The Allergy Epidemic Over 1 Billion People Suffer from Allergies European Academy of Allergy and Clinical Immunology, ClinTransl Allergy. 2012; 2: 21. Do you suffer from: Weight Gain? 1 2 3 4 Fatigue? 5 6 7 8 9 Depression? 10 11 12 Headaches? 13 14 15 16 Insomnia? 17 18 Stomach Aches? 19 20 Brain Fog? 21 s e i g r e l l A could be the culprit 1. Childhood overweight/obesity and asthma: is there a link? A systematic review of recent epidemiologic evidence. Papoutsakis C, Priftis KN, Drakouli M, Prifti S, Konstantaki E, Chondronikola M, Antonogeorgos G, Matziou V. J Acad Nutr Diet. 2013 Jan;113(1): 77-105. 2. Mast cell stabilization: novel medication for obesity and diabetes. Wang J, Shi GP. Diabetes Metab Res Rev. 2011 Nov;27(8):919-24. Mice fed a Western diet were able to reduce obesity through treatment with anti-allergic drugs that stabilize mast cells (cromolyn and ketotifen). 3. Adipokines and their role in allergies. Ciprandi G, Caimmi D, Raschetti R, Miraglia Del Giudice M, Salpietro C, Caimmi S, Castellazzi AM. Int J Immunopathol Pharmacol. 2011 Oct;24(4 Suppl):136. 4. Asthma and obesity: common early-life influences in the inception of disease. Litonjua AA, Gold DR. J Allergy Clin Immunol. 2008 May;121(5):1075-84 5. Systemic manifestations due to allergy. Report of fifty patients and a review of the literature on the subject (sometimes referred to as allergic toxemia and the allergic tension-fatigue syndrome). CROOK WG, HARRISON WW, CRAWFORD SE, EMERSON BS. 6. Pediatrics. 1961 May;27:790-9.The allergic tension-fatigue syndrome. Young EJ. Calif Med. 1970 Jun;112(6):46. 7. Allergic tension-fatigue syndrome. Weinberg EG, Tuchinda M. Ann Allergy. 1973 Apr;31(4):209-11 8. In vitro response of lymphocytes in patients with allergic tension-fatigue syndrome. Valverde E, Vich JM, Garcia-Calderon JV, Garcia-Calderon PA. Ann Allergy. 1980 Sep;45(3):185-8 9. Proliferative responses of lymphocytes to food antigens are useful for detection of allergens in nonimmediate types of food allergy. Kondo N, Fukutomi O, Agata H, Yokoyama Y. J Investig Allergol Clin Immunol. 1997 Mar-Apr;7(2):122-6 10. Higher risk of developing major depression and bipolar disorder in later life among adolescents with asthma: a nationwide prospective study. Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH, Chen TJ, Bai YM. J Psychiatr Res. 2014 Feb;49:25-30 11.Impact of allergy treatment on the association between allergies and mood and anxiety in a population sample. Goodwin RD, Galea S, Perzanowski M, Jacobi F. Clin Exp Allergy. 2012 Dec;42(12):1765-71. 12.Can allergic exposure provoke psychological symptoms? A double-blind test. King DS. Biol Psychiatry. 1981 Jan;16(1):3-19. 13. Food allergy and headache. Whom to evaluate and how to treat. Mansfield LE. Postgrad Med. 1988 May 15;83(7):46-51, 55. 14.Is food allergy giving me a headache? Alam R. Immunol Allergy Clin North Am. 2012 Feb;32(1):xiii-xiv. 15.Allergy and immunotherapy: are they related to migraine headache?Martin VT, Taylor F, Gebhardt B, Tomaszewski M, Ellison JS, Martin GV, Levin L, Al-Shaikh E, Nicolas J, Bernstein JA. Headache. 2011 Jan;51(1):8-20. 16.Nonmigrainous headache from food allergy. Stefanini GF, Marsigli L, Foschi FG, Emiliani F, Biselli M, Caputo F, Leefield GH, Castelli E, Gasbarrini G. Allergy. 1996 Sep;51(9):657-8. 17. Asthma symptoms and nasal congestion as independent risk factors for insomnia in a general population: results from the GA(2)LEN survey. Sundbom F, Lindberg E, Bjerg A, Forsberg B, Franklin K, Gunnbjörnsdottir M, Middelveld R, Torén K, Janson C. Allergy. 2013 Feb;68(2):213-9. 18. Increased sleep latency and reduced sleep duration in children with asthma. Jensen ME, Gibson PG, Collins CE, Hilton JM, Latham-Smith F, Wood LG. Sleep Breath. 2013 Mar;17(1):281-7. 19. Recurrent abdominal pain, food allergy and endoscopy. Husby S, Høost A. Acta Paediatr. 2001 Jan;90(1):3-4. 20. Int Arch Allergy Immunol. 2006;140(4):334-41. Measurements of eosinophil activation before and after food challenges in adults with food hypersensitivity. van Odijk J1, Peterson CG, Ahlstedt S, Bengtsson U, Borres MP, Hulthén L, Magnusson J, Hansson T. 21. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. Skoner DP. J Allergy Clin Immunol. 2001 Jul;108(1 Suppl):S2-8. I’d like to change the way you think about allergy. 3 Levels of Environment that Matter 1. The Outdoor Environment MMuullttiiddiisscipp RReessppiirr MMeedd.. 22001111 FFeebb 2288;;66((11))::2288--3377.. ddooii:: 1100.1186/2049-69558-66-1-22288888888... 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