Respiratory Regulation – Clinical Advances Advances in Experimental Medicine and Biology Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy For further volumes: http://www.springer.com/series/5584 Mieczyslaw Pokorski Editor Respiratory Regulation – Clinical Advances Editor Mieczyslaw Pokorski Polish Academy of Sciences Medical Research Center Department of Respiratory Research Warsaw, Poland ISSN 0065-2598 ISBN 978-94-007-4545-2 ISBN 978-94-007-4546-9 (eBook) DOI 10.1007/978-94-007-4546-9 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2012943590 © Springer Science+Business Media Dordrecht 2013 This work is subject to copyright. 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Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Preface The book contains the articles related to the clinical advances in the regulation of the respiratory system. The research presented herein was communicated and discussed at the International Conference ‘Advances in Pneumology,’ which was held in Bonn, Germany, on June 17–18, 2011. The articles are a selection of peer-reviewed manuscripts to demonstrate the scope of the issues tackled at the conference. The conference is thought as a merger between basic and clinical research concerning respiratory medicine, neural and chemical respiratory regulation, and the mutual relationship between respiration and other neurobiological functions. Clinical pathophysiology of the respiratory system is always at the core of these meetings. The topics included lung function, hypoxic lung pathologies, pharmacotherapy, epidemiology, and cardiovascular-respiratory interactions, particularly during sleep. Other essential topics of interest were infections and in fl ammatory conditions exempli fi ed by asthma and chronic obstructive pulmonary disease (COPD), respiratory allergy and cough, and also psychosomatic issues which broadened the scope of the conference. In the articles presented in this volume, the cutting-edge knowledge is communicated and discussed by prominent experts in the areas of science outlined above. I want to thank all the speakers at the conference and the authors and reviewers of the articles; their contributions certainly will enhance the value of this volume. The ‘Advances in Pneumology’ is an annual conference organized alternately in Poland and Germany. It refers to the long-standing contacts between Polish and German clinicians and researchers in the fi eld of respiration. The contacts have begun decades ago from the common interest in prophylaxis and treatment of respiratory ailments in coal miners and in populations inhabiting the mining regions of both countries. Nowadays, the coal mining is limited, but the diseases and clinical problems persist. The 2011 conference was the fruit of many collaborative efforts. The Local Organizing Committee was headed by Dr. Rüdiger Siekmeier of the Federal Institute for Drugs and Medical Devices (BfArM) in Bonn, Germany. I am indebted to him for his efforts and to all those who extended a helping hand and advice in the organization, particularly Prof. Dr. med. Kurt Rasche of HELIOS Klinikum Wuppertal Lungenzentrum, Klinik für Pneumologie, Allergologie, Schlaf- und Beatmungsmedizin and Ms. Anke Hastenrath of Wuppertal, and Dr. Tadeusz M. Zielonka of Warsaw Medical University and the Polish Respiratory Society in Warsaw, Poland. I also want to thank the non-pro fi t research and academic institution which kindly cooperated and supported the organization of the conference and the publication of this book, particularly the Medical Research Center of the Polish Academy of Sciences in Warsaw, the Polish Respiratory Society, and the Rhein-Ruhr-Stiftung in Essen. Finally, I am also grateful to Mr. Max Haring, Ph.D., and Ms. Tanja van Gaans of Springer for their expert management of the production process of this book. v vi Preface Due to the efforts of all involved in the conference, the participants could not only bene fi t from scienti fi c knowledge and contacts but also could enjoy the vibrant Bonn’s life. It had been decided at the conference that the next conference of this series will be held in the city of Wroclaw in southwest Poland on October 5–6, 2012; details can be accessed at http://www.pneumology.pl. Warsaw, Poland Mieczyslaw Pokorski Contents 1 Assessment of Airway Hyperresponsiveness: Comparison of Spirometry and Body Plethysmography ................................................ 