TEXTBOOK OF MEDICAL ONCOLOGY FOURTH EDITION EDITED BY FRANCO CAVALLI STAN B KAYE HEINE H HANSEN JAMES O ARMITAGE MARTINE J PICCART-GEBHART TEXTBOOK OF MEDICAL ONCOLOGY CAVALLI KAYE HANSEN ARMITAGE PICCART-GEBHART TEXTBOOK OF MEDICAL ONCOLOGY FOURTH EDITION About the book Effective care of the cancer patient increasingly involves systemic treatment, and as the range of available therapeutic agents continues to expand, the medical oncologist must be fully aware of the rationale for choosing specific drugs and combinations. Textbook of Medical Oncology, 4th edition, is written by a highly acclaimed list of international authors and is a key source of reference for all working in the field of oncology. About the editors Franco Cavalli MD FRCP is Director of the Oncology Institute of Southern Switzerland and Professor in Medical Oncology at the University of Bern, Switzerland and University of Varese, Italy. He is the Founder of the International Extranodal Lymphoma Study Group and the founding Editor of Annals of Oncology. He is the immediate past President of the International Union Against Cancer. Stan B Kaye BSc MD FRCP FMedSci is Cancer Research UK Professor of Medical Oncology, and Head of the Section of Medicine at the Institute of Cancer Research, London. He is also Head of the Drug Development Unit at The Royal Marsden Hospital, London, United Kingdom. Heine H Hansen MD FRCP is Professor of Medical Oncology at the Finsen Center, National University Hospital, Copenhagen, Denmark and Professor of Clinical Oncology at the University of Copenhagen since 1991. He is also the past executive Director and President of the International Association for the Study of Lung Cancer and European Society of Medical Oncology. James O Armitage MD FRCP is The Joe Shapiro Professor of Internal Medicine, Section of Hematology & Oncology, at the University of Nebraska Medical Center, USA. He was President of the American Society of Clinical Oncology 1996-1997 and the President of the American Society for Blood and Marrow Transplantation 2000-2001. Martine J Piccart-Gebhart MD PhD is Professor of Oncology at the Université Libre de Bruxelles and Director of the Medicine Department at the Institut Jules Bordet, Brussels, Belgium. She is a member of the American Society of Clinical Oncology board and the President of European Organisation for Research and Treatment of Cancer. Also available Extranodal Lymphomas: Pathology and Management Edited by Franco Cavalli, Harald Stein and Emanuele Zucca (ISBN: 9780415426763) Textbook of Lung Cancer, 2nd edition Edited by Heine Hansen (ISBN: 9780415385107) ESMO Handbook of Cancer Diagnosis and Treatment Evaluation Edited by Hans-Joachim Schmoll, Laura Van’t Veer, Jan Vermorken and Dirk Schrijvers (ISBN: 9780415390866) Lung Cancer Therapy Annual 6 Edited by Heine Hansen (ISBN: 9780415465458) Contents • Molecular biology of cancer • Principles of systemic therapy • Principles and examples of cancer (cell) specific therapies • Principles of clinical trials • Breast cancer • Gynecologic cancer • Head and neck cancer • Primary malignant tumors of the lung and pleura • Gastrointestinal cancer • Cancers of the genitourinary tract • Sarcomas • Leukemias • Non-Hodgkin’s lymphomas • Hodgkin lymphoma • Multiple myeloma • Management of gliomas, medulloblastoma, CNS germ cell tumors and carcinomas metastatic to the CNS • Malignant melanoma • Cancer of unknown primary site • Medical emergencies • Symptom control and palliative care • Psycho-oncology and communication • Inherited predisposition to cancer: genetic counseling and clinical management • Agents used in the treatment of cancer FOURTH EDITION www.informahealthcare.com Telephone House, 69-77 Paul Street, London EC2A 4LQ, UK 52 Vanderbilt Avenue, New York, NY 10017 Textbook of Medical Oncology Fourth Edition Edited by Franco Cavalli, MD FRCP Professor and Director Oncology Institute of Southern Switzerland Ospedale San Giovanni Bellinzona, Switzerland Stan B. Kaye, BSc MD FRCP FMedSci CRUK Professor of Medical Oncology Head of Section of Medicine Institute of Cancer Research Royal Marsden Hospital Sutton, Surrey, United Kingdom Heine H. Hansen, MD FRCP Professor of Medical Oncology The Finsen Center Rigshospitalet Copenhagen, Denmark James O. Armitage, MD FRCP The Joe Shapiro Professor of Internal Medicine Section of Oncology Hematology University of Nebraska Medical Center Omaha, Nebraska, USA Martine J. Piccart-Gebhart, MD PhD Head of Medicine Department Institut Jules Bordet Université Libre de Bruxelles Brussels, Belgium © 2009 Informa UK Ltd First published in the United Kingdom in 2009 by Informa Healthcare, Telephone House, 69-77 Paul Street, London EC2A 4LQ. Informa Healthcare is a trading division of Informa UK Ltd. Registered Office: 37/41 Mortimer Street, London W1T 3JH. Registered in England and Wales number 1072954. Tel: +44 (0)20 7017 5000 Fax: +44 (0)20 7017 6699 Website: www.informahealthcare.com All rights reserved. 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