The American Journal of PATHOLOG Official Publication of the American Society for Investigative Pathology VOLUME 151, 1997 (July through December) Editor-in-Chief Associate Editors Editorial Board UNneiivserosni ty Foafu sWtaos hington CUnhiavrelriseist yE .o fA lWpaesrhsi ngton AMbaurlc o K. BaAgbgbiaolsi ni AYagsnhepsa l B. S.K aKnaen war Tucker Collins Dorothy F. Bainton Robert S. Kerbel Senior Editor Brigham & Women’s Hospital Sandra Bigner Dontscho Kerjaschki Harvard Medical School Kim Boekelheide Daniel M. Knowles SUntievveresni ty L.o f KMuinckheigla n JHaornvaatrhda n MeAd.i cFalle tScchehro ol TRiatjou CaS.v alK.l o Chaganti RDaivciadr doN . V.L ouLilso yd Brigham & Women's Hospital Yuan Chang James L. Madara Managing Editor Robert B. Colvin Jay M. McDonaid Philip Furmanski Priscilla Smith New York University Carlos Cordon-Cardo James K. McDougall Bethesda, Maryland Jeffrey Cossman Glenn Merlino Avrum |. Gotlieb Riccardo Dalla-Favera George F. Murphy The Toronto Hospital Dennis W. Dickson Ruth J. Muschel Editorial Assistants University of Toronto Vishva M. Dixit Brian J. Nickoloff Maria Giorla Stanley R. Hamilton Isaiah J. Fidler Paul K. Pattengale Bethesda, Maryland Johns Hopkins University Martha B. Furie Janardan K. Reddy Giulio Gabbiani Russell Ross BCeotdhyes daM,o oMnaeryylhaannd GCaesoer geW esPteerrrny Reserve University Michael A. Gerber Eric P. Sandgren Michael A. Gimbrone, Jr. Eveline E. Schneeberger Sem H. Phan Joe W. Grisham Patricia Steeg Editor’s Assistant University of Michigan Nancy L. Harris Gary E. Striker Tamara Carlson Darryl Shibaia Mary J. Hendrix John Q. Trojanowski Seattle, Washington University of Southern California Meenhard Herlyn Mark L. Tykocinski Setsuo Hirohashi Manjeri A. Venkatachalam William G. Stetler-Stevenson David Hockenbery Sharon M. Wahi Executive Officer National Institutes of Health Ralph H. Hruban Peter A. Ward Frances A. Pitlick Lawrence M. Weiss Harriet C. Isom Roger A. Warnke Bethesda, Maryland City of Hope National Medical Center Elaine S. Jaffe David P. Witte Copyright © 1997 By The American Society for Investigative Pathology The American Journal of PATHOLOGY CONTENTS FOR VOLUME 151 July 1997 Editorial Cellular and Molecular Mechanisms of Disease: A 5-Year Cycle in the Long Life of The American Journal of Pathology Nelson Fausto Pathology: A Historical Opportunity Juan Rosai Commentaries Discovery of New Lesions in Neurodegenerative Diseases with Monoclonal Antibody Techniques: Is There a Non-Amyloid Precursor to Senile Plaques? Dennis W. Dickson Vascular Endothelial Growth Factor and Ocular Neovascularization Joan W. Miller Short Communications Telomerase Activation in Cervical Cancer Suzanne Anderson, Katherine Shera, Jennifer Ible, Lisa Billman, Barbara Goff, Benjamin Greer, Hisham Tamimi, James McDougall, and Aloysius Klingelbutz Transforming Growth Factor-B Receptor Type 2 Mutations and Microsatellite Instability in Sporadic Colorectal Adenomas and Carcinomas Wade S. Samowitz and Martha L. Slattery Expression of HMGI-C and HMGI(Y) in Ordinary Lipoma and Atypical Lipomatous Tumors: Immunohistochemical Reactivity Correlates with Karyotypic Alterations Giovanni Tallini, Paola Dal Cin, Kerry J.R boden, Gennaro Chiapetta, Guidalberto Manfioletti, Vincenzo Giancotti, Alfredo Fusco, Herman Van den Berghe, and Raf Sciot Expression of Occludin, Tight-Junction-Associated Protein, in Human Digestive Tract Yutaka Kimura, Hitoshi Shiozaki, Motohiro Hirao, Yoshito Maeno, Yuichiro Doki, Masatoshi Inoue, Takushi Monden, Yubko Ando-Akatsuka, Mikio Furuse, Shoichiro Tsukita, and Morito Monden Immunohistochemical and in Situ Hybridization Detection of Growth-Hormone-Producing Cells in Human Thymoma Libero Lauriola, Nicola Maggiano, Fabio G. Serra, Simonetta Nori, Maria L. Tardio, Arnaldo Capelli, Mauro Piantelli, and Franco O. Ranelletti Technical Advance Microbeam MOMeNT: Non-Contact Laser Microdissection of Membrane-Mounted Native Tissue Malte Béhm, Ilse Wieland, Karin Schiitze, and Herbert Rtibben Regular Articles Monoclonal Antibodies to a 100-kd Protein Reveal Abundant AB-Negative Plaques throughout Gray Matter of Alzheimer’s Disease Brains Marie Luise Schmidt, Virginia M.