SCANDINAVIAN JOURNAL OF Cuistioenen ogy Volume 27, 1992 — December 1992 SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY Scandinavian Journal of Gastroenterology is the scientific periodical for Dansk Gastroenterologisk Selskab, Finsk Gastroenterologisk Férening, Islandsk Gastroenterologisk Forening, Norsk Gastroenterologisk Forening, and Svensk Forening for Gastroenterologi EDITORS E. Gione, Editor-in-Chief, Oslo 1. Ihse, Lund O. Kronborg, Odense Oddsson, Reykjavik QO. Sereide, Bergen K. Varis, Helsinki ASSOCIATE EDITORS L. E. Hanssen and E. Schrumpf, Oslo FOUNDING EDITOR J. Myren EDITORIAL BOARD C. F. Kiire, Harare S. Rune, Glostrup S. Aase, Oslo E. Kivilaakso, Helsinki M. Salaspuro, Helsinki S. R. Banerje Jesudason, Vellore S. J. Konturek, Cracow O. B. Schaffalitzky de Muckadell, F. Barany, Stockholm E. Krag, Copenhagen Odense 1. S. Benjamin, London A. S. Loginov, Moscow H. Schj@nsby, Oslo A. Berstad, Bergen M. Makuuchi, Matsumoto K. Seppala, Espoo B. Borgstrém, Lund U. F. Malt, Oslo Sheila Sherlock, London P. Brandtzaeg, Oslo M. Manialawi, Cairo J. J. Sidorov, Halifax P. Burhol, Troms@ J. Martinson, Varberg M. V. Singer, Mannheim J.-A. Chayvialle, Lyon N. McIntyre, London P. Sipponen, Helsinki F. T. de Dombal, Leeds A. |. Mendeloff, Baltimore R. Sj6dahl, Linképing W. Domschke, Minster T. Midtvedt, Stockholm T. Sgrensen, Copenhagen K. Einarsson, Huddinge T. Miettinen, Helsinki K. Svanes, Bergen K. Elgjo, Oslo P. B. Mortensen, Copenhagen R. K. Tandon, New Delhi QO. Fausa, Oslo K. Nygaard, Oslo E. Hess Thaysen, Aalborg C. Fenger, Odense L. M. Nyhus, Chicago A. Torsoli, Rome R. Hakanson, Lund K. Okuda, Chiba City G.N. J. Tytgat, Amsterdam F. W. Henriksen, Copenhagen L. Olbe, Gothenburg B. Uvnis, Stockholm J. H. Henriksen, Copenhagen H. Petersen, Trondheim M. H. Vatn, Oslo B. I. Hirschowitz, Birmingham, Ala D. W. Piper, St. Leonards F. Vilardell, Barcelona K. Héckerstedt, Helsinki D. Rachmilewitz, Jerusalem J. J. Villalobes, Mexico City J. J. Holst, Copenhagen J. Rask-Madsen, Copenhagen O. Weiland, Huddinge G. Jarnerot, Orebro S. N. Rasmussen, Aalborg K. G. Wormsley, Dundee S. J. Jiang, Shanghai P. Riis, Herlev H. Worning, Glostrup A.-L. Karvonen, Tampere S. Ritland, Drammen SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (ISSN 0036-5521) is published monthly by Scandinavian University Press. Supplements are supplied free of charge to subscribers, and copies may also be purchased on application to the publishers. Annual subscription price for 1992 is USD 449.00 (NOK 2500 for the Nordic countries), to be paid in advance. Airmailed to subscribers worldwide. This journal can be ordered in microform from University Microfilms International, 300 N. Zeeb Rd., Dept P.R., Ann Arbor, MI 48106, USA Air freight and mailing in the USA by Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003, USA. Second-class postage paid at Jamaica, NY 11431. U.S. Postmaster: send address changes to Scandinavian Journal of Gastroenterology, Scandinavian University Press, 200 Meacham Ave., Elmont, NY 11003, USA. All subscriptions in Japan should be ordered through Maruzen Co. Ltd., 3-10 Nihonbashi 2-chome, Chuo-ku, Tokyo 103, Japan Articles in Scandinavian Journal of Gastroenterology are covered by the following indexing and abstracting services: Biological Abstracts; Cambridge Scientific Abstracts Part 3, Amino-Acids Peptides & Proteins; Chemical Abstracts; Current Contents/Clinical Medicine; Energy Research Abstracts; Excerpta Medica; Index Medicus; lowa Drug Information Services (1968—); Life Sciences Collection; Medical; PESTDOC; Ringdoc; Science Citation Index; VETDOC Spanish edition distributed by Sanidad Ediciones, $.A Chinese edition distributed by the Shanghai Institute of Digestive Diseases EDITORIAL CORRESPONDENCI Manuscripts should be addressed to The Editors, Scandinavian Journal of Gastroenterology, Medical Dept. A, Riks- hospitalet, N-0027 Oslo, Norway The editors have no objection to the reproduction of short passages and illustrations from this journal without further formality than acknowledgement of the source PUBLISHER Business communications, including subscriptions and orders for offprints or advertisements, should be sent to Scandinavian University Press. P.O. Box 2959 Toyen, N-0608 Oslo, Norway (phone: 47 2 677600; fax: 47 2 677575). U.S. address: c/o Publications Expediting Inc. (see above) rsity Press (Universitetsforlaget AS) Authorization to photocopy items for internal or personal use or the internal or personal S granted Dy y Scandinavian