Curriculum Vitae October, 2016 PETER ANTHONY CROOKS, MSc, PhD, DSc (Manc), FRSC, FRPharmS, CSci, CChem Simmons Chair in Cancer Research Professor and Chairman Department of Pharmaceutical Sciences College of Pharmacy University of Arkansas for Medical Sciences 4301 W. Markham St., #522-3 Little Rock, AR 72205-7199 Email: [email protected] Tel. (501)686-6495 Fax (501)686-8136 Emeritus Professor Department of Pharmaceutical Sciences College of Pharmacy University of Kentucky Lexington, KY 40356 I. General Information Home Address: 22 Ridgefield Cove, Little Rock, AR 72223 Telephone: (859) 321-6001 Email [email protected] Licensure: Registered Pharmacist Year Certified: 1969 Name of Speciality Board: Royal Pharmaceutical Society of Great Britain State/Country: Great Britain II. Education 1958-1966 Sir Percy Jackson Grammar School, Doncaster, Yorkshire, United Kingdom 1966 University of Manchester, United Kingdom B.Sc. (Hons) First Class in Pharmacy 1967 University of Manchester, United Kingdom M.Sc. in Pharmacy 1970 University of Manchester, United Kingdom Ph.D. in Pharmacy 2011 University of Manchester, United Kingdom D.Sc., Faculty of Medical and Human Sciences 1 III. Professional Experiences 1966-1967 Preregistration pharmacy training, University of Manchester, UK IV. Academic Appointments 1966-1967 Laboratory Demonstrator (full time), University of Manchester, United Kingdom 1968-1970 Assistant Lecturer in Pharmacy (full time), University of Manchester, United Kingdom 1969-1972 Assistant Warden and Tutor-in-residence, Moberly Tower, Graduate Student Hall of Residence, University of Manchester Campus, United Kingdom 1970-1980 Lecturer in Pharmacy (with tenure) (full time), University of Manchester, United Kingdom 1976 Visiting Professor*, (Academic Links Scheme) (full time) University of Naples, Italy 1976-1978 Research Associate*, (Secondment) (full time) Yale Medical School, Department of Pharmacology, USA 1980-1981 Senior Lecturer in Pharmacy (full time) University of Manchester, United Kingdom 1981-1991 Associate Professor (full time) College of Pharmacy University of Kentucky, USA 1983-pres. Associate Professor (joint appointment) Graduate Center for Toxicology, University of Kentucky, USA 1988-1989 Visiting Scientistx (sabbatical leave) (full time) Southern Research Institute, Birmingham, Alabama, USA 1991-pres. Professor (full time) College of Pharmacy University of Kentucky, USA 1991-pres. Professor (joint appointment) Graduate Center for Toxicology, University of Kentucky, USA 1996-1997 Visiting Scientistx (sabbatical leave) (full time) RJR/Targacept, Winston-Salem, North Carolina, USA 2002-2004 Commonwealth University Professor in Pharmaceutical Sciences 2 College of Pharmacy, University of Kentucky, USA 2004-2011 George A. Digenis Professor in Drug Design and Discovery Department of Pharmaceutical Sciences College of Pharmacy, University of Kentucky, USA 2011-pres. Professor and Chairman, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, USA 2011-pres. Simmons Chair in Cancer Research, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, USA Other Appointments 1986-2011. Member, Lucille P. Markey Cancer Center, University of Kentucky 1989-2011. Member, Center on Aging, University of Kentucky 1994-2011. Member, Center of Membrane Sciences, University of Kentucky *On leave of absence (secondment) from the University of Manchester