-Y. Lee, Mark Forman, Ting-Shan Chiu, and John Q. Trojanowski Signal Transducer and Activator of Transcription 1 in Human Muscle: Implications in Inflammatory Myopathies Isabel Illa, Eduard Gallardo, Ram6n Gimeno, Carmen Serrano, Isidre Ferrer, and Candido Juarez Active Replication of HIV-1 at the Lymphoepithelial Surface of the Tonsil Sarah S. Frankel, Klara Tenner-Racz, Paul Racz, Bruce M. Wenig, Christian H. Hansen, Dennis Heffner, Ann M. Nelson, Melissa Pope, and Ralph M. Steinman Human Mucosal Addressin Cell Adhesion Molecule-1 Is Preferentially Expressed in Intestinal Tract and Associated Lymphoid Tissue Michael Briskin, Dawn Winsor-Hines, Anne Shyjan, Nancy Cochran, Stuart Bloom, Joanne Wilson, Leslie M.M cEvoy, Eugene C. Butcher, Nasim Kassam, Charles R. Mackay, Walter Newman, and DouglasJ . Ringler Activation of Naive Xenogeneic but Not Allogeneic Endothelial Cells by Human Naive Neutrophils: A Potential Occult Barrier to Xenotransplantation Futwan Al-Mohanna, Kate Collison, Ranjit Parhar, Aaron Kwaasi, Brian Meyer, Soad Saleh, Sean Allen, Sultan Al-Sedairy, David Stern, and Magdi Yacoub Enhanced Lymphocyte Longevity and Absence of Proliferation and Lymphocyte Apoptosis in Quilty Effects of Human Heart Allografts Chunming Dong, Gayle L. Winters, Janet E. Wilson, and Bruce M. McManus Systemic Injection of Products of Activated Neutrophils and H.O. in Myeloperoxidase-immunized Rats Leads to Necrotizing Vasculitis in the Lungs and Gut Peter Heeringa, Pascal Foucher, Pieter A. Klok, Minke G. Huitema, Jan-Willem Cohen Tervaert, Jan J. Weening, and Cees G. M. Kallenberg Role of Interleukin-1 in Mesangial Cell Proliferation and Matrix Deposition in Experimental Mesangioproliferative Nephritis Gregory H. Tesch, Hui Y. Lan, Robert C. Atkins, and DavidJ . Nikolic-Paterson Animal Models Helicobacter mustelae-Associated Gastric MALT Lymphoma in Ferrets Susan E. Erdman, Pelayo Correa, Leslie A. Coleman, Mark D. Schrenzel, Xiantang Li, and James G. Fox Transgenic Mice with Increased Expression of Vascular Endothelial Growth Factor in the Retina: A New Model of Intraretinal and Subretinal Neovascularization Naoyuki Okamoto, Takao Tobe, Sean F. Hackett, Hiroaki Ozaki, Melissa A. Vinores, William LaRochelle, DonaldJ . Zack, and Peter A. Campochiaro Harlequin Ichthyosis (ichq): A Juvenile Lethal Mouse Mutation with Ichthyosiform Dermatitis Jobn P. Sundberg, Dawnalyn Boggess, Margaret E. Hogan, Beth A. Sundberg, Michael H. Rourk, Belinda Harris, Kenneth Johnson, Robert W. Dunstan, and Muriel T. Davisson Correspondence Announcements August 1997 Commentary Fibroblasts as Sentinel Cells: Synthesis of Chemokines and Regulation of Inflammation Roger S. Smith, TerryJ . Smith, Timothy M. Blieden, and Richard P. Phipps Short Communications Molecular Analysis of Oral Lichen Planus: A Premalignant Lesion? Lewei Zhang, Carmen Michelsen, Xing Cheng, Tao Zeng, Robert Priddy, and Miriam P. Rosin Increased B-Catenin Protein and Somatic APC Mutations in Sporadic Aggressive Fibromatoses (Desmoid Tumors) Benjamin A. Alman, Catherine Li, Mandy E. Pajerski, Salvatore Diaz-Cano, and HubertJ . Wolfe High-Level DNA Amplifications Are Common Genetic Aberrations in B-Cell Neoplasms Claudius A. Werner, Hartmut Débner, Stefan Joos, Lorenz H. Trtimper, Michael Baudis, Thomas F. E. Barth, German Ott, Peter Moller, Peter Lichter, and Martin Bentz The