vesicular, radionuclide uptake me- Adenocarcinomas diated by, human midgut carcinoid tumor transplanted of the cardia, Barrett's mucosa, ADCE and, 33 (nude mouse), 745 of the esophagus, Barrett's mucosa, ADCC and, 33 Amyloid af peptide, VSMC disruption in mouse model precursor lesions and, gastric cardia, CGH, 1961 of CAA (transgenic mouse), 1065 prostatic, early localized, CGH, screening studies, 399 Amyloid B Adenomas, gastric, CGH of carcinomas and, 655 accumulation in low-density membrane domain and Adenosine triphosphate, cells depleted of, protection B-amyloid in brain (mouse), 2209 by impermeant strychnine derivatives, MDCK cells and deposition, PS-1 gene mutations, PS-1-linked AD, rat hepatocytes, 1021 2165 Adoptive cell transfer, GFP-expressing leukocyte sub- inflammatory processes in microglial cells induced by sets (mouse), 41 (APP23 transgenic mouse), 63 Aging Amyloid-Bri, deposition of, NFD and, FBD, 515 BACE mRNA expression (APP transgenic mouse), 173 Amyloid precursor protein induction of congophilic neurofibrillary tau inclusions in inflammatory responses to amyloidosis, AD model (tau transgenic mouse), 555 (transgenic mouse), 1345 AIF. see Apoptosis-inducing factor senile plaque load, aged female-BAPP transgenic AILD. see Angioimmunoblastic lymphadenopathy with mouse (mouse), 1173 dysproteinemia Amyloidosis Akt, loss of PTEN expression and, ovarian cancer, 2097 AA and AL, cathepsin K in degradation of, 1029 Allelic loss, in biallelic inactivation of p53 and DPC4 inflammatory responses to, model of AD (transgenic genes, pancreatic carcinogenesis, 1677 mouse), 1345 Allergic contact dermatitis, cytotoxic proteins in psori- primary, t(4;14)(p16.3\.2) translocation, 1599 asis and, 803 Anaplastic large cell lymphoma, Bic-2 in, 1889 Allergies, late phase intestinal reactions (rat), 681 Anaplastic lymphoma kinase, detection of NPM-ALK Alzheimer’s disease and ATIC-ALK fusion genes, non-neoplastic cells, age-dependent induction of congophilic neurofibrillary 2185 tau inclusions in (tau transgenic mouse), 555 Angiogenesis AB accumulation in low-density membrane domain and chondromodulin-| and chondroid formation, salivary B-amyloid in brain (mouse), 2209 pleomorphic adenomas, 1465 2229 2230 ~=Index of Subjects AJP June 2001, Vol. 158, No. 6 choroidal neovascularization and VEGF overexpres- platelet- and coagulation-dependent thrombi, laser-in- sion (transgenic mouse), 1161 duced vascular injury models (mouse), 1613 effect of TIMP-1 on Burkitt's lymphomas (mouse), 1185, prostate adenocarcinoma, PSCA in fetal and adult tis- 1207 sues (transgenic mouse), 809 endometrium after menstruation, VEGFR phosphoryla- renal failure, atrophic tubules in interstitial fibrosis (rat), tion by sFLT-1, 1399 75 glomeruloid microvascular proliferation following VPF/ senile plaque load, aged female-BAPP transgenic VEGF-164 gene delivery (nude mouse), 1145 mouse (mouse), 1173 glucose, VEGF-A and diabetic complications, 1181 Annexin 1 hyperglycemia-induced vasculopathy, VEGF-A and effect of neutrophil interaction with postcapillary venule VEGF receptor activation (mouse), 1199 endothelium (rat), 603 inflammation-associated, capillary EC production of FPR and anti-migratory actions of (mouse), 1969 decorin, in vitro, 345 Antiartherosclerosis, activity of singlet oxygen, 781 molecular determinants of ovarian cancer plasticity, ANX-A1. see Annexin 1 1279 Aorta, allotransplantation, recipient vascular SMCs me- diate intimal expansion (mouse), 1943 staging and gene regulation of, RCCs, 735 AP-1. see Activator protein | tumoral, angiopoietin-2 and regulation of, 563 AP12-MALT1 fusion transcripts, MALT lymphoma and, vascular dependence of tumor cells, 1325 699 VEGF-induced, effect of HGF on, 1111 Apert syndrome, osteoblast apoptosis in craniosynosto- VEGF-mediated EC protection, survivin targeting, 1757 sis, 1833 VPF/VEGF regulation of glomeruloid microvascular Apolipoproteins, ApoE4 and risk of AD (man and trans- proliferation, 789 genic mouse), 797 Angioimmunobliastic lymphadenopathy with dyspro- Apoptosis teinemia, T cell subpopulation analysis, 1851 CsA-induced, HGF protection of podocytes against, Angiopathies, Af deposition, PS-7 gene mutations, PS- 275 1-linked AD, 2165 EC, and internalization of PR3 and MPO, 581 Angiopoietin-2, and regulation of tumor angiogenesis, Fas-induced, alveolar epithelial cells in vivo (mouse), 563 153 Angiotensin ll, systemic infusion, and activation of Fas-L-expressing T cells, identification in human pe- NF-«B and AP-1, 1743 ripheral blood, 387 Angiotensin type-1 receptor, SCC and KA, 1633 hippocampal, in major depression and, GC overexpo- Animal models sure, 453 AD, inflammatory responses to amyloidosis (transgenic neuronal death, 1 mouse), 1345 osteoblast, in craniosynostosis, Apert