OFFICIAL JOURNAL OF THE SCANDINAVIAN SOCIETY FOR IMMUNOLOGY Volume 41 Numbers 1—6/1995 MANAGING EDITORS . P. BRANDTZAEG, J. B. NATVIG AND G. MOLLER Volume Contents Blackwell Science © 1995 Blackwell Science Ltd. Authorization to photocopy items for internal or personal use, or the internal or personal use ofs pecific clients, is granted by Blackwell Science Ltd for libraries and other users registered within the Copyright Clearance Center (CCC) Transactional Reporting Service provided that the base fee of $11.00 per copy is paid directly to CCC, 27 Congress Street, Salem, MA 01970, USA. This consent does not extend to other kinds of copying, such as copying for general distribution for advertising or promotional purposes, for creating new collective works or for resale. Special requests should be addressed to the Editor; 0300-9475/94 $11.00. Published for the Scandinavian Society for Immunology by Blackwell Science Ltd ISSN 0300-9475 Contents Volume 41, No. 1, January 1995 T. Yamada, J. J. Liepnieks, B. Kluve-Beckerman & M. D. Benson Characteristics of Cytotoxic T Lymphocytes Directed to Cell-Cycle Kinetics of Proliferating Mouse B Lympho- Influenza Virus Haemagglutinin Elicited by Immuniza- cytes In Vitro. E. Kallberg & T. Leanderson tion with Muramyldipeptide-Influenza Liposome Vaccine. Erratum H. linuma, K. Nerome, Y. Yoshioka & K. Okinaga Subpopulations of T Lymphocytes in the Peripheral Blood, Dermal Lesions and Lymph Nodes of Post Kala-azar Dermal Leishmaniasis Patients. M. K. Ghosh, A. Nandy, M. Addy, T. K. Maitra & A. C. Ghose Volume 41, No. 2, February 1995 Enhancement of Infectivity ofa Non-Syncytium Inducing HIV-1 by sCD4 and by Human Antibodies that Regional Specialization of Intraepithelial T Cells in the Neutralize Syncytium Inducing HIV-1. M. Schutten, Murine Small and Large Intestine. G. Boll, A. Rudolphi, A. C. Andeweg, M. L. Bosch & A. D. M. E. Osterhaus S. SpieB & J. Reimann Accessory Signalling by B7-1 for T Cell Activation Three-Colour Flow Cytometric Immunophenotyping in Induced by Anti-CD2: Evidence for IL-2-Independent HIV-Patients; Comparison to Dual-Colour Protocols. CTL Generation and CsA-Resistant Cytokine Produc- S. T. Lillevang, U. Sprogoe-Jakobsen, B. Simonsen & tion. S. W. Van Gool, A. Kasran, G. Wallays, M. de Boer T. Kristensen & J. L. Ceuppens Interferon-a Production and Tissue Localization of Inter- Cytokines and Murine Autoimmune Encephalomyelitis: feron-a/@ Producing Cells after Intradermal Admini- Inhibition or Enhancement of Disease with Antibodies stration of Aujeszky’s Disease Virus-Infected Cells in Pigs. to Select Cytokines, or by Delivery of Exogenous Cyto- K. Artursson, M. Lindersson, N. Varela, A. Scheynius & kines Using a Recombinant Vaccinia Virus System. G. V. Alm D. O. Willenborg, S. A. Fordham, W. B. Cowden & I. A. Ramshaw IgG2 Deficiency Associated with Defects in Production of Interferon-Gamma; Comparison with Common Vari- Freshly Isolated Tumour-Infiltrating T-Lymphocytes have able Immunodeficiency. R. Inoue, N. Kondo, Y. Kobayashi, a High Cytotoxic Potential, as Measured by their O. Fukutomi & T. Orii Ability to Induce Apoptosis in the Target Cell. Clustering of B and T Epitopes Within Short Sequence