Monoclonal Antibody ALK1 Identifies a Distinct Morphological Subtype of Anaplastic Large Cell Lymphoma Associated with 2p23/ALK Rearrangements Stefania Pittaluga, Iwona Wlodarska, Karen Pulford, Elias Campo, Stephan W. Morris, Herman Van den Berghe, and Chris De Wolf-Peeters Evaluation of the Differentiation Potential of WB-F344 Rat Liver Epithelial Stem-Like Cells in Vivo: Differentiation to Hepatocytes after Transplantation into Dipeptidy!peptidase-lV-Deficient Rat Liver William B. Coleman, Karen D. McCullough, Gwyn L. Esch, Ronald A. Faris, Douglas C. Hixson, GaryJ . Smith, and Joe W. Grisham Editor’s Note Replication of Hepatitis C Virus in Tissue Culture: A Potential Breakthrough in Need of Confirmation Nelson Fausto Technical Advance Transfection of HepG2 Cells with Infectious Hepatitis C Virus Genome Srikanta Dash, Abdel-Baset Halim, Hideyuki Tsuji, Naoki Hiramatsu, and Michael A. Gerber Regular Articles RelB Regulation of Chemokine Expression Modulates Local Inflammation Yiyang Xia, Mary E. Pauza, Lili Feng, and David Lo Asbestos Causes Translocation of p65 Protein and Increases NF-xB DNA Binding Activity in Rat Lung Epithelial and Pleural Mesothelial Cells Yvonne M. W. Janssen, Kevin E. Driscoll, Brian Howard, Timothy R. Quinlan, Melinda Treadwell, Aaron Barchowsky, and Brooke T. Mossman Loss of EDB* Fibronectin Isoform Is Associated with Differentiation of Alveolar Epithelial Cells in Human Fetal Lung Hirokazu Arai, Hisanobu Hirano, Sotaro Mushiake, Masahiro Nakayama, Goro Takada, and Kiyotoshi Sekiguchi Mosaic Pattern of Ornithine Transcarbamylase Expression in spf**" Mouse Liver Nobuyoshi Shiojiri, Hirokazu Imai, Shinya Goto, Tomoaki Ohta, Katsuhiro Ogawa, and Masataka Mori Sinus-Lining Cells of the Lymph Nodes Recognized as a Dendritic Cell Type by the New Monoclonal Antibody Ki-M9 Hans-Heinrich Wacker, Sven Olaf Frahm, Hans Jtirgen Heidebrecht, and Reza Parwaresch Intraepithelial Lymphocytes in Normal Human Intestine Do Not Express Proteins Associated with Cytolytic Function Andreas Chott, Dirk Gerdes, Amy Spooner, Isabella Mosberger, J. Alain Kummer, Ellen C. Ebert, Richard S. Blumberg, and Steven P. Balk Distribution of Epidermal Growth Factor Receptor and Ligands during Bronchiolar Epithelial Repair from Naphthalene-Induced Clara Cell Injury in the Mouse Laura S. Van Winkle, Jonathan M. Isaac, and Charles G. Plopper Analysis of p21“"’"'P' Expression in Normal, Premalignant, and Malignant Cells during the Development of Human Lung Adenocarcinoma Hiroyuki Hayashi, Hiroshi Miyamoto, Takaaki Ito, Yoichi Kameda, Nobuo Nakamura, Yoshinobu Kubota, and Hitoshi Kitamura Expression of P-Cadherin Identifies Prostate-Specific-Antigen-Negative Cells in Epithelial Tissues of Male Sexual Accessory Organs and in Prostatic Carcinomas: Implications for Prostate Cancer Biology Alejandro Peralta Soler, Gary D. Harner, Karen A. Knudsen, Francis X. McBrearty, Edina Grujic, Hernando Salazar, Aaron C. Han, and Albert A. Keshgegian Tumor Cell and Connective Tissue Cell Interactions in Human Colorectal Adenocarcinoma: Transfer of Platelet-Derived Growth Factor-AB/BB to Stromal Cells Christian Sundberg, Maria Branting, Bengt Gerdin, and Kristofer Rubin Molecular Analysis of T-Cell Clonality in Ulcerative Jejunitis and Enteropathy-Associated T-Cell Lymphoma Margaret Ashton-Key, Timothy C. Diss, Langxing Pan, Ming Q. Du, and Peter G. Isaacson Expression of Collagenase-3 (Matrix Metalloproteinase-13) in Squamous Cell Carcinomas of the Head and Neck Nina Johansson, Kristiina Airola, Reidar Grénman, Arja-Leena Kariniemi, Ulpu Saarialbo-Kere, and Veli-Matti Kabdari Transforming Growth Factor-B, Transforming Growth Factor-B Receptor II, and p27“'®' Expression in Nontumorous and Neoplastic Human Pituitaries Long Jin, Xiang Qian, Elzbieta