Regional Anaesthesia Basic Sciences Anaesthetic Course Dr Vassilis ATHANASSOGLOU FRCA Consultant Anaesthetist and Lecturer in Medicine Oxford University Hospitals NHS Trust, UK Geneva, 5th June 2017 Faculty Disclosure ✓ No, nothing to disclose Yes, please specify: Acknowledgements Dr Svetlana Galitzine Dr Soumitra Ghosh Dr Paul Townsley Dr Istvan Daroc Dr Michael Mould Dr Chris Spiteri Nuffield Orthopaedic Centre (NOC) “Regional anaesthesia always works – if you put the right amount of the right stuff in the right place” Learning Objectives 40 min to refresh your knowledge in: • Physiology and pathophysiology • Pharmacology • Physics and equipment • Applied anatomy and selected blocks Learning Objectives 40 min to refresh your knowledge in: • Physiology and pathophysiology • Pharmacology • Physics and equipment • Applied anatomy and selected blocks Regional anaesthesia intends to block generation and conduction of the action potential in the central and peripheral nervous system Key concepts to understand • How this works at cellular level - Action potential of the nerve cell • Some of the molecular mechanisms behind it – Na+ and K+ voltage gated channels • Propagation of action potential https://commons.wikimedia.org/wiki/F ile:Action_potential_reloaded.jpg http://droualb.faculty.mjc.edu/Course %20Materials/Physiology%20101/Chap ter%20Notes/Fall%202011/chapter_7% 20Fall%202011.htm https://www.studyblue.com/notes/not e/n/4-the-action- potential/deck/15442360 http://www.zoology.ubc.ca/~gardner/action_potential.htm https://www.studyblue.com/notes/note/n/ch-11/deck/15452839