syndrome, 1833 asthma induced by dust mites (Rhesus monkeys), 333 p53 in hair follicle catagen (mouse), 1913 ATL-associated HHM (mouse), 2219 protective p27*"’ function, SCLC, 87 Caroli’s disease associated with congenital hepatic fi- regulation of hair follicle regression (mouse), 1899 brosis (polycystic kidney rat), 1605 role of NF-«B activation in cholestastatic liver injury choroidal neovascularization (transgenic mouse), 1161 (mouse), 967 fatal human monocytotropic erlichiosis (C57BL/6 and Rudolf Virchow, 1543 mouse), 757 Apoptosis-inducing factor, retinal detachment-induced glomeruloid microvascular proliferation following VPF/ photoreceptor apoptosis (rat and mouse), 1271 VEGF-164 gene delivery (nude mouse), 1145 APP23, AB-induced inflammatory processes in microglial heregulin B1 treatment (EroB gene-targeted mouse), cells (transgenic mouse), 63 1871 Archival tissues, gene expression analysis, 419 HGE, IGN-y-mediated pathology (mouse), 1881 Arteries Hu-PBMC-SCID mouse grafted with human skin, che- copper-induced injury, PAI-1 and vessel wall remodel- mokines in cutaneous inflammation (mouse), 1053 ing (mouse), 107 human EBV-associated hemophagocytic syndrome generation of CPR and complement components in (rabbit), 1533 atherosclerotic plaques, 1039 human midgut carcinoid tumor transplants (nude PC-1 deficiency in IIAC, 543 mouse), 745 Arteriosclerosis, grafts, chronic cardiac allograft rejec- hyalinosis and Ym1/Ym2 gene expression, 323 tion, CD28-B7-mediated T cell costimulation (rat), 977 liver replacement by transplanted hepatocytes without Asthma, induced by dusi mites (Rhesus monkey), 333 growth stimuli (DPPIV™ rat), 771 Astrocytes, AD brain, SR-B type | (mouse and man), 825 Index of Subjects 2231 AJP June 2001, Vol. 158, No. 6 Astrocytomas, high-grade, chromosomal imbalances in osteoblast apoptosis in craniosynostosis, Apert syn- pediatric and adult cases, 1525 drome, 1833 Atherosclerosis Bone marrow GM-SCF regulation of macrophage MPO in, 879 JL1 expression, 1473 plaque, CPR and complement components, 1039 transfer, GFP-expressing leukocyte subsets (mouse), ATL. see Lipoxin A,, aspirin-triggered 41 Atrophic tubules, in interstitial fibrosis, microembolism- Brain induced renal failure (rat), 75 AD, SR-B type |, astrocytes and VSMCs (mouse and Ax1, Gas6 and mesangial cell proliferation through, Thy1 man), 825 GN (mouse), 1423 age-dependent induction of congophilic neurofibrillary Axons, pathology in IL-12-induced EAE relapses (Lewis tau inclusions (tau transgenic mouse), 555 rat), 2127 quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes, AD, 293 tau deposited in, FTDP-17 R406W patients, 373 B7-1, cardiac allograft rejection, CD28-B7-mediated T Breast cancer cell costimulation (rat), 977 amplicon profiling, DOP-PCR-based array CGH, 1623 B7-2, cardiac allograft rejection, CD28-B7-mediated T CGH of apocrine breast lesions, 207 cell costimulation (rat), 977 DCIS, CA9 and CA712 gene expression, 1011 B cells, monocytoid, phenotypic profile, 1363 ductal carcinoma gene expression profiling by LCM BACE. see B-site APP cleaving enzyme and oligonucleotide arrays, 2005 Bacillus Calmette-Guerin, |ung granuloma formation af- epigenetic change, and RAR B2 gene, 299 ter (SCID mouse), 1890 ER-positive, NHE-RF expression, 57 Barrett’s mucosa, ADCC, ADCE and, 33 heregulin B1 treatment (ErobB gene-targeted mouse), Basal cell carcinoma, early-onset, 053 and PTCH genes 1871 in, 381 human, GHR expression, 1217 Basement membranes IL-8 in metastatic phenotype of carcinoma cells, 639 MMP-10 and MMP-3 overexpression, human DM cor- matriptase and HAI-1, epithelial cells, 1301 neas, 723 Bronchi, human, basement membrane pores in epithe- pores, human bronchial epithelium, 673 lium, 673 Bax, osteoblast apoptosis, craniosynostosis, Apert syn- Bronchiolitis obliterans syndrome, CXCR3 and drome, 1833 CXCL10 and chemotaxis, lung allografts, 1703 Bcl-2, osteoblast apoptosis, craniosynostosis, Apert syn- Burkitt’s lymphomas, effect of TIMP-1 (mouse), 1185, drome, 1833 1207 Bcl-x, overexpression and CRC prognosis, 1289 Bystander cells, NPM-ALK and ATIC-ALK fusion genes, BECs. see Biliary epithelial cells non-neoplastic cells, 2185 B-site APP cleaving enzyme, MRNA expression (APP transgenic mouse), 173 Bile ducts c-MET, myofibroblasts, 1451 epithelial cell proliferation and CTGF production, biliary c-Myb, overexpression and CRC prognosis, 1289 fibrosis (rat), 1239 C-Reactive protein, generation in atherosclerotic loss of, CR and replicative senescence of BECs, 1379 plaques, 1039 NF-«xB activation and cholestastatic liver injury E-Cadherin, RCC staging and gene regulation of metas- (mouse), 967 tasis and angiogenesis, 735 Biliary epithelial cells Calcification, arterial, PC-1 deficiency in IIAC, 543 early proliferating