University Press for libraries and other users registered with the Copyright Clearance Center (CCC) nal Reporting Service. pre vided that the base fee of $3.00 per copy is paid directly to CCC 27 Congress Street, Salem, MA 01970, USA. 0036 0). All other mghts, including microfilm reserved Computer typeset and printed offset litho by Page Bros, Norwich, England Endosonographic Diagnosis of Submucosal M. ESKELINEN, P. LIPPONEN, S. MARIN, H Upper Gastrointestinal Tract Tumors HAAPASALO, K. MAKINEN, J. PUITTINEN, E Tr. ROSCH, R. LORENZ, H. DANCYGIER, A. VON ALHAVA & S. NORDLING WICHERT & M. CLASSEN Nocturnal Gastric Secretion in Duodenal Ulcer A Steroid Enema, Budesonide, Lacking Patients and Healthy Controls. Ranges and Systemic Effects for the Treatment of Distal Reproducibility Ulcerative Colitis or Proctitis E. J. S.B OYD & K. G.W ORMSLEY A. DANIELSSON, R. LOFBERG, T. PERSSON, I Causes of Death during the First 5 Years of a SALDE, R. SCHIOLER, O. SUHR & R. WILLEN Randomized Trial of Mass Screening for Effect of Duodenal Ulcer Healing Induced by Colorectal Cancer with Fecal Occult Blood Test Omeprazole and Ranitidine on the Generation O. KRONBORG, C. FENGER, J.W ORM,S . A of Gastroduodenal Eicosanoids, Platelet- PEDERSEN. J. HEM, K. BERTELSEN & J. OLSEN Activating Factor, Pepsinogen A, and Gastrin Effects of Acute Psychologic Stress on Small- in Duodenal Ulcer Patients Intestinal Motility in Health and the Irritable J. LYSY, F.K ARMELI, D.W ENGROWER & D Bowel Syndrome RACHMILEWITZ J. E. KELLOW, P. M. LANGELUDDECKE, G. M Effect of Helicobacter pylori on Serum ECKERSLEY, M. P. JONES & C. C. TENNANT Pepsinogen I and Plasma Gastrin in Duodenal Reliability of in situ Measurements of Ulcer Patients Colorectal Polyps R. S.C HITTAJALLU, C. A. DORRIAN, J. E. S B. HOFSTAD, M. VATN, S. LARSEN & M. OSNES ARDILL & K. E. L.M CCOLI Unilateral Vagal Denervation Suppresses Breath Methane and Colorectal Cancer Omeprazole-Induced Trophic Effects on the S. M. SIVERTSEN, A. BJORNEKLETT. H. P Denervated Side of the Rat Stomach GULLESTAD & K. NYGAARD R. HAKANSON, J. AXELSON, Y. TIELEMANS, A.-G Adrenergic and Cholinergic Regulation of JOHANSSON, G. WILLEMS & F. SUNDLER Gastric Mucus Phospholipid Secretion Radiolucent and Calcified Pancreatic Lithiasis: S. SENGUPTA, E. PIOTROWSKI, A. SLOMIANY & Two Different Diseases. Role of Alcohol and B. L.S LOMIANY Heredity Trophic Doses of E, Prostaglandins Do Not H. SARLES, J. CAMARENA & C. GOMEZ-SANTANA Influence the Exocrine and Endocrine Pancreas Experimental Clogging of Biliary in the Presence of High Levels of Plasma Endoprostheses. Role of Bacteria, Somatostatin Endoprosthesis Material, and Design A. URIBE, M. KAPRAALI, L.G RIMELIUS & A. HOOG N. DOWIDAR, H. J. KOLMOS & P. MATZEN DNA Ploidy, S-Phase Fraction, and G2 Fraction as Prognostic Determinants in Human Pancreatic Cancer Combination Therapy of Sucralfate and H. J. van WIJK, A. J. P. M.S MOUT, L. M. A Ranitidine, Compared with Sucralfate AKKERMANS, J. M. M. ROELOFS& O. J. ten THIUJE Monotherapy, in Patients with Peptic Reflux Acute Cytotoxic Effect of Cyclosporin A on Esophagitis Pancreatic Acinar Cells in Rats. Protective J. R. VERMEIJDEN, G.N. J. TYTGAT, R. H EEf3f1e2c3t of the Synthetic Protease Inhibitor SCHOTBORGH, W. DEKKER, D. M. vd BOOMGAARD, G. H. van OLFFEN, M. SCHRIJVER, T. HIRANO, T. MANABE, K. ANDO& T. TOBE G. D. C. VOSMAER & C. P. M. DEKKERS Enzyme Substitution in Pancreatic Disease: Is Effect of Pancreaticobiliary Diversion on Liver Colipase Activity Sufficient? Regeneration C. ERLANSON-ALBERTSSON & O. WISEN S. SKULLMAN, M. CHU. I. IHSE & J. LARSSON Serum and Tissue Transglutaminase Correlates Burn-Induced Gastric Mucosal Hemodynamic with the Severity of Inflammation in Induced Disturbance in the Rat. Role of Platelet- Colitis in the Rat Activating Factor G. D'ARGENIO, I.S ORRENTINI, V.C OSENZA, A lr. BINNAKA, T. YAMAGUCHI, Y. KUBOTA, K GATTO,P . IOVINO, F. P. D’ARMIENTO, F FUJIMURA, K. TANI, S. KITAGAWA, T. MIZUNO & BALDASSARRE & G. MAZZACCA Gallbladder Function in Acromegalic Patients K. INOUE Helicobacter pylori and Hypergastrinaemia Taking Long-Term Octreotide: Evidence of during Proton Pump Inhibitor Therapy Rebound Hypermotility on Cessation of K. E. L.M cCOLL, A. M. EL NUJUMI, C. A.D ORRIAN Treatment A.M. . MACDONALD. G. M. FULLARTON & J M. RHODES, R. A. JAMES, M. BIRD, B. CLAYTON, P HARWOOD KENDALL-TAYLOR & T. W. J. LENNARD Gastric Emptying and Dyspeptic Symptoms in the Irritable Bowel Syndrome The Effects of Omeprazole on Interdigestive Role of Gastric Mucosal Eicosanoid Production Motility and Early Postprandial Levels of in the Cytoprotection Induced by Nitecapone Gastrin and Secretin P. A. AHO& 1.