ACS Symposium Series 979 Sweetness and Sweeteners: Biology, Chemistry and Psychophysics g acs.orw001 Deepthi K. Weerasinghe, Editor bs.9.f u7 p9 The Coca-Cola Company p://8-0 htt00 9 | k-2 0b er 21, 2010.1021/ GrTahne tC oEc.a D-CuolBa oCiosm, pEandyi tor 8 on Octob2008 | doi: Based on a symposium at the 231st ACS National 34.4h 4, 2c Meeting, Atlanta, Georgia, March 26-30, 2006 16.Mar 1 200.ate: y D d bon deati wnloaPublic Sponsored by o D ACS Division of Agricultural and Food Chemistry Ajinomoto Company Linguagen Corporation Cargill Mastertaste Firmenich Nestlé Givaudan Quest International T. Hasegawa Senomyx Treat PLC The Coca-Cola Company Kraft Foods Global Inc. The NutraSweet Company International Flavors & Fragrances Inc. In Sweetness and Sweeteners; Weerasinghe, D., el al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2008. g acs.orw001 bs.9.f u7 p9 p://8-0 htt00 9 | k-2 0b er 21, 2010.1021/ ITShBe N:p a9p7e8r -0u-s8e4d1 2in-7 4th3i2s -7p ublication meets the minimum requirements of 8 on Octob2008 | doi: ACfoomr pePyrrriiicngathnet d ©N L ai2tbi0ro0anr8ay l A MSmateaternirdciaaalrnsd ,C AfhoNerm SIIi ncZfao3l r9Sm.o4ac8tiie-o1tny9 8S4c.i ences—Permanence of Paper 34.4h 4, Distributed by Oxford University Press 2c 116.Mar The cover art structures were provided by Harish Radhakrishna and 200.ate: Fariba Assadi-Porter. y D d bon All Rights Reserved. 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The citation of trade names and/or names of manufacturers in this publication is not to be construed as an endorsement or as approval by ACS of the commercial products or services referenced herein; nor should the mere reference herein to any drawing, spec-ification, chemical process, or other data be regarded as a license or as a conveyance of any right or permission to the holder, reader, or any other person or corporation, to manufacture, reproduce, use, or sell any patented invention or copyrighted work that may in any way be related thereto. Registered names, trademarks, etc., used in this publi-cation, even without specific indication thereof, are not to be considered unprotected by law. PRINTED IN THE UNITED STATES OF AMERICA In Sweetness and Sweeteners; Weerasinghe, D., el al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2008. ACS Symposium Series 979 Sweetness and Sweeteners: Biology, Chemistry and Psychophysics g acs.orw001 Deepthi K. Weerasinghe, Editor bs.9.f u7 p9 The Coca-Cola Company p://8-0 htt00 9 | k-2 0b er 21, 2010.1021/ GrTahne tC oEc.a D-CuolBa oCiosm pEadnyi tor 8 on Octob2008 | doi: Based on a symposium at the 231st ACS National 34.4h 4, 2c Meeting, Atlanta, Georgia, March 26-30, 2006 16.Mar 1 200.ate: y D d bon deati wnloaPublic Sponsored by o D ACS Division of Agricultural and Food Chemistry Ajinomoto Company Linguagen Corporation Cargill Mastertaste Firmenich Nestlé Givaudan Quest International T. Hasegawa Senomyx Treat PLC The Coca-Cola Company Kraft Foods Global Inc. The NutraSweet Company International Flavors & Fragrances Inc. In Sweetness and Sweeteners; Weerasinghe, D., el al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2008. Foreword The ACS Symposium Series was first published in 1974 to pro vide a mechanism for publishing symposia quickly in book form. The purpose of the series is to