Current Topics in Microbiology and Immunology Volume 361 SeriesEditors KlausAktories MedizinischeFakultät,InstitutfürExperimentelleundKlinischePharmakologieundToxikologie,Abt.IAlbert- Ludwigs-UniversitätFreiburg,Albertstr.25,79104Freiburg,Germany RichardW.Compans DepartmentofMicrobiologyandImmunology,EmoryUniversity,1518CliftonRoad,CNR5005,Atlanta, GA30322,USA MaxD.Cooper Department of Pathology and Laboratory Medicine, Georgia Research Alliance, Emory University, 1462 CliftonRoad,Atlanta,GA30322,USA JorgeE.Galan BoyerCtr.forMolecularMedicine,SchoolofMedicine,YaleUniversity,295CongressAvenue,room343, NewHaven,CT,06536-0812,USA YuriY.Gleba ICONGeneticsAG,BiozentrumHalle,Weinbergweg22,06120Halle,Germany TasukuHonjo DepartmentofMedicalChemistry,FacultyofMedicine,KyotoUniversity,Sakyo-ku,Yoshida,Kyoto606-8501, Japan YoshihiroKawaoka SchoolofVeterinaryMedicine,UniversityofWisconsin-Madison,2015LindenDrive,Madison,WI53706, USA HilaryKoprowski BiotechnologyFoundation,Inc.,119SibleyAvenue,Ardmore,PA19003,USA BernardMalissen Centred’ImmunologiedeMarseille-Luminy,ParcScientifiquedeLuminy,Case906,13288MarseilleCedex9, France FritzMelchers MaxPlanckInstituteforInfectionBiology,Charitéplatz1,10117Berlin,Germany MichaelB.A.Oldstone DepartmentofImmunologyandMicrobialScience,TheScrippsResearchInstitute,10550NorthTorreyPines Road,LaJolla,CA92037,USA RinoRappuoli NovartisVaccines,ViaFiorentina1,Siena,53100,Italy PeterK.Vogt DepartmentofMolecularandExperimentalMedicine,TheScrippsResearchInstitute,10550NorthTorrey PinesRoad,BCC-239,LaJolla,CA92037,USA Current Topics in Microbiology and Immunology Previously publishedvolumes Further volumes canbe foundatwww.springer.com Vol.328:vanEtten,(Ed.): Vol.343:Johnson,JohnE.(Ed.): LesserKnownLargedsDNAViruses.2008. 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Orth • Ben Adler Editors Pasteurella multocida Molecular Biology, Toxins and Infection Responsible series editor: Klaus Aktories 123 Editors Klaus Aktories BenAdler Inst.für Experimentelle undKlinische Department of Microbiology Pharmakologie undToxikologie Monash University Universität Freiburg Melbourne,VIC Freiburg Australia Germany JoachimH.C. Orth Inst.für Experimentelle undKlinische Pharmakologie undToxikologie Universität Freiburg Freiburg Germany ISSN 0070-217X ISBN 978-3-642-31016-4 ISBN 978-3-642-31017-1 (eBook) DOI 10.1007/978-3-642-31017-1 SpringerHeidelbergNewYorkDordrechtLondon LibraryofCongressControlNumber:2012943375 (cid:2)Springer-VerlagBerlinHeidelberg2012 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartof the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionor informationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purposeofbeingenteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthe work. Duplication of this publication or parts thereof is permitted only under the provisions of theCopyrightLawofthePublisher’slocation,initscurrentversion,andpermissionforusemustalways beobtainedfromSpringer.PermissionsforusemaybeobtainedthroughRightsLinkattheCopyright ClearanceCenter.ViolationsareliabletoprosecutionundertherespectiveCopyrightLaw. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. While the advice and information in this book are believed to be true and accurate at the date of publication,neithertheauthorsnortheeditorsnorthepublishercanacceptanylegalresponsibilityfor anyerrorsoromissionsthatmaybemade.Thepublishermakesnowarranty,expressorimplied,with respecttothematerialcontainedherein. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Preface It is more than 125 years since Louis Pasteur identified as the causative agent of ‘‘choléra des poules’’ the bacterium that now bears his name. Since that time, Pasteurellamultocidahasbeenrecognizedasthecausativeagentofawide range of infections in a wide range of animal species as well as in humans. Indeed, the species name multocida could be literally translated as ‘‘multi-killer’’. The term pasteurellosis is now widely applied to describe infections in mammals and birds caused byP. multocida.It istherefore surprisingthat adetailed knowledge ofthe cellular and molecular basis for pathogenesis in pasteurellosis lags behind what has been elucidated for many other bacterial species. In particular, the molecular basisforhostpredilectionremainscompletelyunknown.Forexample,whydoesa B:2strainkill cattle, buffaloes (or mice)at avery lowdose, yet seems tohave no effectwheninjectedintochickens,evenatveryhighdoses?Oneofthereasonsfor this dearth of information may well be that the construction of defined targeted mutants, the standard trade tool of molecular bacteriology, has only become routinelyavailableinthelastdecadeorso.Nevertheless,thedevelopmentofsuch tools and the availability of genome sequences in recent years have facilitated significant advances in the understanding of the biology and pathogenesis of this enigmaticpathogen.Asignificantexceptiontothislackofknowledgeisthemode ofactionofPasteurellamultocidatoxin (PMT),akeyvirulencefactorspecifically inatrophicrhinitis.ThemechanismsinvolvedintheinteractionofPMTwithhost cells and target molecules are now understood in exquisite detail. This volume brings together contributions from experts in the field of Pasteurella research. It covers areas such as comparative genomics, pathogenic mechanisms,bacterialproteomics,aswellasadetaileddescriptionandanalysisof PMT and its interaction with host tissues, cells, immune system, and signaling pathways. Each review article is intended to provide a stand-alone treatise. There is, therefore, some unavoidable overlap between the various chapters. 