Progress in Biophysics & Molecular Biology Contents Focussed Issue From funny current to current physiome Editorial From funny current to current physiome Kohl, P. and Richard, S. | Prologue Some deconstructed dogmas Hutter, O.F: 2 Reviews Serious workings of the funny current DiFrancesco, D. 13 Endogenous channels in HEK cells and potential roles in HCN ionic current measurements Varghese, A., TenBroek, E.M., Coles Jr., J. and Sigg, D.C. 26 Voltage-dependent calcium channels and cardiac pacemaker activity: From ionic currents to genes Mangoni, M.E., Couette, B., Marger, L., Bourinet, E., Striessnig, J. and Nargeot, J. 38 Modelling of calcium handling in airway myocytes Roux, E., Noble, P.J., Noble, D. and Marhl, M. 64 Electron-conformational model of ryanodine receptor lattice dynamics Moskvin, A.S., Philipiev, M.P., Solovyova, O.E., Kohl, P. and Markhasin, VS. 88 Voltage- and calcium-dependent inactivation in high voltage-gated Ca** channels Cens, T., Rousset, M., Leyris, J.-P., Fesquet, P. and Charnet, P. 104 ‘Ca**-induced Ca** entry’ or how the L-type Ca** channel remodels its own signalling pathway in cardiac cells Richard, S., Perrier, E., Fauconnier, J., Perrier, R., Pereira, L., Gomez, A.M. and Bénitah, J.-P. 118 Multi-scale models of local control of calcium induced calcium release Hinch, R., Greenstein, J.L. and Winslow, R.L. 136 Arrhythmogenic Ca** release from cardiac myofilaments ter Keurs, H.E.D.J., Wakayama, Y., Miura, M., Shinozaki, T., Stuyvers, B.D., Boyden, P.A. and Landesberg, A. 151 The Ca** leak paradox and “rogue ryanodine receptors”: SR Ca** efflux theory and practice Sobie, E.A., Guatimosim, S., Gomez-Viquez, L., Song, L.-S., Hartmann, H., Saleet Jafri, M. and Lederer, W.J. 172 Role of stretch-activated channels on the stretch-induced changes of rat atrial myocytes Boum Youm, J., Han, J., Kim, N., Zhang, Y.-H., Kim, E., Joo, H., Hun Leem, C., Joon Kim, S., A Cha, K. and Earm, Y.E. 186 Contents continued on inside back cover... Indexed/Abstracted in: Elsevier BLOBASE/Current Awareness in Biological Sciences; CAB Inter.; Ind. Med.; MEDLINE: Biosis Data; PASCAL-CNRS Data: Chem. Abstr. Serv., Curr. Cont.: Life Sci., Ind. Sci. Rev., ISI/ BIOMED Database, Sci. Cit. Ind. and SCISEARCH Data; Res. Alert.; Reference Update PRINTED AND BOUND IN GREAT BRITAIN BY POLESTAR WHEATONS LTD. EXETER 408 Progress in Biophysics & Molecular Biology contents continued from outside back cover Spatial aspects of intracellular pH regulation in heart muscle Vaughan-Jones, R.D., Spitzer, K.W. and Swietach, P. Protein phosphatase modulation of the intercellular junctional communication: Importance in cardiac myocytes Herve, J.C. and Sarrouilhe, D. Actions of emigrated neutrophils on Na’ and K’ currents in rat ventricular myocytes Ward, C.A., Bazzazi, H., Clark, R.B., Nygren, A. and Giles, W.R. Non-beating HL-1 cells for confocal microscopy: Application to mitochondrial functions during cardiac preconditioning Pelloux, S., Robillard, J., Ferrera, R., Bilbaut, A., Ojeda, C., Saks, V., Ovize, M. and Tourneur, Y. Dietary long-chain omega-3 fatty acids of marine origin: A comparison of their protective effects on coronary heart disease and breast cancers Judé, S., Roger, S., Martel, E., Besson, P., Richard, S., Bougnoux, P., Champeroux, P. and Le Guennec, J.-Y. Comparison of electrophysiological models for human ventricular cells and tissues Ten Tusscher, K.H.W.J., Bernus, O., Hren, R. and Panfilov, A.V. The Noble cardiac ventricular electrophysiology models in CellIML Nickerson, D.P. and Hunter, P.J. simBio: A Java package for the development of detailed cell models Sarai, N., Matsuoka, S. and Noma, A. Phase singularities and filaments: Simplifying complexity in computational models of ventricular fibrillation Clayton, R.H., Zhuchkova, E.A. and Panfilov, A.V. Dierences between left and right ventricular anatomy determine the types of reentrant circuits induced by an external electric shock. A rabbit heart simulation study Rodriguez, B., Eason, J.C. and Trayanova, N. Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart Bottino, D., Penland, R.C., Stamps, A., Traebert, M., Dumotier, B., Georgieva, A., Helmlinger, G. and Lett, G.S. Soft tissue impact characterisation kit (STICK) for ex situ investigation of heart rhythm responses to acute mechanical stimulation Cooper, P.J., Epsiein, A., MacLeod, 1.A., Schaaf, S.T.M., Sheldon, J., Boulin, C. and Kohl, P.