Kulig, Naoko Sanno, Bernd W. Scheithauer, Kalman Kovacs, William F. Young, Jr., and Ricardo V. Lloyd Dysregulation of Carcinoembryonic Antigen Group Members CGM2, CD66a (Biliary Glycoprotein), and Nonspecific Cross-Reacting Antigen in Colorectal Carcinomas: Comparative Analysis by Northern Blot and in Situ Hybridization Peter Nollau, Friedrich Prall, Udo Helmchen, Christoph Wagener, and Michael Neumaier Macrophage Apoptosis in Rat Crescentic Glomerulonephritis Hui Y. Lan, Hideki Mitsuhashi, Yee-Yung Ng, DavidJ . Nikolic-Paterson, Niansheng Yang, Wei Mu, and Robert C. Atkins Role of Complement in Acute Tubulointerstitial Injury of Rats with Aminonucleoside Nephrosis Atsushi Nomura, Yoshiki Morita, Shouichi Maruyama, Nigishi Hotta, Masayuki Nadai, Li Wang, Takaaki Hasegawa, and Seiichi Matsuo Pattern of Superoxide Dismutase Enzymatic Activity and RNA Changes in Rat Heart Ventricles after Myocardial Infarction Mabhfoud Assem, Jean-Raymond Teyssier, Marc Benderitter, Jeréme Terrand, Aline Laubriet, Anne Javouhey, Michel David, and Luc Rochette Nitric Oxide Mediates Angiogenesis Induced in Vivo by Platelet-Activating Factor and Tumor Necrosis Factor-a@ Giuseppe Montrucchio, Enrico Lupia, Antonella De Martino, Edda Battaglia, Marco Arese, Allessandro Tizzani, Federico Bussolino, and Giovanni Camussi Evidence for Clonai Origin of Neoplastic Neuronal and Glial Cells in Gangliogliomas Jay Jiguang Zhu, Steven P. Leon, Rebecca D. Folkerth, Shang-Zhi Guo, Julian K. Wu, and Peter M. Black Intestinal Stem Cell Division and Genetic Diversity: A Computer and Experimental Analysis Jen-Lan Tsao, Scott D. Davis, Sean M. Baker, R. Michael Liskay, and Darryl Shibata X Inactivation in Human Testicular Tumors: X/ST Expression and Androgen Receptor Methylation Status Leendert H. J. Looijenga, Ad J. M. Gillis, Ruud J.H . L. M. van Gurp, AnnemiekeJ . M. H. Verkerk, and J. Wolter Oosterhuis Rat Stem Cells Developing in Irradiated SCID Mice Fail to Become Tolerized and Cause Lethal Graft-versus-Host Disease Charles D. Surh, Hiroshi Kosaka, and Jonathan Sprent Presenilin-1 Is Associated with Alzheimer’s Disease Amyloid Thomas Wisniewski, Wieslaw K. Dowjat, Bruno Permanne, Joana Palha, Asok Kumar, Gloria Gallo, and Blas Frangione Pathological Characterization of Astrocytic Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Shinsuke Kato, Hiroko Hayashi, Kenji Nakashima, Eiji Nanba, Masako Kato, Asao Hirano, Imabaru Nakano, Kobtaro Asayama, and Eisaku Obama Extrasynaptic Localization of Laminin B2 Chain in Developing and Adult Human Skeletal Muscle Ulla M. Wewer, Lars-Eric Thornell, Frosty Loechel, Xiaomin Zhang, Marian E. Durkin, Satoshi Amano, Robert E. Burgeson, Eva Engvall, Reidar Albrechtsen, and Ismo Virtanen Animal Model Timed Appearance of Lymphocytic Choriomeningitis Virus after Gastric Inoculation of Mice Sharath K. Rai, Bruce K. Micales, Mary S. Wu, Dorothy S. Cheung, Thomas D. Pugh, Gary E. Lyons, and Maria S. Salvato Announcements Information for Authors September 1997 Review Molecular Tumor Clocks and Dynamic Phenotype Darryl Shibata Commentary Role of Interleukin-6 in the Pathogenesis of Murine Plasmacytoma and Human Multiple Myeloma Paul K. Pattengale Short Communications Osteonectin (SPARC) Expression in Human Liver and in Cultured Human Liver Myofibroblasts Sylvie Blazejewski, Brigitte Le Bail, Liliane Boussarie, Jean-Frédéric Blanc, Luc Malaval, Kousaku Okubo, Jean Saric, Paulette Bioulac-Sage, and Jean Rosenbaum Aging Accelerates but Life-Long Dietary Restriction Suppresses Apoptosis-Related Fas Expression on Hepatocytes Yoshikazu Higami, Isao Shimokawa, Masato Tomita, Tomoaki Okimoto, Takehiko Koji, Nobuyuki Kobayashi, and Takayoshi Ikeda Expression of Gelatinase B and the Extracellular Matrix Metalloproteinase Inducer