-B. LINDEN L. RASMUSSEN, E. OSTER-JORGENSEN, N. OVIST Faecal Elastase Reflects Disease Activity in C. P.H OVENDAL, K. KRAGLUND, O. OLSEN, O. B Active Ulcerative Colitis SCHAFFALITZKY DE MUCKADELL, J. REHFELD & E.O. ADEYEMI & H. J. F.H ODGSON S. A. PEDERSEN Does Nicotine Administration Influence Decreased in vitro Production of Tumor Intragastric Acidity? Necrosis Factor in Primary Biliary Cirrhosis G. LINDELL, L. BRUDIN, P. OHLIN & H. GRAFFNER Patients Flow-Cytometric Analysis of Growth- U. BROOME, L. S. ERIKSSON, U. SUNDIN & K.-G Regulatory Peptides and Their Receptors in SUNDOVIST Barrett's Oesophagus and Oesophageal IgG Subclass Response to Helicobacter pylori in Adenocarcinoma Patients with Chronic Active Gastritis and J. JANKOWSKI, D. HOPWOOD & K. G. WORMSLEY Duodenal Ulcer Reversibility of the Cell Kinetic Changes H. J. BONTKES, R. A. VEENENDAAL., A. S. PENA Induced by Omeprazole in the Rat Oxyntic 1. G.G OEDHARD, W. van DUUN, I. KUIPER, J. I Mucosa. An Autoradiographic Study Using MEUER & C. B. H. W. LAMERS Tritiated Thymidine Y. TIELEMANS, D. CHEN, F. SUNDLER. R HAKANSON & G. WILLEMS No. Review. Cholecystokinin and the Regulation of Influence of Smoking on Basal and on Vagally Insulin Secretion and Maximally Stimulated Gastric Acid and S. KARLSSON & B. AHREN Pepsin Secretion Disappearance of Hepatitis C Virus RNA in A. LANAS & B. I. HIRSCHOWITZ Plasma during Interferon Alpha-2B Treatment Cisapride Treatment of Patients with Non- in Hemophilia Patients Ulcer Dyspepsia and Erosive Prepyloric D. BRESTERS, E. P.M AUSER-BUNSCHOTEN Changes. A Double-Blind, Placebo-Controlled H. T. M. CUYPERS, P. N. LELIE, J. H. HAN Trial P.L. M. JANSEN, M. HOUGHTON & H. W. REESINK T. HAUSKEN & A. BERSTAD Tumour Markers CA 19-9 and CA 50 in Helicobacter pylori-Related Hypergastrinaemia Digestive Tract Malignancies Is Not Due to Elevated Antral Surface pH C. HAGLUND, P. J. ROBERTS, H. JALANKO & P Studies with Antral Alkalinisation KUUSELA R. S. CHITTAJALLU, W. D. NEITHERCUT, J. E. S Effect of ¢ isapride on Relapse of Reflux ARDILL & K. E. L. McCOLI Oecesophagitis, Healed with an Antisecretory Treatment of Pruritus in Cholestatic Jaundice Drug by Bilirubin- and Bile Acid-Adsorbing Resin G.N. J. TYTGAT, O. J. ANKER HANSEN, I Column Plasma Perfusion CARLING, G. H. de GROOT, H. GELDOF, H. GLISE A. A. ALARABI, B. WIKSTROM, L. LOOF & B. G P. EFSKIND, L. ELSBORG, A. L. KARVONEN, B DANIELSON OHLIN, O. H. SOLHAUG, B. VERMEERSCH & Effects of Acute Pancreatitis on Hepatic OTHER SCANEDCIS TRIALISTS Secretion of Lysosoma! Enzymes into Bile and \ Model of Inflammatory Bowel Disease Hepatic Lysosomal Fragility: Protective Effects Induced by 2.4-Dinitrofluorobenzene in of a New Synthetic Protease Inhibitor, ONO Previously Sensitized BALB-c Mice 3307 lr. BRKIC, M. BANIC, B. ANIC, Z. GRABAREVIC, I Tl. HIRANO, T. MANABE, R. CALNE & T. TOBE ROTKVIC, B. ARTUKOVIC, M. DUVNJAK, P. SIKIRIC Erosive Prepyloric Changes in Dyspeptics and B. TROSKOT & D. E. HERNANDEZ Non-Dyspeptics in a Defined Population. The Cimetidine On-Demand in Dyspepsia S¢rreisa Gastrointestinal Disorder Study Experience with Randomized Controlled B. BERNERSEN. R. JOHNSEN, B. STRAUME & P. G Single-Subject Trials BURHOI l. JOHANNESSEN, H. PETERSEN, P. KRISTENSEN, D Influence of Dehydrocholic and Cholic Acids FOSSTVEDT,. P. M. KLEVELAND, J. DYBDAHL & I on the Biliary Secretion of Anionic Polypeptide LOGI Fraction, the Major Apoprotein of the Biliary The Effect of Dietary Yeast on the Activity of Lipoprotein Complex Stable Chronic Crohn’s Disease F. CHANUSSOT, N. DOMINGO, B. TUCHWEBER, H G. R. BARCLAY. H. McKENZIE, J. PENNINGTON, D LAFONT & I. YOUSEF PARRATT & C. R. PENNINGTON Antrectomy Does Not Accelerate Reversal of Bile Acid Malabsorption Caused by Omeprazole-Induced Trophic Effects in the Rat Gastrointestinal Motility Dysfunction? An Stomach Investigation of Gastrointestinal Disturbances J. AXELSON, R. HAKANSON & F. SUNDLER in Familial Amyloidosis with Polyneuropathy ©. SUHR, A. DANIELSSON & L. STEEN Double-Blind Randomized Trial of Bismuth Diagnosis of Bacterial Overgrowth after Subsalicylate and Clindamycin for Treatment of Culturing Proximal Small-Bowel Aspirate Helicobacter pylori Infection Obtained during Routine Upper lr. U.W ESTBLOM, E. MADAN, M. A. SUBIK, D. E Gastrointestinal Endoscopy DURIEX & B. R. MIDKIFF P. K.B ARDHAN, K. GYR, C. BEGLINGER, J VOGTLIN, R. FREY & W. VISCHER Review: Stress-Induced Gastric Ulceration: Its Pre- and Post-Synaptic Effects of Spiradoline Aetiology and Clinical Implications and U-50488H, Selective Kappa Opioid C. H. CHO, M. W. L. KOO,G . P. GARG & C. W. OGLE Receptor Agonists, in Isolated Ileum Interaction of Liquid Aluminium Phosphate Y. NOMURA & S. HAYASHI and Aluminium Hydroxide with the Gastric Viability, Prostaglandin E, Production, and Acid Profile. Influence of Food Components Protein Handling in Normal and Inflamed and Timing of Meals Human Colonic Mucosa Cultured for up to 48h C.