6973tp.indd 1 12/11/08 9:28:52 AM TThhiiss ppaaggee iinntteennttiioonnaallllyy lleefftt bbllaannkk edited by Decheng Yang University of British Columbia, Canada World Scientific NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI 6973tp.indd 2 12/11/08 9:28:56 AM Published by World Scientific Publishing Co. Pte. Ltd. 5 Toh Tuck Link, Singapore 596224 USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601 UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE Library of Congress Cataloging-in-Publication Data RNA viruses : host gene responses to infections / editor, Decheng Yang. p. ; cm. Includes bibliographical references and index. ISBN-13: 978-981-283-379-2 (hardcover) ISBN-10: 981-283-379-X (hardcover) 1. RNA viruses. 2. Viral genetics. I.Yang, Decheng. [DNLM: 1. Host-Pathogen Interactions. 2. RNA Viruses--physiology. 3. Gene Expression Regulation, Viral. 4. RNA Interference. 5. RNA Viruses--genetics. QW 168 R6268 2009] QR395.R584 2009 579.2'5--dc22 2008035064 British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library. Copyright © 2009 by World Scientific Publishing Co. Pte. Ltd. All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system now known or to be invented, without written permission from the Publisher. For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to photocopy is not required from the publisher. Typeset by Stallion Press Email: [email protected] Printed in Singapore. Shelley - RNA Viruses.pmd 1 4/9/2009, 11:22 AM b681_FM.qxd 11/29/2008 11:34 AM Page v Contents Contributors ix Preface xxiii Section I Retrovirus 1 1 Efforts to Characterize Host Response to HIV-1 Infection 3 Monty Montano& Paola Sebastiani 2 Signaling Pathways Activated by HIVand Their Impact 31 on Immune Responses Katrina Gee, Sasmita Mishra, Wei Ma, Marko Kryworuchko & Ashok Kumar 3 Host Immune Responses in HIVInfection 59 Robert D. Allison & Shyam Kottilil 4 HIV-1 and RNAInterference — Examining a Complex 83 System Zachary A. Klase, Kuan-Teh Jeang & Fatah Kashanchi Section II Negative Single-Stranded RNAVirus 107 5 Signaling Pathways Induced by Influenza Viruses 109 Stephan Pleschka, Stephan Ludwig, Oliver Planz & Thorsten Wolff v b681_FM.qxd 11/29/2008 11:34 AM Page vi vi Contents 6 Host Immune Response to Influenza Virus 131 Thomas M. Moran & Carolina B. López 7 Signaling Pathways in the Host Cell Response 157 to RSVInfection Allan R. Brasier, Ping Liu, Bing Tian & Sanjeev Choudhary 8 Protective and Pathologic Host Responses to Pulmonary 185 Respiratory Syncytial Virus Infection Dennis M. Lindell & Nicholas W. Lukacs 9 Innate Recognition of Viral Infection and the Involvement 209 of Autophagy Balaji Ramanathan & Akiko Iwasaki 10 VSVInfection Elicits Distinct Host Responses 229 in the Periphery and the Brain Carol Shoshkes Reiss 11 Hantavirus Infection and Innate Immunity 247 Nandini Sen, Adrish Sen, Peter Alff, Irina Gavrilovskaya & Erich R. Mackow 12 Measles Virus Captures Specific Host Machineries to Cause 269 Immunosuppression and Disease Bumsuk Hahm & Michael B. A. Oldstone Section III Positive Single-Stranded RNAVirus 293 13 Severe Acute Respiratory Syndrome Coronavirus 295 Induces Differential Host Gene Expression Responses Associated with Pathogenesis Vincent T. K. Chow & W. F. Leong b681_FM.qxd 11/29/2008 11:34 AM Page vii Contents vii 14 Characterization of Signaling Pathways in Cells Infected 321 with SARS-CoV Tetsuya Mizutani 15 Impact of Filovirus Infection upon Cellular Signaling 345 Pathways Christopher F. Basler 16 Responses to Ebola and Marburg Virus Infections 371 Thomas W. Geisbert, Friederike Feldmann, Joan Geisbert & Heinz Feldmann 17 Host Gene Expression Triggered by West Nile Virus 391 Infection Janusz T. Paweska 18 West Nile Virus-host Interaction: An Immunological 415 Prospective Raghavan Bhuvanakantham & Mah-Lee Ng 19 Hepatitis C Virus (Flaviviridae): Host Immune Responses 445 to Hepatitis C Virus Christoph Neumann-Haefelin & Robert Thimme 20 Host responses to Hepatitis C Virus Infection: Gene 471 Expression Profiles and Viral Pathogenesis Melanie Lambotin, Françoise Stoll-Keller & Thomas F. Baumert 21 Differential Gene Expression in Coxsackievirus Infection 495 and Its Effect on Viral Pathogenesis Huifang M. Zhang, Travis Lim, Honglin Luo, Bruce McManus & Decheng Yang b681_FM.qxd 11/29/2008 11:34 AM Page viii viii Contents 22 Host Signaling Responses to Coxsackievirus 525 Infection Guang Gao, Decheng Yang, Bruce M. McManus & Honglin Luo 23 Endothelial Damage Response by Dengue Virus Infection 547 Irene Bosch, Katherine J. Martin, Aniuska Becerra Artiles & Rajas V. Warke 24 Molecular Pathogenesis of Human Norovirus 575 Ming Tan, Tibor Farkas & Xi Jiang 25 Host Responses During Sindbis Virus Encephalomyelitis 601 in Mice: New Implications for Understanding the Pathogenesis of Alphavirus Infections of the Central Nervous System David N. Irani & Natalie A. Prow Section IV Double-Stranded RNAVirus 625 26 Host Signaling Responses to Reovirus Infection 627 Da Pan, Paola Marcato, Maya Shmulevitz & Patrick W. Lee 27 Rotavirus Antagonism of the Host Innate Immune Response 655 John T. Patton & Mario Barro Index 679 b681_FM.qxd 11/29/2008 11:34 AM Page ix Contributors PeterAlff Molecular and Cellular Biology Graduate Program Department of Medicine, Stony Brook University, Stony Brook N.Y. 11794 USA Robert D. Allison Infectious Diseases and Immunogenetics Section Department of Transfusion Medicine Clinical Center, NIH Building 10, Room 1C711, 900 Rockville Pike Bethesda, MD 20892 USA Aniuska Becerra Artiles University of Massachusetts Medical School Center for Infectious Disease and Vaccine Research 55 Lake Ave. North, Worcester MA01655 USA Mario Barro Global Vaccines, Inc. 7020 Kit Creek Road, Research Triangle Park, NC, 27709-4827 USA ChristopherF. Basler Department of Microbiology Box 1124, Mount Sinai School of Medicine 1 Gustave L. Levy Place New York, NY10029 USA ix