PROGRESS in GROWTH FACTOR RESEARCH Executive Editor John K Heath, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK Associate Editors Andrew Baird, Whittier Institute for Diabetes and Endocrinology, Cripps Memorial Hospital, Department of Molecular and Cellular Growth Biology, 9894 Genesee Ave, La Jolla, CA 92037, USA Mike Dexter, Paterson Laboratories, Christie Hospital, Holt Radium Institute, Manchester M20 9BX, UK Bengt Westermark, Department of Pathology, University Hospital, 75185 Uppsala, Sweden International Editorial Board D Barritault, Paris, France T Kishimoto, Osaka, Japan K Brown, Cambridge, UK F Lee, California, USA D Crowther, Manchester, UK C Marshall, London, UK M Czech, Massachusetts, USA W Moolenaar, Amsterdam, Holland A Dunn, Melbourne, Australia J Pledger, Tennessee, USA C-H Heldin, Uppsala, Sweden A Roberts, Maryland, USA T Honjo, Kyoto, Japan R Ross, Washington, USA C Hopkins, London, UK J J Van Wyk, North Carolina, USA Progress in Growth Factor Research is published as 1 volume of 4 issues per year (March, June, September, December) This journal is to be re-launched in 1996 as Cytokine and Growth Factor Reviews. Annual Institutional Subscription Rates for this journal are: North, Central and South America, US$334.U0, Rest of World £210.00. Sterling prices exclude VAT. Non-VAT registered customers in the European Community will be charged the appropriate VAT in addition to the price listed. Prices include postage and insurance and are subject to change without notice. Subscription enquiries from customers in North America should be sent to Elsevier Science Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, USA and for the remainder of the world to: Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK. Second class postage paid at NEWARK NJ. Postmaster send address corrections to Progress in Growth Factor Research, c/o Elsevier Science Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, USA. PUBLISHING/ADVERTISING OFFICES Elsevier Science Ltd Elsevier Science Inc. The Boulevard 660 White Plains Road Langford Lane Tarrytown, NY 10591-5153 Kidlington USA Oxford OX5 1GB UK PROGRESS in GROWTH FACTOR RESEARCH Executive Editor John K Heath, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK Associate Editors Andrew Baird, Whittier Institute for Diabetes and Endocrinology, Cripps Memorial Hospital, Department of Molecular and Cellular Growth Biology, 9894 Genesee Ave, La Jolla, CA 92037, USA Mike Dexter, Paterson Laboratories, Christie Hospital, Holt Radium Institute, Manchester M20 9BX, UK Bengt Westermark, Department of Pathology, University Hospital, 75185 Uppsala, Sweden International Editorial Board D Barritault, Paris, France T Kishimoto, Osaka, Japan K Brown, Cambridge, UK F Lee, California, USA D Crowther, Manchester, UK C Marshall, London, UK M Czech, Massachusetts, USA W Moolenaar, Amsterdam, Holland A Dunn, Melbourne, Australia J Pledger, Tennessee, USA C-H Heldin, Uppsala, Sweden A Roberts, Maryland, USA T Honjo, Kyoto, Japan R Ross, Washington, USA C Hopkins, London, UK J J Van Wyk, North Carolina, USA Progress in Growth Factor Research is published as 1 volume of 4 issues per year (March, June, September, December) This journal is to be re-launched in 1996 as Cytokine and Growth Factor Reviews. Annual Institutional Subscription Rates for this journal are: North, Central and South America, US$334.U0, Rest of World £210.00. Sterling prices exclude VAT. Non-VAT registered customers in the European Community will be charged the appropriate VAT in addition to the price listed. Prices include postage and insurance and are subject to change without notice. Subscription enquiries from customers in North America should be sent to Elsevier Science Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, USA and for the remainder of the world to: Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK. Second class postage paid at NEWARK NJ. Postmaster send address corrections to Progress in Growth Factor Research, c/o Elsevier Science Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, USA. PUBLISHING/ADVERTISING OFFICES Elsevier Science Ltd Elsevier Science Inc. The Boulevard 660 White Plains Road Langford Lane Tarrytown, NY 10591-5153 Kidlington USA Oxford OX5 1GB UK CONTENTS The Human and Mouse Fibroblast Growth Factor 6 (FGF6) Genes and their Products: Posssible Implication in Muscle Development F. COULIER, S. PIZETTE, V. OLLENDORFF, O. DELAPEYRIERE and D BIRNBAUM Cytokine Receptors and Signal Transduction A. L.-F. MUI and A. MIYAJIMA Signal Transduction by the PDGF Receptors L. CLAESSON-WELSH Serine/Threonine Kinase Receptors P. TEN DIJKE, P. FRANZEN, H. YAMASHITA, H. ICHIJO, C.-H. HELDIN and K. MIYAZONO Growth Factors in Parkinson’s Disease K. UNSICKER Vascular Endothelial Growth Factor and its Receptors G. NEUFELD, S. TESSLER, H. GITAY-GOREN, T. COHEN and B.-Z. LEVI Evolution of the Transforming Growth Factor-Beta Superfamily D. W. BURT and A. S. LAW Bibliographic Update: Nerve Growth Factor Growth Factors in Mouse Primordial Germ Cell Migration and Proliferation M. DE FELICI and M. PESCE Are Fibroblast Growth Factors Regulators of Myogenesis Jn Vivo? B. B.O LWIN, K. HANNON and A. J. KUDLA Mitogenic Factors of Corpora Lutea L. P. REYNOLDS, A. T. GRAZUL-BILSKA, S. D. KILLILEA and D. A. REDMER Regulation of Cell Proliferation and Growth by Angiotensin II W. R. HUCKLE and H. S. EARP Involvement of JAK-family Tyrosine Kinases in Hematopoietin Receptor Signal Transduction R. A. KIRKEN, H. RUI, O. M. Z. HOWARD and W. L. FARRAR Regulatory Issues in Clinical Applications of Cytokines and Growth Factors K. D. WEISS, J. P. SIEGEL and T. L.G ERRARD Cytokine Control of Cell Motility: Modulation and Mediation by the Extracellular Matrix S. L. SCHOR Bibliographic Update: Epidermal Growth Factor The Role of Neurotrophins During Successive Stages of Sensory Neuron Development A. M. DAVIES Deciphering the MAP Kinase Pathway G. L’ALLEMAIN Bibliographic Update: Transforming Growth Factors Control of Nitric Oxide Synthase Expression by Transforming Growth Factor-B: Implications for Homeostasis Y. VODOVOTZ and C. BOGDAN Fibroblast Growth Factors and Their Receptors: An Information Network Controlling Tissue Growth, Morphogenesis and Repair D. G. FERNIG and J. T. GALLAGHER Growth Factors in CNS Repair and Regeneration A. LOGAN, J. J. OLIVER and M. BERRY Bibliographic Update: Hepatocyte Growth Factor