Innovative therapies for optimizing outcomes of coronary artery disease Tarek A.N. Ahmed TTaarreekk AAhhmmeedd bbww..iinndddd 11 1155--1111--1111 1188::0044 The studies described in this thesis were performed at the department of Cardiology of the Leiden University Medical Center, Leiden, the Netherlands. Copyright © 2011 Tarek A.N. Ahmed, Leiden, the Netherlands. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, without prior written permission of the author. Layout and printing: Optima Grafi sche Communicatie, Rotterdam, the Netherlands ISBN: 978-94-6169-183-5 Financial support to the costs associated with the publication of this thesis from the depart- ment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. TTaarreekk AAhhmmeedd bbww..iinndddd 22 1155--1111--1111 1188::0044 Innovative therapies for optimizing outcomes of coronary artery disease PROEFSCHRIFT ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnifi cus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties te verdedigen op donderdag 15 December 2011 klokke 15:00 uur door Tarek Abdel-Hameed Nagib Ahmed Geboren te Asyut, Egypte 1976 TTaarreekk AAhhmmeedd bbww..iinndddd 33 1155--1111--1111 1188::0044 PROMOTIECOMMISSIE Promotors: Prof. Dr. J.W.Jukema Prof. Dr. M.J.Schalij Overige leden: Prof. Dr. E.E. van der Wall Prof. Dr. A. van der Laarse Dr. H.F. Verwey Dr. B.L. van der Hoeven Dr. S.A.M. Said, Ziekenhuis Groep Twente, Hengelo TTaarreekk AAhhmmeedd bbww..iinndddd 44 1155--1111--1111 1188::0044 To Heba and Ayah TTaarreekk AAhhmmeedd bbww..iinndddd 55 1155--1111--1111 1188::0044 TTaarreekk AAhhmmeedd bbww..iinndddd 66 1155--1111--1111 1188::0044 CONTENTS OF THE THESIS Chapter 1: General introduction and outline of the thesis. 9 Chapter 2: Aspiration thrombectomy during primary percutaneous coronary inter- 27 vention as adjunctive therapy to early (in-ambulance) abciximab administration in patients with acute ST elevation myocardial infarction: An analysis from Leiden MIS- SION! Acute Myocardial Infarction Treatment Optimization Program. Journal of Interventional Cardiology 2011 Nov 8 [Epub ahead of print] Chapter 3: Pre-infarction angina predicts thrombus burden in patients admitted for 47 ST-segment elevation myocardial infarction. Submitted for publication Chapter 4: Clinical performance of drug eluting stents with Biodegradable polymeric 67 coating, a meta-analysis and systematic review. EuroIntervention 2011; Aug; 7(4):505-16 Chapter 5: Emerging drugs for coronary artery disease. From past achievements and 89 current needs to clinical promises. Expert Opinion on Emerging Drugs. 2011 Jun; 16(2):203-233. Chapter 6: Restenosis after PCI- Part II: Prevention and therapy. 145 Nature Reviews Cardiology 2011 Oct 11[Epub ahead of print] Chapter 7: Late stent malapposition in the bare metal stent and drug eluting stent era. 173 Book Chapter In: Coronary Stent Restenosis (eds. Tintoiu IC, Popma JJ, Bae J-H, Rivard A, Galassi AR, Gabrie C. – Bucharest: The Publishing House of the Romanian Academy, 2011, ISBN 978-973-27-2034-9. Chapter 16) Chapter 8: Summary, conclusions and future perspectives. 187 Chapter 9: Samenvatting, conclusies en toekomstperspectief. 195 Acknowledgement 205 Curriculum Vitae 209 List of Publications 215 TTaarreekk AAhhmmeedd bbww..iinndddd 77 1155--1111--1111 1188::0044 TTaarreekk AAhhmmeedd bbww..iinndddd 88 1155--1111--1111 1188::0044 Ch apter 1 General introduction and outline of the thesis TTaarreekk AAhhmmeedd bbww..iinndddd 99 1155--1111--1111 1188::0044 TTaarreekk AAhhmmeedd bbww..iinndddd 1100 1155--1111--1111 1188::0044