-C. SCHURER-MALY, L. VARGA & F. HALTER in Vitro Changes in the Gastrointestinal Mucosa after G. NYGARD, A. LARSSON, B. GERDIN, S Long-Distance Running EJERBLAD& T. BERGLINDH O. OKTEDALEN,O . C. LUNDE, P. K. OPSTAD, Olsalazine-Related Diarrhoea: Does Rat L. AABAKKEN & K. KVERNEBO Intestine Adapt in Vivo? Protein Kinase C Activity of Colonic Mucosa in C. SCHEURLEN, S. WEDEL,W . KRUIS, F. M Ulcerative Colitis ZWIEBEL, H. ALLGAYER & R. SCHOLZ Y. SAKANOUE, T. HATADA, T. HORAI, Y. SHOJI, Carcinoma of the Pancreas and Papilla of M. KUSUNOKI & J.U TSUNOMIYA Vater: Presenting Symptoms, Signs, and Helicobacter pylori Eradication with Diagnosis Related to Stage and Tumour Site. A Doxycycline—Metronidazole—Bismuth Subcitrate Prospective Multicentre Trial in 472 Patients Triple Therapy K. E. BAKKEVOLD, B. ARNESJ@ & B. KAMBESTAD l. J. BORODY, L. L.G EORGE, S. BRANDL, P Local Deterioration of the Cutaneous ANDREWS, J. LENNE, D. MOORE-JONES, M. DEVINE Venoarterial Reflex of the Hand in Cirrhosis & M. WALTON G. LEONARDO, M. R. ARPAIA, R. DEL GUERCIO & The Influence of Induced Hyperglycaemia on M. COLTORTI the Characteristics of Intestinal Motility and Bismuth Absorption from *’Bi-Labelled Bile Kinetics in Healthy Men Pharmaceutical Bismuth Compounds Used in E. @STER-JORGENSEN, N. OVIST, S. A. PEDERSEN, the Treatment of Peptic Ulcer Disease L. RASMUSSE&N C. P. HOVENDAIL B. DRESOW, R. FISCHER, E. E. GABBE, J. WENDEL Fecal Immunoreactive Lipase: A New Tubeless & H. C.H EINRICH Pancreatic Function Test R. MUENCH & R. AMMANN No. Review: Hepatitis C: Virology, Epidemiology, Duodenal Ulcer and Eradication of Clinical Course, and Treatment Helicobacter pylori in a Developing Country. O. WEILAND & R. SCHVARCZ An 18-Month Follow-up Study Relative Importance of Pancreatic, Hepatic, L. G. V. COELHO,M . C. F. PASSOS, Y.C HAUSSON, and Mucosal Bicarbonate in Duodenal E. L. COSTA, A. F. MAIA, M. J. C. C.B RANDAO, Neutralization of Acid in Anaesthetized Pigs D. C. RODRIGUES& L. P. CASTRO M. A. AINSWORTH, P. SVENDSEN, L. LADEGAARD, Selective IgA Deficiency and Coeliac Disease P. CANTOR, O. OLSEN & O. B. SCHAFFALITZKY DE P. COLLIN, M. MAKI, O. KEYRILAINEN, O MUCKADELL HALLSTROM, T. REUNALA & A. PASTERNACK Oesophageal pH-Metry: Should Meals Be Stimulatory Effect of Epidermal Growth Factor Standardized? on Liver Regeneration after Partial F. CASTIGLIONE, C. EMDE, D. ARMSTRONG, Hepatectomy in Rats P. BAUERFEIND, C. SCHNEIDER, G. STACHER & T. N. RASMUSSEN, P. E. JORGENSEN, T. ALMDAL, A. L. BLUM P. KIRKEGAARD & P. SKOV OLSEN Variation in Hepatic Estrogen Receptor Pituitary Adenylate Cyclase-Activating Concentrations in Patients with Liver Disease. Polypeptide Relaxes Rat Gastrointestinal A Multivariate Analysis Smooth Muscle U. BECKER, J.A NDERSEN, H. SKOVGAARD Z. MUNGAN, A. ARIMURA, A. ERTAN,W . J POULSEN & T. HORN ROSSOWSKI & D. H. COY Islet Amyloid Polypeptide-Producing Pancreatic Assimilation of Wheat Starch in Patients with Islet Cell Tumor. A Clinical and Biochemical Chronic Pancreatitis. Positive Effect of Enzyme Characterization Replacement M. STRIDSBERG, E. WILANDER, K. OBERG, G 1. NORDGAARD, J. J. RUMESSEN & E. GUDMAND- LUNDOVIST & B. ERIKSSON H@YER Frequency of Helicobacter pylori and Gastritis Antireflux Mechanism of Nissen in Healthy Subjects without Gastrointestinal Fundoplication. A Manometric Study Symptoms L. MARTINEZ DE HARO, P. PARRILLA PARICIO }. FALLINGBORG, L. O. POULSEN, A. GROVE & M. A. ORTIZ ESCANDELL, G. MORALES CUENCA, P. STUBBE TEGLBJARG D. VIDELA TRONCOSO, J. CIFUENTES TEBAR & Branched-Chain Amino Acid Metabolism in V. GARAY PELEGRIN Isolated Perfused Liver of Cirrhotic Rats Longitudinal Study of Influence of Helicobacter F. BLONDE-CYNOBER., J. P. DE BANDT, F. BALLET pylori on Current Risk of Duodenal Ulcer C. REY, C.C OUDRAY-LUCAS, P. JOSSET, J Relapse GIBOUDEAU & L. CYNOBER M. RYE CLAUSEN, M. B. FRANZMANN, C. HOLST, The Patterns of Motility Are Maintained in the T. I. A. SORENSEN, P. CHRISTOFFERSEN, Human Small