’ Spencer s Pathology of the Lung Sixth Edition ’ Spencer s Pathology of the Lung Sixth Edition Edited by PhilipHasleton,MDFRCPath ProfessorofPathology,UniversityofManchester,UK,andVisitingProfessorofPathology,HebrewUniversity,HaddasahMedicalSchool,Jerusalem,Israel and DouglasB.Flieder,MD ProfessorofPathology,FoxChaseCancerCenter,Philadelphia,PA,USA CAMBRIDGEUNIVERSITYPRESS Cambridge,NewYork,Melbourne,Madrid,CapeTown, Singapore,SãoPaulo,Delhi,MexicoCity Cambridge University Press, United VRG The Edinburgh Building, Cambridge CB2 8RU, UK PublishedintheUnitedStatesofAmerica byCambridgeUniversityPress,NewYork www.cambridge.org Informationonthistitle:www.cambridge.org/9780521509954 Sixthedition©CambridgeUniversityPress2013 LegacymaterialbyHerbertSpencer ©TheEstateofthelateHerbertSpencer2013 First,Second,Third,FourthandFiftheditions ©TheMcGraw-HillCompaniesInc.1962,1968,1977,1985,1996 Thispublicationisincopyright.Subjecttostatutoryexception andtotheprovisionsofrelevantcollectivelicensingagreements, noreproductionofanypartmaytakeplacewithout thewrittenpermissionofCambridgeUniversityPress. Sixtheditionfirstpublished2013 PrintedandboundintheUnitedKingdombytheMPGBooksGroup AcataloguerecordforthispublicationisavailablefromtheBritishLibrary LibraryofCongressCataloging-in-PublicationData Spencer’spathologyofthelung.–6thed./editedbyPhilipHasleton,DouglasB.Flieder. p.;cm. Pathologyofthelung Includesbibliographicalreferencesandindex. ISBN978-0-521-50995-4(set:Hardback)–ISBN978-1-107-02433-5 (volume 1 : Hardback) – ISBN 978-1-107-02434-2 (volume 2 : Hardback) I. Hasleton, P. S. II. Flieder, Douglas B. III. Spencer, United VRG, Herbert, 1915– Pathology of the lung. IV. Title: Pathology of the lung. [DNLM:1. LungDiseases–pathology. 2. Lung–pathology. 3. LungDiseases–diagnosis. WF600] 616.20407–dc23 2011046214 TwovolumesetISBN978-0-521-50995-4Hardback Volume1 ISBN978-1-107-02433-5Hardback Volume2 ISBN978-1-107-02434-2Hardback CambridgeUniversityPresshasnoresponsibilityforthepersistenceor accuracyofURLsforexternalorthird-partyinternetwebsitesreferredto inthispublication,anddoesnotguaranteethatanycontentonsuch websitesis,orwillremain,accurateorappropriate. AllmaterialcontainedwithintheCD-ROMisprotectedbycopyright andotherintellectualpropertylaws.Thecustomeracquiresonlythe righttousetheCD-ROManddoesnotacquireanyotherrights,express orimplied,unlessthesearestatedexplicitlyinaseparatelicence. Everyefforthasbeenmadeinpreparingthisbooktoprovideaccurateand up-to-dateinformationwhichisinaccordwithacceptedstandardsand practiceatthetimeofpublication.Althoughcasehistoriesaredrawnfrom actualcases,everyefforthasbeenmadetodisguisetheidentitiesofthe individualsinvolved.Nevertheless,theauthors,editorsandpublisherscan makenowarrantiesthattheinformationcontainedhereinistotallyfree fromerror,notleastbecauseclinicalstandardsareconstantlychanging throughresearchandregulation.Theauthors,editorsandpublishers thereforedisclaimallliabilityfordirectorconsequentialdamagesresulting fromtheuseofmaterialcontainedinthisbook.Readersarestrongly advisedtopaycarefulattentiontoinformationprovidedbythemanufacturer ofanydrugsorequipmentthattheyplantouse. PSH To my wife for her infinite patience and understanding and to my childrenand grandchildren, whom Ihope to now see more often. DBF To my wonderful parentsSally andBilland truly exceptional wife Rita. For my terrific children Anna and Jonny. Contents List of contributors ix Forewordtothe First Edition xiv Preface to theSixth Edition xv