2 3 Acquisitions Editor: Matt Hauber Development Editor: Andrea Vosburgh Editorial Coordinator: Tim Rinehart Editorial Assistant: Brooks Phelps Marketing Manager: Mike McMahon Production Project Manager: Linda Van Pelt Design Coordinator: Holly McLaughlin Manufacturing Coordinator: Margie Orzech Prepress Vendor: S4Carlisle Publishing Services Copyright © 2018 Wolters Kluwer. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at [email protected], or via our website at lww.com (products and services). 9 8 7 6 5 4 3 2 1 Printed in the United States of America Library of Congress Cataloging-in-Publication Data eISBN: 978-1-4963-9961-8 Cataloging-in-Publication data available on request from the Publisher. This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work. This work is no substitute for individual patient assessment based upon healthcare professionals’ examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments. 4 Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturer’s package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work. LWW.com 5 DEDICATION To Bear, A, and Little Voldy, you are my inspiration and truly make me a better person. 6 ORSON J. AUSTIN, MD Associate Professor of Clinical Family Medicine Department of Family and Community Medicine University of Cincinnati Cincinnati, Ohio SEAN BOYLE, DO Volunteer Assistant Professor Department of Family and Community Medicine University of Cincinnati Cincinnati, Ohio SUSAN SCHRIMPF DAVIS, DO Associate Clinical Professor Department of Family and Community Medicine Division of Geriatric Medicine University of Cincinnati College of Medicine Cincinnati, Ohio PHILIP M. DILLER, MD, PhD Fred Lazarus, Jr. Professor and Chair Department of Family and Community Medicine University of Cincinnati Cincinnati, Ohio KATHLEEN DOWNEY, MD Associate Professor of Clinical Family Medicine Department of Family and Community Medicine University of Cincinnati Cincinnati, Ohio ROBERT V. ELLIS, MD Assistant Professor of Family Medicine Department of Family and Community Medicine University of Cincinnati Cincinnati, Ohio 7 JERRY A. FRIEMOTH, MD Emeritus Associate Professor Family and Community Medicine University of Cincinnati Cincinnati, Ohio MICHAEL B. HOLLIDAY, MD Assistant Professor Vice Chair, Clinical Operations Department of Family and Community Medicine University of Cincinnati Cincinnati, Ohio CHRISTOPHER LEWIS, MD Assistant Dean of Diversity and Inclusion Associate Professor of Family Medicine Department of Family and Community Medicine University of Cincinnati Cincinnati, Ohio HILLARY MOUNT, MD Assistant Professor of Family Medicine Director of Inpatient Family Medicine Services The Christ Hospital/University of Cincinnati Family Medicine Residency Program Cincinnati, Ohio SOUMYA NADELLA, MD Outpatient Physician Sycamore Internal Medicine Kettering Physician Network Miamisburg, Ohio LAURI E. NANDYAL, MD, NCMP Adjunct Associate Professor of Family Medicine Department of Family and Community Medicine University of Cincinnati Cincinnati, Ohio EDWARD ONUSKO, MD Program Director 8 Adena Family Medicine Residency Program Adena Health System Chillicothe, Ohio RONALD REYNOLDS, MD, FAAFP Professor of Family Medicine Department of Family and Community Medicine University of Cincinnati Cincinnati, Ohio RICK RICER, MD Professor Emeritus Family and Community Medicine University of Cincinnati Cincinnati, Ohio MEGAN RICH, MD Associate Program Director The Christ Hospital/University of Cincinnati Family Medicine Residency Program Associate Professor Department of Family and Community Medicine University of Cincinnati Cincinnati, Ohio MONTIEL T. ROSENTHAL, PhD Associate Clinical Professor Department of Family and Community Medicine Directory of Maternity Services University of Cincinnati Cincinnati, Ohio LEILA J. SAXENA, MD Adjunct Assistant Professor Department of Family and Community Medicine University of Cincinnati Cincinnati, Ohio RACHEL SNEED, MD Physician, Family Medicine Healthsource of Ohio Wilmington 9 Wilmington, Ohio ZACHARY THURMAN, MD Assistant Professor Family Medicine University of Cincinnati Cincinnati, Ohio BARBARA B. TOBIAS, MD Robert and Myfanwy Smith Professor Vice Chair Department of Family and Community Medicine University of Cincinnati College of Medicine Cincinnati, Ohio ELIZABETH WEAGE, MD Physician Family Medicine Southwestern Medical Clinic Niles, Michigan 10