Intestine Throughout the Process P. MATZEN, E. KRAG & THE HVIDOVRE ULCER of Aging PROJECT GROUP E. HUSEBYE & K. ENGEDAI Wide Gastric Antrum in Patients with Non- Sulfur Amino Acid Metabolism in Ulcer Dyspepsia. Effect of Cisapride Hepatobiliary Disorders T. HAUSKEN & A. BERSTAD J. MARTENSSON, U. FOBERG, A. FRYDEN, M. K SCHWARTZ, B. SORBO & O. WEILAND No. Review: The Role of Resective Surgery in the Functional Aspects of Small-Bowel Treatment of the Carcinoid Syndrome Transplantation in Rats E. GRONBECH, O. SOREIDE & A. BERGAN R. W. F. DE BRUIN, E. HEINEMAN, J. JEEKEL, M. A Gastroprotective and Antisecretory Effects of C. MEUSSEN, J. LINDEMANS, F. BONTHUIS & R. | Ebrotidine MARQUET S. J. KONTUREK, J. MACZKA, K. KAMINSKI, E Interaction between Heparin and Acetylsalicylic SITO, J. TORRES & J. OLEKSY Acid on Gastric Mucosal and Skin Bleeding in Anti-Hepatitis C Virus Screening Will Reduce Humans the Incidence of Post-Transfusion Hepatitis C C. J. BANG, B. RIEDEL, I. TALSTAD & A. BERSTAD Also in Low-Risk Areas Binding of Epidermal Growth Factor to U. L.M ATHIESEN, B. EKERMO, U. FOBERG, | Receptors in Preparations of Enriched Porcine FRANZEN, A. FRYDEN, R. NORLIN, L.-G Parietal Cells and Inhibition of Aminopyrine PETTERSSON, H. STERLING, A. WIDELI Uptake & G. BODEMAR L. SJODIN, H. G.D AHLEN& E. VIITANEN Acid and Pepsin Secretion in Patients with Changes in Splanchnic Hemodynamics in Esophagitis Refractory to Treatment with H, Inflammatory Bowel Disease. Non-Invasive Antagonists Assessment by Doppler Ultrasound Flowmetry B. |.H IRSCHOWITZ L. BOLONDI, S. GAIANI, C. BRIGNOLA, M Quantification of Lipopolysaccharides in CAMPIERI, A. RIGAMONTI, G. ZIRONI, P Human Bile with or without Gram-Negative GIONCHETTI, C. BELLOLI, M. MIGLIOLI & L Bacteria BARBARA lr. OSNES, P. KIERULF, V. SKAR, A.-G. SKAR, R Has Smoking Changed the Epidemiology of OVSTEBO & M. OSNES Ulcerative Colitis? Aspects on Diagnosis and Treatment of the C. TYSK & G. JARNEROT Foregut Carcinoid Syndrome Significance of Serum Type-IV Collagen Levels H. AHLMAN, B. WANGBERG, O. NILSSON, | in Various Liver Diseases. Measurement with a GRIMELIUS, G. GRANERUS, I. M.M ODLIN, O One-Step Sandwich Enzyme Immunoassay STENOVIST & T. SCHERSTEN Using Monoclonal Antibodies with Specificity Evaluation of Ketogenesis in Seriously Reduced for Pepsin-Solubilized Type-IV Collagen Hepatic Mitochondrial Redox State. An l. UENO, S. INUZUKA, T. TORIMURA, H. OOHIRA Analysis of Survivors and Non-Survivors in H. KO, K. OBATA, M. SATA, H. YOSHIDA & K Critically Ill Hepatectomized Patients TANIKAWA lr. YAMAGUCHI, Y. SHIMAHARA, Y. TAKADA, K Omeprazole Does Not Cause Unscheduled INO, K. MORI, N.K OBAYASHI, Y. YAMAOKA & K DNA Synthesis in Rabbit Parietal Cells in OZAWA Vitro Somatostatin Celis in the Oxyntic Mucosa of J. FRYKLUND, A.-K. FALKNAS & H. F. HELANDER Hypo- or Hyper-Gastrinemic Rats D. CHEN, A. URIBE, R. HAKANSON & F. SUNDLER Review: Experimental Colitis in Animal Allergen-Induced Mucosal Exudation of Plasma Models into Rat Ileum and Its Inhibition by H.-S. KIM & A. BERSTAD Budesonide Interdigestive Gastroduodenal Motility and B. GUSTAFSSON& C. G. A. PERSSON Cycling of Putative Regulatory Hormones in Long-Term Treatment with 300 Mg Ranitidine Severe Obesity Once Daily after Dilatation of Peptic O. PIERAMICO, P. MALFERTHEINER, D. K. NELSON, Oesophageal Strictures B. GLASBRENNER & H. DITSCHUNEIT P. G. FARUP, B. MODALSLI & J. K. THOLFSEN The Colon in Carbohydrate Malabsorption: Serodiagnosis of Helicobacter pylori-Associated Short-Chain Fatty Acids, pH, and Osmotic Gastritis with a Monoclonal Antibody Diarrhoea Competitive Enzyme-Linked Immunosorbent K. HOLTUG,M . R. CLAUSEN,H . HOVE, Assay J. CHRISTIANSEN & P. B. MORTENSEN R. NEGRINI, I. ZANELLA, A. SAVIO, C. POIESI, Human Papillomavirus Involvement in R. VERARDI, S. GHIELMI, A. ALBERTINI, Esophageal Precancerous Lesions and O. SANGALETTI, M. LAZZARONI & Squamous Cell Carcinomas as Evidenced by G. BIANCHI PORRO Microscopy and Different DNA Techniques Does Vagotomy Affect the Growth of the F. CHANG, S. SYRJANEN, Q. SHEN, L. WANG, Pancreas in the Rat? D. WANG & K. SYRJANEN D. CHEN, A.-G. NYLANDER, J. F. REHFELD, The Importance of the Centroacinar Region in J. AXELSON, I. IHSE & R.H AKANSON Cerulein-Induced Mouse Pancreatic Growth Incidence and Prevalence of Crohn’s Disease in T. GASSLANDER, I. IHSE & S. SMEDS the County of Copenhagen, 1962-87: A Sixfold Incidence and Pattern of Peptic Ulcer Bleeding Increase in Incidence in a Defined Geographical Area P. MUNKHOLM, E. LANGHOLZ, C. OHMANN, K. THON, K.