oval cells, in liver (rat), 1313 Cancers. see also Specific cancers replicative senescence, bile duct loss in liver allograft human, hypoxia-inducible cell-surface transmembrane CR and, 1379 CAs, human cancer, 905 Biliary tree architecture, ANIT visualization, 3D recon- validation of tissue microarrays, 1245 struction (rat), 2079 Capillaries, decorin production by ECs, inflammation- Bladder cancer, human, COX-2 in TCC, 849 associated angiogenesis, in vitro, 345 Bic-2, in ALCL, 1889 Carbonic anhydrases Bmal1 genes, human, circadian expression in oral mu- hypoxia-inducible and tumor-associated, DCIS of the cosa and skin, 1793 breast, 1011 BMT. see Bone marrow, transfer hypoxia-inducible cell-surface transmembrane, human Bone cancer, 905 formation (eNOS gene-deficient mouse), 247 Carcinogenesis 2232 Index of Subjects AJP June 2001, Vol. 158, No. 6 B-catenin dysregulation in thyroid neoplasms, 987 CX3CL1, transmembrane form in epithelial cells, 855 CGH, gastric adenomas and carcinomas, 655 dynamics in pulmonary granuloma formation (mouse), PAH of the prostate gland, 1767 1503 pancreatic, allelic loss in biallelic inactivation of p53 local to systemic ratios, and neutrophil recruitment, 715 and DPC4 genes, 1677 MDC and CCR4 in T cell-DC clusters in inflamed skin 18q22-qter loss in tumorigenesis of midgut carcino- and secondary lymphoid tissue, 1263 mas, CGH, 1803 synthesis by human peritoneal fibroblasts, 1441 Carcinomas, gastric, CGH of adenomas and, 655 Chemotaxis, CXCR3 and CXCL10 and, lung allografts, Caroli’s disease, congenital hepatic fibrosis and (poly- 1703 cystic kidney rat), 1605 CHI. see Congenital hyperinsulinism Cartilage, chondromodulin-| and chondroid formation, Cholestasis, NF-«B activation and, liver injury (mouse), salivary pleomorphic adenomas, 1465 967 CAs. see Carbonic anhydrases Chondromodulin-l, chondroid formation and, salivary Caspases pleomorphic adenomas, 1465 activation and NFT formation in AD, 189 Chordomas, differentiation pattern, 1571 neuronal death, 1 Choroidal neovascularization, VEGF overexpression osteoblast apoptosis in craniosynostosis, Apert syn- and (transgenic mouse), 1161 drome, 1833 Chromosomes B-Catenin acentric double minutes, in vivo elimination of, and dysregulation in thyroid neoplasms, 987 MYCN oncogene amplification in micronuclei, neuro- mutations in JNAs, 1073 blastomas, 1579 B-Catenin gene, mutations, and sporadic FGPs, 1005 alterations, gastric adenomas and carcinomas, CGH, Cathepsin K, role in degradation of AA and AL amyloid- 655 osis, 1029 9p, CDKN2A mutation analysis, deletion mapping of, Cavalieri principle, application to volume determination CRCCs, 593 of lung metastasis (mouse), 1997 11q, loss, CGH, parasympathetic paragangliomas, Caveolin-1, down-regulation in sarcomas, 833 1937 CD18, leukocyte-mediated EC death in diabetic retinop- 11q22-23, LOH and MMP-1 SNP, 691 athy (rat), 147 11q23 deletion and cyclin D1 overexpression, parathy- CD28-B7, T cell costimulation mediated by, cardiac allo- roid adenomas, 1355 graft rejection (rat), 977 18q22-qter, loss in tumorigenesis of midgut carcino- CD31, molecular determinants of ovarian cancer plastic- mas, CGH, 1803 ity, 1279 tumor suppressor loci at 6q22 and 6q23-q24, malig- CD74, renal neoplasms, expression profiling, 1639 nant progression, EPTs, 1903 CD80. see B7-1 CHS. see Contact hypersensitivity CD86. see B7-2 Chymases, mast cell, MITF and (mouse), 281 CD95. see Fas Circadian rhythms, Clock gene expression in human CDKN2A gene, mutation analysis, chromosome Qp in oral mucosa and skin, 1793 CRCCs, 593 Clear-cell renal carcinomas, chromosome 9p, CDKN2A Cell cycle, circadian Clock gene expression in human mutation analysis, deletion mapping, 593 oral mucosa and skin, 1793 Clock genes, circadian expression in human oral mu- Cerebral amyloid angiopathy, disruption of VSMCs in cosa and skin, 1793 (transgenic mouse), 1065 Coagulation, targeted combined deficiency of aPC and Chemokine receptor ligands, CXCL10, infiltrating in- Factor XI (mouse), 469 flammatory cells, chemotaxis and, 1703 Collagen Chemokine receptors damaged, inhibition of type | procollagen synthesis by, CCR4, MDC and, T cell-DC cluster formation, inflamed 931 skin and secondary lymphoid tissue, 1263 type 4, labeling in pediatric renal neoplasm, 2089 CXCR3, infiltrating inflammatory cells, chemotaxis and, Collagen-induced arthritis, early synovial cytokines 1703 (rat), 491 D6, in lymphatic endothelium and vascular tumor sub- Colon cancer sets, 867 identification with MSI-H, 527 Chemokines K-ras and p53 gene alterations and MSI in, 1517 allergic CHS, 431 Colorectal cancers cutaneous _ inflammation, Hu-PBMC-SCID mouse c-Myb and Bcl-x overexpression and prognosis, 1289 grafted with human skin (mouse), 1053 MMR-deficient, stepwise