EMMPRIN in Benign and Malignant Pigment Cell Lesions of the Skin Joost J.v an den Oord, Liesbet Paemen, Ghislain Opdenakker, and Chris De Wolf-Peeters Involvement of Endothelial PECAM-1/CD31 in Angiogenesis Horace M. DeLisser, Melpo Christofidou-Solomidou, Robert M. Strieter, Marie D. Burdick, Candy S. Robinson, Roseanne S. Wexler, Janet S. Kerr, Cecilia Garlanda, June R. Merwin, Joseph A. Madri, and Steven M. Albelda Technical Advance Effect of Host Microenvironment on the Microcirculation of Human Colon Adenocarcinoma Dai Fukumura, Fan Yuan, Wayne L. Monsky, Yi Chen, Rakesh K. Jain Regular Articles Defective Development of Pristane-Oil-Induced Plasmacytomas in Interleukin-6-Deficient BALB/c Mice Giuseppe Lattanzio, Claude Libert, Massimo Aquilina, Manuela Cappelletti, Gennaro Ciliberto, Piero Musiani, and Valeria Poli Monoclonality of Smooth Muscle Cells in Human Atherosclerosis Charles E. Murry, Catherine T. Gipaya, Trudy Bartosek, Earl P. Benditt, and Stephen M. Schwartz Relationship of Polymorphonuclear Leukocytes to Capillary Dropout in the Human Diabetic Choroid Gerard A. Lutty, Jingtai Cao, and D. Scott McLeod Differential Expression and Localization of Insulin-Like Growth Factors | and II in Cutaneous Wounds of Diabetic and Nondiabetic Mice David L. Brown, Christine D. Kane, Steven D. Chernausek, and David G. Greenhalgh The Kidneys of Mice with Autoimmune Disease Acquire a Hypofibrinolytic/Procoagulant State That Correlates with the Development of Glomerulonephritis and Tissue Microthrombosis Koji Yamamoto and DavidJ . Loskutoff Oncogenic Transformation and Inhibition of Adipocytic Conversion of Preadipocytes by TLS/FUS- CHOP Type II Chimeric Protein Masahiko Kuroda, Tsuyoshi Ishida, Masakatsu Takanashi, Mayumi Satoh, Rikuo Machinami, and Toshiki Watanabe The Cell-Cell Adhesion Receptor Mel-CAM Acts as a Tumor Suppressor in Breast Carcinoma Ie-Ming Shib, Mei-Yu Hsu, Juan P. Palazzoa,n d Meenhard Herlyn Chromosome 8p Deletions Are Associated with Invasive Tumor Growth in Urinary Bladder Cancer Urs Wagner, Lukas Bubendorf, Thomas C. Gasser, Holger Moch, Jean-Philippe Gorég, Jan Richter, MichaelJ .M ibatsch, Frederick M. Waldman, and Guido Sauter Amplification of the c-erbB-2 (HER-2/neu) Gene in Gastric Cancer Cells: Detection by Fluorescence in Situ Hybridization Toshihiro Ishikawa, Masako Kobayashi, Masayoshi Mai, Toshimitsu Suzuki, and Akishi Ooi Overexpression of the Growth-Hormone-Releasing Hormone Gene in Acromegaly-Associated Pituitary Tumors: An Event Associated with Neoplastic Progression and Aggressive Behavior Kamal Thapar, Kalman Kovacs, Lucia Stefaneanu, Bernd Scheithauer, Donald W. Killinger, Ricardo V. Lloyd, Harley S. Smyth, Aiela Barr, Michael O. Thorner, Bruce Gaylinn, and Edward R. Laws, Jr. Lymphocyte Apoptosis During Early Phase of Listeria Infection in Mice J. Clinton Merrick, Brian T. Edelson, Vatsala Bhardwaj, Paul E. Swanson, and Emil R. Unanue Pathogenesis of SIV Encephalitis: Selection and Replication of Neurovirulent SIV M. Christine Zink, Angela Martin Amedee, Joseph L. Mankowski, Linden Craig, Peter Didier, Darryl L. Carter, Alvaro Munoz, Michael Murphey-Corb, and Janice E. Clements Epstein-Barr Virus Latent Membrane Protein-1 Oncogene Deletion in Post-Transplantation Lymphoproliferative Disorders Anke G. Scheinfeld, Roland G. Nador, Ethel Cesarman, Amy Chadburn, and Daniel M. Knowles Depletion of Eosinophil Infiltration by Anti-IL-5 Monoclonal Antibody (TRFK-5) Accelerates Open Skin Wound Epithelial Closure James Yang, Angel Torio, R. Bruce Donoff, George T. Gallagher, Robert Egan, Peter F. Weller, and David T. W. Wong Analysis of Cell Damage and Proliferation in Helicobacter pylori-infected Human Gastric Mucosa from Patients with Gastric Adenocarcinoma Noritaka Yabuki, Hironobu