1 F. Nensa, N. Kotschy-Lang, H.-J. Smith, W. Marek, and R. Merget 2 Hospital Management of Patients with Exacerbation of Severe Chronic Obstructive Pulmonary Disease ......................................................... 11 Beata Chmielowicz-Frontczak, Bernard Panaszek, and Andrzej Obojski 3 Pulmonary Rehabilitation in Patients Referred for Lung Transplantation .................. 19 D. Jastrzebski, M. Ochman, D. Ziora, L. Labus, K. Kowalski, J. Wyrwol, W. Lutogniewska, M. Maksymiak, B. Ksiazek, A. Magner, A. Bartoszewicz, P. Kubicki, G. Hydzik, A. Zebrowska, and J. Kozielski 4 Effects of Nasal Insufflation on Arterial Gas Exchange and Breathing Pattern in Patients with Chronic Obstructive Pulmonary Disease and Hypercapnic Respiratory Failure .............................................................................. 27 Georg Nilius, Karl-Josef Franke, Ulrike Domanski, Karl-Heinz Rühle, Jason P. Kirkness, and Hartmut Schneider 5 Exposure to Traffic-Related Air Pollutants as a Risk of Airway Obstruction .............. 35 Artur J. Badyda, Piotr Dabrowiecki, Wojciech Lubinski, Piotr O. Czechowski, and Grzegorz Majewski 6 Occupational Immediate-Type Allergic Asthma due to Potassium Tetrachloroplatinate in Production of Cytotoxic Drugs .................................................. 47 E. Thanasias, I. Polychronakis, V. van Kampen, T. Brüning, and R. Merget 7 Comparison of Different Non-invasive Methods for Detection of Allergic Asthma ....................................................................................... 55 M. Raulf-Heimsoth, V. van Kampen, E. Heinze, S. Bernard, G. Borowitzki, S. Freundt, K. Sucker, C. Eliakopoulos, A. Nienhaus, T. Brüning, and R. Merget 8 Deep Nasal Inspirations Increase the Cough Threshold in Children with Mild Asthma ........................................................................................... 65 R. Pecova, T. Michnova, J. Fabry, T. Zatko, M. Neuschlova, P. Klco, J. Hanacek, M. Tatar, and Z. Tomori vii viii Contents 9 Reproducibility of Sensitivity to Capsaicin Assessed by Single Breath Inhalation Methodology ........................................................................ 71 Frank Hoffmeyer, Kirsten Sucker, Nina Rosenkranz, Hans Berresheim, Christian Monse, Thomas Brüning, and Jürgen Bünger 10 Occupational Non-immediate Type Allergic Asthma due to Ammonium Persulfate ............................................................................................ 79 Ioannis Polychronakis, Efthimios Thanasias, Monika Raulf-Heimsoth, and Rolf Merget 11 Bronchial Allergen Challenges: Doubling or Quadrupling Dose Steps? ....................... 85 S. Mousalli, V. van Kampen, and R. Merget 12 Evaluation of Laryngopharyngeal Reflux in Pediatric Patients with Asthma Using a New Technique of Pharyngeal pH-Monitoring ............................ 89 A. Banaszkiewicz, L. Dembinski, A. Zawadzka-Krajewska, M. Dziekiewicz, P. Albrecht, M. Kulus, and A. Radzikowski 13 Latent Airway Hyperresponsiveness: A Phenomenon Bordering Bronchial Asthma Definition ........................................................................... 97 Lubomir Legath, Slavomir Perecinsky, Marek Varga, Martin Orolin, Zoltan Tomori, and Jaroslav Legath 14 Impact of Daytime Sleepiness on Rehabilitation Outcome in the Elderly ..................... 103 H. Frohnhofen, R. Popp, K. Frohnhofen, and S. Fulda 15 Pulmonary Physiotherapy in Patients with Bronchial Asthma ...................................... 