PolyA deletions, 1867 Index of Subjects 2233 AJP June 2001, Vol. 158, No. 6 MSI-L status in, 779 CTLA4Ig, fusion protein, CD28-B7-mediated T cell co- Comparative genomic hybridization stimulation, cardiac allograft rejection (rat), 977 adenocarcinomas and precursor lesions, gastric car- Cyclin D1, loss of PTEN expression and, ovarian cancer, dia, 1961 2097 apocrine breast lesions, 207 Cyclin D5, overexpression, parathyroid adenomas, 1355 B-cell SMZL genomic inbalances, cytogenetics and, Cyclooxygenase-2 1843 in human TCC of the urinary bladder, 849 categorization of ependymal tumors, 1137 inflammatory responses to amyloidosis, AD model chromosomal alterations, gastric adenomas and carci- (transgenic mouse), 1345 nomas, 655 and pulmonary fibrosis (mouse), 1411 chromosome 11q loss, parasympathetic paraganglio- Cyclosporin, CR, bile duct loss and replicative senes- mas, 1937 cence of BECs, 1379 DOP-PCR-based array, amplicon profiling of breast Cyclosporin A, apoptosis induced by, HGF protection of cancers, 1623 podocytes, 275 high-grade astrocytomas, chromosomal imbalances in Cystic fibrosis transmembrane conductance regula- pediatric and adult cases, 1525 tors loss of 18q22-qter, tumorigenesis of midgut carcino- cytokine regulation of gap junction connectivity, 1565 mas, 1803 role of TNF-a in gap junction communications, CF air- 11q23 deletion and cyclin D1 overexpression, parathy- roid adenomas, 1355 way cells, 1775 1q gain and outcomes, Wilms’ tumors, 393 Cytokines screening for early localized prostatic adenocarcino- early synovial, in CIA (rat), 491 mas, 399 regulation of gap junction connectivity, 1565 tumor suppressor loci at 6q22 and 6q23-q24 and ma- T. cruzi infection, in IFN-y and TNF-R1 deficiency lignant progression, EPTs, 1903 (mouse), 1433 Compiement component generation in atherosclerotic plaques, 1039 Decorin, production by capillary ECs, inflammation-as- 1q, inflammatory responses to amyloidosis, AD model sociated angiogenesis, in vitro, 345 (transgenic mouse), 1345 Dementia, hereditary, characterization of Ser52, 227 Complementary DNA microarrays, gene expression Dendritic cells profiles, progression of T cell lymphomas, 1231 BM-derived, expressing eGFP, cellular tracking, adop- Congenital hepatic fibrosis, Carolis disease associ- tive host (mouse), 1975 ated with (polycystic kidney rat), 1605 MDC and CCR4 and T cell-DC clusters, inflamed skin Congenital hyperinsulinism, focal, unbalanced H19/ and secondary lymphoid tissue, 1263 IFG2 expression, 2177 Depression, major, hippocampal apoptosis in, GC over- Connective tissue growth factor, production of, bile exposure, 453 duct epithelial cell proliferation and, biliary fibrosis Dermatophagoides farinae, asthma induced by (Rhe- (rat), 1239 sus monkey), 333 Contact hypersensitivity, allergic, chemokine expres- Diabetes mellitus sion during, 431 glucose, VEGF-A and complications due to, 1181 Corneas, human, MMP-10 and MMP-3 overexpression hyperglycemia-induced vasculopathy, role of VEGF-A in, DM, 723 and VEGF receptor activation (mouse), 1199 Cotran, Ramzi Suliman, in memoriam, 343 leukocyte-mediated EC death in retinopathy (rat), 147 COX-2. see Cyclooxygenase-2 MMP-10 and MMP-3 overexpression in human cor- CR. see Rejection, chronic neas, 723 Cranial sutures, fate of, FGF-2 in vivo modulation of p27"?! inhibition of glucose-induced mesangial cell biological activity and (rat and mouse), 441 hypertrophy (transgenic mouse), 1091 Craniosynostosis, Apert, osteoblast apoptosis in, 1833 CRC. see Colorectal cancers TGF-B1 and TGFR type 2, Smad signaling pathway CRCCs. see Clear-cell renal carcinomas (db/db mouse), 1653 Crohn’s disease, monocyte/macrophage activation by Differential subtraction chain technology, SAPC gene bacteria, 1101 suppression in high grade prostate cancer, 19 CRP. see C-Reactive protein Dimerization co-factor of hepatocyte nuclear factor Cry1 genes, human, circadian expression in oral mucosa 1/Pterin-4a-carbinolamine dehydratase, Xenopus and skin, 1793 pigmentation and melanomas, 2021 2234 Index of Subjects AJP June 2001, Vol. 158, No. 6 Dipentidyl-peptidase type !V-deficient rat, liver re- human EBV-associated hemophagocytic syndrome placement by transplanted hepatocytes without growth model (rabbit), 1533 stimuli (rat), 771 TIMP-1 and Surkitt’s lymphomas (mouse), 1207 Dpc4, nuclear localization in HNPCC, relation to TGFBRII, EPTs. see Endocrine pancreatic tumors §37 ErbB, heregulin B1 treatment (ErbB gene-targeted DPC4 gene, allelic loss in biallelic inactivation, pancre- mouse), 1871 atic carcinogenesis, 1677 Erlichiosis Ductal carcinomas, gene expression profiling by LCM fatal human monocytotropic (C57BL/6 mouse), 757 and oligonucleotide arrays, 2005 human granulocytic, IFN-y-mediated pathology Dust mites, asthma