B. QOstenstad, M. Sioud, E. Schlichting, T. Lea & M. Harboe Regions of the Nicotinic Acetylcholine Receptor. M. Bellone, P. I. Karachunski, N. Ostlie, S. Lei & B. M. Increased Levels of Antibodies to IFN-y in Human and Conti-Fine Experimental African Trypanosomiasis. C. Bonfanti, A. Caruso, M. Bakhiet, T. Olsson, A. Turano & A Polyclonal T Cell Repertoire of V-Alpha and V-Beta T Cell Receptor Gene Families in Intrathyroidal K. Kristensson T Lymphocytes of Graves’ Disease Patients. E. Caso- Alteration of the Immune Response During Cancer Devel- Pelaez, A. M. McGregor & J. P. Banga opment and Prevention by Administration of a Myco- bacterial Antigen. H. Maes, H. Taper & C. Cocito Monosialoganglioside GM3 Induces CD4 Internalization in Human Peripheral Blood T Lymphocytes. M. Sorice, Intraembryonic Haemopoietic Cells and Early T Cell A. Pavan, R. Misasi, T. Sansolini, T. Garofalo, L. Lenti, Development. M. Lampisuo, J. Karvinen, T. Petteri G. M. Pontieri, L. Frati & Arstila & O. Lassila M. R. Torrisi Requirement of CD4* Lymphocytes in IL-2-Stimulated Abnormal Splenic and Thymic IL-4 and TNF-a Expres- NK Cell Proliferation. P. E. Kovanen, S. Knuutila & sion in MRL-I/pr/lpr Mice. C.-Y. Tsai, T.-H. Wu, S.-F. T. Timonen Huang, K.-H. Sun, S.-C. Hsieh, S.-H. Han, H.-S. Yu & Monocyte Activation by Tumour Cells: a Role for C-E. Yu Carbohydrate Structures Associated with CD2. E. F. Cytokine Gene Expression During Infection of Mice Putz & D. N. Mannel Lacking CD4 and/or CD8 with Trypanosoma cruzi. Peptide Mapping of Bovine T-Cell Epitopes for the 38 kDa M. E. Rottenberg, L. Sporrong, I. Persson, H. Wigzell Tuberculosis Antigen. J. M. Pollock, A. J. Douglas, D. P. & A. Orn Mackie & S. D. Neill Increased mRNA Expression of IL-10 in Mononuclear SHORT PAPERS. Cathepsin B Generates the Most Cells in Multiple Sclerosis and Optic Neuritis. Common Form of Amyloid A (76 Residues) as a V. Navikas, J. Link, W. Palasik, M. Séderstrém, Degradation Product from Serum Amyloid A. S. Fredrikson, T. Olsson & H. Link iv Contents Composition and Immunoreactivity of the A60 Complex In Vivo Evidence for a Non-T Cell Origin of Interleukin-5. and Other Cell Fractions from Mycobacterium bovis A.G. Castro, R.A. Silva, P. Minoprio & R. Appelberg BCG. C. Cocito & F. Vanlinden Specific and Non-Specific T-Cell Activation in High and Aberrant Patterns of Immunoglobulin Levels in Wiskott- Low Antibody-Producing Mice (Selection IV-A). W.H. Aldrich Syndrome. R. Inoue, N. Kondo, N. Kuwabara & Cabrera, M. Siqueira, N.S.H. Takahashi, O.G. Ribeiro, T. Orii L.M. Araujo, D. Mouton & O.M. Ibanez PKC Activity and Protein Phosphorylation in Regulation Induction of Anti-Tumour Immunity in Syngeneic Mice of slg Mediated B Cell Activation. M.-L. Lindsberg, by a Leukaemic Cell Line. C. Mongini, C.I. Waldner, N. Feuerstein, A. K. Balapure & J. J. Mond E. Alvarez, M.I. Roig, M. Sanchez Lockhart, M.J. Gravisaco & S.E. Hajos Visceral Leishmaniasis in Ververt Monkeys: Immunological Responses During Asymptomatic Infections. M. M. SHORT PAPERS. Dendritic Leucocytes Pulsed with Gicheru, J. O. Olobo, T. M. Kariuki & C. Adhiambo Monoclonal Antibody-Hapten Conjugates Elicit Vigorous Primary Humoral Responses In Vivo. SHORT PAPER. A Dysbalanced