Non-pharmacological interventions for dementia Henry Brodaty Dementia Collaborative Research Centre, UNSW www.dementiaresearch.org.au Translating dementia research into practice Potential conflict of interests • Advisor, consultant, remunerated speaker and/or investigator: – Parke-Davis, Eisai, Pfizer, Sanofi, Servier – Janssen, Lilly, Hoechst-Marion-Roussel – Lundbeck, Novartis, AstraZenica, Elan, Wyeth – Neotherapeutics, Cromedica, Voyager, Searle, Quintiles Translating dementia research into practice Non-pharmacological interventions • Cognitive training • Psychosocial interventions for BPSD • Pharmacological interventions • Policy implications Translating dementia research into practice Partner logo here MIND your BRAIN Cognitive training Translating dementia research into practice Partner logo here Cognitive Training •What is brain exercise? •What is evidence that it works? •Computerised cognitive training •Choosing a training product Slides courtesy of Nicola Gates Partner logo here What is Cognitive Training? •Repeated practice •Exercises Activities that challenge and stimulate your brain Partner logo here Computerised cognitive training •Individual programs •Multi‐modal •Multiple cognitive domains •Graded difficulty •Feedback •Accessible Evidence supporting Partner logo here cognitive training Randomised Clinical Review Populations Control trials trials articles Healthy Adults 7 6 2 Mild Cognitive 5 5 4 Impairment Alzheimer’s 8 4 4 Disease Multiple 4 4 1 Sclerosis Partner logo here Results from research trials Healthy older adults •Meta analysis  positive At risk adults or with MCI •Systematic review  positive Adults with AD •Meta analysis  positive Partner logo here Results from research trials Healthy ACTIVE trial  • Improved daily function at 5 yrs MCI  Rozinni trial •Improved memory function AD Galante trial • Delayed symptom progression