111 Grazyna Osiadlo, Michal Plewa, Aleksandra Zebrowska, and Zbigniew Nowak 16 Hypoxemia During Bilevel Positive Airway Pressure Treatment in Patients with Obstructive Sleep Apnea Syndrome and Chronic Respiratory Insufficiency ............................................................................. 117 Anna Brzecka, Pawel Piesiak, Monika Kosacka, and Renata Jankowska 17 Validation of the Essener Questionnaire of Age and Sleepiness in the Elderly Using Pupillometry ........................................................... 125 H. Frohnhofen, S. Fulda, K. Frohnhofen, and R. Popp 18 Lung Function at Age 18–25 Years: A Comparison of Different Reference Value Systems ............................................................................... 133 E. Marek, J. Volke, H.-J. Smith, B. Serbetci, H. Kalhoff, N. Kotschy-Lang, R. Merget, and W. Marek 19 Pulmonary Function Impairment in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation............................................................... 143 Pawel Piesiak, Ewa Gorczynska, Anna Brzecka, Monika Kosacka, and Renata Jankowska 20 Lung Impairment in Scleroderma ..................................................................................... 149 T. Piorunek, B. Kuznar-Kaminska, S. Cofta, H. Batura-Gabryel, D. Poplawski, D. Majewski, M. Puszczewicz, and E. Wysocka 21 Severity of Nocturnal Cardiac Arrhythmias Correlates with Intensity of Sleep Apnea in Men ............................................................................... 155 E. Szaboova, D. Holoubek, Z. Tomori, P. Szabo, V. Donic, and B. Stancak Contents ix 22 b2-Adrenergic Receptor Gene Polymorphism and Response to Bronchodilating Treatment Evaluated by Spirometry ................................................ 169 I. Poziomkowska-Gesicka, A. Gawlikowska-Sroka, E. Dzieciolowska-Baran, I. Teul, G. Adler, A. Ciechanowicz, and M. Kurek 23 Costs of Smoking-Attributable Productivity Losses in Poland ....................................... 179 Joanna Lasocka, Michal Jakubczyk, and Rüdiger Siekmeier 24 Cigarette Smoking Among Students and the Influence of Legal Regulations on Passive Smoking ......................................................................... 189 A. Gawlikowska-Sroka, E. Dzieciolowska-Baran, J. Szczurowski, I. Teul, I. Poziomkowska-Gesicka, and E. Kamienska 25 Medical Students’ Aptitude Toward Smoking in Warsaw, Strasbourg and Teheran ................................................................................. 195 Rafal Machowicz, Joanna Ciechanska, Katarzyna Zycinska, Nastaran Mahboobi, Emilia Wnekowicz, Michael H. Obrowski, and Tadeusz M. Zielonka 26 Epidemiology of Pertussis in an Urban Region of Poland: Time for a Booster for Adolescents and Adults ................................................................ 203 Aneta Nitsch-Osuch, Ernest Kuchar, Grazyna Modrzejewska, Iwona Pirogowicz, Katarzyna Zycinska, and Kazimierz Wardyn 27 Rhinitis as a Cause of Respiratory Disorders During Pregnancy .................................. 213 Edyta Dzieciolowska-Baran, Iwona Teul-Swiniarska, Aleksandra Gawlikowska-Sroka, Iwona Poziomkowska-Gesicka, and Zbigniew Zietek 28 Subglottic and Tracheal Stenosis due to Wegener’s Granulomatosis ............................ 221 K. Zycinska, K. Wardyn, T.M. Zielonka, A. Nitsch-Osuch, S. Zarzycki, U. Demkow, W. Lukas, and I. Pirogowicz 29 Pulmonary Aspergillosis: Therapeutic Management and Prognostic Factors from 16 Years of Monocenter Experience ................................ 225 Stefan Pabst, Michael Krüger, Dirk Skowasch, H. Zhou, Jens Bürmann, and Marcel Kaminski 30 Influence of Rapid Influenza Test on Clinical Management of Children Younger than Five with Febrile Respiratory Tract Infections ................................................................................................................... 