SUBJECT INDEX Absence epilepsy, genetic model 37 Angiotensin receptors, in subretrofacial Acetylcholine nucleus 218 function in nucleus accumbens 721, 752 Anoxia, ion transport in cochlea 715 in subretrofacial nucleus 217 Antennapedia homeobox 309 effect on synaptic transmission in Anticonvulsants hippocampus 596 effect on kainic acid seizures 20 Achaete-scute genes 294 tiagabine 589 Acoustic trauma, ion transport in outer hair Antidepressants cells 715 histamine interaction 693 Action potential, Pacinian corpuscles 96, 97 effect on NMDA receptor-mediated Adaptive problem solving 230 responses 423 Addiction Antihistamines morphine, role of histamine 694 induced convulsions 691 opiates, nucleus accumbens 753 effect on muricide 693 Adenosine, kainic acid seizures 23 Antihypertensive drugs, effect on subretrofacial Adenosine-3’ ,5'-monophosphate neurons 219 learning in Drosophila 302 Antinociception, role of histamine 694 synaptic transmission 564 Anxiety, role of histamine 694 Adenosine triphosphate, role in transmitter Apoptosis 481 release 559 Arachidonic acid ADR mouse 314 intracellular messenger 564 Adrenaline ROS formation 443 in subretrofacial nucleus 211 Arginosuccinate lyase, in brain 135 transduction in Pacinian corpuscles 115 Arginosuccinate synthase, in brain 135 8-Adrenoceptor antagonists, effect on Artificial neural networks, problem subretrofacial nucleus 219 solving 229-281 . Aggressive behaviour basic network components and processes 234 nucleus accumbens 723 goal representation and utilization 251 role of histamine 693 learned evaluation and sequential credit Aging assignment 235 free radicals and brain injury 446 simulated search 244 histamine in brain 692 variations 268 AIDS, neuronal disorders and macrophages 480, Astrocytes, monoamine oxidase B containing 71 482 Aversion, role of histamine 694 Alcohols, effect on membrane fluidity and phase transitions 625 Baclofen n-Alkanols inhibition of IPSPs 593 effect on calcium currents 641 effect on kainic acid seizures 20 effect on potassium currents 641 pre- and postsynaptic actions 581, 582 effect on sodium currents in invertebrates 630, Band-pass filter, Pacinian corpuscles 109 662 Barbiturates, modulation of GABA, effect on sodium channels in vertebrates 636, receptor/channel complex 590 662, 669 Baroreceptor neurons, subretrofacial nucleus 207 n-Alkyl detergents, effect on sodium currents 641, Basal ganglion, nitric oxide system in 143 662, 667 Basket cell 576 Alphaxalone, effect on GABA,-gated Cl- BCECF 511 channels 590 Behaviour Alzheimer’s disease kainic acid induced changes 3 molecular screening for genes involved in 329 nucleus accumbens 720 monoamine oxidase B in brain 73 Bahavioural disorders, role of histamine 691 role of histamine 692 Benzodiazepines, GABA, receptor 495, 590 Amine precursor uptake and decarboxylation Benzyl alcohol, effect on sodium currents in cells 70 invertebrate neurons 630 cis-4-Aminocrotonic acid 583 Bicarbonate, GABA, receptors 515, 521, 523, 3-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate 525, 526 receptors Biogenic amines, effect on kainic acid seizures 11, 7? effect of kainic acid seizures 12 molecular biology 354 Birds, magnetic orientation and D(-)-2-Amino-7-phosphonoheptanoate 22 magnetoreception 449-473 2-Amino-5-phosphonovalerate 22 Blood-brain barrier, kainic acid-induced 9-Amino-1,2,3,4-tetrahydroacridine 692 changes 9 Amygdala, nitric oxide system in 140 Blood pressure Amygdaloid complex, kainic acid induced role of histamine 690 damage 7 subretrofacial nucleus 198, 200, 207, 219 x SUBJECT INDEX Blood vessels, cerebellum, cisplatin-induced Citrulline, production and metabolism in changes 164, 167 neurons 135 Boolean network formalism 231, 234 Clonidine 22 Brain edema, therapy 23 effect on subretrofacial nucleus 219 Brainstem, nitric oxide system in 148 Clorgyline, effect on dopamine metabolism 383 Bulbospinal barosensitive neurons, subretrofacial Cochlea, ion transport mechanisms in outer hair nucleus 207 cells 703-717 Conditioned avoidance, nucleus accumbens 723 Conditioned place preference, nucleus Calbindin, in Purkinje cells, effect of cisplatin 180 accumbens 723 Calcitonin gene-related peptide, effect of kainic Conditioned reinforcement, nucleus acid seizures 17 accumbens 723 Calcium Conditioning, models 