J. Ring H. Behrendt (Eds.) New Trends in Allergy V Springer-Verlag Berlin Heidelberg GmbH J. Ring H. Behrendt (Eds.) New Trends in Allergy V With 60 Figures and 56 Tables Hi Springer IV Johannes Ring, Prof. Dr. Dr. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein Klinikum Rechts der Isar Technische Universität München Biedersteiner Straße 29 80802 München, Germany Heidrun Behrendt, Prof. Dr. ZAUM - Zentrum für Allergie und Umwelt Klin. Kooperationsgruppe Umweltdermatologie und Allergologie GSF Technische Universität München Biedersteiner Straße 29 80802 München, Germany ISBN 978-3-642-62768-2 Library of Congress Cataloging-in-Publication Data. New trends in allergy V / [Johannes Ring, Heidrun Behrendt (eds.)]. p. ; cm. Includes bibliographical references and index. ISBN 978-3-642-62768-2 ISBN 978-3-642-55994-5 (eBook) DOI 10.1007/978-3-642-55994-5 1. Allergy-Congresses. I. Title: New trends in allergy 5. II. Title: New trends in allergy five. III: Ring, Johannes, 1945- IV. Behrendt, H. (Heidrun), 1945- [DNLM: 1. Hypersensitivity-Congresses. 2. Dermatitis, Atopic-Congresses. 3. Environmen¬ tal Illness-Congresses. 4. Environmental Pollutants-immunology-Congresses. 5. Hypersen- sitivity-genetics-Congresses. 6. Hypersensitivity-therapy-Congresses. WD 300 N5324 2003] RC584.N484 2003 616.97--dc21 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. 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Cover design: design & production GmbH, Heidelberg Typesetting: Goldener Schnitt, Sinzheim SPIN: 10857920 24/3130 5 4 3 2 1 0 - Printed on acid-free paper V Contents Epidemiology, Genetic and Environmental Factors 1 Pollen Grains Contain and Release Not Only Allergens, but Also Eicosanoid-Like Substances with Neutrophil Chemotactic Activity: A New Step in the Initiation of Allergic Sensitization? H. Behrendt, A. Kasche, C. Traidl, S. Plötz, J. Huss-Marp, U. risse, C. Ebner von Eschenbach, J. Ring . . . . . . . . . . . 3 2 House Dust Mites in Stuffed Toys as a Cause of Allergy in Lithuania R. Dubakiene, A. Dautartiene . . . . . . . . . . . . . . . . . . . . . . 9 3 Pharmacogenetics of β2-Adrenoceptor and Asthmatic Phenotypes M.L. Kowalski, G. Woszczek . . . . . . . . . . . . . . . . . . . . . . . . . 13 4 Pertussis Vaccination Is Not Associated with a Higher Prevalence of Allergies in Six-Year-Old Children from West Germany U. Krämer, H. Behrendt, U. Ranft, T. Schäfer, J. Ring . 21 5 Human Allergogeneticists Should Listen to Their Dog’s Barking A.L. de Weck, M. Griot-Wenk, H. Schneider, B. Schiessl, B. Zeemann, P. Mayer, E. Liehl . . . . . . . . . . . 27 Pathophysiology 6 Neuro-Immune Interaction in Allergy and Asthma A. Braun, H. Renz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 7 Cadherin Biology of Langerhans Cells T. Jakob . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 8 CD8 T Cell–Dendritic Cell (DC) Interaction in the Regulation of IgE D.M. Kemeny, M.J. Thomas . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 VI Contents 19 MHC Class II-Restricted T Cell Activation by Mouse and Human Mast Cells: Potential Clinical Implications S. Mécheri . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 10 T Cell Reactivity Against Timothy Grass Pollen Allergens in Allergic Versus Non-Allergic Human Donors: Epitope Recognition and Cytokine Profile R.L. Oropeza-Wekerle, E. Albert, U. Darsow, J. Ring, H. Behrendt . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 11 α1,3-Fucosyltransferase VII mRNA Expression Is Induced by Superantigens and Blocked by Inhibitors of NF-κB M. Podda, H.A. Beschmann, A.M. Duijvestijn, U.H. v. Andrian, R. Kaufmann, T.M. Zollner . . . . . . . . . 70 12 Dendritic Cells and Tolerance J. Saloga, I. Bellinghausen, U. Brand, K. Steinbrink, A.H. Enk, J. Knop . . . . . . . . . . . . . . . . . . . . . 76 13 Eosinophils Maintain Their Capacity to Degranulate upon Repetitive Stimulation with the Same Agonist H.-U. Simon, F. Levi-Schaffer . . . . . . . . . . . . . . . . . . . . . . . 85 14 Mast Cells as Initiators and Effectors of Allergic Inflammation A. Solomon, A.M. Piliponsky, J. Pe’er, F. Levi-Schaffer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92 Atopic Eczema and Allergic Skin Diseases 15 Modulation of Skin Barrier Function W. Wohlrab, C. Huschka, D. Fröde, J.-M. Schneider . . 105 16 T Cells and Effector Mechanisms in Atopic Dermatitis M. Akdis, A. Trautmann, S. Klunker, K. Blaser, C.A. Akdis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 17 Material-Odor Analysis as a Prerequisite for the Allergological Evaluation of Outgassing Odoractive Volatile Compounds K. Breuer, F. Mayer, E. Mayer . . . . . . . . . . . . . . . . . . . . . . . 121 18 The Atopy Patch Test: Use and Perspectives U. Darsow, J. Ring . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 128 Contents VII 19 The Intrinsic Type of Atopic Dermatitis Is Characterised by a Low Expression of the High-Affinity IgE Receptor FcεRI on Epidermal Dendritic Cells A. Wollenberg, T. Oppel, K. Reiser, M. Moderer, J. Haberstok, S. Günther, T. Bieber, E. Schuller . . . . . 137 20 Staphylococcal Exotoxins as Trigger Factors of Atopic Dermatitis K. Breuer, T. Werfel, A. Kapp . . . . . . . . . . . . . . . . . . . . . . . 145 Food Allergy and Anaphylaxis 21 Peanut Allergy: Are Clinical Symptoms Associated with IgE-Reactivity to Certain (Recombinant) Peanut Allergens? W.M. Becker, T. Kleber-Janke, U. Lepp . . . . . . . . . . . . . . . 159 22 Challenge Tests with Food Additives and Aspirin in the Diagnostics of Chronic Urticaria. A Case of Immediate Cutaneous Hypersensitivity to Sodium Bisulphite (E-222) Confirmed by Patch Testing M. Kurek, E. Grubska-Suchanek . . . . . . . . . . . . . . . . . . . . 166 23 Serum Sickness as a Clinical Model for Food Intolerance V.A. Marinkovich . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175 24 Role of Tryptase in Anaphylaxis B. Przybilla, D. Ludolph-Hauser . . . . . . . . . . . . . . . . . . . 181 25 Practical Approach to Adverse Food Reactions I. Vieluf, M. Besler, A. Paschke, H. Steinhart, D. Vieluf 190 Occupational and Environmental Aspects 26 Multiple Chemical Sensitivity and Others: Allergological, Environmental and Psychological Investigations in Individuals with Indoor Air-Related Complaints B. Eberlein-König, B. Przybilla, P. Kühnl, G. Golling, I. Gebefügi, J. Ring . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205 27 Latex Allergens and Latex Allergy K. Turjanmaa, T. Palosuo . . . . . . . . . . . . . . . . . . . . . . . . . . . 217 VIII Contents 28 Long-Term Course of Natural Rubber Latex Sensitization and Allergy E. Vocks, W. van der Leeden, J. Rakoski, J. Ring . . . . . . . 221 Pharmacotherapy 29 Long-Term Continuous Antiallergic Treatment Reduces Symptoms and Controls Allergic Inflammation Better than Symptomatic Treatment G. Ciprandi, M. Tosca, V. Ricca, G. Passalacqua, G.W. Canonica . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229 30 Rapid Onset and Sustained Efficacy of Desloratadine in Treatment of Chronic Idiopathic Urticaria A. Gauger, R. Hein, G. Rikken, H. Staudinger, J. Ring . 233 31 Preclinical Efficacy and Antiallergic Profile of Desloratadine, a Potent Histamine H-Receptor Antagonist 1 W. Kreutner, J.A. Hey, J.C. Anthes, A. Barnett . . . . . . . 241 32 Desloratadine Is Effective at Relieving Nasal Congestion, as Demonstrated in Three Placebo-Controlled Trials in Patients with Seasonal Allergic Rhinitis R. Lorber, L.M. Salmun, M.R. Danzig . . . . . . . . . . . . . . . . 252 33 Novel Concepts on Allergic Rhinitis: From Pathogenesis to Treatment R. Pawankar, S. Yamagishi, R. Takizawa, C. Ozu, T. Yagi 260 Immunotherapy 34 CpG Oligodeoxynucleotides and Their Potential Role in the Immunotherapy of Allergic Diseases A.M. Krieg . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273 35 Allergen 3-D Structure-Based Design of Future Vaccines for Specific Allergy Vaccination H. Løwenstein, H. Ipsen, M.D. Spangfort, J.N. Larsen . 279 36 Immunological Mechanisms of Anti-IgE Treatment R.J.J. van Neerven, C.P.A.A. van Roomen, E.F. Knol . . . . 284 Subject Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293 IX List of Chairpersons (not listed as First Authors) W. ABERER, Graz P. ARENBERGER, Praha J. BIENENSTOCK, Hamilton K. BLASER, Davos O. BRAUN-FALCO, München O. HERBARTH, Leipzig K. NEKAM, Budapest U. MÜLLER, Bern T. PLATTS-MILLS, Charlottesville E. RICHTER, München J. RING, München M. SCHLAAK, Borstel G. SCHULTZE-WERNINGHAUS, Bochum K. THESDRUP-PEDERSEN, Aarhus CH. VIRCHOW, Freiburg J. WENNING, Villingen-Schwenningen List of Contributors XI List of First Authors AKDIS M., MD Schweizerisches Institut für Allergie und Asthmaforschung, Obere Strasse 22, 7270 Davos, Switzerland BECKER W.-M., Dr. rer. nat. Forschungsinstitut Borstel, Parkallee 35, 23845 Borstel, Germany BEHRENDT H., Prof. Dr. med. ZAUM – Zentrum Allergie und Umwelt, Klin. Kooperationsgruppe Umweltdermatologie und Allergologie GSF/TU München, Biedersteinerstraße 29, 80802 München, Germany BRAUN A., Dr. med. Klinikum der Phillips-Universität Marburg, Abteilung für Klinische Chemie und Molekulare Diagnostik, Marburg, Germany BREUER K., Dr. Fraunhofer Institut für Bauphysik, Postfach 1182, 83601 Holzkirchen, Germany BREUER K., Dr. Hautklinik Linden, Medizinische Hochschule Hannover, Germany CIPRANDI G., Dr. Clinica de Malattie dell’Apparato Respiratorio E Allergologia, Universitá de Genova, Largo Rosanna Benzi 10, 16132 Genova, Italy DARSOW U., Priv. Doz. Dr. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, TU München, Biedersteinerstraße 29, 80802 München, Germany DUBAKIENE R., Prof. Dr. Allergy Centre Vilnius University, Zemynos 17–10, Vilnius 2022, Lithuania