Immune System in S. Mjaaland & S. Fossum Cryptogenic Lennox-Gestaut Syndrome. B. G. M. van Engelen, C. M. R. Weemaes, W. O. Renier, J. A. J. M. Differential Effects of Interleukin-2 and Interleukin-7 on Bakkeren, G. F. Borm & P. F. W. Strengers the Induction of CD4 and CD8 Expression by Double- Negative Human Thymocytes. W. He & D. Kabelitz Spleen Cells from Antithymocyte Serum Pretreated Mice Volume 41, No. 3, March 1995 Do Not Induce GVHD but Exert Increased Repopulat- ing Activity in Irradiated Semiallogeneic Recipients. Reduced IL-2 Expression Upon Antigen Stimulation is C. Vizler, J. Janossy & P. Végh Accompanied by Deficient IL-9 Gene Expression in T Cells of Patients with CVID. J. Hauber, M.B. Erratum Fischer, M. Maris & M.M. Eibl Human Anti-Ro Autoantibodies Bind Peptides Accessible Volume 41, No. 4, April 1995 to the Surface of the Native Ro Autoantigen. S.-C. Huang, H. Yu, R.H. Scofield & J.B. Harley Anti-IL-10 Treatment Does Not Block Either the Induc- Iron Requirements of Human Lymphocytes: Relative tion or the Maintenance of Orally Induced Tolerance to Contributions of Intra- and Extra-Cellular Iron. Ova. L.S. Aroeira, F. Cardillo, D.A. de Albuquerque, S. Golding & S.P. Young N.M. Vaz & J. Mengel Apoptosis among CD45RA“"°” CD3* Progeny Accom- Predominant V-Region Gene Configurations in the panies Differentiation of Human Multinegative Thymo- Human Antibody Response to Haemophilus influenza cytes . L.M. Pilarski, M.P. Laderoute & D. Rutkowski Capsule Polysaccharide. G.V. Pinchuk, C. Nottenburg & Analysis of the Proliferative T Cell Response to Human E.C.B. Milner Cytomegalovirus Major Immediate-Early Protein (IE1): The T Cell Receptor and AIDS Pathogenesis. G.W. Phenotype, Frequency and Variability. J.-L. Davignon, Hoffman D. Clément, J. Alriquet, S. Michelson & C. Davrinche Expression of the Human Interleukin-2 Receptor Gamma Monospecific Polyclonal Anti-Anti-Idiotypic Antibodies Chain in Insect Cells Using a Baculovirus Expression to the Carboxyterminal Undecapeptide of the SV40 Large Vector. E. Raivio, C. Oetken, C. Oker-Blom, C. Engberg, Tumour Antigen. H.7. Agostini, B. Gerstenecker, K. Akerman & C. Lindqvist C. Haessler, D.G. Braun, G. Brandner & R.D. Hess Interleukin-4 and Interferon-Gamma Production by Native Human Serum Amyloid P Component is a Single Leishmania Stimulated Peripheral Blood Mononuclear Pentamer. /.J. Sorensen, O. Andersen, E. Holm Nielsen & Cells from Nonexposed Individuals. J.A.L. Kurtzhals, S.-E. Svehag M. Kemp, L.K. Poulsen, M.B. Hansen, A. Kharazmi & Interleukin-4 Gene Expression in Mercury-Induced Auto- T.G. Theander immunity. K.M. Gillespie, F.J. Qasim, L.M. Tibbatts, The Influence of Tumour Necrosis Factor-a, Interleukin- S. Thiru, D.B.G. Oliveira & P.W. Mathieson 18 and Interferon-y on the Expression and Function of Characteristics of Immune Responses to Native and the Complement Regulatory Protein CD59 on the Protein Conjugated Pneumococcal Polysaccharide Human Colonic Adenocarcinoma Cell Line HT29. Type 14. G.P.J.M. van den Dobbelsteen, H. Kroes & L. Bjorge, T. Skeie Jensen, E. Ulvestad, C.A. Vedeler & E.P. van Rees R. Matre Cloning and Segencing ofa Unique Antigen MPT70 from A Human Melanoma Cell Line, Recognized by