241 modulation of GABA, receptors 507 Connectionistic modeling 230 role in cisplatin induced Purkinje neuron Convulsions, effect of histamine 691 degeneration 180 CPG 39551 22 role in GABA responses 580 Crayfish muscle fibre, GABA, receptors 515 sodium channel gating 620 Creutzfteld—Jacob disease 481 transmitter release 541-552, 560, 563 Cytokines transport in cochlea hair cells 704, 709, 712, 715 macrophage-derived, effect on monoaminergic use dependence of guanidinium toxins in frog processes 476 nerve 368, 370 in neural tissues, evolution 482 Calcium-calmodulin-dependent kinase II 550, 555 Cytoskeleton, neuronal, effect of cisplatin 174, Calcium channels 179 exocytosis 541-552, 560 zinc 397 Defensive behaviour, role of subretrofacial Calcium channel blockers, effect on kainic acid nucleus 220 seizures 23 Delayed matching to position, nucleus Calcium current, effect of n-alkanols 641 accumbens 724 Calcium-sodium exchange, in cochlea hair Dementia cells 711, 712 monoamine oxidase B in brain 73 Carbonic anhydrase, in cochlea hair cells 714 role of histamine 692 Cardiopulmonary bypass, cardiotomy dementia and (-)Deprenyl, effect on dopamine metabolism 383, the macrophage 478 Cardiotomy dementia 478 Depression, role of histamine 693 Cardiovascular regulation, subretrofacial 2-Desoxyglucose autoradiography, kainic acid nucleus 200, 205, 207, 219, 220 seizures 9 Catalepsy, histamine induced 691 Development Catecholamines cerebellum, effect of cisplatin 162, 163, 173 storage and release 556 GABA, receptors 522 in subretrofacial nucleus 211 magnetic orientation 460 transduction of Pacinian corpuscles 115 nigral control of epilepsy 38 Catechol-O-methyl transferase, dopamine role of zinc 396, 402, 416 metabolism 384 Diazepam-binding inhibitor 592 Central respiratory rhythm generator 209 cis-Dichlorodiammineplatinum II, effect on rat Cerebellum cerebellum 161-196 cisplatin and development of 161-196 damage to blood vessels 164, 167 nitric oxide system in 145 differentiating postmitotic cells 166 c-fos, effect of kainic acid on expression of 9 interference with inhibitory CGP 35, 348, 600 neurotransmission 180 Channel lifetime 503, 505 proliferating cells 165 Chemokinesis 476 therapeutic and side effects 162 Chemotaxis 476 Diencephalon, monoamine oxidase A in 56 HIV gp120 480 Diethyldithiocarbamate, effect on synaptic Chloramine-T, inactivation of Na+ channels 366 transmission 426, 434 P Chloride, GABA, receptors 499, 509, 512, 519, Differentiating cells, cerebellum, effect of 520, 523, 524, 581, 587, 590 cisplatin 166 Chloride—bicarbonate exchange Dihydrofolate reductase, effect of cisplatin 174 in cochlea hair cells 713 Disinhibition 601 in neurons and glia 514 Displacement behaviour, nucleus accumbens 720 Chloride channels DNA, cisplatin interaction in cerebellum 162, 163, cochlea hair cells 709, 710 166, 173 effect of zinc 397, 434 cDNA, synthesis 341 Cholecystokinin, effect of kainic acid seizures 17 cDNA libraries, neural cells 339-346 Cholinergic system Docking-fusion complexes 549 effect of kainic acid seizures 11 Dopamine nitric oxide and cyclic GMP 139, 141, 145 function in nucleus accumbens 720, 725, 748 Chromogranin B, effect of kainic acid seizures 18 metabolism by monoamine oxidase in mammalian Circadian rhythms, role of histamine 688 CNS 383 SUBJECT INDEX xi reward-dependent learning 752 effect of kainic acid seizures 13 Dopaminergic system, nigral control of nigral control of epilepsy 34, 37, 40, 45 epilepsy 41 nucleus accumbens, locomotor activity 720, 725 Dorsal raphe nucleus, monoamine oxidase B effect of opioids on release 593 in 61, 67 receptors 491 Dorsal root ganglia, sodium currents in 640 in subretrofacial nucleus 217 Drinking, role of histamine 689 targets 490 Drosophila uptake in CNS 589 position reading and sense organ GABA, receptors 396, 489-537 emergence 293-297 activity-dependent modulation 597 sevenless receptor tyrosine kinase in 287-292 Cl- 499, 509, 512, 519, 520, 523, 524, 581, 587 Dynorphin, effect of kainic acid seizures 15 desensitization 505, 597 glial cells 523 ionic modulation 506 Ellipticity model, transduction 117 Endolymphatic hydrops, ion transport 714 ionic selectivity, conductance and gating 497 Endothelium-derived relaxing factor 130 ionic shifts mediated by 523 membrane potential changes 