-J. HENGELS, M. IMHOF & O. HAAGEN NIELSEN, S. KREINER & V. BINDER DUSUK STUDY GROUP Serum Pre-S1 and Pre-S2 Antigens as Leucocyte Scintigraphy to Localize Prognostic Markers in Interferon Therapy for Inflammatory Activity in Ulcerative Colitis and Chronic Hepatitis B Crohn’s Disease Y. HARUNA, N. HAYASHI, N. YUKI, A.K ASAHARA, M. VILIEN, S. L. NIELSEN, M. JORGENSEN, H. FUSAMOTO & T. KAMADA The Effects of Intravenous Urea Infusions on V. BINDER, K. HVID-JACOBSEN, D. BERILD & Portal and Arterial Plasma Ammonia and Urea H. KELBAK Enrichment of Jejunal and Colonic Infusions. Acute Experiments with Growing Pigs K. MALMLOF & C. SIMOES NUNES Review: The Role of Bile in the Regulation of Argyrophil Cells, Mast Cells, and Histamine in Exocrine Pancreatic Secretion the Fundic Mucosa of Antrectomized Patients R. L. RIEPL & P. LEHNERT A. COURILLON-MALLET, J. CALLEBERT, Absorption of Wheat Starch in Patients A. M. ROUCAYROL, V. COSTIL, J. M. LAUNAY & Resected for Left-Sided Colonic Cancer D. CATTAN I. NORDGAARDJ,. J.R UMESSEN, Colonoscopic Screening Examination of S. Aa. DAMGAARD NIELSEN & Relatives of Patients with Colorectal Cancer. E. GUDMAND-H@YER I. A Comparison with an Endoscopically Clinical Evaluation of Pancreatic Cancer- Screened Normal Population Associated Mucin Expressing CA19-9, CASO, J. SAUAR, T. HAUSKEN,G . HOFF, A. BJORKHEIM, Span-1, Sialyl SSEA-1, and Dupan-2 A. FOERSTER & P. MOWINCKEIL S. KAWA, M. KATO, H. OGUCHI, G. L. HSUE, Colonoscopic Screening Examination of l. KOBAYASHI, T. KOIWAI, M. TOKOO, S. FURUTA, Relatives of Patients with Colorectal Cancer. T. ICHIKAWA & M. KANAI II. Relations between Tumour Characteristics Evidence of a Stimulatory Effect of Cyclic and the Presence of Polyps AMP on Pancreatic Lipase and Colipase J. SAUAR, G. HOFF, T. HAUSKEN, A. BJ@RKHEIM, Synthesis in Rats A. FOERSTER & P. MOWINCKEL R.-D. DUAN & C.E RLANSON-ALBERTSSON Effect of Platelet-Derived Growth Factor-BB Transforming Growth Factor Alpha and on Indomethacin-Induced Gastric Lesions in Epidermal Growth Factor in Protection and Rats Healing of Gastric Mucosal Injury A. GUGLIETTA, T. HERVADA, R. V. NARDI & S. J.K ONTUREK, T. BRZOZOWSKI, J.M AJKA, C. A. LESCH A. DEMBINSKI, A. SLOMIANY & B. L. SLOMIANY Vagal Control of the Release of Somatostatin, Antigliadin Antibody, D-Xylose, and Vasoactive Intestinal Polypeptide, Gastrin- Cellobiose/Mannitol Permeability Tests as Releasing Peptide, and HCI from Porcine Non- Indicators of Mucosal Damage in Children with Antral Stomach Coeliac Disease J. J. HOLST, T. SKAK-NIELSEN, C. ORSKOV & R. TRONCONE, A. STARITA, S. COLETTA S. SEIER-POULSEN M. MAYER & L. GRECO Increased Protein Tyrosine Kinase Activity of Long-Term Results after ‘Floppy’ Nissen the Colonic Mucosa in Ulcerative Colitis Rossetti Fundoplication for Gastroesophageal Reflux Disease Y. SAKANOUE, T. HATADA, T. HORAI rl. OKAMOTO, M. KUSUNOKI & J. UTSUNOMIYA Tl. BJERKESET, T.-H. EDNA & U. FJOSNE Initiation of Anastomotic Recurrence of Changes in the Glutathione Redox System Crohn's Disease after Ileocolic Resection. during Ischemia and Reperfusion in Rat Liver Onset Proximal to the Junction and Preceded H. KOBAYASHI, T. NONAMI, T. KUROKAWA by Increased Phospholipase A, Activity S. KITAHARA, A. HARADA, A. NAKAO K. SMEDH, G. OLAISON & R. SJODAHI S$. SUGIYAMA, T. OZAWA & H. TAKAGI Pancreatic Morphology and Function in Adult Hypoxaemia and Myocardial Ischaemia Patients with Cystic Fibrosis during and after Endoscopic E. H. J. VAN HAREN, W. P. M. HOPMAN Cholangiopancreatography: Call for Further G. ROSENBUSCH, J. B. M. J. JANSEN & Studies Cc. L. A. VAN HERWAARDEN J. ROSENBERG, L. NANNESTAD JORGENSEN 699 Postprandial Gallbladder Emptying Is Related V. RASMUSSEN, H. VIBITS & P. E. HANSEN to Intestinal Motility at the Time of Meal Ingestion E. OSTER-JORGENSEN, N. OVIST, S. A. PEDERSEN L. RASMUSSEN & C. P. HOVENDAI No. Review: The Intestinal Permeability Barrier. A Experimental Colonic Inflammation and Hypothesis as to Its Regulation and Ulceration. Permeation of a Water-Soluble Involvement in Crohn’s Disease Contrast Medium as a Measure of ‘Disease’ D. HOLLANDER Activity Hepatitis B Core Antigen-Specific Interferon R. ANDERSEN, F. LRUM, D. BAY, K. AAS Gamma Production of Peripheral Blood T. S.H ALSTENSEN & A. STORDAHI Mononuclear Cells during Acute Exacerbation Effects of the M, Muscarinic Receptor of Chronic Hepatitis B Antagonist Pirenzepine on Gastric Mucus l. TAKEHARA, N. HAYASHI, K. KATAYAMA Glycoprotein in Rats with or without Ethanoi- A. KASAHARA, H. FUSAMOTO & T. KAMADA Induced Gastric Damage Primary Sclerosing Cholangitis in Patients with Y. KOJIMA, K. ISHIHARA, S. OHARA, K. SAIGENJI Ulcerative Colitis & K. HOTTA H. H. RASMUSSEN, J. FALLINGBORG Simultaneous Administration of Lactulose and P. B.M ORTENSEN, L. FREUND, U. TAGE-JENSEN *'Cr-Ethylenediaminetetraacetic Acid. A Test V. KRUSE & S. N. RASMUSSEN to Distinguish Colonic from Small-Intestinal Cellular Distribution of a Colonic Adenoma- Permeability Change Associated Antigen as Defined by Monoclonal A. P. JENKINS, W. S. NUKAJAM, |. S. MENZIES & Antibody Adnab-9 B. CREAMER M. TOBI, B. J. MALIAKKAL, M. A. ALOUSI Evaluation of Different Laboratory Tests and V. VORUGANTI, M. SHAFIUDDIN, S. YANG Activity Indices Reflecting the Inflammatory M. S. GESELL, T. AN. J. S. HATFIELD, S. FLIGIEL Activity of Crohn’s Disease V. KAILA, R. H. GOO& G. D. LUK A. TROMM, C. D. TROMM, D. HUPPE Pancreatic Atrophy in Rats Produced by the U. SCHWEGLER, M. KRIEG & B. MAY Cholecystokinin-A Receptor Antagonist Interval Cancers in Screening with Fecal Occult Devazepide Blood Test for Colorectal Cancer 4.-G. NYLANDER, D. CHEN, I. IHSE, J. F.R EHFELD B. M@LLER JENSEN, O. KRONBORG & C. FENGER & R. HAKANSON Effect of Ethanol Intake on Pancreatic Role of the Antrum in the Gastric Emptying of Exocrine Secretion in Mice a Non-Nutrient Liquid in the Rat M. I. VACCARO,O . M. TISCORNIA, E. L. CALVO, 4. D. HOUGHTON, P. LIEPINS, S. CLARKE & M. A. CRESTA & D. CELENER R. MASON Cardiovascular Effects of Omeprazole and Famotidine A. HALABI & W. KIRCH Calcitonin Gene-Related Peptide: Effect on A. CARROCCIO, G. IACONO, G. LI VOTI, Contractile Activity and Luminal Cross- G. MONTALTO, F. CAVATAIO, V. TULONE, Sectional Area in the Isolated, Perfused D. LORELLO, I. KAZMIERSKA, C. ACIERNO & Porcine Ileum A. NOTARBARTOLO T. N.R ASMUSSEN, H. GREGERSEN, H. HARLING & Computer-Aided Analysis of Gastrointestinal J. J. HOLST Pressure Recordings. Comparison with Manual Assessment of the Neutrophil Dominating Scoring Protein Calprotectin in Feces. A Methodologic N. C. MELSEN, M. B. ANDERSEN, K. KRAGLUND& Study B. JUHL A. G. ROSETH, M. K. FAGERHOL, E. AADLAND & Persistence of Viremia in Patients with Type-C H. SCHJONSBY Chronic Hepatitis during Long-Term Follow-up Gastric Emptying in Infants with M. YOUSUF, Y. NAKANO, E. TANAKA, Gastroesophageal Reflux. Ultrasound T. SODEYAMA & K. KIYOSAWA Evaluation before and after Cisapride Administration Editorial Commentary: On Minimum Effect of Helicobacter pylori on Parietal Cell Requirements in Education and Training for Sensitivity to Pentagastrin in Duodenal Ulcer Obtaining a Licence in Gastroenterology Subjects J. MYREN & G. HELLERS R. S. CHITTAJALLU, C. A. HOWIE & Review: Fructose and Related Food K. E. L.M cCOLL Carbohydrates. Sources, Intake, Absorption, Disposition of Mesalazine from Mesalazine- and Clinical Implications Delivering Drugs in Patients with Inflammatory J. J.R UMESSEN Bowel Disease, with and without Diarrhoea Measurement of Gastric Bicarbonate Secretion M. C. M. RISK, A. VAN SCHAIK& in the Human Stomach: Different Methods J. H. M.T ONGEREN Produce Discordant Results Suppression of Anger and Gastric Emptying in H. S. ODES, D. L.H OGAN, J. H. STEINBACH, Patients with Functional Dyspepsia M. A. BALLESTEROS, M. A. KOSS& J. 1. ISENBERG E. J. BENNETT, J. E.K ELLOW, H. COWAN, A. M The Effect of Portal Perfusion on Intrasplenic SCOTT, B. SHUTER, P. M. LANGELUDDECKE, Hepatocytes R. HOSCHL, M. P. JONES & C. C. TENNANT V. JAFFE, H. DARBY & H. J. F.H ODGSON Stereologic Investigations of Human Gastric The Anatomic Range of Examination by Mucosa. II. Oxyntic Mucosa from Patients with Fibreoptic Rectosigmoidoscopy (60 Zollinger—Ellison Syndrome Centimetres) H. F. HELANDER, K. RUTGERSSON, J. JENSEN, J. KEWENTER & J. SWEDENBORG K. G. HELANDER, J. P. PISEGNA, J. D.G ARDNER, Proliferative Activity of Bile Duct Epithelium R. T. JENSEN & P. N.M ATON after Bacterial Infection in Dogs Location and Type of Gastric Carcinoma in T. OHTA, T. NAGAKAWA, Y. TSUKIOKA, Relation to Pepsinogen I Level in Blood H. SANADA, I. MIYAZAKI & T. TERADA F.-Y. CHANG, K.-H. LAI, T.-F. WANG, S.-D. LEE, 1-Year Survey of Patients with Advanced Liver Y.-T. TSAI & S.