Advances in Intelligent Systems and Computing 1005 Florentino Fdez-Riverola Miguel Rocha Mohd Saberi Mohamad Nazar Zaki José A. Castellanos-Garzón Editors Practical Applications of Computational Biology and Bioinformatics, 13th International Conference Advances in Intelligent Systems and Computing Volume 1005 Series Editor Janusz Kacprzyk, Systems Research Institute, Polish Academy of Sciences, Warsaw, Poland Advisory Editors Nikhil R. Pal, Indian Statistical Institute, Kolkata, India Rafael Bello Perez, Faculty of Mathematics, Physics and Computing, Universidad Central de Las Villas, Santa Clara, Cuba Emilio S. Corchado, University of Salamanca, Salamanca, Spain Hani Hagras, School of Computer Science & Electronic Engineering, University of Essex, Colchester, UK László T. Kóczy, Department of Automation, Széchenyi István University, Gyor, Hungary Vladik Kreinovich, Department of Computer Science, University of Texas at El Paso, El Paso, TX, USA Chin-Teng Lin, Department of Electrical Engineering, National Chiao Tung University, Hsinchu, Taiwan Jie Lu, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW, Australia Patricia Melin, Graduate Program of Computer Science, Tijuana Institute of Technology, Tijuana, Mexico NadiaNedjah,DepartmentofElectronicsEngineering,UniversityofRiodeJaneiro, Rio de Janeiro, Brazil Ngoc Thanh Nguyen, Faculty of Computer Science and Management, Wrocław University of Technology, Wrocław, Poland Jun Wang, Department of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong Theseries“AdvancesinIntelligentSystemsandComputing”containspublications on theory, applications, and design methods of Intelligent Systems and Intelligent Computing.Virtuallyalldisciplinessuchasengineering,naturalsciences,computer and information science, ICT, economics, business, e-commerce, environment, healthcare,lifesciencearecovered.Thelistoftopicsspansalltheareasofmodern intelligentsystemsandcomputingsuchas:computationalintelligence,softcomput- ingincludingneuralnetworks,fuzzysystems,evolutionarycomputingandthefusion of these paradigms, social intelligence, ambient intelligence, computational neuro- science, artificial life, virtual worlds and society, cognitive science and systems, Perception and Vision, DNA and immune based systems, self-organizing and adaptive systems, e-Learning and teaching, human-centered and human-centric computing, recommender systems, intelligent control, robotics and mechatronics including human-machine teaming, knowledge-based paradigms, learning para- digms,machineethics,intelligentdataanalysis,knowledgemanagement,intelligent agents, intelligent decision making and support, intelligent network security, trust management,interactiveentertainment,Webintelligenceandmultimedia. The publications within “Advances in Intelligent Systems and Computing” are primarily proceedings of important conferences, symposia and congresses. They cover significant recent developments in the field, both of a foundational and applicable character. An important characteristic feature of the series is the short publication time and world-wide distribution. This permits a rapid and broad dissemination of research results. ** Indexing: The books of this series are submitted to ISI Proceedings, EI-Compendex, DBLP, SCOPUS, Google Scholar and Springerlink ** More information about this series at http://www.springer.com/series/11156 Florentino Fdez-Riverola (cid:129) Miguel Rocha Mohd Saberi Mohamad (cid:129) (cid:129) é ó Nazar Zaki Jos A. Castellanos-Garz n (cid:129) Editors Practical Applications of Computational Biology and Bioinformatics, 13th International Conference 123 Editors Florentino Fdez-Riverola Miguel Rocha Edificio Politécnico Department deInformática Escuela SuperiordeIngenieríaInformática, Universidade doMinho CampusUniversitario AsLagoas Braga,Portugal Ourense,Spain Nazar Zaki MohdSaberiMohamad Department ofComputer Science Faculty of Bioengineering andTechnology andSoftware Engineering Leader, Universiti Malaysia Kelantan Data ScienceResearch Group Kelantan, Malaysia Collegeof Information Technology (CIT) JoséA.Castellanos-Garzón UnitedArab Emirates University (UAEU) IBSAL/BISITE Research Group AlAin, UnitedArab Emirates University of Salamanca Salamanca, Salamanca, Spain ISSN 2194-5357 ISSN 2194-5365 (electronic) Advances in Intelligent Systems andComputing ISBN978-3-030-23872-8 ISBN978-3-030-23873-5 (eBook) https://doi.org/10.1007/978-3-030-23873-5 ©SpringerNatureSwitzerlandAG2020 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission orinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped. 