509 Enhancer-trapping 303 modulatory substances 590 Enkephalins, function in nucleus accumbens 721, molecular biology 579 733, 752 paroxysmal inhibitory potentials 599 Epilepsy permeability 499 endogenous control, role of substantia single channel properties 580 nigra 33-52 structural and pharmacological properties 494 GABAergic inhibitory synaptic transmission 601 synaptic activation 515 kainic acid seizures in rats 1-32 effect of zinc 400-414, 434 role of histamine 692 GABAg receptors 396, 492, 581 Evaluation, training the Stimulus—Response activity-dependent modulation 597 network 236 Evaluation—Response associations 242 effect of GABA uptake 589 mediated IPSPs 586 Evolution, immune-neuro-link and paroxysmal inhibitory potentials 599 macrophages 482 effect of zinc 414 . Excitatory amino acids effect on nitric oxide synthase system 135, 141, GABA/benzodiazepine receptors, effect of kainic acid seizures 14 146 GABA¢g receptors 583 ROS generation 444 GABAergic neurons vasomotor effects in subretrofacial nucleus 205 effect of kainic acid seizures on sprouting 19 Excitatory amino acid neurotoxicity, effect of morphology 576 zinc 428 physiology 583 Excitatory amino acid receptors GABA-mimetic drugs effect of kainic acid seizures 12 effect on generalized seizures in rats 35 nigral control of epilepsy 38 effect on kainic acid seizures 20 effects of zinc 415-433 GAL4 304 Excitatory synaptic transmission, effect of zinc 426 Gamma-vinyl-GABA, nigral control of Excitotoxicity epilepsy 34, 37, 39 kainic acid 7 Gene expression, kainic acid induced seizures 9 role of nitric oxide 140 Generator potentials, Pacinian corpuscles 97 Exocytosis, role of calcium 541-552, 560 Gene-targeting 322 External granular layer, cerebellum, effect of neuropeptide functions in CNS 325 cisplatin 165, 168, 170 Genetics Drosophila 287-291, 293-297, 299-308 F-actin, in cochlea hair cells 709 leech 336 Feed-forward inhibition, nucleus accumbens 746 mouse 313-317, 319-331 Feeding Giant depolarizing potentials, GABA, receptors nucleus accumbens 723, 748 and zinc 405 role of histamine 689 Glial cells Filopodia, Pacinian corpuscles 94, 117 GABA, receptor channels 523 FK 33-824, effect on synaptic transmission in monoamine oxidase B containing 71 hippocampus 594 transmitter receptors 491 Free radicals Glucocorticoid receptor, nucleus accumbens 734 aging 446 Glutamate cerebral ischaemia/reperfusion injury 444 effect of kainic acid seizures 11 lipid peroxidation 441 nucleus accumbens, locomotor activity 721 sources 442 in subretrofacial nucleus 212, 217 Frog nerve, use dependence of guanidinium Glutamate agonists, ROS generation 444 toxins 359-374 Glutamate antagonists, effect on kainic acid seizures 20 GABA Glutamate decarboxylase co-transmitters 579 immunoreactivity in cisplatin-treated rats 174, inhibitory transmitter 490 191 xii SUBJECT INDEX effect of kainic acid seizures 14 I factors 304 Glutamate diethyl ester 22 Immediate-early genes, effect of kainic acid on Glutamate receptors expression of 9 mediated neuronal cell death 353 Immune-neuro-link, macrophages 475-488 molecular biology 354 cardiopulmonary bypass and cardiotomy subtypes 354 dementia 478 Glutamate receptors, effects of zinc 415-433 evolution 482 Glutaminergic synapses, nucleus accumbens 747 HIV gp120 479 y-D-Glutamylaminomethylsulphonic acid 22 monoaminergic processes 476 Glycine, binding in brain, effect of zinc 423 Inhibitory amino acid receptor-ion channels, effect Goal representation and utilization, artificial neural of zinc 396 networks 251 Inhibitory postsynaptic potential G protein, linked glutamate receptors, effect of chloride homeostasis 587 zinc 425 GABA, receptors 405, 519 Gramicidin channel 623 GABAg receptor mediated 586 Growth factors, effect of kainic acid seizures 19 monosynaptic 586 Guanidinium toxins, use dependence in frog polysynaptic 584 nerve 359-374 potentiation by tiagabine 589 Guanosine-3’ ,5'-monophosphate, nitric oxide unitary 586 interaction 137, 139, 149, 143, 144, 146, Inhibitory synaptic transmission, 149 hippocampus 575-609 Guanosine triphosphate-binding proteins, epilepsy 601 transmitter release 554 modulatory substances 590 Guanylyl cyclase, soluble nitric oxide receptor 136 plasticity 597 Guarded receptor hypothesis, ion channels 626 receptors and effectors 579 