Progress in Inflammation Research Series Editor Prof. Michael J. Parnham PhD Director of Preclinical Discovery Centre of Excellence in Macrolide Drug Discovery GlaxoSmithKline Research Centre Zagreb Ltd. Prilaz baruna Filipovic´a 29 HR-10000 Zagreb Croatia Advisory Board G. Z. Feuerstein (Wyeth Research, Collegeville, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a.d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands) Forthcoming titles: New Therapeutic Targets in Rheumatoid Arthritis, P.-P. Tak (Editor), 2009 Inflammatory Cardiomyopathy (DCM) – Pathogenesis and Therapy, H.-P. Schultheiß, M. Noutsias (Editors), 2009 Occupational Asthma, T. Sigsgaard, D. Heederick (Editors), 2009 Nuclear Receptors and Inflammation, G.Z. Feuerstein, L.P. Freedman, C.K. Glass (Editors), 2009 (Already published titles see last page.) Th 17 Cells: Role in Inflammation and Autoimmune Disease Valérie Quesniaux Bernhard Ryffel Franco Di Padova Editors Birkhäuser Basel · Boston · Berlin Editors Valérie Quesniaux Bernhard Ryffel Franco Di Padova University of Orléans University of Orléans Novartis Institutes for and CNRS and CNRS Biomedical Research UMR6218 UMR6218 NIBR Molecular Immunology Molecular Immunology WSJ 386-906 and Embryology and Embryology 4002 Basel 45071 Orléans 45071 Orléans Switzerland France France Library of Congress Control Number: 2008935061 Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de ISBN 978-3-7643-8680-1 Birkhäuser Verlag AG, Basel – Boston – Berlin The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on micro- films or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2009 Birkhäuser Verlag AG Basel · Boston · Berlin P.O. Box 133, CH-4010 Basel, Switzerland Part of Springer Science+Business Media Printed on acid-free paper produced from chlorine-free pulp. TCF (cid:99) Cover design: Markus Etterich, Basel Cover illustration: IL-17 positive cells in rheumatoid synovium. With friendly permission of Pierre Miossec, University of Lyon. Printed in Germany ISBN 978-3-7643-8680-1 e-ISBN 978-3-7643-8681-8 9 8 7 6 5 4 3 2 1 www.birkhauser.ch Contents List of contributors ................................................................. vii Preface .............................................................................. xi Franco Di Padova, Bernhard Ryffel and Valérie Quesniaux Introduction ......................................................................... 1 Discovery and IL-17 family Robert Sabat, Katrin Witte and Kerstin Wolk IL-22 and IL-17 – common and different properties .............................. 13 Marie-Laure Michel and Maria C. Leite-de-Moraes Other sources of IL-17: iNKT cells ................................................. 39 Jean-Christophe Renauld and Laure Dumoutier Contributions of IL-22 to Th17 responses: Repairing and protecting peripheral tissues .................................................................... 49 Daniel Mucida and Hilde Cheroutre Retinoic acid in mucosal immune-regulation ...................................... 61 Pornpimon Angkasekwinai and Chen Dong IL-25, another promoter of allergy ................................................ 69 Experimental models of disease Marije I. Koenders and Wim B. van den Berg Critical role of IL-17 in experimental arthritis ..................................... 83 Bruno Schnyder and Silvia Schnyder-Candrian Dual role of IL-17 in allergic asthma ............................................... 95 DCoalnipte Jn.Sts. Sirinathsinghji and Ray G. Hill Isabelle Couillin, Pamela Gasse, Francois Huaux, Silvia Schnyder-Candrian, Bruno Schnyder, François Erard, René Moser and Bernhard Ryffel Contribution of IL-17 to the pulmonary inflammatory response ................. 105 Alan Valaperti and Urs Eriksson The role of IL-17 in experimental autoimmune myocarditis ...................... 115 Ye Chen and Kathryn J. Wood Th17 cells in organ transplantation ................................................ 127 Role of IL-23/IL-17 in infection and tumor control Andrea M. Cooper Is IL-17 required to control tuberculosis? .......................................... 135 Shabaana A. Khader and Jay K. Kolls IL-17 and mucosal host defense ................................................... 149 Martin Oft IL-23 orchestrates the switch from tumor immune surveillance to tumor-promoting inflammation ................................................. 161 IL-17 in clinical autoimmune disease Pierre Miossec IL-17 and Th17 cells in rheumatoid arthritis ....................................... 175 Aaron J. Martin and Stephen D. Miller Targeting Th17 cells in CNS immune pathology .................................. 185 Anders Lindén IL-17 cytokines in asthma .......................................................... 201 Isabelle Wolowczuk, Matthieu Allez and Mathias Chamaillard IL-17/23, potential targets for Crohn’s disease ................................... 211 Novel tools and therapeutic avenues Franco Di Padova IL-17A and Th17 cells as therapeutic targets for autoimmune diseases ......... 227 Index ................................................................................ 