publish timely, comprehensive books devel oped from ACS sponsored symposia based on current scientific re g acs.orw001 osethaercr ho. rOgacncaizsaiotinoanlsl yw, bhoeno ktsh ea reto dpeicv eisl oopfe dk eferno min steyrmespt otsoi at hsep ocnhseomreids tbryy ubs.79.f audience. p9 p://8-0 Before agreeing to publish a book, the proposed table of con 9 | httk-200 tents is reviewed for appropriate and comprehensive coverage and for 0b interest to the audience. Some papers may be excluded to better focus er 21, 2010.1021/ tahpep rbooporika; teo,t hoevrse rmviaeyw boer aidndtreodd utoc tporroy vcidhea pctoemrs praerhe enasdidveedn.e sDs.r aWftsh eonf 8 on Octob2008 | doi: cmhaanputesrcsr Aipastr se a a prreeu elprer-,e repovanirleyewd oeirdni gcpiarnmiaole rr rateo-sr eefaainrdcaylh fapocarcmpeeparttsa. nacned oor rrigeijnecalt iorenv, iaenwd 34.4h 4, papers are included in the volumes. Verbatim reproductions of previ 2c 16.Mar ously published papers are not accepted. 1 200.ate: y D ded bation ACS Books Department ac wnloPubli o D In Sweetness and Sweeteners; Weerasinghe, D., el al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2008. Preface Most living beings aspire for satiety and in acceptance of food products sweet taste plays a major role. Sugar, which is one of the most commonly used materials to impart sweet taste, has the disadvantage of being associated with a number of adverse health related issues. As a result, many research hours are spent in trying to produce low and non- caloric sweeteners and to modify the temporal profiles of these to mimic that of sugar. g or1 09 | http://pubs.acs.bk-2008-0979.pr00 caSfgiudreionldldtuciu teprio vsitfnh e hgSesa wotvdhfeei asep tcdtr eoriinremveseeacurrrstlyeyt da oitnn aftd hsatt ae tensih rtebe eteui rfrrd feepo cdcereeturpslccl testtoipo,r otwssniu oa abonrnfsd. d tc Ua eatnnhtltioheilari azirlnee ipncscr.gie on Tntggthhr isebesws r sskeey anehmkotantpwshe orslbsoesei,duu eggbnmhey m, w wisnaoaa dmtsyhe o ee ori fngr e atshneeiaz recdh er 21, 2010.1021/ tfoin hdiignhglsi ginh tB thioel ocguyrr, eCnht esmtaitset royf, tahned s Pciseynccheo apnhdy stioc sr eopfo srwt ereecteennet rssi gannidfi csawnete tness. 8 on Octob2008 | doi: Thahse sspyemntp ohsisiu emnt iwrea ss coipeenntiefdic wciatrhe earn ienx ucnedlleernstt aonvdeirnvgie sww beye tmneys sc.o organizer, who 34.4h 4, 2c The book will follow the seven sessions of the symposium as separate chapters: 6.ar 1M by 200.1n Date: (R1e)c Septrtuocrt, u(r3a)l SSwtuedeite sT oafs tteh eT rSawnsedeutecnteior nR, e(4c)e pQtoura,n (t2if)y Mingo dtehlei nRge ospf othnes eSsw oef etener nloaded ublicatio CSwelle eSti-gSneanlsiintgiv, e( 6T)a Astde vBanucde Cs eilnl st,h (e5 D) Miscoodvuelrayti aonn do Cf Sowmemeet-rScieanls Ditievvee Tloapsmte eBnut do f wP Synthetic Non-Caloric Sweeteners, and (7) Advances in the Discovery and o D Commercial Development of Natural Non-Caloric Sweeteners Deepthi Κ Weerasinghe Grant Ε DuBois Flavor Creation Department Strategic Research Department The Coca-Cola Company The Coca-Cola Company P.O.Box 1734 P.O.Box 1734 Atlanta, GA 30301 Atlanta, GA 30301 xv In Sweetness and Sweeteners; Weerasinghe, D., el al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2008. Página 1de 6 Hide My Ass! Home Pro VPN Free Proxy