Sasano, Muneshige Tobita, Akira Imatani, Tatsuya Hoshi, Katsuaki Kato, Shuichi Ohara, Shigeru Asaki, Takayosi Toyota, and Hiroshi Nagura Increased Levels of Endothelin-1 and Differential Endothelin Type A and B Receptor Expression in Scleroderma-Associated Fibrotic Lung Disease David J.A braham, Rama Vancheeswaran, Michael R. Dashwood, Vineeth S. Rajkumar, Panagiotis Pantelides, Xu Shi-wen, Rowland M. du Bois, and Carol M. Black Effects of Epidermal Growth Factor and Dimethylhydrazine on Crypt Size, Cell Proliferation, and Crypt Fission in the Rat Colon: Cell Proliferation and Crypt Fission are Controlled Independenily Hyun-Sook Park, Robert A. Goodlad, Dennis J.A bnen, Angela Winnett, Peter Sasieni, Chung Y. Lee, and Nicholas A. Wright Molecular Genetic Analysis of Giant Cell Glioblastomas Birgit Meyer-Puttlitz, Yutaka Hayashi, Andreas Waba, Britta Rollbrocker, Jan Bostrém, Otmar D. Wiestler, David N. Louis, Guido Reifenberger, and Andreas von Deimling Frequent p76'\* (MTS1) Gene Inactivation in Testicular Germ Cell Tumors Pascal Chaubert, Louis Guillou, Anne-Marie Kurt, Marie-Martine Bertholet, Genevieve Metthez, Hans-/tirg Leisinger, Fred Bosman, and Phil Shaw Effects of Basic Fibroblast Growth Factor on the Differentiation, Growth, and Viability of a New Human Medulloblastoma Cell Line (UM-MB1) Rhoda L. Kenigsberg, Yanguo Hong, Hong Yao, Nicole Lemieux, Jean Michaud, Constantin Tautu, and Yves Théorét Meeting Report Recent Advances in Breast Cancer Research: From Genes to Management Mary J.C. Hendrix, RuthJ .M uschel, and Martin. Padarathsingh Announcements Information for Authors October 1997 Short Communications Inhibition of NF-«B Activity Induces Apoptosis in Murine Hepatocytes Robert E. Bellas, MarkJ . FitzGerald, Nelson Fausto, and Gail E. Sonenshein Evidence for Intrathecal Synthesis of Alternative Pathway Complement Activation Proteins in Experimental Meningitis Philip F. Stabel, Karl Frei, Adriano Fontana, Hans-Pietro Eugster, Bettina H. Ault, and Scott R. Barnum Bile Ductular Damage Induced By Methylene Dianiline Inhibits Oval Cell Activation Bryon E. Petersen, Valerie F. Zajac, and George K. Michalopoulos Amyloid A Protein Amyloidosis Induced in Apolipoprotein-E-Deficient Mice Yoshinobu Hoshii, Hiroo Kawano, Dan Cui, Tsuyoshi Takeda, Toshikazu Gondo, Mutsuo Takahashi, Kumiko Kogishi, Keiichi Higuchi, and Tokubiro Ishihara Inducible Nitric Oxide Synthase Expression in Coronary Arteries of Transplanted Human Hearts with Accelerated Graft Arteriosclerosis Anne Lafond-Walker, Chi-Long Chen, Sharon Augustine, Tzyy-Choou Wu, Ralph H. Hruban, and CharlesJ . Lowenstein Feline Atopic Dermatitis: A Model for Langerhans Cell Participation in Disease Pathogenesis PetraJ . Roosje, Diana Whitaker-Menezes, Michael H. Goldschmidt, Peter F. Moore, Ton Willemse, and George F. Murphy Regular Articles Increased Oxidative DNA Damage and Hepatocyte Overexpression of Specific Cytochrome P450 Isoforms in Hepatitis of Mice Infected with Helicobacter hepaticus Marek A. Sipowicz, Pascaie Chomarat, Bhalchandra A. Diwan, Miriam A. Anver, Yogesh C. Awasthi, Jerrold M. Ward, Jerry M. Rice, Kazimierz S. Kasprzak, Christopher P. Wild, and Lucy M. Anderson Can K-ras Codon 12 Mutations Be Used to Distinguish Benign Bile Duct Proliferations from Metastases in the Liver?: A Molecular Analysis of 101 Liver Lesions from 93 Patients Ralph H. Hruban, Patrick D. J. Sturm, RobbertJ . C. Slebos, Robb E. Wilentz, Alex R. Musler, CharlesJ . Yeo, Taylor A. Sohn, Marie-Louise F. van Velthuysen, and G. Johan A. Offerhaus Allelic Deletion and Mutation of the von Hippel-Lindau (VHL) Tumor Suppressor Gene in Pancreatic Microcystic Adenomas Alexander Oliver Vortmeyer, Irina A. Lubensky, Franz Fogt, W. Marston Linehan, Urmila Khettry, and Zhengping Zhuang