Interleukin-1, effect on monoaminergic processes 476, 482 Ion channels, GABA, receptor 497 H+, modulation of GABA, receptors 507 lonotrope transmitters 556 Heat shock proteins, effect of kainic acid on Ion-selective microelectrodes 510 expression of 10 lon transport Hilar interneurons 579 mammalian cochlea 703-717 Hippocampus mechanisms 512 inhibitory transmission in 575-609 Ischaemia/reperfusion injury, free radicals 441-448 anatomy 576 modulatory substances 590 Kainic acid physiology 583 induced seizures 1-32 plasticity 597 behavioural and electrographic changes 3 receptors and effectors 579 neurochemical changes _ 11 kainic acid induced damage 7 neuronal plasticity and changes in growth nitric oxide system in 140 factors 20 Histamine, monoamine oxidase B coexistence in neuropathy 4 hypothalamus 68, 72 pharmacological treatments 21 Histamine receptors, in brain 695 effect of zinc on responses to 423 Histaminergic neuron system 685-702 Ketamine 22 behavioural disorders and their clinical Kynurenic acid 22 implication 691 localization and distribution in brain 686 Lanthanum, use dependence of guanidinium toxins motion sickness 695 in frog nerve 369 physiological functions 688 Lateral inhibition, nucleus accumbens 744 HIV gp120, dementia and the macrophage 479 Learned evaluation 237 Hodgkin—Huxley sodium channel 612 Learning Homobox peptide, neurotrophic activity 309-311 artificial neural networks 233, 235 Homing, magnetic orientation 451, 453, 458 reverse genetics 301 5-Hydroxyindoleacetic acid, effect of kainic acid role of histamine 692 » seizures 11 role of nucleus accumbens 723, 752 5-Hydroxytryptamine Leech effect of kainic acid seizures 11 cDNA libraries from neural cells 340 metabolism by monoamine oxidase 385 neural repair 333-338 monoamine oxidase C coexistence in brain 67 Leukotrienes, effect of kainic acid seizures 18 in subretrofacial nucleus 218 Limbic seizure, kainic acid induced 3 effect on synaptic transmission in Limbic system, evaluation/reinforcement hippocampus 596 learning 239, 273 Hypothalamus Linear Threshold Unit 234 monoamine oxidase A in 56, 60 Lipid peroxidation, ROS formation 442 monoamine oxidase B in 68 Local anaesthetics, sodium channels 626, 648 nitric oxide system in 144 Locomotion reward centres 239 effect of histamine 691 Hypothermia, histamine induced 690 nucleus accumbens 720, 725, 729 SUBJECT INDEX xiii Locus coeruleus, monoamine oxidase A Monoamine oxidase, mammalian CNS activity 55 cat brain 53-78 Long term depression, role of nitric oxide 148 cellular compartmentation 382 Long term potentiation containing fibres 70 nucleus accumbens 747, 753 containing glial cells 71 role of nitric oxide 141 distribution 381 underlying mechanisms 540 enzyme histochemistry 54 effect of zinc 427 functional role 383 Luciferase model, ion channels 627 in hypothalamus 56, 60, 68, 71 immunohistochemistry 55 isoenzyme classification 376 Macrophage, immune-neuro-link 475-488 in mes- and diencephalon 56 cardiopulmonary bypass and cardiotomy in pons and medulla oblongata 55 dementia 478 reaction mechanism 375 derived cytokines, monoaminergic processes 476 in serotonergic system 67 evolution 482 species distribution 377 HIV gp120 479 in spinal cord 70 implications for psychiatry 481 structure 376 Magnetic field 450 subcellular localization 377 Magnetic orientation, birds 449 tissue distribution 379 behavioural evidence 451 Morphine conditioned responses to stimuli 460 nucleus accumbens, locomotor activity 721 ontogeny 460 role of histamine in addiction and tolerance 694 physiological evidence 465 Mossy cell 576 Magnetite, in birds 465 Mossy fibres, effect of kainic acid seizures on Magnetoreception, birds 449 sprouting 19 conditioned responses 460 Motion sickness, role of histaine 695 transduction mechanisms 465 Motivation and reward, models 262 Mannitol, prevention of brain edema 23 Mouse Mechanical transduction, theories 116 mutations, neuromuscular diseases 313-319 Medulla oblongata, monoamine oxidase A reverse genetics, neurodegenerative | activity 55, 58 disease 319-331 Membrane fluidity, ion channels 625 Muricide, role of histamine 693 Membrane potential, GABA, receptors 509 Mutagenesis, Drosophila 299 Membranes, effect of surface-active compounds on Mutations, neuromuscular diseases, mouse 313 neuronal sodium channels 