Name: Professor K. Ravi Acharya Affiliation: Department of Biology and Biochemistry, University of Bath Structure-function studies on proteins involved in Cancer Structural studies on proteins involved in Cancer leading to drug development Internal telephone number 6238 http://www.bath.ac.uk/bio- sci/contacts/academics/ravi_acharya/ Name: Timothy Atkins Affiliation: Royal United Hospital Medical Physics Radiation therapy aims to deliver a radiation dose to the cancerous tissue while giving minimal dose and damage to surrounding tissue. To ensure modern treatment techniques fulfil these aims an accurate 3-dimensional method of measuring the dose delivered (dosimetry) is required. One 3-dimensional dosimetry technique involves the use of radiation sensitive gels. Such gels are made of materials which alter their physical properties when exposed to radiation. This project aims to investigate changes in these gels using ultrasonic scanning and develop a 3-dimensional dosimetry system based on these gels. Ultrasound is an established and cost-effective technology which, if applied to gel dosimetry, will improve the availability of the technique and therefore the advanced treatment options. [email protected] Name: Stefan Bagby Affiliation: Department of Biology & Biochemistry, University of Bath Protein structure and function Structure and function of proteins involved in the Hippo pathway, particularly YAP, TAZ and TEAD. YAP and TAZ orchestrate diverse cellular processes involved in contact inhibition, organ size control, stem cell maintenance and cancer. TEAD is the cognate DNA binding partner of YAP. (Collaboration with Makoto Furutani-Seiki, Biology & Biochemistry). Internal telephone number 6436 http://www.bath.ac.uk/bio- sci/contacts/academics/stefan_bagby/ [email protected] Name: Dr Linda Bauld Affiliation: Department of Social and Policy Sciences and Tobacco Control Research Group, University of Bath Cancer prevention through tobacco control Evaluation of public health policies, in particular policies and interventions to prevent smoking uptake and to help people stop smoking. Internal telephone number 3160 (direct line) 4159 (tobacco control research group administrator) [email protected] http://www.bath.ac.uk/health/tobacco/linda.html Name: Dr Mark Beresford Affiliation: Royal United Hospital, Bath Breast and Urological cancers Radiotherapy Prediction of response to neoadjuvant chemotherapy Endocrine resistance Functional imaging techniques (DCE-MRI, PET including novel tracers) Member of breast NCRI clinical studies group [email protected] Name: Dr Rebecca Bowen Affiliation: Department of Oncology, Royal United Hospital, Bath Breast and gynaecological cancers Molecular profiling of cancers, inherited malignancies and epigenetics. Cytotoxics and targeted molecules. 01225 824831 [email protected] Name: Lorenzo Caggiano Affiliation: Department of Pharmacy and Pharmacology, University of Bath Efficient Synthesis of Pancratistatin Analogues Pancratistatin is a natural product obtained from the daffodil (narcissus) that has shown very interesting anti- cancer activities. We wish to synthesize new pancratistatin analogues that retain the important features necessary for biological activity, yet can be synthesised using robust chemical transformations in a short, efficient route that is amenable to large scale production. Internal telephone number 5709 http://people.bath.ac.uk/lc287/ Name: Jim Caunt Affiliation: Department of Biology and Biochemistry, University of Bath Understanding and overcoming cell signalling alterations that cause cancer and cancer drug resistance Our specialist area is cell signalling. Our work focuses on a family of enzymes called the dual specificity phosphatases (DUSPs), many of which directly inactivate members of the mitogen-activated protein kinase (MAPK) family. We use robotic automated microscopy techniques to understand how DUSPs alter MAPK signalling at high spatial resolution in cells in large scale experiments. This in turn can reveal why DUSPs have apparently paradoxical roles in tumour development and drug resistance. high content microscopy, kinase, phosphatase, signalling Internal telephone number 3346 http://www.bath.ac.uk/bio- sci/contacts/academics/christopher_caunt/ Name: Andrew Chalmers Affiliation: Department of Biology and Biochemistry, University of Bath. Epithelial cell junctions. Formation in normal tissue and loss in cancer cells. Approximately 90% of tumours originate from epithelial organs. In these tissues cells are held together by specialised Cell-Cell junctions. During cancer formation these junctions are lost allowing cells to metastasise. We study how epithelial junctions form and what happens to cell behaviour when junction formation is blocked. For example we study the oncogene PKCiota which regulates junctions. Internal telephone number 5054 http://www.bath.ac.uk/bio- sci/contacts/academics/andrew_chalmers/ Name: Ben Colleypriest Affiliation: - Department of Biology and Biochemistry, University of Bath and - Department of Gastroenterology, RUH Bath Reversion of Barrett’s Metaplasia I am looking at the role of the homeobox gene, cdx2, in the development of Barrett’s metaplasia and oesophageal adenocarcinoma. Internal telephone number 5548 [email protected] Name: Susan Doshi Affiliation: - Department of Mathematical Sciences, University of Bath - Department of Medical Physics and Bioengineering, Royal United Hospital Statistical image analysis Statistical image analysis, applied to cone-beam CT imaging of prostate radiotherapy patients with implanted fiducial markers. [email protected] Name: Christopher Eccleston Affiliation: Centre of Pain Research, University of Bath Pain  Pain management at end of life  Mechanisms of pain and analgesia  Parental and family models of pain  Evidence based pain medicine Internal telephone number 6439 [email protected] Name: Dr Ian M. Eggleston Affiliation: Department of Pharmacy & Pharmacology, University of Bath Synthetic organic chemistry and medicinal chemistry Synthesis of biologically active peptides and enzyme inhibitors, including. inhibitors of carbohydrate- processing enzymes as antifungals, anti-asthma agents. Peptide prodrugs for aminolevulinic acid-based photodynamic therapy of cancer, peptide-targeted reagents for photochemical internalisation of anticancer drugs. Novel iron chelators as skin photoprotectants/anticancer agents. Internal telephone number 3101 [email protected] Name: Dr Pedro Estrela Affiliation: Department of Electronic and Electrical Engineering, University of Bath Electrical and electrochemical biosensors Development of sensors for label-free electrical detection of biomolecular interactions such as cancer markers. Use of solid state devices and electrochemical devices for biosensing. Internal telephone number 6324 http://people.bath.ac.uk/pmdlce20/ [email protected] Name: Anna Gilmore Affiliation: School for Health, University of Bath Public Health and Tobacco Control  Evaluation of social/policy change (including globalisation and macro-economic change) and specific policy interventions on health and health behaviours (notably smoking).  Tobacco industry influence on public health and policy  Evidence based approaches to public health / tobacco control policies Internal telephone number 6810 http://www.bath.ac.uk/health/tobacco/anna.html or http://www.bath.ac.uk/pip/directory/profile/505002 Name: Richard Graham Affiliation: Consultant Radiologist (subspecialty interest in oncological imaging and nuclear medicine) Department of Radiology, Royal United Hospital Imaging of angiogenesis Using Tc99m labelled RGD to image tumour angiogenesis with SPEC-CT Internal telephone number RUH Ext 1174 [email protected] Name: Mrs Maria Hassard, CEO. Affiliation: NHS Innovations SW, Enterprise House, 25- 29 Boathouse Meadow Business Pk, Cherry Orchard Lane, Salisbury, SP2 7LD Intellectual Property protection, development and commercialisation for the NHS and its partners. Working In all healthcare areas to provide Legal advice and guidance, market research, feasibility testing, project and business planning, regulatory advice, financial planning, identification of commercialising / social enterprise partners, technology licensing and spin out company formation. telephone number: 01722 326006 [email protected] Name: Dr. Momna Hejmadi Affiliation: - Dept. Biology & Biochemistry - Centre for Extremophile Research University of Bath Hypoxia signalling pathways and DNA repair in tumours Integration of hypoxic signalling cascades with oncogenic and apoptotic pathways UV-induced DNA repair by novel photolyases Internal telephone number 3129 [email protected] http://www.bath.ac.uk/bio- sci/contacts/academics/momna_hejmadi/ Name: Tony D James Affiliation: Department of Chemistry, University of Bath Sensors for carbohydrates Synthetic / analytical chemist with supramolecular chemistry background. Particularly interested in the detection of carbohydrates, including those associated with disease states such as cancer. Methods employed include fluorescence, electrochemical and colorimetric methods etc. Internal telephone number 3810 [email protected] www.chemosensors.com Name: Robert Kelsh Affiliation: - Department of Biology & Biochemistry, University of Bath and - Centre For Regenerative Medicine, University of Bath Zebrafish developmental genetics, especially neural crest fate choice, differentiation and patterning How do multipotent neural crest (stem) cells choose in vivo between alternative fates, stably differentiate as that chosen fate and become correctly positioned (i.e. patterned) within the developing embryo? Zebrafish in vivo screens for RTK inhibitors Internal telephone number 3828 [email protected] http://www.bath.ac.uk/bio- sci/contacts/academics/robert_kelsh/