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ThisSpringerimprintispublishedbytheregisteredcompanySpringerNatureSwitzerlandAG Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland Preface Next-generation sequencing technologies, together with other emerging and quite diverse experimental techniques, are evolving rapidly, creating numerous types of omics data. These are creating new challenges for the expanding fields of bioin- formaticsandcomputationalbiology,whichseektoanalyze,process,integrate,and extract meaningful knowledge from these data. This calls for new algorithms and approachesfromfieldssuchasdatabases,statistics,datamining,machinelearning, optimization, computer science, machine learning, and artificial intelligence. Clearly,biologyis increasinglybecominga scienceof information,requiring tools from the computational sciences. To address these challenges, we have seen the surgeofanewgenerationofinterdisciplinaryscientistswithastrongbackgroundin the biological and computational sciences. The International Conference on Practical Applications of Computational Biology&Bioinformatics(PACBB)isanannualinternationalmeetingdedicatedto emerging and challenging applied research in bioinformatics and computational biology. Building on the success of previous events, this volume gathers the accepted contributions for the 13th edition of the PACBB Conference after being reviewedbydifferentreviewers,fromaninternationalcommitteefrom21countries. PACBB’19 technical program includes 21 papers from authors of many countries (Australia, Colombia, Egypt, Germany, India, Malaysia, Portugal, Saudi Arabia, Slovakia,SouthKorea,Spain,Switzerland,Turkey,UnitedArabEmirates,UK,and USA) and different subfields in bioinformatics and computational biology. There will be special issues in JCR-ranked journals such as Interdisciplinary Sciences: Computational Life Sciences, Integrative Bioinformatics, Information Fusion, Neurocomputing, Sensors, Processes, and Electronics. Therefore, this event will strongly promote the interaction of researchers from diverse fields and distinct international research groups. The scientific content will be challenging and will promote the improvement of the valuable work that is being carried out by the participants. This symposium was organized by the University of Malaysia Kelantan, UniversityofMinho,UniversityofVigo,andUniversityofSalamanca.Thisedition was held in Avila, Spain, from June 26–28, 2019. We thank the sponsors (IEEE v vi Preface Systems Man and Cybernetics Society Spain Section Chapter and the IEEE Spain Section(TechnicalCo-Sponsor),IBM,Indra,Viewnext,Globalexchange,AEPIA, APPIandAIRInstitute),thefundingsupportingofthewiththeproject“Intelligent and sustainable mobility supported by multi-agent systems and edge computing” (Id.RTI2018-095390-B-C32),andfinally,theLocalOrganizationmembersandthe Program Committee members for their hard work, which was essential for the success of PACBB’19. Florentino Fdez-Riverola Miguel Rocha Mohd Saberi Mohamad Nazar Zaki José A. Castellanos-Garzón Organization General Co-chairs Mohd Saberi Mohamad Universiti Malaysia Kelantan, Malaysia Miguel Rocha University of Minho, Portugal Florentino Fdez-Riverola University of Vigo, Spain Nazar Zaki United Arab Emirates University, United Arab Emirates José Antonio Castellanos University of Salamanca, Spain Garzón Program Committee Vera Afreixo University of Aveiro, Portugal Amparo Alonso-Betanzos University of A Coruña, Spain Rene Alquezar Technical University of Catalonia, Spain Manuel Álvarez Díaz University of A Coruña, Spain Jeferson Arango Lopez Universidad de Caldas, Colombia Joel Arrais University of Coimbra, Portugal Julio Banga Instituto de Investigaciones Marinas (CSIC), Spain Carlos Bastos University of Aveiro, Portugal Carole Bernon IRIT/UPS, France Lourdes Borrajo University of Vigo, Spain Ana Cristina Braga University of Minho, Portugal Boris Brimkov Rice University, USA Guillermo Calderon Autonomous University of