x On leave of absence (sabbatical) from the University of Kentucky V. Teaching Activity Organic Chemistry for 1st Year Pharmacy Students, (4 credits, major responsibility), University of Manchester, Department of Pharmacy. Advanced Heterocyclic and Alicyclic chemistry for Final Year Honors Pharmacy Students, (3 credits, major responsibility), University of Manchester, Department of Pharmacy. Absorption Spectroscopy of Organic Compounds, (2 credits, major responsibility), University of Manchester, Department of Pharmacy. Natural Products Chemistry/ Biogenesis of Natural Products of Medicinal Interest, (3 credits, major responsibility), University of Manchester, Department of Pharmacy. Basic Understanding of Spectroscopic Methods in Pharmaceutical Chemistry and their Application to Drug Analysis, (3 credit didactic, 3 credit lab; secondary responsibility), University of Manchester, Department of Pharmacy. Pharmaceutical Chemistry-Drug Design: Physico-chemical Aspects of Drug Actions, Drug- Receptor Interactions, Drug Metabolism and Chemotherapeutic Agents, (6 credit, 2 semester course, major responsibility), University of Manchester, Department of Pharmacy. Bio-organic Mechanisms in Drug Action, (Honors option, 3 credit course, major responsibility), University of Manchester, Department of Pharmacy. 3 Principles of Medicinal Chemistry, (PHR 340) (4 credit hours, joint responsibility), University of Kentucky College of Pharmacy. Bio-organic Mechanisms (PHR 762) (3 credit, primary responsibility), University of Kentucky College of Pharmacy. Graduate Seminars in Medicinal Chemistry, (PHR 778) (1 credit per semester, 3 semester course), University of Kentucky College of Pharmacy. All-College Graduate Seminar in Pharmacy (PHR 776) (Coordinator-Major responsibility), University of Kentucky College of Pharmacy. Pharmaceutical Analysis (PHR 801), (4 credit course, secondary responsibility) University of Kentucky College of Pharmacy. Drug Metabolism, Theory and Practice, (PHR 664) (3 credit course, primary responsibility), University of Kentucky College of Pharmacy. Detoxification Mechanisms, (TOX 640), (3 credit course, secondary responsibility), University of Kentucky, Graduate Center for Toxicology. Modern Methods in Pharmaceutical Analysis (PHR 510), (5 credit course, secondary responsibility), University of Kentucky College of Pharmacy. Topics in Pharmaceutical Sciences - Use of High Field Nuclear Magnetic Resonance Spectroscopy in Structural Analysis (PHR 760-003) (2 credit course, primary responsibility), University of Kentucky College of Pharmacy. Drug Form Design, (PHR 944), (3 credit course), University of Kentucky College of Pharmacy, primary responsibility. Topics in Pharmaceutical Sciences: Drug Targets and Actions, (PHR 760-008, 3 credit course), University of Kentucky College of Pharmacy, secondary responsibility. Special Topics in Pharmaceutical Sciences: Drug Design (FAGG 6213, 2 credit course, Fall 2004), School of Pharmacy, University of Puerto Rico San Juan, primary responsibility. Topics in Pharmaceutical Sciences: Molecular Neurobiology of Abused Drugs, (PHR 760-008, 3 credit course, Fall semester), University of Kentucky College of Pharmacy, secondary responsibility. Biosynthesis of Natural Products (PHR 620, 3 credit course, Fall semester), University of Kentucky College of Pharmacy, secondary responsibility. Design of Molecules with Drug-like Properties (PHS 760-019, 3 credit course, Fall semester), University of Kentucky College of Pharmacy, primary responsibility. Good Regulatory Practices (PHSC 6043, 3 credit course, Spring semester), College of Pharmacy, University of Arkansas for Medical Sciences, primary responsibility. 