induced by (Rhesus monkey), 333 (mouse), 1881 Erythroblasts, primary human, induction of megakaryo- cytic differentiation, 1191 EB. see Epidermolysis bullosa simplex Esophagus, ADEC and gastric cardia, 33 Embryos, kidney, 3-D imaging by two-photon micros- Estrogen receptors, NHE-RF in luminal epithelia, prolif- copy (mouse), 49 erative endothelium and breast carcinomas, 57 EMMPRIM. see Extracellular matrix metalloproteinase in- Estrogens, gender as AD risk factor (man and trans- ducer genic mouse), 797 Emphysema, HOX genes in human lung, 955 Experimental autoimmune encephalomyelitis, |-12- Endocrine pancreatic tumors, tumor suppressor loci at induced relapses, myelin/axonal pathology (Lewis rat), 6q22 and 6q23-q24 and malignant progression, 1903 2127 Endoglin Extracellular matrix, Ti/MP-1 and Burkitt's lymphomas, HHT modified genes and TGF-B1 levels in vascular 1185 defect development (endoglin heterozygous Extracellular matrix metalloproteinase inducer, fibro- mouse), 2011 blast synthesis of MMPs, breast cancer cells, 1921 molecular determinants of ovarian cancer plasticity, Eyes, leukocyte-mediated EC death in diabetic retinop- 1279 athy (rat), 147 Endometriosis, human, expression of |L-1Rl!, 481 Endometrium endometriotic implants and, RANTES mRNA expres- Factor XI, targeted combined deficiency aPC and sion, 1949 (mouse), 469 repair after menstruation, VEGFR phosphorylation by Familial British dementia, neurofibrillary degeneration SFLT-1, 1399 and ABri deposition, 515 Endothelial cells Fas apoptosis, and internalization of PR3 and MPO, 581 induction of alveolar epithelial cell apoptosis in vivo capillary, production of decorin by, inflammation-asso- (mouse), 153 ciated angiogenesis, in vitro, 345 osteoblast apoptosis in craniosynostosis, Apert syn- chronic inflammation, microvascular remodeling, N. drome, 1833 pulmonis (C3H mouse), 2043 Fas-associated phosphatase-1, in ovarian cancer, 1335 leukocyte-mediated death, diabetic retinopathy (rat), Fas ligand, apoptotic T cells expressing, human periph- 147 eral blood, 387 VEGF-mediated protection, suppression by survivin Fatal human monocytotropic erlichiosis (C57BL/6 targeting, 1757 mouse), 757 Endothelin-1, receptor blockade and proliferation of KS FBD. see Familial British dementia cells, 841 FE65, in AD, 1585 Endothelium, proliferative, NHE-RF expression, 57 Fetal growth restriction, human trophoblast invasion Ependymal tumors, categorization using CGH, 1137 and spiral artery transformation, 1713 Epidermolysis bullosa simplex, with plectin deficiency, FGPs. see Fundic gland polyps plectin gene mutation, 617 Fibrinolytic system, PAI-1 and vessel wall remodeling, Epithelial cells copper-induced injury (mouse), 107 bile duct, proliferation and CTGF production, biliary Fibroblast growth factor fibrosis (rat), 1239 basic CX3CL1 transmembrane form in, 855 effect of UV and, on melanocytes from human skin matriptase and HAI-1, 1301 (mouse xenografts), 943 tumors, VEGFR-2 regulation by VEGFR-1, 265 in vivo modulation of biological activity and cranial Epstein-Barr virus suture fate (rat and mouse), 441 Index of Subjects 2235 AJP June 2001, Vol. 158, No. 6 basic, RCC staging and gene regulation of metastasis Gastrointestinal stromal tumors, nestin in |CCs and, and angiogenesis, 735 817 Fibroblast growth factor receptor-2, osteoblast apopto- Gastrointestinal tract sis in craniosynostosis, Apert syndrome, 1833 B-catenin gene mutations and sporadic FGPs, 1005 Fibroblast growth factor receptor 3 gene, mutations in chromosomal alterations in adenomas and carcino- pla, 1955 mas, 655 Fibroblastic tumors, human, validation of tissue mi- H. pylori genotypes and histopathology, 647 croarrays, 1245 late phase allergic intestinal reactions (rat), 681 Fibroblasts Gender, risk factor for AD (man and transgenic mouse), human peritoneal, chemokine synthesis by, 1441 797 human skin, effect of UV and bFGF on melanocytes Gerstmann-Straussler-Scheinker disease, prion pro- (mouse xenografts), 943 tein isoforms, 2201 photoaged skin, inhibition of type | procollagen synthe- GFP. see Green fluorescent protein sis by damaged collagen, 931 GHR. see Growth hormone receptor stromal, PAR-1 and PAR-2 in, normal, benign and ma- GIST. see Gastrointestinal stromal tumors lignant tissues, 2031 Glomeruloid bodies, microvascular proliferation follow- synthesis of MMPs enhanced by EMMPRIM, breast ing VPF/VEGF-164 gene delivery (nude mouse), 789, cancer cells, 1921 1145 Fibrosis Glomerulonephritis bile duct epithelial cell proliferation and CTGF produc- effect of vitamin D analog on glomerular injury (rat), tion, biliary fibrosis (rat), 1239 1733 MHV-68 infection (IFN-yR-knockout mouse), 2117 nephrin on podocytes and proteinuria in acquired ne- pulmonary, COX-2 and (mouse), 1411 phrotic