620 Myotonia, mouse model 314 Memory reverse genetics 30] NADPH-diaphorase neurons 130, 138 role of histamine 692 L-NAME, effect on cerebral ischaemia 444 Meniere’s disease, ion transport in outer hair Neocortex, nitric oxide system in 138 cells 714 Nerve growth factor, effect of kainic acid Mesencephalon, monoamine oxidase A in 56 seizures 19 Mesopontine cholinergic system, nitric oxide system Nerve growth factor receptor 348 in 145 Nerve terminal boutons, zinc in 395 Metabotrope transmitters 556 Nerve terminals, zinc release 395 Met-enkephalin, effect of kainic acid seizures 15 Neural modeling 230 N-Methyl-D-aspartate receptors Neurodegenerative diseases, reverse genetic dependent plasticity, nucleus accumbens 747 screening for genes involved 328 effect of kainic acid seizures 12 Neuromodulators 557 molecular biology 355 Neuromuscular diseases, mouse models 313 nigral control of epilepsy 38 Neuronal death, cerebral ischaemia 443 nitric oxide interaction 139, 140, 141, 144, 146 Neuronal specification, AS-C genes 295 effect of zinc 416-423, 430, 434 Neurons N-Methyl-D-aspartate receptor antagonists, effect kainic acid induced damage 4 on kainic acid seizures 22 leech, cellular and molecular approaches to tele-Methylhistamine, monoamine oxidase B and repair 333-338 oxidation of 72 Neuron specific enolase, effect of cisplatin 173 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Neuropeptides oxidation by monoamine oxidase B73 GABA co-transmitters 579 Microglia 475 functions in CNS, gene-targeting 322 Microtubules, cisplatin-induced damage 174 effect of kainic acid seizures 14 Midazolam, effect on inhibitory synaptic release 557, 558 currents 591 Neuropeptide Y Migration, magnetic orientation 449, 451, 457, 462 effect of kainic acid seizures 16 Milacemide, effect on dopamine metabolism 383 in subretrofacial nucleus 211 MK801 22 Neurotensin, effect of kainic acid seizures 17 binding in brain, effect of zinc 422, 434 Neurotensin receptor gene, mutation 326 Modulated receptor hypothesis, sodium Neurotransmitters channels 625 availability for release 552 xiv SUBJECT INDEX differential release 556 n-Octyl-B-D-glucopyranoside, effect on neuronal endogenous control of epilepsy 37 sodium currents 646, 658, 661 effect of kainic acid seizures 11 n-Octyl sulphate anions, effect on sodium local modulation of release by external currents 642, 643, 666 factors 561 Opener muscle fibre, GABA, receptors 515 metabolism by monoamine oxidase 385 Operant conditioning, nucleus accumbens 724 release, presynaptic plasticity 541-574 Opiates subretrofacial nucleus 217 reward action, nucleus accumbens 753 Neurotrophin receptors 347-352 in subretrofacial nucleus 218 Neutrophils, free radicals and cerebral Opioid peptides ischaemia 443 effect on inhibitory transmission in Next-state scanning 247 hippocampus 592 Nifedipine, effect on kainic acid seizures 23 effect of kainic acid seizures 14 Nigral control of epilepsy 33-52 Optical pumping, magnetoreception 466 Nipecotic acid 589 Ornithine decarboxylase, effect of kainic acid 10 Nitric oxide Outer hair cell, ion transport mechanisms 703-717 AIDS associated neuronal damage 480 Oxygen radicals intracellular messenger 565 aging 446 neurotransmitter in CNS 129-160 cerebral ischaemia/reperfusion injury 444 basal ganglia 143 lipid peroxidation 44] brainstem 148 sources 442 cerebellum 145 Oxypurinol, cerebroprotective activity 446 cyclic GMP 137 guanylyl cyclase 136 Pacinian corpuscles 79-128 hippocampus, septum and amygdala 140 function 96 hypothalamus 144 deformation properties of the capsule 109 mesopontine cholinergic system 145 pharmacology of transductions 113 metabolism 135 receptor and action potentials 97 neocortex 138 quantitative models 118 retina 144 structure 82 spinal cord 148 transducer mechanisms 119 role in cerebral ischaemia 444 Parkinson's disease Nitric oxide synthase molecular screening for genes involved in 329 basal ganglia 143 monoamine Oxidase B in brain 73 brainstem 148 role of histamine 69] cerebellum 145 Paroxysmal inhibitory potentials 599 characterization 130 Patch-clamping, GABA, receptor channels 497 citrulline production and metabolism 135 P-elements, mutagenesis in Drosophila 300 hippocampus, septum and amygdala 140 Pentobarbital, effect on inhibitory synaptic hypothalamus 144 