Manizales, Colombia Rui Camacho University of Porto, Portugal José Antonio Castellanos University of Salamanca, Spain Garzón vii viii Organization Luis Fernando Castillo Universidad de Caldas, Colombia José Manuel Colom University of Zaragoza, Spain Fernanda Brito Correia DETI/IEETA, University of Aveiro, and DEIS/ISEC/Polytechnic Institute of Coimbra, Portugal Daniela Correia University of Minho, Portugal Roberto Costumero Technical University of Madrid, Spain Francisco Couto Faculty of Sciences, University of Lisbon, Portugal Yingbo Cui National University of Defense Technology, China Masoud Daneshtalab KTH Royal Institute of Technology in Stockholm, Sweden Javier De Las Rivas University of Salamanca, Spain Sergio Deusdado Polytechnic Institute of Bragança, Portugal Oscar Dias University of Minho, Portugal Fernando Diaz University of Valladolid, Spain Ramón Doallo University of A Coruña, Spain Xavier Domingo-Almenara Rovira i Virgili University, Spain Pedro Ferreira Ipatimup—Institute of Molecular Pathology and Immunology of the University of Porto, Portugal João Diogo Ferreira Faculty of Sciences, University of Lisbon, Portugal Nuno Filipe University of Porto, Portugal Mohd Firdaus-Raih National University of Malaysia, Malaysia Nuno A. Fonseca University of Porto, Portugal Dino Franklin Federal University of Uberlandia, Spain Alvaro Gaitan Café de Colombia, Colombia Narmer Galeano Universidad Catolica de Manizales, Colombia Vanessa Maria Gervin Hathor Group, Brazil Rosalba Giugno University of Verona, Italy Josep Gómez Rovira i Virgili University, Spain Patricia Gonzalez University of A Coruña, Spain Consuelo Gonzalo-Martin Universidad Politécnica de Madrid, Spain David Hoksza Univerzita Karlov, Czech Republic Natthakan Iam-On Mae Fah Luang University, Thailand Gustavo Isaza University of Caldas, Colombia Paula Jorge University of Minho, Portugal Martin Krallinger National Center for Oncological Research, Spain Rosalia Laza Universidade de Vigo, Spain Thierry Lecroq University of Rouen, France Giovani Librelotto Federal University of Santa Maria, Portugal Filipe Liu CEB, University of Minho, Portugal Ruben Lopez-Cortes University of Vigo, Spain Organization ix Hugo López-Fernández University of Vigo, Spain Eva Lorenzo Iglesias University of Vigo, Portugal Analia Lourenco University of Vigo, Spain Sara Madeira Faculty of Sciences, University of Lisbon, Portugal Marcelo Maraschin Federal University of Santa Catarina, Brazil Marcos Martinez-Romero Stanford University, USA Sérgio Matos IEETA, Universidade de Aveiro, Portugal Mohd Saberi Mohamad Universiti Teknologi Malaysia, Spain Loris Nanni University of Padua, Italy José Luis Oliveira University of Aveiro, Portugal Maria Olivia Pereira University of Minho, Centre of Biological Engineering, Portugal Alexandre Perera Lluna Technical University of Catalonia, Spain Martin Pérez Pérez University of Vigo, SING group, Spain Gael Pérez Rodríguez University of Vigo, SING group, Spain Cindy Perscheid Hasso Plattner Institute, Denmark Armando Pinho University of Aveiro, Portugal Ignacio Ponzoni National South University, Argentina Antonio Prestes Garcia Universidad Politécnica de Madrid, Spain Heri Ramampiaro Norwegian University of Science and Technology, Norway Juan Ranea University of Malaga, Spain Miguel Reboiro-Jato University of Vigo, Spain Jose Ignacio Requeno University of Zaragoza, Spain João Manuel Rodrigues DETI/IEETA, University of Aveiro, Portugal Alejandro Rodriguez Universidad Politécnica de Madrid, Spain Alfonso Rodriguez-Paton Universidad Politécnica de Madrid, Spain Miriam Rubio Camarillo National Center for Oncological Research, Spain Gustavo Santos-Garcia Universidad de Salamanca, Spain Pedro Sernadela University of Aveiro, Portugal Amin Shoukry Egypt Japan University of Science and Technology, Egypt Naresh Singhal University of Auckland, New Zealand Ana Margarida Sousa University of Minho, Portugal Niclas Ståhl University of Skovde, Sweden Carolyn Talcott SRI International, USA Mehmet Tan TOBBUniversityofEconomicsandTechnology, Turkey Rita Margarida Teixeira ESTG - IPL, Portugal Ascenso Mark Thompson LUMC, Netherland Antonio J. Tomeu-Hardasmal University of Cadiz, Spain Alicia Troncoso Universidad Pablo de Olavide, Spain Turki Turki New Jersey Institute of Technology, USA