IP:PORT Lists Anonymous Email File Upload All Tools Our other proxies http://pubs.acs.org/isbn/9780841274327?prevSearch=&searchHistoryKey= ACS Journals C& Publications A–Z Home | Authors & Reviewers | Librarians | ACS Anywhere Search ACS Symposium Series All Publications/Website Personalize your experience: Log In | R Table of Contents ACS Sympos Online–FRE Sweetness andSweeteners Enjoy free acc Symposium Se Biology, Chemistry, andPsychophysics during Nation ISBN13: 9780841274327 Week 2009, O Editor(s): Deepthi K. Weerasinghe1, GrantE. DuBois2 eISBN: 9780841221116 24th. To exte Volume 979 trial period, p Publication Date (Print): March 04,2008 DOI:10.1021/bk-2008-0979 the recommen Copyright © 2008 American ChemicalSociety notify your Lib Information S 1 The Coca-Cola Company 2 The Coca-Cola Company Sponsoring Divisions:Division of Agricultural & FoodChemistry TheACS Symp Online Select All For Selected Articles: Sweetness and Sweeteners, Copyright, Foreword First Page Biology, Chemistry, and Psychophysics pp i-vii Hi-Res PDF[280K] D DOI: 10.1021/bk-2008-0979.fw001 PDF w/ Links[281K] Facts Sponsored Access Approxima added eac 900+ books Symposium 250+ books Preface First Page Advances i Deepthi K Weerasinghe and Grant E DuBois Book Serie Hi-Res PDF[188K] 19,000+ pe pp xv chapters DOI: 10.1021/bk-2008-0979.pr001 PDF w/ Links[189K] Features Sponsored Access Browseable publication organizatio Fully integ advanceds Sweetness and Sweeteners: What Is All the Excitement About? Abstract Indexed by Grant E. DuBois Downloada Hi-Res PDF[1341K] Chapter 1, pp 1-16 chaptercit DOI: 10.1021/bk-2008-0979.ch001 PDF w/ Links[1362K] More Inform Sponsored Access FAQs Subscriptio Recommen library STRUCTURAL STUDIES OF THE SWEETENER RECEPTOR Genetic Architecture of Sweet Taste Abstract StayCurrent Alexander A. Bachmanov Get your rese Hi-Res PDF[2756K] Chapter 2, pp 18-47 e-Alerts|RSS DOI: 10.1021/bk-2008-0979.ch002 Sponsored Access Making Sense of the Sweet Taste Receptor Abstract Peihua Jiang, Emeline Maillet, Meng Cui, Roman Osman, Marianna Max, and Robert F. Margolskee Hi-Res PDF[1901K] Chapter 3, pp 48-64 DOI: 10.1021/bk-2008-0979.ch003 PDF w/ Links[1902K] Sponsored Access http://w3.hidemyass.com/index.php?q=aHR0cDovL3B1YnMuYWNzLm9yZy9pc2Ju... 23/10/2009 Página 2de 6 T1R2, T1R3, and the Detection of Sweet Stimuli Abstract Stephan Vigues, Jeanette R. Hobbs, Yiling Nie, Graeme L. Conn, and Steven D. Munger Hi-Res PDF[955K] Chapter 4, pp 65-75 DOI: 10.1021/bk-2008-0979.ch004 PDF w/ Links[973K] Sponsored Access In Vitro Models to Study Taste: Can Sweetness Be Modeled in a Dish? Abstract Nancy E. Rawson and M. Hakan Ozdener Hi-Res PDF[1993K] Chapter 5, pp 76-93 DOI: 10.1021/bk-2008-0979.ch005 PDF w/ Links[2001K] Sponsored Access MODELING OF THE SWEETENER RECEPTOR Structure-Activity Relationship and AH-B after 40 Years Abstract Terry E. Acree and Michael Lindley Hi-Res PDF[1243K] Chapter 6, pp 96-108 DOI: 10.1021/bk-2008-0979.ch006 PDF w/ Links[1248K] Sponsored Access Crystal Structures of the Sweet Protein MNEI: Insights into Sweet Protein-Receptor Abstract Interactions Hi-Res PDF[919K] Jeanette R. Hobbs, Steven D. Munger, and Graeme L. Conn Chapter 7, pp 109-116 PDF w/ Links[933K] DOI: 10.1021/bk-2008-0979.ch007 Sponsored Access Molecular Models of Sweet Taste