Both HLA Mycobacterium tuberculosis H37Rv and Expression in Class I and Class II Restricted T Cells, is Capable of BCG Using E. coli-Mycobacteria Shuttle Vector. Initiating both Primary and Secondary Immune S. Matsumoto, T. Matsuo, N. Ohara, H. Hotokezaka, Responses. A.C. Olsen, B. Fossum, A.F. Kirkin, M. Naito, J. Minami & T. Yamada J. Zeuthen & G. Gaudernack Contents v Complete Coding Sequence of Rainbow Trout Mhc II 8 . Typhi Vaccine Strain Ty21a Can Cause a Generalized Chain. J. Glamann Infection in Whole Body-Irradiated But Not in Hydro- cortisone-Treated Mice. J.T. van Dissel, K. Kwappen- Acute Graft-versus-Host Reaction in SCID Mice Leads to berg & R. van Furth an Abnormal Expansion of CD8* V14* and a Broad Inactivation of Donor T Cells Followed by a Host- Interleukin-10 Directly Inhibits the Interleukin-6 Pro- Restricted Tolerance and a Normalization of the TCR duction in T-Cells. L. Hempel, K. Kérholz, H. Bénig, V6 Repertoire in the Chronic Phase. M.K.J. Schneider & M. Schneider, A. Klein-Vehne, J. Packeisen, C. Mauz- K.-O. Grénvik Kérholz & S. Burdach Limitations of the Severe Combined Immunodeficiency Impaired Antigen-Specific B-Cell Response and Altered (SCID) Mouse Model for Study of Human B-Cell Splenic Microstructure in Mice Following Continuous Responses. R. Somasundaram, L. Jacob, K. Adachi, Administration of IL-4 In Vivo. B.M. Schilizzi, R. Class, S. Scheck, H. Maruyama & D. Herlyn H.F.J. Savelkoul, M.W.A. de Jonge, T.H. The & L. de Leij Subclass Distribution of IgA and IgG Antibodies Against Clq in Patients with Rheumatic Diseases. [.E.M. Anti-GD 3 Antibodies are Potent Activators of Human Coremans, M.R. Daha, E.A.M. van der Voort, C.E.H. 7/6 and a/G Positive T Cells. J.F. Schlaak, C. Claus, Siegert & F.C. Breedveld K.-H. Meyer zum Btischenfelde & W. Dippold Biological Implications of HLA-DR Expression in The Identification of Germinal Centres and Follicular Tumours. T. Cabrera, F. Ruiz-Cabello & F. Garrido Dendritic Cell Networks in Rheumatoid Synovial Tissue. I. Randen, O.J. Mellbye, @. Forre & J.B. Natvig First Evidence for the Existence of Multiple Isoforms of Bovine Serum Amyloid-A (apoSAA). S.P.M. Alsemgeest, V6-Specific Activation ofT Cells by the HIV Glycoprotein A. Horadagoda, C.K. Hulskamp-Koch, P.C.J. Tooten, gp160. P.N. Akolkar, N. Chirmule, B. Gulwani-Akolkar, D.H. Kim, Th.A. Niewold & E. Gruys S. Pahwa, V.S. Kalyanaraman, R. Pergolizzi, S. Macphail & J. Silver Origin and Immunoregulation of Autoantibodies Against Intestinal Alkaline Phosphatase. N. Kolbus, W. Beuche, Identification of Two Distinct Function y¥6 TCR Com- G. Schlaf, H.G. Niisslein, K. Felgenhauer & M. Mader plexes on the Surface ofa Human T Cell Clone. D.L.M. Orsini, Y.M.C. Kooy, L. Struyk, F. Ossendorp, P. van den Elsen & F. Koning T Lymphocytes Bearing the 75 T Cell Receptor are Susceptible to Steroid-Induced Programmed Cell Death. F. Spinozzi, E. Agea, O. Bistoni, A. Travetti, Volume 41, No. 5, May 1995 G. Migliorati, R. Moraca, I. Nicoletti, C. Riccardi, F. P. Paoletti, R. Vaccaro & A. Bertotto Local T-Cell Proliferation and Differentiation in The Distribution and Abnormal Morphology of Plasma Inflammatory Myopathies. C. Lindberg, A. Oldfors & Cells in Rheumatoid