237 Aneta Nitsch-Osuch, Ilona Stefanska, Ernest Kuchar, Lidia B. Brydak, Iwona Pirogowicz, Katarzyna Zycinska, and Kazimierz Wardyn 31 Influenza Immunization Rates in Children and Teenagers in Polish Cities: Conclusions from the 2009/2010 Season ........................................................................... 243 Ernest Kuchar, Aneta Nitsch-Osuch, Katarzyna Zycinska, Katarzyna Miskiewicz, Leszek Szenborn, and Kazimierz Wardyn 32 Pharmacotherapy for Sarcoidosis: An Example of an Off-Label Procedure ................ 251 A. Zimmermann, A. Dubaniewicz, and J.M. Slominski 33 Invasive Pneumococcal Bacteremia in a 9-Year-Old Boy Caused by Serotype 1: Course, Treatment and Costs ..................................................... 257 Teresa Jackowska, Joanna Zaleska-Ponganis, and Dominik Dziurda x Contents 34 Nosocomial Rotovirus Gastroenetrocolitis in Children Hospitalized Primarily Due to Respiratory Infections .................................................... 267 Aneta Nitsch-Osuch, Ernest Kuchar, Anna Kosmala, Katarzyna Zycinska, and Kazimierz Wardyn 35 Mental Health of Polish Students and the Occurrence of Respiratory Tract Infections .......................................................................................... 275 Sylwia Baran, Iwona Teul-Swiniarska, Edyta Dzieciolowska-Baran, Jacek Lorkowski, and Aleksandra Gawlikowska-Sroka 36 Atherosclerotic Factors in PR3 Pulmonary Vasculitis ..................................................... 283 K. Zycinska, K. Wardyn, T.M. Zielonka, A. Nitsch-Osuch, R. Smolarczyk, S. Zarzycki, U. Demkow, W. Lukas, and I. Pirogowicz 37 Vagal Heart Rate Control in Patients with Atrial Fibrillation: Impact of Tonic Activation of Peripheral Chemosensory Function in Heart Failure ................................................................................................... 287 T. Drexel, C. Eickholt, J. Mühlsteff, A. Ritz, M. Siekiera, K. Kirmanoglou, V. Schulze, D.-I. Shin, J. Balzer, T. Rassaf, M. Kelm, and C. Meyer 38 Pulmonary Arterial Hypertension in Patients with Sarcoidosis: The Pulsar Single Center Experience ............................................................................... 299 Stefan Pabst, Christoph Hammerstingl, Natalie Grau, Jens Kreuz, Christian Grohe, Uwe R. Juergens, Georg Nickenig, and Dirk Skowasch 39 Cutaneous Changes: An Initial Manifestation of Pulmonary Wegener’s Granulomatosis ........................................................................ 307 Katarzyna Zycinska, Kazimierz Wardyn, Tadeusz M. Zielonka, Aneta Nitsch-Osuch, and Roman Smolarczyk 40 Posturography in Differential Diagnosis of Normal Pressure Hydrocephalus and Brain Atrophy ................................................................... 311 Leszek Czerwosz, Ewa Szczepek, Beata Sokolowska, Jerzy Jurkiewicz, and Zbigniew Czernicki 41 Psychological Background of Pro-health Behavior ......................................................... 325 Agnieszka Wilczynska, Kamilla Bargiel-Matusiewicz, Marta Troc, and Leslaw Niebroj 42 Cardiovascular Effects of the Valsalva Maneuver During Static Arm Exercise in Elite Power Lifting Athletes........................................................ 335 Aleksandra Zebrowska, Zbigniew Gasior, and Dariusz Jastrzebski 43 Computer Games and Fine Motor Skills .......................................................................... 343 Lukasz Borecki, Katarzyna Tolstych, and Mieczyslaw Pokorski 44 Toward the Clarification of Ideas: Medical Futility, Persistent/Obstinate Therapy and Extra/Ordinary Means ............................................ 349 Leslaw Niebroj, Kamilla Bargiel-Matusiewicz, and Agnieszka Wilczynska 45 Psychological Attachment in Patients with Spondylosis of Cervical and Lumbar Spine ........................................................................................... 357 Henryk Pedziwiatr 46 Fear and Anger Among Adolescents and the Behavior of Their Mothers .................... 365 Anna Jarmolowska