syndrome, 1723 FLT-1, phosphorylation of, endometrial repair after men- Thy1-induced, Gas6 and mesangial cell proliferation struation, 1399 through Ax1 (mouse), 1423 Focal adhesion kinase, phosphorylation of, during hyp- Glucocorticoid hormones, overexposure, hippocampal oxia/reoxygenation, kidney proximal tubules (rabbit), apoptosis in major depression, 453 2153 Glucose Fodrin hyperglycemia-induced vasculopathy, role of VEGF-A caspase activation and NFT formation in AD, 189 and VEGF receptor activation (mouse), 1199 neuronal death, 1 VEGF-A and, diabetic complications, 1181 Formalin-fixed tissues Glycine, protection of ATP-depleted cells by cell-imper- archival, gene expression analysis, 419 meant strychnine derivatives, MDCK cells, MDCK cells cellular growth, MIB-5 detection of (mouse), 1991 and rat hepatocytes, 1021 Formylated peptide receptor, anti-migratory actions of Granulocyte macrophage colony-stimulating factor ANXA1 (mouse), 1969 regulation of macrophage MPO in atherosclerosis, 879 Fractalkine, transmembrane form in epithelial cells, 855 in zymocel-induced hepatic granuloma formation Frontotemporal dementia and parkinsonism linked to (mouse), 131 chromosome 17, tau deposited in the brain, R406W Granulomas patients, 373 lung, formation after BCG infection (SCID mouse), FTDP-19. see Frontotemporal dementia and parkinson- 1890 ism linked to chromosome 17 pulmonary formation, chemokine dynamics (mouse), Fundic gland polyps, sporadic, and B-catenin gene mu- 1503 tations, 1005 Granzyme B Furin, as TFG-B1-converting enzyme, 305 cytotoxic molecules in CD8 CD56 cutaneous lympho- mas, 1593 psoriasis and ACD, 803 Galectin-3, renal neoplasms, expression profiling, 1639 Green fluorescent protein Gap junctions cells expressing, characterization and microenviron- Cytokine regulation of connectivity, 1565 ment in adoptive host (mouse), 1975 role of TNF-a in CFTR, CF airway cells, 1775 leukocytes expressing, in adoptive cell transfer and TNF-a in CFTR, CF airway cells, 1775 BMT studies (mouse), 41 Gas6, in experimental glomerulonephritis (mouse), 1423 peritoneal mast cells !abeled with, tissue-dependent Gastric cardia, CGH of adenocarcinoma and precursor alteration of protease expression (mouse), 1695 lesions, 1961 Growth 2236 Index of Subjects AJP June 2001, Vol. 158, No. 6 cellular, MIB-5 detection of, formalin-fixed and PET Hibernation, mode! of neuroprotection (arctic ground (mouse), 1991 squirrels), 2145 size-dependent in vivo growth potential (rat), 97 HMB45, labeling in pediatric renal neoplasm, 2089 Growth hormone receptor, human breast cancer, 1217 HNPCC. see Hereditary nonpolyposis colorectal cancers GSS. see Gerstmann-Straussler-Scheinker disease HO-1. see Heme oxygenase-1 HOX genes, in human lung, 955 hsRPB7 gene, suprabasal overexpression, psoriatic epi- HAI-1, epithelial cells, 1301 dermis, 367 Hair follicles Human granulocytic erlichiosis, |FN-y-mediated pa- apoptotic regulation of regression (mouse), 1899 thology (mouse), 1881 p53 in catagen (mouse), 1913 Human T-cell lymphotropic virus type 1, HHIV associ- Heart ated with (SCID mouse), 2219 chronic allograft rejection, CD28-B7-mediated T cell Humoral hypercaicemia of malignancy, AT\-associ- costimulation (rat), 977 ated (mouse), 2219 GM-SCF regulation of macrophage MPO, acute coro- Hyalinosis, Ym1/Ym2 gene expression (mouse), 323 nary syndromes, 879 Hydroxyapatite, PC-1 deficiency in IIAC, 543 heat stress and mitochondrial complex activity (rat), Hypoxia, hypoxia-inducible cell-surface transmembrane 1821 carbonic anhydrases, human cancer, 905 integrin function and hypertrophic response (mouse), Hypoxia-inducible factor-1a, vascular dependence of 1079 tumor cells, 1325 myocytes, adult liver-derived stem cells differentiate into (rat), 1929 Heat shock proteins, heat stress and cardiac mitochon- idiopathic infantile arterial calcification, PC-1 defi- drial complex activity (rat), 1821 ciency, 543 Heat stress, cardiac mitochondrial complex activity (rat), Idiopathic pulmonary fibrosis, PG490-—88 blockade of 1821 bleomycin-induced lung fibrosis (mouse), 997 Helicobacter pylori, genotypes and gastric histopathol- NAC. see Idiopathic infantile arterial calcification ogy, 647 immune complexes, formation after xenotransplantation Heme oxygenase-1, oxidative stress and, kidneys, sickle (baboon and pig), 627 cell disease (mouse), 893 Immunodeficiency, !ung granuloma formation after BCG Hemophagocytic syndrome, human EBV-associated infection (SCID mouse), 1890 (rabbit), 1533 Immunohistochemistry Hepatitis C virus, in situ detection in salivary glands, 259 cancers, validation of tissue microarrays, 1245 Hepatocyte growth factor chondromodulin-| and chondroid formation, salivary c-MET in myofibroblasts, 1451 pleomorphic adenomas, 1465 effect on