PHARMACOLOGY & THERAPEUTICS Chemotherapy, Toxicology and Metabolic Inhibitors Executive Editor: A. C. Sartorelli Yale University School of Medicine, Department of Pharmacology, 333 Cedar Street, New Haven, Connecticut 06510, USA General and Systemic Pharmacology Executive Editor: W. C. Bowman University of Strathclyde, Department of Physiology & Pharmacology, Royal College, 204 George Street, Glasgow GI 1XW, Scotland Clinical Pharmacology and Therapeutics Executive Editor: A. M. Breckenridge University of Liverpool, Department of Pharmacology & Therapeutics, P.O. Box 147, Liverpool L69 3BX, England Subscription Rates—Annual Institutional Subscription Rate (1993): £1100.00 (US$1760.00). Sterling prices are definitive. US dollar prices are quoted for convenience only, and are subject to exchange rate fluctuation. Prices include postage and insurance and are subject to change without notice. Subscription rates for Japan are available on request. Subscription enquiries from customers in North America should be sent to Pergamon Press Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, U.S.A., and for the remainder of the world to Pergamon Press Ltd, Headington Hill Hall, Oxford OX3 OBW, England. At the end of the year, the Subscriber will receive, free, the annual subject index. © 1993 Pergamon Press Ltd Published monthly —twelve issues per annum Second class postage paid at RAHWAY NJ. Postmaster send address corrections to Pergamon Press Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, U.S.A. Back Issues Back issues of all previously published volumes are available direct from Pergamon Press offices. Publishing and Advertising Offices Pergamon Press Ltd Pergamon Press Inc. Headington Hill Hall 660 White Plains Road Oxford OX3 0BW Tarrytown England New York 10591-5153, U.S.A. PHARMACOLOGY & THERAPEUTICS Chemotherapy, Toxicology and Metabolic Inhibitors Executive Editor: A. C. Sartorelli Yale University School of Medicine, Department of Pharmacology, 333 Cedar Street, New Haven, Connecticut 06510, USA General and Systemic Pharmacology Executive Editor: W. C. Bowman University of Strathclyde, Department of Physiology & Pharmacology, Royal College, 204 George Street, Glasgow GI 1XW, Scotland Clinical Pharmacology and Therapeutics Executive Editor: A. M. Breckenridge University of Liverpool, Department of Pharmacology & Therapeutics, P.O. Box 147, Liverpool L69 3BX, England Subscription Rates—Annual Institutional Subscription Rate (1993): £1100.00 (US$1760.00). Sterling prices are definitive. US dollar prices are quoted for convenience only, and are subject to exchange rate fluctuation. Prices include postage and insurance and are subject to change without notice. Subscription rates for Japan are available on request. Subscription enquiries from customers in North America should be sent to Pergamon Press Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, U.S.A., and for the remainder of the world to Pergamon Press Ltd, Headington Hill Hall, Oxford OX3 OBW, England. At the end of the year, the Subscriber will receive, free, the annual subject index. © 1993 Pergamon Press Ltd Published monthly —twelve issues per annum Second class postage paid at RAHWAY NJ. Postmaster send address corrections to Pergamon Press Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, U.S.A. Back Issues Back issues of all previously published volumes are available direct from Pergamon Press offices. Publishing and Advertising Offices Pergamon Press Ltd Pergamon Press Inc. Headington Hill Hall 660 White Plains Road Oxford OX3 0BW Tarrytown England New York 10591-5153, U.S.A. Volume 51, 1991, Numbers 1-3 CONTENTS Number! Assays for angiogenesis: A review: R. Auerbach, W. Auerbach and I. Polakowski Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function: W. J. Thompson The inhibition of glutathione S-transferases: Mechanisms, toxic consequences and therapeutic benefits: P. J. van Bladeren and B. van Ommen Gene expression of nonsegmented negative strand RNA viruses: A. K. Banerjee, S. Barik and B. P. De Protein kinase C: S. Stabel and P. J. Parker Structure and function of inositol trisphosphate receptors: C. W. Taylor and A. Richardson The role of glutathione-dependent enzymes in drug resistance: S. M. Black and C. R. Wolf Number 2 Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy: A. Meister Macrophage-derived angiogenesis factors: C. Sunderkétter, M. Goebeler, K. Schulze-Osthoff, R. Bhardwaj and C. Sorg The biochemistry of compounds with anti-microtubule activity in plant cells: L. C. Morejohn and D. E. Fosket Rhythms in second messenger mechanisms: K. Witte and B. Lemmer The biochemical pharmacology of nogalamycin and its derivatives: L. H. Li and W. C. Krueger Interactions of the catharanthus (vinca) alkaloids with tubulin and microtubules: R. H. Himes The cardiovascular system and daily variation in response to antihypertensive and antianginal drugs: Recent advances: B. Lemmer Drug metabolism in carcinogenesis and cancer chemotherapy: M. A. Graham, R. J. Riley and D. J. Kerr Number 3 Significance and measurement of DNA double strand breaks in mammalian cells: M. C. Elia, J. G. DeLuca and M. O. Bradley Unique features of the trophoblast interferons: R. M. Roberts, J. C. Cross and D. W. Leaman Drug glucuronidation in humans: J. O. Miners and P. I. Mackenzie Embryonic angiogenesis factors: W. Risau Interactions of colchicine with tubulin: S. B. Hastie Structure and function of G proteins: J. Olate and J. E. Allende Rhythms in neurotransmitter turnover: Focus on the serotonergic system: K. F. Martin