currents 59] mesopontine cholinergic system 145 Periaqueductal grey, subretrofacial nucleus neocortex 138 connections 220 nitric oxide metabolism 136 PH regulation, cochlea hair cells 713 pharmacology 135 Phaclofen 598 retina 144 Phencyclidine 22 spinal cord 148 Phenobarbital, effect on kainic acid seizures 20 Noise trauma, ion transport in outer hair cells 715 a-Phenyl-i-butylnitrone 444 Noradrenaline cerebroprotection and effect on ROS effect of kainic acid seizures 11 formation 445 metabolism by monoamine oxidase 385 2-Phenylethylamine, metabolism by monoamine effect on synaptic potentials in hippocampus 595 oxidase 385 NSF-attachment proteins 550 Phosphorylation, sodium channels 629 1-Nuciferine 22 Photolithography, neuron culture 333 Nucleus accumbens 719-761 Photoreceptors alternative hypothesis of function 726 magnetic field perception 466 2 behavioural function 720 R7, Drosophila, model for inductive cortical, thalamic and amygdalar relationships signalling 287 to 742 Pigeon functional heterogeneity of neurons 729 magnetic orientation 451, 453, 458 functionally distinct ensembles 733 magnetite in 465 learning 723 Pineal gland, response to magnetic field locomotor activity 720, 725, 729 stimuli 467 output pathways 734 Plasticity recruitment of neuronal ensembles in integration activity-dependent modulation 597 of multiple functions 740 paroxysmal inhibitory potentials 599 short- and long-range lateral inhibition 744 Polyamines, effect of kainic acid on synthesis 10 striatal neurochemical systems, network Polymerase chain reaction, Drosophila brain functions 746 structure and function 301, 307 Nucleus tractus solitarius, immune-neuro-link 475 Pons, monoamine oxidase A activity 55 SUBJECT INDEX Xv Position reading, sense organ emergence, Septum, nitric oxide system in 140 Drosophila 294 Sevenless receptor tyrosine kinase, Potassium, Pacinian corpuscles and Drosophila, genetic dissection of signal transduction 113 transduction 287-292 Potassium channels Sexual behaviour cochlea hair cells 709, 710 nucleus accumbens 723 synaptic transmission 564 role of histamine 695 effect of zinc 398, 433 Sib-selection, Drosophila 301, 302 Potassium-chloride cotransport mechanism 513, Signal transduction 556 514 sevenless receptor tyrosine kinase in Potassium currents, effect of n-alkanols 641 Drosophila 287, 292 Presynaptic plasticity, regulation of Ca?+-dependent Simulated search 244 transmitter release 539-574 model 247 Presynaptic receptors 561 Single-channel conductances, GABA, Problem solving, artificial neural receptors 502 networks 229-281 Skin, Pacinian corpuscles 80 Proliferating cells, cerebellum, effect of Sleep, role of histamine 688 cisplatin 165 SNAP-25 550 Proneural genes 293 SNARF 511 Prostaglandin F2a, effect of kainic acid Sodium-bicarbonate cotransport 515 seizures 18 Sodium-—calcium exchange, cochlea hair cells 711, Protein kinase A, sodium channels 630 712 Protein kinase C Sodium channels 611-683 ion channel phosphorylation 629 alcohols and h,, shift 669 presynaptic secretion 563 alcohols, n-alkyl cations and activation of Purkinje cells, effect of cisplatin 172, 173, 175-193 In, 662 Putrescine, in brain, effect of kainic acid 10 effect of n-alkanols and benzyl alcohol 630 effect of n-alkyl detergents 641 Quisqualate, effect of zinc on responses to 423 diversity 619 frog nerve, use dependence of guanidinium rab3A 554 toxins 359-374 : Raf kinase, Drosophila 289 hypotheses of phasic block and gating shifts 670 Ras |, sev signal in Drosophila 288 mechanisms of purturbation by surface-active Reactive oxygen species compounds aging 446 membrane-based 620 cerebral ischaemia/reperfusion injury 444 protein-based 625 lipid peroxidation 441 n-octyl sulphate and voltage dependence of sources 442 current inactivation 666 Receptor potential, Pacinian corpuscles 96, 97 properties 612 Regeneration, leech neurons, gene isolation 336 structure 617 Reinforcement learning 235 use-dependent block Respiratory modulation, subretrofacial charged compounds 647 neurons 209 neutral compounds 658 Retina, nitric oxide system in 144 similarities and differences 659 Retrograde messengers 564, 580 effect of zinc 399 Retzius cells Sodium—H* exchange 515 culture 333 cochlea hair cells 713 cDNA libraries 340 Sodium-—potassium—chloride cotransport 514 