Correlation between Bcl-2 Expression and Histopathology in Diethylnitrosamine-Induced Mouse Hepatocellular Tumors Gang-Hong Lee Selective Deposits of Versican in the Extracellular Matrix of Restenotic Lesions from Human Peripheral Arteries Thomas N. Wight, Stephanie Lara, Reimer Riessen, Richard Le Baron, and Jeffrey Isner Expression and Function of Endothelial Cell av Integrin Receptors in Wound-Induced Human Angiogenesis in Hurnan Skin/SCID Mice Chimeras Melpo Christofidou-Solomidou, Mark Bridges, George F. Murphy, Steven M. Albelda, and Horace M. DeLisser Dedifferentiation of Atrial Cardiomyocytes as a Result of Chronic Atrial Fibrillation Jannie Ausma, Maurits Wijffels, Guillaume van Eys, Masafumi Koide, Frans Ramaekers, Maurits Allessie, and Marcel Borgers The Potential Role of BAX and BCL-2 Expression in Diffuse Alveolar Damage Donald Guinee, Jr., Elisabeth Brambilla, Marian Fleming, Tomayoshi Hayashi, Mark Rabn, Michael Koss, Victor Ferrans, and William Travis Respiratory Infection in Lipid-Fed Rabbits Enhances Sudanophilia and the Expression of VCAM-1 Mary Richardson, Marnie De Reske, Kathleen Delaney, Andrew Fletch, Lindsey H. Wilcox, and Raelene L. Kinlough-Rathbone Pulmonary Hemodynamics Modify the Rat Pulmonary Artery Response to Injury: A Neointimal Model of Pulmonary Hypertension Kazushige Okada, Yoshihiro Tanaka, Matthew Bernstein, Wei Zhang, G. Alexander Patterson, and Mitchell D. Botney Detection of Numerical and Structural Alterations and Fusion of Chromosomes 16 and 1 in Low-Grade Papillary Breast Carcinoma by Fluorescence in Situ Hybridization Hitoshi Tsuda, Teruko Takarabe, Nobuyuki Susumu, Johji Inazawa, Shuichi Okada, and Setsuo Hirohashi CXCR-4 (Fusin), a Co-Receptor for the Type 1 Human Immunodeficiency Virus (HIV-1), Is Expressed in the Human Brain in a Variety of Cell Types, Including Microglia and Neurons Ehud Lavi, Julie M. Strizki, Anthony M. Ulrich, Wei Zhang, Li Fu, Qian Wang, Michael O’Connor, James A. Hoxie, and Francisco Gonzdlez-Scarano Involvement of Transcription Factor Encoded by the Mouse mi Locus (MITF) in Apoptosis of Cultured Mast Cells Induced by Removal of Interleukin-3 Tohru Tsujimura, Koji Hashimoto, Eiichi Morii, Ghulam Mubammad Tunio, Kumiko Tsujino, Taizo Kondo, Yuzuru Kanakura, and Yukibiko Kitamura Expression of Cytokine mRNA in Lentivirus-Induced Arthritis Franziska Lechner, Hans-Rudolf Vogt, Heng F. Seow, Giuseppe Bertoni, William P. Cheevers, Uta von Bodungen, Andreas Zurbriggen, and Ernst Peterbans HOXC4, HOXC5, and HOXC6 Expression in Primary Cutaneous Lymphoid Lesions: High Expression of HOXC5 in Anaplastic Large-Cell Lymphomas JanetJ . Bijl, Edgar Rieger, Johan W. van Oostveen, Jan M. M. Walboomers, Marja Kreike, Rein Willemze, and ChrisJ . L. M. Meijer Postnatal Lung Function and Morphology in Transgenic Mice Expressing Transforming Growth Factor-a William D. Hardie, Michael D. Bruno, Karen M. Huelsman, Harriet S. lwamoto, Patricia E. Carrigan, George D. Leikauf, Jeffrey A. Whitsett, and Thomas R. Korfhagen Activation of the NF-«B and Ix B System in Smooth Muscle Cells after Rat Arterial Injury: Induction of Vascular Cell Adhesion Molecule-1 and Monocyte Chemoattractant Protein-1 Deborah B. Landry, Leslie L. Couper, Shane R. Bryant, and Volkbard Lindner Loss of Type IV Collagen a5 and a6 Chains in Human Invasive Prostate Carcinomas Pierre Dehan, David Waltregny, Alain Beschin, Agnés Noel, Vincent Castronovo, Karl Tryggvason, Jean De Leval, and Jean-Michel Foidart Expression of Interleukin-8 by Human Melanoma Cells Up-Regulates MMP-2 Activity and Increases Tumor Growth and Metastasis Mario Luca, Suyun Huang, Jeffrey E. Gershenwald, Rakesh K. Singh, Reuven Reich, and Menashe Bar-Eli Role of Glycosaminoglycans in Determining the Helicity of Paired Helical Filaments