241 vi List of contributors Matthieu Allez, Inserm, U662, Avenir, Paris, 75010, France; e-mail: [email protected] Pornpimon Angkasekwinai, Department of Immunology, MD Anderson Cancer Center and Graduate School of Biomedical Science, University of Texas, 7455 Fan- nin St., Houston, TX 77030, USA; e-mail: [email protected] Wim B. van den Berg, Rheumatology Research and Advanced Therapeutics, Rad- boud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands; e-mail [email protected] Mathias Chamaillard, Inserm, U801, Lille, 59037, France; e-mail: [email protected] Ye Chen, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK; e-mail: [email protected] Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA; e-mail: [email protected] Andrea M. Cooper, Trudeau Institute, Inc. Saranac Lake, NY 12983, USA; e-mail: [email protected] Isabelle Couillin, University of Orleans and CNRS, UMR6218 Molecular Immunol- ogy and Embryology, 45071 Orleans, France; e-mail: [email protected] Franco Di Padova, Novartis Institutes for Biomedical Research, WSJ 386-906, 4002 Basel, Switzerland; e-mail: [email protected] vii List of contributors Chen Dong, Department of Immunology, MD Anderson Cancer Center and Gradu- ate School of Biomedical Science, University of Texas, 7455 Fannin St., Houston, TX 77030, USA; e-mail: [email protected] Laure Dumoutier, Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain, 1200 Brussels, Belgium François Erard, University of Orleans and CNRS, UMR6218 Molecular Immunol- ogy and Embryology, 45071 Orleans, France; e-mail: [email protected] Urs Eriksson, Department of Cardiology, University Hospital, Ramistrasse 100, 8091 Zürich, Switzerland; e-mail: [email protected] Pamela Gasse, University of Orleans and CNRS, UMR6218 Molecular Immunology and Embryology, 45071 Orleans, France; e-mail: [email protected] François Huaux, ULB Bruxelles, Belgium Shabaana A. Khader, Division of Pulmonology, Department of Pediatrics, Children’s Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, PA, USA Marije I. Koenders, Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Neth- erlands; e-mail: [email protected] Jay K. Kolls, Children’s Hospital of Pittsburgh, Suite 3765, 3705 Fifth Ave., Pitts- burgh, PA 15213, USA; e-mail: [email protected] Maria C. Leite-de-Moraes, CNRS UMR 8147, Faculté de Médecine René Descartes, Paris V, Hôpital Necker, 161 rue de Sèvres, 75743, Paris, Cedex 15, France; e-mail: [email protected] Anders Lindén, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Bruna Stråket 11B, S-413 45 Göteborg, Sweden; e-mail: [email protected] Aaron J. Martin, Northwestern University, Feinberg School of Medicine, Depart- ment of Microbiology & Immunology, 6-713 Tarry Building, 303 E. Chicago Ave., Chicago, IL 60611, USA viii List of contributors Marie-Laure Michel, CNRS UMR 8147, Faculté de Médecine René Descartes, Paris V, Hôpital Necker, 161 rue de Sèvres, 75743, Paris, Cedex 15, France; e-mail: [email protected] Stephen D. Miller, Northwestern University, Feinberg School of Medicine, Depart- ment of Microbiology & Immunology, 6-713 Tarry Building, 303 E. Chicago Ave., Chicago, IL 60611, USA; e-mail: [email protected] Pierre Miossec, Department of Immunology and Rheumatology, Hôpital Edouard Herriot, University of Lyon, 69437 Lyon Cedex 03, France; e-mail: [email protected] René Moser, Biomedical Research Foundation, SBF, Matzingen, Switzerland Daniel Mucida, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA; e-mail: Martin Oft, Schering-Plough Biopharma (formerly DNAX), 901 California Avenue, Palo Alto, CA 94304-1104, USA; e-mail: [email protected] Valérie Quesniaux, University of Orleans and CNRS, UMR6218 Molecular Immu- nology and Embryology, 45071 Orleans, France; e-mail: [email protected] Jean-Christophe Renauld, Ludwig Institute for Cancer Research, UCL 74.59, Avenue Hippocrate, 74, 1200 Brussels, Belgium; e-mail: [email protected] Bernhard Ryffel, University of Orleans and CNRS, UMR6218 Molecular Immunol- ogy and Embryology, 45071 Orleans, France; e-mail: [email protected] Robert Sabat, Interdisciplinary Group of Molecular Immunopathology, Dermatol- ogy/Medical Immunology, Campus Charité Mitte, University Hospital Charité, Charitéplatz 1, 10117 Berlin, Germany; e-mail: [email protected] Bruno Schnyder, CNRS, UMR6218, Molecular Immunology and Embryology, 3B rue de la Férollerie, 45071 Orléans Cedex 2, France; e-mail: [email protected] Silvia Schnyder-Candrian, CNRS, UMR6218, Molecular Immunology and Embry- ology, 3B rue de la Férollerie, 45071 Orléans Cedex 2, France; e-mail: [email protected] ix List of contributors Alan Valaperti, Experimental Critical Care Medicine, Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland; e-mail: [email protected] Katrin Witte, Interdisciplinary Group of Molecular Immunopathology, Dermatol- ogy/Medical Immunology, Campus Charité Mitte, University Hospital Charité, Charitéplatz 1, 10117 Berlin, Germany; e-mail: [email protected] Kerstin Wolk, Interdisciplinary Group of Molecular Immunopathology, Dermatol- ogy/Medical Immunology, Campus Charité Mitte, University Hospital Charité, Charitéplatz 1, 10117 Berlin, Germany; e-mail: [email protected] Isabelle Wolowczuk, Laboratoire NIE, Institut Pasteur de Lille, 59019 Lille, France; e-mail: [email protected] Kathryn J. Wood, Transplantation Research Immunology Group, Nuffield Depart- ment of Surgery, University of Oxford, Oxford, UK x