Reverse genetics Sodium pump, cochlea hair cells 710, 712 Drosophila brain structure and function 299-308 Somatostatin, effect of kainic acid seizures 16 mouse CNS 319-331 Spatial learning, nucleus accumbens 724 Reward centres, hypothalamus 239 Spermidine, in brain, effect of kainic acid 10 Reward motivation, models 262 Spermine, in brain, effect of kainic acid 10 Reward-related learning, nucleus accumbens 724, Spinal cord 750, 752 monoamine oxidase B containing structures 70 Rolled, Drosophila 289 nitric oxide system in 148 Spinal muscular atrophy, mouse model 313 Saxitoxin, use dependence in frog nerve 359-374 Spontaneously hypertensive rats, histamine in Schizophrenia hypothalamus 690 neuropathy 481 Squid role of histamine 694 effect of alcohols on neuronal sodium Secretogranin II, effect of kainic acid seizures 18 currents 630 Sedation, histamine 691 effect of n-alkyl detergents on sodium Seizures, kainic acid induced 1-32 currents 641, 659 Senescence accelerated mice, histamine in Stimulus—Evaluation system 235 brain 692 Stimulus—Response models 231, 233, 235 Senile dementia, role of histamine 692 goal representation and utilization 251 Sense organ precursors, Drosophila 293-297 simulated search 244 Sensory Mother Cell 294 training using evaluation 236 Xvi SUBJECT INDEX variations 268 Touch, Pacinian corpuscles 79 Stimulus-secretion coupling 541, 556 Transduction, Pacinian corpuscles 96 impact of presynaptic receptor activation 562 deformational properties of the capsule 109 Stress, role of histamine 690 mechanisms 120 Stretch-receptor neurons, GABA, receptors 517 pharmacology 113 Striatum quantitative models 118 monoamine oxidase Ain 56 theories 116 nigral control of epilepsy 41 Trimethylammonium cations, effect on sodium Subretrofacial vasomotor nucleus 197-227 currents 641, 647, 659 action of antihypertensive drugs 219 Tryptamine, regulation by monoamine oxidase B in chemical properties of neurons 210 5-HT cells 67 definition 198 Tuberomammillary neurons, neuroactive substances inputs to neurons 215 in 687 neurotransmitters and neuromodulators 217 physiological properties of neurons 200 Ubisemiquinone radical 442 role in cardiovascular regulation 200, 207, 220 Use dependence, guanidinium toxins in frog Substantia nigra nerve 359-374 endogenous control of epilepsy 33-52 monoamine oxidase A in 56 Vasoactive intestinal polypeptide, effect of kainic Sun compass 458 acid seizures 17 Superior colliculus, nigral control of epilepsy 42 Vasomotor neurons, sunretrofacial nucleus 205 Surface tension, ion channels 623 Ventral medulla, cardiovascular regulation 198 Surfactants Vibratory stimuli, Pacinian corpuscles 79 ion channels 624 Vicarious trial-and-error 247 effect on sodium currents 630-674 Virus, neurological and neuropsychiatric Synapsin I 550, 555, 561 deficits 480, 481 Synaptic inhibition 575-609 Viscerotopic organization of vasomotor Synaptic plasticity, transmitter release 540 subretrofacial nucleus cells 200 Synaptic transmission, effect of zinc 426 Synaptic vesicles, zinc in 395 Wakefulness, role of histamine 688 Synaptobrevin 550, 561 Water balance, role of histamine 690 Synaptophysin 550 Wernicke—Korsakoff’s syndrome, role of Synaptotagmin 550 histamine 693 Syntaxin 550, 561 Wet-dog shakes, kainic acid induced 3 Wobbler mouse 313 Tachykinins, effect of kainic acid seizures 17 Tegmentum, nigral control of epilepsy 42 Xanthine dehydrogenase, cerebral ischaemia 442 Tetrodotoxin Xanthine oxidase, cerebral ischaemia 442, 446 sodium currents 619, 641 transduction in Pacinian corpuscles 114 Zinc 393-441 use dependence in frog nerve 359-374 in CNS 394 Thalamus, nigral control of epilepsy 41 excitatory amino acid receptors 415, 434 Thermoregulation, role of histamine 690 excitatory synaptic transmission 426 Thiamine deficiency, histamine in brain 693 inhibitory amino acid receptor-ion channels 396, Thyreotropin releasing hormone, effect of kainic 434 acid seizures 17 modulation of GABA, receptors 507 Tiagabine, GABA uptake and IPSP 589 neurotoxicity 428 Tolerance, morphine, role of histamine 694 physiological role 395 LIST OF PREVIOUS REVIEW ARTICLES VOLUME 30 D. R. NASSEL Serotonin and serotonin-immunoreactive neurons in the nervous system of insects R. W. Dykes, P. LANDRY, Specificity of connections in the ventroposterior nuclei of T. P. Hicks, P. DIADORI and the thalamus R. METHERATE J. C. VENTER, U. Di Porzio, Evolution of neurotransmitter receptor systems D. A. RoBInson, S. M. SHREEVE, J. Lai, A. R. KERLAVAGE, P. FRACEK JR, K.