4 VI. Supervision of Graduate Students, Post-doctoral Fellows and Visiting Scientists Major Professor for the following students who have graduated with the degree of Ph.D. or M.S. Ph.D. Students Graduation Year Howard E. Rosenberg (University of Cambridge, U.K.) 1975 Richard Szyndler (University of Manchester, U.K.) 1976 Trevor Deeks (University of Manchester, U.K.) 1979 Peter Burn (University of Manchester, U.K.) 1981 Eric Benghiat (University of London, U.K.) 1982 Mohamad S. Shaker (University of Jordan) 1983 Kenneth C. Cundy (University of Manchester, U.K.) 1984 Abdul Al-Ghani Hoodi (University of Bagdhad, Iraq) 1986 Samirah Hassan (University of Baghdad, Iraq) 1987 Chukwemeka G. Nwosu (University of Pennsylvania, U.S.A.) 1987 Riad Awad (University of Jordan) 1987 William F. Pool (University of California, San Diego, U.S.A.) 1987 C. Steven Godin (University of Massachusetts, U.S.A.) 1988 Hana Dannan (University of Damascus, Syria) 1988 Santosh C. Kottayil (University of Poona, India) 1993 Supinan Na-Phuket (University of the Phillipines) 1997 Jyothi Matharu (University of Bombay, India) 1997 Omar Ghosheh (University of Jordan) 2000 Michelle Howard-Sparks (University of Kentucky, U.S.A.) 2000 Aimee Bence (Houghton College, U.S.A.) 2001 Joshua R. Ring (Georgia Tech., U.S.A.) 2006 Joshua T. Ayers (Dartmouth College, U.S.A.) 2006 Aaron Haubner (University of Kentucky, U.S.A.) 2008 Harpreet K. Dhooper (Delhi University, New Delhi, India) 2010 Ujjwal Chakraborty (Delhi University, New Delhi, India) 2011 Joshua Eldridge (Kentucky State University, USA) 2013 John Culver (Western Kentucky University, USA) 2014 Nikhil Reddy Madadi (Eastern Kentucky University) 2014 Jai Shankar Yadlapalli (Andhra University, Andhra Pradesh, India) 2015 Zheng Chen (Brandeis University) 2015 M.S. Students Graduation Year Trevor Deeks (University of Manchester, UK) 1976 Nabil N. Daoud (University of Baghdad, Iraq) 1981 Jeffrey Leigh (University of Manchester, UK) 1982 Amal N. A. Al-Taae (University of Baghdad, Iraq) 1983 Shyamala Chandrasekaran (University of Poona, India) 1993 Min Li (University of Beijing, People’s Republic of China) 1996 David Worthen (St. Johns University, U.S.A.) 1997 Jason Swango (Berea College, U.S.A.) 1997 5 SungHee Park (South Korea) 2011 Research Supervision of the following Post-doctoral Fellows, Visiting Scientists, and Scholars: Postdoctoral Fellows Graduation Year Dr. Francesco DeSimone (University of Naples, Italy) 1974,1975 Dr. Eliseo Ramundo (University of Naples, Italy) 1975 Dr. Antonio Dini (University of Naples, Italy) 1975 Dr. E. Huq (Bangladesh) 1976 - 1977 Dr. Michio Sato (Japan) 1982 - 1983 Dr. Abdulghani A. Houdi (University of Manchester, United Kingdom) 1985 - 1986 Dr. Terence Tita (University of Kentucky, U.S.A.) 1987 Dr. Chen-Yie Chien (U.S.A.) 1986 - 1988 Dr. Anita Rathore (India) 1989 - 1991 Dr. Balwinder Bhatti (India) 1990 - 1999 Dr. Alain Ravard (France) 1991 - 1995 Dr. Naranjan Deo (Clemmson University, U.S.A.) 1992 - 1995 Dr. Grazyna Cynkowska (Poland) 1993 - 2000 Dr. Tadeusz Cynkowski (Poland) 1993 - 2000 Dr. Latch Trifonov (Bulgaria) 1994 - 1995 Dr. Chongxi Yu (USA) 1995 - 1996 Dr. Muhammad Qureshi (Pakistan) 1996 - 1998 Dr. Haeil Park (South Korea) 1996 - 1998 Dr. Srishailkumar B. Hadimani (India) 1996 - 1999 Dr. Raj Puri (India) 1997 - 1998 Dr. Wenkui Li (Hong Kong) 1998 - 1999 Dr. Xu- Rui (People’s Republic of China) 1998 - 2001 Dr. Xiaochen Wei (University of Kentucky, U.S.A.) 1999 - 2005 Dr. Vijayakumar Sonar (India) 2000 - 2008 Dr. Marhaba Hojahmat (Japan) 2000 - 2002 Dr. Neelakantan Sundar (India) 2000 - 2009 Dr. Guangrong Zheng (People's Republic of China) 2000 - 2011 Dr. Jianjun Gao (Japan) 2000 - 2001 Dr. Xiao Ming Yu (People's Republic of China) 2002 - 2003 Dr. Jianhong Chen (People's Republic of China) 2002 - 2006 Dr. Abeer M. Al Ghananeem (University of Kentucky, U.S.A.) 2002 - 2007 Dr. Mohamed Hamad (University of Sudan) 2002 - 2006 Dr. Timothy Benson (University of Manchester, U.K.) 2003 Dr. Fang Zheng (People’s Republic of China) 2003 - 2008 Dr. Zhenfa Zhang (People’s Republic of China) 2004 - 2009 Dr. Ahmad Malkawi (University of Jordan) 2004 - 2011 Dr. Shama Nasim (University of Karachi) 2004 - 2010 Dr. Venkatraj Muthusamy (Bharathidasan University, India) 2005 - 2006 Dr. Zaineb Fadhel (University of Bhagdad, Iraq) 2005 - present Dr. Buchi N. Nalluri (Andhra University, India) 2005 - 2007 Dr. Ashish Vartak (University of Minnesota, U.S.A) 2006 - 2009 Dr. Thirupathi Reddy (National Institute of Technology, Warangal, India) 2006 - 2011 Dr. Vipin Purushothaman Nair (South Africa) 2006 - 2008 Dr. Syed Raziullah Hussaini (University of Oxford, UK) 2006 - 2007 Dr. Vijender R. Adelli (Indian Institute of Chemical Technology) 2007 6 Dr. Narismha R. Penthala (National Institute of Technology, Warangal, India) 2007 - present Dr. Purushothama Rao Ponugoti (Indian Institute of Chemical Technology, Hyderabad, India) 2009 - 2011 Dr. Derong Ding (Shanghai Institute of Materia Medica; CAS) 2010 - 2011 Dr. Raghotham Reddy Pinninti (National Institute of Technology, Warangal, India) 2010 - 2011 Dr. J. Venu Madhav (National Institute of Technology, Warangal, India) 2012 - present Dr. Shoban Babu Bommagani 2013 - present Dr. Shyamsunder R. Joolakanti 2013 – 2015 Dr. Punnamchandar Ramidi 2016 Dr. Soma Shekar Dachavaram 2016 - present Visiting Scientists Dr. Jerzy W. Krechniak (Poland) 1984 - 1985 Dr. Lyaquatali A. Damani (University of Manchester, U.K.) 1985 - 1986 Dr. Zhao-Xia Fang (People's Republic of China) 1988 - 1991 Dr. Talal A. Aburjai (University of Jordan) 2004 Dr. Bavntula Rajitha (National Institute of Technology, Warangal, India) 2008, 2012 Dr. Yucel Kadioglu (Ataturk University, Turkey) 2009 - 2010 Dr. Adejuwon Adewale Adeneye (Fulbright Scholar; University of Lagos, Africa) 2010 - 2011 Current Chairman or Member of the Following Ph.D. Dissertation Committees: (University of Kentucky, University of Arkansas for Medical Sciences, University of Colorado): Mike Clark (Member) Yibin Qiu (Member) Jay Shanker Yadlappalli (Chairman) Zheng Chen (Chairman) Kevin Howk (Chairman) Trey Curtis-Lowery (Chairman) Anqi Wan (Chairman) Gauri Lamture (Chairman) Maroof K. Zafar (Member) Daesong Jang (Member) Jessica Ponder (Member) Past Chairman or Member of the following Ph.D. dissertation committees (University of Kentucky): K. Abdul-Nabi Ali, Pharmaceutical Sciences (Member) Michael B. Maurin, Pharmaceutical Sciences (Member) William Rencher, Pharmaceutical Sciences (Member) George Garbolis, Pharmaceutical Sciences (Member) Kenneth Cundy, Pharmaceutical Sciences (Chairman) Prince Hinson, Pharmaceutical Sciences (Member) Rong Fong Shen, Pharmaceutical Sciences (Member) Lee Young Chau, Chemistry (Member) Carl Niehaus, Pharmaceutical Sciences (Member) David Wells, Pharmaceutical Sciences (Member) 7 Ralph Bouvette, Pharmaceutical Sciences (Member) Fatima Tawfig, Pharmaceutical Sciences (Member) Riad Awad, Pharmaceutical Sciences (Co-Chairman) Samirah Hassan, Pharmaceutical Sciences (Chairman) Chukwuemeka Nwosu, Toxicology (Chairman) William Pool, Toxicology (Chairman) Steven Godin, Pharmaceutical Sciences (Chairman) Hana Dannan, Pharmaceutical Sciences (Co-Chairman) Nurul Islam, Chemistry (Member) Chang-Jin Wang, Pharmaceutical Sciences (Member) Margaret Britto, Pharmaceutical Sciences (Member) Janan Jona, Pharmaceutical Sciences (Member) Santosh C. Kottayil, Chemistry (Co-Chairman) Paul Yeary, Chemistry (Member) Trupti Deshmukh, Pharmaceutical Sciences (Member) Zhinan Xia, Pharmaceutical Sciences (Member) Bin-Sun, Chemistry (Co-Chairman) Danita M. Saxon, Nutritional Sciences (Member) Randy Finch, Pharmaceutical Sciences (Member) Shrong-Shi Lin, Pharmaceutical Sciences (Member) Danny Kao, Pharmaceutical Sciences (Member) Donna Isbell, Biochemistry (Member) Yi Li, Chemistry, Chemistry (Member) Min Li, Toxicology (Chairman) Robert Trupp, Chemistry (Member) Bassam Tashtoush, Pharmaceutical Sciences (Member) Ashraf Traboulsi, Pharmaceutical Sciences (Member) Prakash N. Nair, Toxicology (Member) Mohammed S. Siddiqui, Chemistry (Member) LiHong Teng, Toxicology (Member) David Worthen, Pharmaceutical Sciences (Chairman) Supinan Na Phuket, Pharmaceutical Sciences (Chairman) Jyothi Matharu, Pharmaceutical Sciences (Chairman) Chris Lockwood, Pharmaceutical Sciences (Member) Mark Strohm, Pharmaceutical Sciences (Member) Jason Swango, Pharmaceutical Sciences (Chairman) Melissa Varner, Chemistry (Member) Jaber Qasem, Pharmaceutical Sciences (Member) Chinh Vu, Pharmaceutical Sciences (Member) Omar Ghosheh, Pharmaceutical Sciences (Chairman) Michelle Howard-Sparks, Pharmaceutical Sciences (Chairman) Freddie Hughes, Jr., Chemistry (Member) Marlon Jones, Chemistry (Chairman) Xiaochen Wei, Agronomy (Member) Alison Anderson, Pharmaceutical Sciences (Co-Chairman) Aimee Bence, Pharmaceutical Sciences (Chairman) Lincoln Wilkins, Pharmaceutical Sciences (Member) Dong Zhang, Pharmaceutical Sciences (Co-Chairman) Joshua R. Ring, Pharmaceutical Sciences, (Chairman) Lisa Middleton, Pharmaceutical Sciences (Member) Chandra Patel, Pharmaceutical Sciencs (Co-Chairman) Joshua T. Ayers, Pharmaceutical Sciences (Chairman) Tao Liu, Pharmaceutical Sciences (Member) Korie G. Sell, Pharmaceutical Sciences (Chairman) 8 Joseph Medendorp, Pharmaceutical Sciences (Member) Paul Kiptoo, Pharmaceutical Sciences (Member) Stan Banks, Pharmaceutical Sciences (Member) Aaron Haubner, Pharmaceutical Sciences (Chairman) Yik Ho, Pharmaceutical Sciences (Member) Hapreet K. Dhooper (Chairman) Mikolaj Milewski (Member) Yolanda Williams (Member) Ujjwal Chakraborty (Chairman) David Horton (Member) Cao Zheng (Member) Joshua Eldridge (Chairman) Asif Pathan (Member) Nisha Nanaware (Member) John Culver (Chairman) Nikhil Reddy Madadi (Chairman) Zheng Chen (Chairman) VII. Administrative Activity and University Service At the University of Manchester Staff-Student