VEGF-induced angiogenesis, 1111 Inducible protein-10, allergic CHS, 431 protection of podocytes against CsA-induced apopto- Inflammation sis, 275 angiogenesis associated with, capillary EC production Hepatocytes of decorin, in vitro, 345 size-dependent in vivo growth potential (rat), 97 transplanted, liver replacement by, without growth AB-induced processes in microglial cells (APP23 trans- stimuli (DPPIV™ rat), 771 genic mouse), 63 Hereditary hemorrhagic telangiectasia, modified chronic, EC proliferation and microvascular remodel- genes influencing TGF-B1 levels in vascular defect ing, N. pulmonis (C3H mouse), 2043 development (endoglin heterozygous mouse), 2011 cutaneous, chemokines in, Hu-PBMC-SCID mouse Hereditary nonpolyposis colorectal cancers, Dpc4 grafted with human skin (mouse), 1053 (Smad4, Madh4) nuclear localization in, relation to TG- CXCR3 and CXCL10 and chemotaxis, lung allografts, FBRII, 537 1703 Heregulin £1, treatment (EroB gene-targeted mouse), generation of CPR and complement components in 1871 atherosclerotic plaques, 1039 Herpesvirus papio, human EBV-associated hemoph- immune cell infiltration and basement membrane pores agocytic syndrome model (rabbit), 1533 in bronchial epithelium, 673 HGE. see Human granulocytic erlichiosis lung, integrin and selectin mediation of neutrophil se- HHM. see Humoral hypercalcemia of malignancy questration (rat), 1809 HHT. see Hereditary hemorrhagic telangiectasia mucosal pathophysiology and changes in late phase HHT1. see Endoglin intestinal allergic reactions (rat), 681 Index of Subjects 2237 AJP June 2001, Vol. 158, No. 6 neutrophil interaction with postcapillary venule endo- JL1, bone marrow and thymus, 1473 thelium and ANX-A1 (rat), 603 JNAs. see Juvenile nasopharyngeal angiofibromas periodontitis, proportion of NK T cells in, 1391 Juvenile nasopharyngeal angiofibromas, {-catenin responses to amyloidosis, mode! of AD (transgenic mutations in, 1073 mouse), 1345 skin, MDC and CCR4 in T cell-DC cluster formation, 1263 K-ras gene, alterations in colon cancer and MSI, 1517 T. cruzi infection, IFN-y and TNF-R1 deficiency Kaposi’s sarcoma, proliferation of, effect of ET-1 recep- (mouse), 1433 tor blockade on, 841 TNF-a@ and CTFR, CF airway cells, 1775 KCNJ11 gene, focal CHI, unbalanced H19/IFG2 expres- insulin-like growth factor I, and CsA-induced apoptosis sion, non-neoplastic cells, 2177 of podocytes, 275 KDR, phosphorylation of, endometrial repair after men- Integrins struation, 1399 2, a4, and a5, mediation of chemotactic factor and Keratoacanthomas, angiotensin type-1 receptor in SCC neutrophil sequestration, lung (rat), 1809 and, 1633 cardiac hypertrophic response (mouse), 1079 Kidneys Intercellular adhesion molecule-1 atrophic tubules in interstitial fibrosis, microembolism- effect of cyclic stretching mesangial cells, 11 induced renal failure (rat), 75 leukocyte-mediated EC death in diabetic retinopathy cyclic stretching of MCs, effect on ICAM-1 and leuko- (rat), 147 cyte adherence, 11 Interferon-y effect of IFN-y on allograft rejection and necrosis, 215 CD8 effector T cell production and pulmonary immu- effect of vitamin D analog on glomerular injury (rat), nopathology, 119 1733 deficiency of, cytokine production and inflammatory embryonic, 3-D imaging by two photon microscopy processes, T. cruzi infection (mouse), 1433 (mouse), 49 effect on renal allograft rejection and necrosis, 215 nephrin on podocytes and proteinuria in acquired ne- HGE pathology mediated by (mouse), 1881 phrotic syndrome, 1723 X-linked vacuolated myopathy, 355 oxidative stress and HO-1 induction, sickle cell disease Interferon-y receptor, mouse lacking, fibrosis and leu- (mouse), 893 kocytosis in MHV-68 infection (IFN-gamma|]-knockout pediatric neoplasm, characterization of, 2089 mouse), 2117 polycystic, model of Caroli’s disease associated with Interleukin 1 receptor type Il, decoy, in human endo- congenital hepatic fibrosis (rat), 1605 metriosis, 481 proximal tubules, phosphorylation, focal adhesion pro- Interleukin 1a, osteoblast apoptosis in craniosynostosis, teins, during hypoxia/reoxygenation (rabbit), 2153 Apert syndrome, 1833 renal neoplasms, expression profiling, 1639 Interleukin 1B, osteoblast apoptosis in craniosynostosis, TGF-B1 and TGFR type 2, Smad signaling pathway Apert syndrome, 1833 (db/db mouse), 1653 Interleukin 2, and accumulation of yd T cells, cerebral malaria (mouse), 163 Interleukin 8 Laminin, molecular determinants of ovarian cancer plas- chemokine synthesis by human peritoneal fibroblasts, ticity, 1279 1441 Laminin 5, loss of expression in prostate cancer, 1129 in metastatic phenotype of breast carcinoma cells, 639 Laser microdissection RCC staging and gene regulation of metastasis and archival tissues, gene expression analysis, 419 