19 March 2012 Klaus Aktories Joachim H. C. Orth Ben Adler v Contents Pasteurella multocida: Diseases and Pathogenesis . . . . . . . . . . . . . . . . 1 I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler Pathogenomics of Pasteurella multocida . . . . . . . . . . . . . . . . . . . . . . . 23 J. D. Boyce, T. Seemann, B. Adler and M. Harper The Key Surface Components of Pasteurella multocida: Capsule and Lipopolysaccharide. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 Marina Harper, John D. Boyce and Ben Adler Pasteurella multocida and Immune Cells. . . . . . . . . . . . . . . . . . . . . . . 53 Katharina F. Kubatzky Molecular Biology of Pasteurella multocida Toxin. . . . . . . . . . . . . . . . 73 Joachim H. C. Orth and Klaus Aktories Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 Brenda A. Wilson and Mengfei Ho Swine Atrophic Rhinitis Caused by Pasteurella multocida Toxin and Bordetella Dermonecrotic Toxin. . . . . . . . . . . . . . . . . . . . . 113 Yasuhiko Horiguchi The Pasteurella multocida Toxin: A New Paradigm for the Link Between Bacterial Infection and Cancer. . . . . . . . . . . . . . . . . . . . . . . 131 Alistair Lax Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145 vii Contributors B. Adler Department of Microbiology, Australian Research Council Centre of Excellence inStructuralandFunctional Microbial Genomics, MonashUniversity, Clayton, VIC 3800, Australia, e-mail: [email protected] Klaus Aktories Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany, e-mail: [email protected] J.D.Boyce DepartmentofMicrobiology,AustralianResearchCouncilCentreof Excellence inStructuralandFunctional Microbial Genomics, MonashUniversity, Clayton, VIC 3800, Australia M.Harper Department ofMicrobiology,Australian ResearchCouncilCentre of Excellence inStructuralandFunctional Microbial Genomics, MonashUniversity, Clayton, VIC 3800, Australia Marina Harper Department of Microbiology, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, VIC 3800, Australia MengfeiHo DepartmentofMicrobiologyandtheHost-MicrobeSystemsTheme oftheInstituteforGenomicBiology,UniversityofIllinoisatUrbana-Champaign, Urbana, IL 61801, USA Yasuhiko Horiguchi Department of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Yamada-oka 3-1, Suita, Osaka 565- 0871, Japan, e-mail: [email protected] Katharina F. Kubatzky Department of Infectious Diseases, Medical Microbi- ology and Hygiene, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany, e-mail: [email protected] Alistair Lax Department of Microbiology, King’s College London Dental Institute, London, UK, e-mail: [email protected] ix x Contributors Joachim H. C. Orth Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany, e-mail: [email protected] T.Seemann DepartmentofMicrobiology,VictorianBioinformaticsConsortium, Monash University, Clayton, VIC 3800, Australia Brenda A. Wilson Department of Microbiology and the Host-Microbe Systems Theme of the Institute for Genomic Biology, University of Illinois at Urbana- Champaign, Urbana, IL 61801, USA, e-mail: [email protected] I. W. Wilkie Department of Microbiology, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash Uni- versity, Clayton, VIC 3800, Australia Pasteurella multocida: Diseases and Pathogenesis I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler Abstract Pasteurellamultocidaisanenigmaticpathogen.Itisremarkablebothfor thenumberandrangeofspecificdiseasesyndromeswithwhichitisassociated,and the wide range of host species affected. The pathogenic mechanisms involved in causing the different syndromesare, for the most part, poorly understood or com- pletely unknown. The biochemical and serological properties of some organisms responsibleforquitedifferentsyndromesappeartobesimilar.Thus,themolecular basis for host predilection remains unknown. The recent development of genetic manipulationsystemstogetherwiththeavailabilityofmultiplegenomesequences should help to explain the association of particular pathological conditions with particularhostsas well ashelpingtoelucidate pathogenic mechanisms. Contents 1 Non-SpecificDiseaseSyndromesCausedbyPasteurellamultocida............................. 2 2 SpecificDiseaseSyndromes............................................................................................. 2 3 AvianCholera.................................................................................................................... 3 4 HaemorrhagicSepticaemia................................................................................................ 6 5 AtrophicRhinitis............................................................................................................... 7 6 SnufflesofRabbits............................................................................................................ 8 7 LowerRespiratoryTractInfectionsofUngulates............................................................ 9 8 SporadicSepticaemiasInvolvingDifferentCapsularTypes........................................... 11 9 MechanismsofPathogenesis:CellularandMolecularAspects...................................... 12 10 ResistancetoHostInnateImmunity................................................................................. 12 I.W.Wilkie(cid:2)M.Harper(cid:2)J.D.Boyce(cid:2)B.Adler(&) DepartmentofMicrobiology, AustralianResearchCouncilCentreofExcellenceinStructural andFunctionalMicrobialGenomics,MonashUniversity, Clayton,VIC3800,Australia CurrentTopicsinMicrobiologyandImmunology(2012)361:1–22 1 DOI:10.1007/82_2012_216 (cid:2)Springer-VerlagBerlinHeidelberg2012 PublishedOnline:25May2012