-H. TSAY Cirrhosis. Prognostic Value of Clinical and Computer-Aided Decision Support in Laboratory Indexes Identified by the Cox Hepatology Regression Model S. J.D ARMONI & T. POYNARD D. FERRO, M. SALIOLA, C. QUINTARELLI, C. ALESSANDRI, S. BASILI, C.C ORDOVA, M. S. BONAVITA & F. VIOLI Review: Cytokines in Inflammatory Bowel Gastric Changes in Coronary-Operated Patients Disease with Low-Dose Aspirin J. BRYNSKOV,O . H. NIELSEN, I. AHNFELT-RONNE M. LEIVONEN, P. SIPPONEN & E. KIVILAAKSO & K. BENDTZEN Influence of Stress on the Healing and Relapse Effects of Interferon-y and Tumour Necrosis of Duodenal Ulcers. A Prospective, Factor-@ on Epithelial HLA Class-II Multicenter Trial of 2109 Patients with Expression on Jejunal Mucosal Biopsy Recurrent Duodenal Ulceration Treated with Specimens Cultured in Vitro Ranitidine R. P. STURGESS, L. B.H OOPER, J. SPENCER, G. HOLTMANN, D. ARMSTRONG, E. POPPEL, C.-H. HUNG, J. M. NELUFER & P. J. CICLITIRA A. BAUERFEIND, H. GOEBELL, R. ARNOLD, M. CLASSEN, L. WITZEL, M. FISCHER, M. HEINISCH, Free Protein S Deficiency in Patients with 4. L. BLUM & MEMBERS OF THE RUDER STUDY Chronic Inflammatory Bowel Disease GROUP E. AADLAND, O. R. ODEGAARD, A. ROSETH & Haemorrhagic Effect of Enoxaparin, a Low K. TRY Molecular Weight Heparin. Comparison with Cyclosporin Pharmacokinetics after Intravenous Unfractionated Heparin in Humans and Oral Administration in Patients with C. J. BANG, B. RIEDEL, I. TALSTAD & A. BERSTAD Crohn’s Disease Can pH Recordings Suggest Defective J. BRYNSKOV, L. FREUND, M. C. CAMPANINI & Esophageal Peristalsis in Patients with J. P.K AMPMANN Gastroesophageal Reflux? Effect of Drugs on Colonic Eicosanoid P. PARRILLA, L. F.M ARTINEZ DE HARO, A. ORTIZ, Accumulation in Active Ulcerative Colitis G. MORALES, J. CIFUENTES, D. VIDELA & R. ELIAKIM, F. KARMELI, M. CHOREV, E. OKON & V. GARAY D. RACHMILEWITZ Observer Homogeneity in the Histologic Triple Therapy of Helicobacter pylori Infection Diagnosis of Helicobacter pylori. Latent Class in Peptic Ulcer. A 12-Month Follow-up Study Analysis, Kappa Coefficient, and Repeat of 93 Patients Frequency K. SEPPALA, M. FARKKILA, H. NUUTINEN, 4. HOJER CHRISTENSEN, T. GJORUP, J. HILDEN K. HAKALA, H. VAANANEN, H. RAUTELIN & C. FENGER, B. HENRIKSEN, M. VYBERG T. U.K OSUNEN K. OSTERGAARD & B. FISCHER HANSEN Biometric Evaluation of Gastric Urease Symptom Provocation in Irritable Bowel Activity in Man Syndrome. Effects of Differing Doses of K. BERSTAD, I. WILHELMSEN & A. BERSTAD Fructose—Sorbitol Estimating Gallstone Incidence from P. SYMONS, M. P. JONES & J. E.K ELLOW Prevalence Data Ulcerative Proctocolitis in Orebro, Sweden. A A. B.L OWENFELS& J. P. VELEMA Retrospective Epidemiologic Study, 1963-1987 Prediction of Major Pathologic Conditions in C. TYSK & G. JARNEROT Dyspeptic Patients Referred for Endoscopy. A No Significant Correlation between Histologic Prospective Validation Study of a Scoring Changes of the Papilla of Vater and System Juxtapapillary Diverticulum. Special Reference P. BYTZER & O. B. SCHAFFALITZKY DE to the Pathogenesis of Gallstones MUCKADELI W. KIMURA, H. NAGAI, A. KURODA& T. MUTO Review: Pancreatic Cancer: The Role of Do Technetium-99m Hexamethylpropylene Cholecystokinin? Amine Oxime-Labeled Leukocytes Truly J. AXELSON, I. IHSE & R. HAKANSON Reflect the Mucosal Inflammation in Patients 999 Normal Inflammatory Bowel Disease Mucosa with Ulcerative Colitis? Conceals Alterations in Natural Killer Cell S. ALMER, L. FRANZEN, A. M. PETERS Activity M. TJADERMO, S. EKBERG, G. GRANERUS & E. A. F. VAN TOL, H. W. VERSPAGET, A. S. PENA & M. STROM Cc. B. H. W. LAMERS Biologic and Immunologic Gastrin Activity in 1006 Is There a Place for Antacids in the Treatment Serum of Patients with Gastrinoma. Bioassay of of Helicobacter pylori Infection? Gastrin Activity in Serum K. BERSTAD, R. WEBERG & A. BERSTAD H. L.W ALDUM, M. MIGNON, A. K. SANDVIK & Eosinophil Cationic Protein and Phospholipase S. BONFILS A» Activity in Human Gastric Juice. With Comparison between Ranitidine and Emphasis on Helicobacter pylori Status and Omeprazole for Protection against Effects of Antacids Gastroduodenal Damage Caused by Naproxen K. BERSTAD, A. BERSTAD JR, R. SJODAHL E. ODDSSON, H. GUDJONSSON & R. WEBERG & A. BERSTAD B. THJODLEIFSSON Omeprazole Therapy for Helicobacter pylori Gastroduodenal Lesions Associated with Two Infection Different Piroxicam Formulations. An P. SHERMAN, B. SHAMES, V. LOO, A. MATLOW Endoscopic Comparison B. DRUMM & J. PENNER L. AABAKKEN, B. OLAUSSEN, P. MOWINCKEL & Absorption of a Nutrient Solution in Chronic M. OSNES Alcoholics without Nutrient Deficiencies and Longitudinal Study of Cortical Bone Loss in Liver Cirrhosis Patients with Inflammatory Bowel Disease \. PFEIFFER, T. SCHMIDT, N. VIDON, C. PEHL & D. CLEMENTS, R. J. MOTLEY, W. D. EVANS, H. KAESS A. D. HARRIES, J. RHODES, R. J. COLES & J. E.C OMPSTON