Montserrat Arrasate, Mar Pérez, José M. Valpuesta, and Jestis Avila Classical Hodgkin's Disease: Clinical Impact of the Immunophenotype Reinhard von Wasielewski, Michael Mengel, Robert Fischer, Martin-Leo Hansmann, Klaus Hiibner, Jeremy Franklin, Hans Tesch, Uta Paulus, Martin Werner, Volker Diehl, and Axel Georgii Diabetes Induces Changes in Glomerular Development and Laminin-B2 (s-Laminin) Expression Christine K. Abrass, Douglas Spicer, Anne K. Berfield, Patricia L. St. John, and Dale R. Abrahamson Podoplin, Novel 43-kd Membrane Protein of Glomerular Epithelial Cells, ls Down-Regulated in Puromycin Nephrosis Silvana Breiteneder-Geleff, Katsuyuki Matsui, Afschin Soleiman, Paul Meraner, Helga Poczewski, Romana Kall, Gotthold Schaffner, and Dontscho Kerjaschki Comparative Genomic Hybridization of Malignant Fibrous Histiocytoma Reveals a Novel Prognostic Marker Marcelo L. Larramendy, Maija Tarkkanen, Carl Blomqvist, Martti Virolainen, Tom Wiklund, Sirpa Asko-Seljavaara, Inkeri Elomaa, and Sakari Knuutila Dephosphorylation of Endotoxin by Alkaline Phosphatase in Vivo Klaas Poelstra, Winston W. Bakker, Pieter A. Klok, Jan A.A.M. Kamps, Machiel J. Hardonk, and Dirk K.F. Meijer Correspondence Use of FISH Analysis for Prostate Tumors and Other Tissue Types The Efficacy of In Situ PCR, CARD and Nanogold Systems for Gene Detection Is HIV Found in the Cytoplasm of Dendritic Cells? Announcements November 1997 Commentaries What Mediates Progressive Glomerulosclerosis?: The Glomerular Endothelium Comes of Age RichardJ .J ohnson Profound Effects on Vascular Development Caused by Perturbations during Organogenesis Robert Auerbach and Wanda Auerbach Hepatocytes Break the Rules of Senescence in Serial Transplantation Studies: Is There a Limit to Their Replicative Capacity? Nelson Fausto Short Communications The Integrin a6B1 Promotes the Survival of Metastatic Human Breast Carcinoma Cells in Mice Ulla M. Wewer, Leslie M. Shaw, Reidar Albrechtsen, and Arthur M. Mercurio Mice Lacking the Thrombin Receptor, PAR1, Have Normal Skin Wound Healing AndrewJ . Connolly, David Y. Sub, Thomas K. Hunt, and Shaun R. Coughlin Technical Advance Internucleosomal DNA Cleavage Triggered by Plasma Membrane Damage during Necrotic Cell Death: Involvement of Serine but Not Cysteine Proteases Zheng Dong, Pothana Saikumar, Joel M. Weinberg, and Manjeri A. Venkatachalam Regular Articles Systemic Activation of the Vascular Endothelial Growth Factor Receptor KDR/flk-1 Selectively Triggers Endothelial Cells with an Angiogenic Phenotype Nathalie Ortéga, Frédéric Jonca, Sylvie Vincent, Catherine Favard, Marie-Madeleine Ruchoux, and Jean Plouét N-Acety! Cysteine Blocks Mesangial VCAM-1 and NF-«B Expression in Vivo Levon M. Khachigian, Tucker Collins, and Jochen W.U. Fries Rare Glomerular Capillary Regeneration and Subsequent Capillary Regression with Endothelial Cell Apoptosis in Progressive Glomerulonephritis Akira Shimizu, Hiroshi Kitamura, Yukinari Masuda, Masamichi Ishizaki, Yuichi Sugisaki, and Nobuaki Yamanaka Time Course and Localization of Endothelin-1 Gene Expression in a Model of Renal Disease Progression Isabella Bruzzi, Daniela Corna, Carla Zoja, Silvia Orisio, Ernesto L. Schiffrin, Daniela Cavallotti, Giuseppe Remuz. zi, and Ariela Benigni Intraglomerular C3 Synthesis in Rats with Passive Heymann Nephritis Osamu Sasaki, Wuding Zhou, Masanobu Miyazaki, Katsushige Abe, Takehiko Koji, Pierre Verroust, Shoko Tsukasaki, Yoshiyuki Ozono, Takashi Harada, Paul K. Nakane, Shigeru Kohno, and Steven H. Sacks Ceramide Is Involved in Triggering of Cardiomyocyte Apoptosis Induced by Ischemia and Reperfusion Alicja E. Bielawska, John P. Shapiro, Li Jiang, Hovsep S. Melkonyan, Christophe Piot, Christopher L. Wolfe, L. David Tomei, Yusuf A.H annun, and Samuil R. Umansky