Synovium. K.A. Brown, M.E. A. Tarkowski Perry, Y. Mustafa, S.K. Wood, M. Crawley, N. Taub Placental Thrombosis and Fetal Loss After Passive & D.C. Dumonde Transfer of Mouse Lupus Monoclonal or Human Polyclonal Anti-Cardiolipin Antibodies in Pregnant Naive BALB/c Mice. A. Piona, L. La Rosa, A. Tincani, Volume 41, No. 6, December 1995 D. Faden, G. Magro, S. Grasso, F. Nicoletti, G. Balestrieri & P.L. Meroni COMMENTARY. The Two-Signal Model and ‘Self’- Characterization of the Gene Encoding the MPBS51, One Reactivity Are They Really Incompatible?. J. Faro & of the Major Secreted Protein Antigens of Mycobac- J. Carneiro terium bovis BCG, and Identification of the Secreted Natural Killer Suppressor Factors in Sera from Protein Closely Related to the Fibronectin Binding 85 HIV-Infected Subjects. M.A. Goicoa, L. Sen, P.S. Complex. N. Ohara, H. Kitaura, H. Hotokezaka, Tannitelli, R.A. Diez & M.E. Estevez T. Nishiyama, N. Wada, S. Matsumoto, T. Matsuo, M. Naito & T. Yamada A Correlation Between the Expression of the bcr-abl Chimeric Gene and Severity of the Clinical State of The Importance of Non-Charged Amino Acids in Anti- CML Patients with Time. D. Amikam, C. Henig, body Binding to Humicola lanuginosa Lipase. H. Naver A. Carter, R. Sharon & Z. Ben-Ishai & U. Lovborg Cytokine Production and Serum Proteins in Depression. Inhibition of Complement-Mediated Red Cell Lysis by A. Seidel, V. Arolt, M. Hunstiger, L. Rink, A. Behnisch & Immunoglobulins is Dependent on the IG Isotype and H. Kirchner its Cl Binding Properties. T.E. Mollnes, K. Hogasen, B.F. Hoaas, Opposing Effects of Interleukin-10 on Mouse Macrophage T.E. Michaelsen, P. Garred & M. Harboe Functions. R. Appelberg vi Contents Chemospecificity and Cross-Reactivity of Target Cell Effects of Anti-CD18 and LPS on CD14 Expression on Recognition by Human CD56" NK and LAK Cells. Human Monocytes. M. Otterlei, A. Sundan, L. Ryan & H.-G. Zhu, W. Voetsch, J. Hauer & F.A. Anderer T. Espevik Expression of the Human Mucosal Lymphocyte Antigen, Molecular Analyses of Anti-DNA Antibodies Induced by HML-1, by T Cells Activated with Mitogen or Specific Polyomavirus BK in BALB/c Mice. O.P. Rekvig, Antigen Jn Vitro. R. Brew, D.C. West, J. Burthem & S.E. K. Fredriksen, K. Hokland, U. Moens, T. Traavik, Christmas M.R. Krishnan & T. Marion Cytotoxic Potency of CD22-Ricin A Depends on Intra- The Involvement of CD14 in Stimulation of TNF Produc- cellular Routing Rather than on the Number of Inter- tion from Peripheral Mononuclear Cells Isolated from nalized Molecules. P.J. van Horssen, Y.V.J.M. van PNH Patients. A. Sundan, L. Ryan, L. Brinch, T. Espevik Oosterhout, T. de Witte & F.W.M.B. Preijers & A. Waage In Vitro Degradation of Serum Amyloid A by Cathepsin D LETTERS TO THE EDITOR and Other Acid Proteases: Possible Protection Against Abstracts from the XX VIth Meeting of the Scandinavian Amyloid Fibril Formation. T. Yamada, B. Kluve- Society for Immunology and the XIth Summer School, Beckerman, J.J. Liepnieks & M.D. Benson G6teborg, Sweden, 25—28 May 1995 Human IgG Rehumatoid Factors and RF-Like Immune Erratum Complexes Induce IgGl Rheumatoid Factor Pro- duction in Mice. M. Abedi-Valugerdi, A. Ridderstad, Author Index S. Al-Balaghi & E. Moller