-U. LENTES and M. FRASER Gorpon, E. E. ALLEN and The role of norepinephrine in plasticity of visual cortex Q. TROMBLEY BELL Dopamine release from sympathetic nerve terminals ZOVOOY . ANNIKO, L.-E. THORNELL and Recent advances in inner ear cytochemistry— . WROBLEWSKI microanalytical and immunomorphological investigations . T. WANN and A. G. MACDONALD Actions and interactions of high pressure and general anaesthetics . J. McComas, G. PRESTWICK and The sick motoneurone hypothesis of muscular dystrophy GARNER W. STONE and N. R. 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GARDNER Functional in vivo correlates of the benzodiazepine agonist-inverse agonist continuum G. BERNROIDER Cell-patterning during sexual neurogenesis J. WICKENS Electrically coupled but chemically isolated synapses: Dendritic spines and calcium in a rule for synaptic modification XVil XVili List OF PREVIOUS REVIEW ARTICLES VOLUME 32 H. PARNAS and L. A. SEGEL Facilitation as a tool to study the entry of calcium and the mechanism of neurotransmitter release T. L. TOROK Neurochemical transmission and the sodium-pump A. SHOSAKU, Y. KAYAMA, Analysis of recurrent inhibitory circuit in rat thalamus: I. Sumitomo, M. SOGITANI and Neurophysiology of the thalamic reticular nucleus K. IWAMA S. KOBAYASHI Temperature-sensitive neurons in the hypothalamus: A new hypothesis that they act as thermostats, not as transducers . A. HOFMAN On the evolution and geometry of the brain in mammals . Merri, Z. BAUM and Dynamic changes in sodium channels at demyelinated . ROSENTHAL axons . WINKLBAUER Development of the lateral line system in Xenopus L. FINLAY and S. L. PALLAS Control of cell number in the developing mammalian visual system . KOLB and I. Q. WHISHAW Plasticity in the neocortex: Mechanisms underlying recovery from early brain damage . MATTHIES In search of cellular mechanisms of memory . L. BORISON Area postrema: Chemoreceptor circumventricular organ of the medulla oblongata . KIDMAN Neurochemical and cognitive aspects of anxiety disorders <IWww> Dw xre . R. KLEMM Drug effects on active immobility responses: What they tell us about neurotransmitter systems and motor functions J.-P. TOUTANT Insect acetylcholinesterase: Catalytic properties, tissue distribution and molecular forms B. H. CuHol The effects of methylmercury on the developing brain R. J. HUXTABLE Taurine in the central nervous system and the mammalian actions of taurine VOLUME 33 M. YEADON and I. KITCHEN Opioids and respiration R. MILLER Schizophrenia as a progressive disorder: Relations to EEG, CT, neuropathological and other evidence F. L. STRAND, K. J. ROSE, ACTH modulation of nerve development and regeneration J. A. Kina, A. C. SEGARRA and L. A. ZUCCARELLI R. D. Fietps, J. M. LE BEAU, Nerve regeneration through artificial tubular implants F. M. LONGO and M. H. ELLISMAN A. NIUJIMA Nervous regulation of metabolism G. B. STEFANO Role of opioid neuropeptides in immunoregulation M. P. Witter, H. J. GROENEWEGEN, Functional organization of the extrinsic and intrinsic F. H. Lopes DA SILVA and circuitry of the parahippocampal region A. H. M. LOHMAN R. H. Evans The pharmacology of segmental transmission in the spinal cord A. PROCHAZKA Sensorimotor gain control: A basic strategy of motor systems? W. WALZ Role of glial cells in the regulation of the brain ion microenvironment A. ISHIDA-YAMAMOTO and Calcitonin gene-related peptide in the nervous tissue M. TOHYAMA T. S. Loric Human EEG and odor response N. BEN-JONATHAN, L. A. ARBOGAST and J. F. HyDE Neuroendocrine regulation of prolactin release 4 VOLUME 34 C. IpE, T. OsAWA and K. TOHYAMA Nerve regeneration through allogeneic nerve grafts, with special reference to the role of the Schwann cell basal lamina J. K. S. JANSEN and T. FLADBY The perinatal reorganization of the innervation of skeletal muscle in mammals J. L. WINSLOW Analysis and numerical solution of the dendrite equation with synapses applied to cochlear neurons Y. STERN MPTP-induced Parkinsonism M. SATOU Synaptic organization, local neuronal circuitry, and functional segregation of the teleost olfactory bulb