Receptors Provide Insights into Function Abstract Meng Cui, Peihua Jiang, Emeline Maillet, Marianna Max, Robert F. Margolskee, and Roman Osman Hi-Res PDF[1835K] Chapter 8, pp 117-132 DOI: 10.1021/bk-2008-0979.ch008 PDF w/ Links[1861K] Sponsored Access Pharmacophore Modeling of Sweet and Bitter Tasting Molecules Abstract Nicolas Froloff Hi-Res PDF[1316K] Chapter 9, pp 133-146 DOI: 10.1021/bk-2008-0979.ch009 PDF w/ Links[1327K] Sponsored Access Multiple Receptors or Multiple Sites? Modeling the Human T1R2-T1R3 Sweet Taste Abstract Receptor Hi-Res PDF[1533K] Gabriella Morini, Angela Bassoli, and Piero A. Temussi Chapter 10, pp 147-161 PDF w/ Links[1564K] DOI: 10.1021/bk-2008-0979.ch010 Sponsored Access Computational Docking to Sweet Taste Receptor Models Abstract D. Eric Walters Hi-Res PDF[659K] Chapter 11, pp 162-167 DOI: 10.1021/bk-2008-0979.ch011 PDF w/ Links[675K] Sponsored Access SWEET TASTE TRANSDUCTION What Can Psychophysical Studies with Sweetness Inhibitors Teach Us about Abstract Taste? Hi-Res PDF[1557K] Veronica Galindo-Cuspinera and Paul A. S. Breslin Chapter 12, pp 170-184 PDF w/ Links[1565K] DOI: 10.1021/bk-2008-0979.ch012 Sponsored Access Abstract Hi-Res PDF[1671K] http://w3.hidemyass.com/index.php?q=aHR0cDovL3B1YnMuYWNzLm9yZy9pc2Ju... 23/10/2009 Página 3de 6 A Method to Measure Taste Qualities, Taste Intensity, and Temporal Profile of PDF w/ Links[1683K] Compounds Aimed at Human Consumption by Taste Nerve Recordings in Sponsored Access Monkeys Göran Hellekant and Yiwen Wang Chapter 13, pp 185-201 DOI: 10.1021/bk-2008-0979.ch013 The Bittersweet Search for Bitter-Sweet Interactions: Cell to Cell Communication Abstract in the Taste Bud Hi-Res PDF[1979K] M. Scott Herness, Fang-li Zhao, and Yu Cao Chapter 14, pp 202-219 PDF w/ Links[1983K] DOI: 10.1021/bk-2008-0979.ch014 Sponsored Access cAMP: A Role in Sweet Taste Adaptation Abstract Nirupa Chaudhari and Sue C. Kinnamon Hi-Res PDF[847K] Chapter 15, pp 220-229 DOI: 10.1021/bk-2008-0979.ch015 PDF w/ Links[863K] Sponsored Access Saccharin: Artificial Sweetener, Bitter Tastant, and Sweet Taste Inhibitor Abstract Marcel Winnig, Christina Kuhn, Oliver Frank, Bernd Bufe, Maik Behrens, Thomas Hofmann, and Wolfgang Meyerhof Hi-Res PDF[1150K] Chapter 16, pp 230-240 PDF w/ Links[1161K] DOI: 10.1021/bk-2008-0979.ch016 Sponsored Access Permeation of Amphipathic Sweeteners into Taste-Bud Cells and Their Abstract Interactions with Post-Receptor Signaling Components: Possible Implications for Sweet-Taste Quality Hi-Res PDF[1708K] M. Naim, M. E. Shaul, A. I. Spielman, L. Huang, and I. Peri PDF w/ Links[1735K] Chapter 17, pp 241-255 Sponsored Access DOI: 10.1021/bk-2008-0979.ch017 QUANTIFYING THE RESPONSES OF SWEET-SENSITIVE TASTE BUD CELLS We Are What We Eat, but Why? Relationships between Oral Sensation, Genetics, Abstract Pathology, and Diet Hi-Res PDF[2670K] Derek J. Snyder, Valerie B. Duffy, Susan E. Marino, and Linda M. Bartoshuk Chapter 18, pp 258-284 PDF w/ Links[2684K] DOI: 10.1021/bk-2008-0979.ch018 Sponsored Access Perception and Acceptance of Sweeteners Abstract Jeannine F. Delwiche and Amanda R. Warnock Hi-Res PDF[1199K] Chapter 19, pp 285-295 DOI: 10.1021/bk-2008-0979.ch019 PDF w/ Links[1215K] Sponsored Access Interindividual Differences of Taste Sensitivity in Humans and Hamsters: Multiple Abstract Receptor Sites for Single Organic Molecules Hi-Res PDF[3694K] Annick Faurion Chapter 20, pp 296-334 PDF w/ Links[3708K] DOI: 10.1021/bk-2008-0979.ch020 Sponsored Access The "Bitter-Sweet" Truth of Artificial Sweeteners Abstract C. T. Simons, C. Adam, G. LeCourt, C. Crawford, C. Ward, W. Meyerhof, and J. P. Slack Hi-Res PDF[1844K] Chapter 21, pp 335-354 DOI: 10.1021/bk-2008-0979.ch021 PDF w/ Links[1848K] Sponsored Access Abstract http://w3.hidemyass.com/index.php?q=aHR0cDovL3B1YnMuYWNzLm9yZy9pc2Ju... 23/10/2009 Página 4de 6 The Use of Rodent Models to Link Neurobiological Processes with the Hi-Res PDF[1192K] Psychophysics of Sweet Taste PDF w/ Links[1202K] A. C. Spector, S. Eylam, and C. D. Dotson Sponsored Access Chapter 22, pp 355-366 DOI: 10.1021/bk-2008-0979.ch022 MODULATION OF SWEET-SENSITIVE TASTE BUD CELL SIGNALING Functional Characterization of the Human Sweet Taste Receptor: High-Throughput Abstract Screening Assay Development and Structural Function Relation Hi-Res PDF[1767K] Xiaodong Li and Guy Servant Chapter 23, pp 368-385 PDF w/ Links[1768K] DOI: 10.1021/bk-2008-0979.ch023 Sponsored Access Development of Transient Receptor Potential Melanostatin 5 Modulators for Abstract Sweetness Enhancement Hi-Res PDF[1729K] R. W. Bryant, K. S. Atwal, I. Bakaj, M. T. Buber, S. Carlucci, R. Cerne, R. Cortés, H. R. Devantier, C. J. Hendrix, S. P. Lee, R. K. Palmer, C. Wilson, Q. Yang, and F. R. Salemme PDF w/ Links[1743K] Chapter 24, pp 386-399 DOI: 10.1021/bk-2008-0979.ch024 Sponsored Access Enhancers for Sweet Taste from the World of Non-Volatiles: Polyphenols as Taste Abstract Modifiers Hi-Res PDF[1059K] Jakob P. Ley, Maria Blings, Susanne Paetz, Günter Kindel, Kathrin Freiherr, Gerhard E. Krammer, and Heinz-Jürgen Bertram PDF w/ Links[1068K] Chapter 25, pp 400-409 DOI: 10.1021/bk-2008-0979.ch025 Sponsored Access Evaluation of High-Intensity Sweetener Modulators Abstract Cheryl R. Mitchell, Richard Ray, and Marian Schwartz Hi-Res PDF[1264K] Chapter 26, pp 410-419 DOI: 10.1021/bk-2008-0979.ch026 PDF w/ Links[1265K] Sponsored Access Improving the Taste of Artificial Sweeteners Using Flavors Abstract Masashi Ishikawa, Akio Nakamura, Ayano Fujiki, Junichi Ide, and Kensaku Mori Hi-Res PDF[1392K] Chapter 27, pp 420-429 DOI: 10.1021/bk-2008-0979.ch027 PDF w/ Links[1395K] Sponsored Access ADVANCES IN THE DISCOVERY AND COMMERCIAL DEVELOPMENT OF SYNTHETIC NON-CALORIC SWEETENERS Why Should an Organic Chemist Study Sweet Taste? Abstract Angela Bassoli, Gigliola Borgonovo, Gilberto Busnelli, and Gabriella Morini Hi-Res PDF[1728K] Chapter 28, pp 432-443 DOI: 10.1021/bk-2008-0979.ch028 PDF w/ Links[1733K] Sponsored Access Sweeteners and Sweetness Modulators: Requirements for Commercial Viability Abstract Grant E. DuBois Hi-Res PDF[2910K] Chapter 29, pp 444-462 DOI: 10.1021/bk-2008-0979.ch029 Sponsored Access Development of New, Low Calorie Sweetener: New Aspartame Derivative Abstract Yusuke Amino, Kenich Mori, Yasuyuki Tomiyama, Hiroyuki Sakata, and Takeshi Fujieda Hi-Res PDF[1650K] Chapter 30, pp 463-480 DOI: 10.1021/bk-2008-0979.ch030 PDF w/ Links[1655K] Sponsored Access Challenges to Reducing Sugar in Foods Abstract D. Kilcast, C. den Ridder, and C. Narain http://w3.hidemyass.com/index.php?q=aHR0cDovL3B1YnMuYWNzLm9yZy9pc2Ju... 23/10/2009