angiogenesis, 735 ductal carcinoma gene expression profiling by oligo- Interleukin 11 receptor, and STATS activation in pros- nucleotide arrays and, 2005 tate carcinoma, 25 LCD. see Laser microdissection Interleukin 12, EAE relapses induced by, myelin/axonal Leukemias, JL1 in bone marrow and thymus, 1473 pathology (Lewis rat), 2127 Leukocyte immunoglobulin-like receptor 1, cytotoxic Intermediate filaments, nestin in |CCs and GISTs, 817 molecules in CD8 CD56 cutaneous lymphomas, 1593 interstitial cells of Cajal, nestin in GISTs and, 817 Leukocytes Interstitial fibrosis, atrophic tubules in, microembolism- adherence, effect of cyclic stretching mesangial cells, induced renal failure (rat), 75 11 IP-10. see Inducible protein-10 EC death mediated by, diabetic retinopathy (rat), 147 lsoprostanes, F-ring and D-/E-ring, brain regional quan- expressing GFP, in adoptive cell transfer and BMT tification in AD, 293 studies (mouse), 41 2238 Index of Subjects AJP June 2001, Vol. 158, No. 6 Leukocytosis, MHV-68 infection (IFN-yR-knockout granuloma formation, after BCG infection (SCID mouse), 2117 mouse), 1890 Leukotriene B, receptor, recombinant human, selectiv- human, HOX genes in, 955 ity with 15-epi-LXA,, 3 immunopathology, CD8 effector T cell IFN-y produc- Leukotriene D, receptor, recombinant human, selectiv- tion and, 119 ity with 15-epi-LXA,, 3 integrin and selectin mediation of neutrophil seques- Lipocortin 1. see Annexin 1 tration (rat), 1809 Lipoxin A,, aspirin triggered, selectivity of recombinant metastasis volume determined by stereologic method human LTD,, LTB,, and LXA, receptors, 3 (mouse), 1997 Lipoxin A, receptor, recombinant human, selectivity PEPT2 localization (rat and mouse), 707 with 15-epi-LXA,, 3 Rab38s (rat), 1665 Listeria monocytogenes, macrophage scavenger re- SCLC, protective p27“"’ function against apoptosis, ceptor response (mouse), 179 87 Liver Lymph nodes acute injury, NF-«B activation in cholestasis (mouse), monocytoid B cell phenotypic profile, 1363 secondary tissue, MDC and CCR4 in T cell-DC cluster 967 formation, 1263 adult, stem cells derived from, differentiate into cardiac Lymphatic vessels, D6 in endothelium and vascular myocytes (rat), 1929 tumors subsets, 867 adult hepatocytes, size-dependent in vivo growth po- Lymphomas tential (rat), 97 CD8 CD56 cutaneous, cytotoxic molecules in, 1593 bile duct epithelial cell proliferation and CTGF produc- MALT, AP712-MALT71 fusion transcripts and, 699 tion, biliary fibrosis (rat), 1239 CR, bile duct loss and replicative senescence of BECs, 1379 Macrophage-derived chemoattractant, allergic CHS, early proliferating oval cells (rat), 1313 431 GM-CSF in zymocel-induced granuloma formation Macrophage-derived chemokine, CCR4 and, role in T (mouse), 131 cell-DC clusters in inflamed skin and secondary lym- polycystic, model of Caroli’s disease associated with phoid tissue, 1263 (polycystic kidney rat), 1605 Macrophages reorganization after injury, role of tPA and uPA in activation by bacteria and bacterial products, Crohn's (mouse), 921 disease, 1101 replacement by transplanted hepatocytes without scavenger receptor response to L. monocytogenes in- growth stimuli (DPPIV™ rat), 771 fection (mouse), 179 repopulation and correction of metabolic disease, Madhé4, nuclear localization in HNPCC, relation to TGF- transplanted adult pancreatic cells (mouse), 571 BRIl, 537 Loss of heterozygosity Major histocompatibility complex class | molecules, chromosome 9p, CDKN2A mutation analysis, deletion X-linked vacuolated myopathy, 355 mapping of, CRCCs, 593 Malignant progression, tumor suppressor loci at 6q22 chromosome 11q22-23, MMP-1 SNP and, 691 and 6q23-q24 and, EPTs, 1903 molecular clonality of in-transit melanoma metastases, MALT. see Mucosa-associated lymphoid tissue 1371 MAP-2. see Microtubule-associated protein 2 relation to intragenic mutation, 1561 Marginal zone B cells, monocytoid B cel! phenotypic Lungs profile, 1363 acute injury, immunecomplex-induced, role of met- Mass spectrometry, urinary bladder TCC in urine, 1491 alloelastase (mouse), 2139 Mast cells adenocarcinoma, c-MET in myofibroblasts, 1451 chymases, MITF and (mouse), 281 allografts, inflammatory cell CXCR3 and CXCL10, role peritoneal, tissue-dependent alteration of protease ex- in chemotaxis, 1703 pression (mouse), 1695 bleomycin-induced fibrosis, PG490-88 blockade of Matriptase, epithelial cells, 1301 (mouse), 997 Matrix gene analysis, chordoma differentiation pattern, chemokine dynamics in granuloma formation (mouse), 1571 1503 Matrix metalloproteinases COX-2 and pulmonary fibrosis (mouse), 1411 fibroblast synthesis of, effect of EMMPRIM, breast can- Fas-induced apoptosis of alveolar epithelial cells in vivo cer cells, 1921 (mouse), 153 MMP-1, chromosome 11qg22-23 LOH and SNP in, 691