Acknowledgements xvi Volume 1 11. Metabolic andinherited connective tissue disorders involving the lung 409 1. The normal lung: histology,embryology, Gail Amir andAnnickRaas-Rothschild development, aging and function 1 12. Hypersensitivitypneumonitis 439 Neil Sahasrabudhe, John R.Gosney John C. English and Philip Hasleton 2. Lung specimen handling andpractical 13. Sarcoidosis 475 considerations 41 Douglas B. Flieder,Abraham Sanders and MichaelN.Koss Leslie Anne Litzky and Anthony Gal 3. Congenital abnormalities and pediatric 14. Occupational lung disease 512 lung diseases, including neoplasms 66 ThomasSpornandVictor L. Roggli StephenJ.Gould,A.K. Webb and Anna Kelsey 15. Eosinophilic lung disease 563 4. Pulmonary bacterial infections 146 HenryD. Tazelaar,Joanne L. Wright and Jay H. Ryu Mark Woodhead, Mary Klassen-Fischer, 16. Drug- and therapy-induced lung injury 585 Ronald C.Neafie,Ann-Marie Nelson,JeffreyR.Galvin Mary Beth Beasley andGlennA. Rudner and Teri J. Franks 17. Chronic obstructive pulmonarydisease anddiseases 5. Pulmonary viralinfections 182 of the airways 605 RichardL. Kradin and Jay Fishman Wim Timens,Hannie SietsmaandJoanneL.Wright 6. Pulmonary mycobacterial infections 206 18. Pulmonary vascular pathology 661 LucianeDreher Irion and Mark Woodhead KatrienGrünbergand Wolter J. Mooi 7. Pulmonary mycotic infections 226 19. Pulmonary vasculitisand pulmonaryhemorrhage Said Khayyata, Caroline B. Moore,Malcolm D. syndromes 711 Richardson, Philip Hasleton and CarolFarver EugeneJ. Mark, Rex Neal Smith,John H. Stone, 8. Pulmonary parasitic infections 288 Douglas B. Flieder,Amita Sharma and Osamu Matsubara Sebastian Lucas, Philip Hasleton, Ann-Marie Nelson and Ronald C.Neafie 20. The pathology of lung transplantation 767 9. Acute lung injury 342 Gerald J.Berry and Helen M. Doran William A.H. Wallace,A. John Simpson andNikHirani 21. The lungs in connective tissue disease 804 10. Interstitial lung diseases 366 DonaldG. GuineeJr.and William D.Travis AndrewG. Nicholson and Alexandra J.Rice vii Contents Volume 2 30. Salivary gland neoplasmsof the lung 1127 Sanja Dacic,Sebastian Gilbert,Iclal Ocak and 22. Benignepithelialneoplasms and tumor-like Joan Lacomis proliferations of the lung 847 31. Neuroendocrinetumorsand other neuroendocrine Douglas B. Flieder proliferations of the lung 1151 23. Pulmonary pre-invasive disease 889 John R.Gosney Keith M. Kerr 32. Sarcomatoid carcinomas and variants 1186 24. Epidemiological andclinical aspects Yukio Nakatani, Kenzo Hiroshima and EugeneJ. Mark of lung cancer 945 33. Mesenchymaland miscellaneousneoplasms 1224 Erik Thunnissen, Michael Unger Timothy C.Allen,Philip T.Cagle and and Douglas B. Flieder Douglas B. Flieder 25. Lung cancerstaging 1004 34. Pulmonary lymphoproliferative diseases 1316 Eric Lim andPeterGoldstraw Bruce J.Addis 26. Immunohistochemistryin the diagnosis of pulmonary tumors 1015 35. Metastases involving the lungs 1375 Bruno Murer,Marco Chilosi,Philip Hasleton Paul William Bishop and Douglas B. Flieder 27. Adenocarcinoma of the lung 1043 36. Diseases of the pleura 1408 Douglas B. Flieder,Alain C.Borczuk Philip Hasleton,Francoise Galateau-Salle,Juliet King, and Masayuki Noguchi GiulioRossi,SylvieLantuejoul,Rebecca Preston, 28. Squamous cellcarcinoma ofthe lung 1093 DurgeshN.Rana and Godfrey Wilson Douglas B. Fliederand ElisabethBrambilla 29. Large cell carcinoma and adenosquamous carcinoma ofthe lung 1114 SylvieLantuejoul,MichèleFior-Gozlan,GilbertR.Ferretti Index 1565 and Denis Moro-Sibilot viii