Committee, Department of Pharmacy 1968 - 1970 Member of the Board of the Faculty of Science 1970 - 1981 Secretary, Safety Committee, Department of Pharmacy 1978 - 1981 Member of Convocation, University of Manchester 1978 - present Co-ordinator for Research Seminars 1978 - 1981 Senate Watchdog Committee (member) 1979 - 1980 Member of Postgraduate Committee, Faculty of Science 1980 - 1981 Postgraduate Admissions Officer, Department of Pharmacy 1980 - 1981 At the University of Kentucky College Student Affairs Committee (Member) 1981 - 1982 Graduate Program Committee (Member) 1981 - 1986 Curriculum Committee (Member) 1982 - 1985 Honors and Recognition Committee (Member) 1982 - 1984 Library Committee (Chairman) 1982 - 1985 Research and Seminar Committee (Member 1983-1984, 1983 - 1988 Chairman 1984-1986; Member 1986-1988) Pharmacy Residency Seminar Committee (Member) 1984 - 1985 Nominations Committee (Member) 1985 - 1986 Buildings, Space, Services and Safety Committee (Member, 1985-1986; Chairman, 1986-1987) 1985 - 1987 Administrative Council Committee (Member) 1985 - 1988 Building and Safety Committee (Chairman) 1987 - 1988 Nuclear Magnetic Resonance Committee (Chairman) 1987 - 1999 Graduate Program Coordinator, Division of Medicinal Chemistry and Pharmaceutics 1989 - 1992 Nominations Committee (Chairman) 1989 - 1990 9 Graduate Program Committee (Member) 1989 - 1996 Building and Lab Safety (Member) 1989 - 1996 History of Drugs and Pharmacy (Member) 1990 - 1991, and 1992 - 1993 Admissions Committee (Member) 1991 - 1996 Continuing Education (Member) 1991 - 1992 Honor Code Committee (Member) 1992 - 1999 College of Pharmacy Safety Committee (Chairman) 1997 - 2003. Executive Committee, Division of Pharmaceutical Sciences, College of Pharmacy (Member) 2000 - 2002 Faculty Search Committee (Pharmaceutics Position)(Member) 2000 - 2001 Faculty Search Committee (Drug Discovery and Design Positions) 2001 - 2002 (Chairman) Nominations Committee (Member) 2003 - 2004 College of Pharmacy Safety Committee (Member) 2004 - 2005 DGRC Committee 2004 - 2005. DDD-AGS Coordinator 2004 - 2005. Faculty Search Committee (Drug Discovery and Design Positions) 2005 - 2006 (Member) DGRC Committee (Member) 2005 - 2006 Faculty Search Committee (Drug Discovery and Design Positions) 2006 - 2007 (Member) Safety and Security Committee (Member) 2007 - 2010 Appointment, Promotion, and Tenure Committee (Member) 2007 - 2010 Conflict of Interest Management Committee (Member) 2007 – 2010 Seminar Committee (Chairman) 2009 - 2010 Promotion and Tenure Committee (Chairman) 2010 Executive Committee, Department of Pharmaceutical Sciences (Member) 2010 - on Medical Center Medical Center Safety Committee (Member) 1987 - 1989 Nuclear Magnetic Resonance Imaging 1987 - pres. Users Committee (Member) International Affairs Committee (Member) 1995 - 1996 College of Medicine Unit Review Team 2002 - 2003 Experimental Therapeutics Steering Committee, Markey Cancer Center 2010 - present University Graduate School (Member) 1982 - present. Faculty Forum (College of Pharmacy representative) 1984 - 1986 International Students Committee (Member) 1986 - 1990 Council for International Programs (Member) 1986 - 1990 Executive Committee, Graduate Center for Toxicology (Chairman) 1988 - 1990 Life Sciences Mass Spectroscopy Oversight Committee (Member) 1990 - 2000 Nuclear Magnetic Resonance Users Committee (Member) 1989 - pres. 10