1. Ring B. Przybilla (Eds.) New Trends . In Allergy III Foreword by O. Braun-Falco With 168 Figures and 152 Tables Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest Prof. Dr. med. Dr. phil. JOHANNES RING Hautklinik und Allergie-Abteilung UniversiHits-Krankenhaus Eppendorf Martinistrasse 52, 2000 Hamburg 20 Federal Republic of Germany Priv.-Doz. Dr. med. BERNHARD PRZYBlLLA Dermatologische Klinik und Poliklinik Ludwig-Maximilians-Universitat Frauenlobstrasse 9-11, 8000 Miinchen 2 Federal Republic of Germany ISBN-13 978-3-642-46719-6 e-ISBN-13: 978-3-642-46717-2 DOl: 10.1007/978-3-642-46717-2 Library of Congress Cataloging-in-Publication Data New trends in allergy III / Johannes Ring, Bernhard Przybilla (eds.); foreword by O. Braun-Falco. p. cm. Contains papers presented at a symposium, held July 13-15, 1990 in Munich. Includes bibliographical references and indexes. (alk. paper) 1. Allergy - Congresses. [1. Hypersensitivity - congresses.] I. Ring, Johannes, 1945-. II. Przybilla, Bernhard, 1949-. III. Title: New trends in allergy three. [DNLM: WD 300 N5321 1990] RC583.2.N483 1991 616.97-dc20 DNLMIDLC This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplica tion of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer Verlag. Violations are liable for prosecution under the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1991 Softcover reprint of the hardcover 1s t edition 1991 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such informa tion by consulting the relevant literature. Production Editor: Isolde Scherich Reproduction of the figures: Gustav Dreher GmbH, Stuttgart Typesetting: K + V Fotosatz GmbH, Beerfelden 27/3145-543210 - Printed on acid-free paper Foreword The international symposium "New Trends in Allergy", held in Munich from July 13 to 15, 1990, brought together for the third time since 1980 some of the most experienced researchers working in the field of allergy. This volume comprises the papers presented at this meeting. All over the world, and not merely in the industrialized countries, allergy is becoming a cause of evermore serious diseases. In recent years, research in the field of allergy has provided numerous impor tant and fascinating results extending our knowledge considerably. Despite the new insights into basic mechanisms of allergic reactions, improved diagnostic methods, and new therapeutic approaches, how ever, many questions remain to be answered, including: Are allergies really increasing in frequency? If so, what are the reasons? Especially, does environmental pollution playa role? Which factors influence IgE synthesis? Can the IgE immune response be switched off? Does the nervous system interact with allergic reactions? If so, what are the mechanisms? Are new approaches in allergy prophylaxis and allergy therapy effi cient? What measures have proven useful and deserve to be employed in daily practice? In this volume, these questions and other current topics are dealt with. As each issue is covered by authors competent in the respective fields, the result is an extensive and critical review of the state of the art. Going through these papers, one comes to the conviction that allergy research is a multifacetted, explosively expanding, most stimulating field of work. I would like to express my gratitude to all those at the Department of Dermatology of the University of Munich who worked hard to in sure the success of the symposium. Furthermore, I am very grateful to Springer-Verlag for publishing this volume so splendidly. May it VI Foreword find a wide distribution and thus improve the understanding of allergic diseases to the benefit of our patients. Munich, March 1991 o. BRAUN-FALCO Contents Foreword ........................................... V 0. BRAUN-FALCO List of Senior Authors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XV List of Chairmen .................................... XXIII Epidemiology Are Allergies Increasing? 3 B. KUNZ and J. RING Epidemiology of Various Allergic Reactions 14 D. VERVLOET and D. CHARPIN Epidemiology of Contact Allergy 23 P. 1. FROSCH and 1. ZIMMERMANN Allergens Epitopes on Allergens ................................ 33 L. JAGER, C. DIENER, W.-D. MULLER, and G. SCHLENVOIGT Cloning of Birch Pollen Allergens ...................... 48 H. BREITENEDER, O. SCHEINER, K. PETTENBURGER, R. VALENTA, M. TEJKL, K. HOFFMANN-SOMMERGRUBER, M. DUCHENE, H. RUMP OLD , M. BREITENBACH, and D. KRAFT Molecular Structure of Allergens .. . . . . . . . . . . . . . . . . . . . . . 57 X. BAUR, G. MAZUR, and V. LIEBERS VIII Contents Characterization of Antigens and Allergens of Bird Feathers and Bird Sera ......................................... 63 1. TAUER, G. FRUHMANN, and X. BAUR Hop Allergy: Cross-Reactivity to Birch Pollen ............. 65 C. M. KALVERAM, C. CRONEMEYER, and K. J. KALVERAM Immunoglobulin E Response Possible Approaches to Controlling the IgE Antibody Response ............................. 73 K. ISHIZAKA Human FceRII/CD23 in the Regulation of the Allergic Immune Response ....................... 82 E. P. RIEBER, U. PIRRON, N. ENDRES, and 1. C. PRINZ Inbred Strains of Guinea Pigs in Studies of Allergy . . . . . . . . 92 L.K. POULSEN, L. LUNDBERG, D. SOMPOLINSKY, J. V. SPARCK, M. PLOUG, C. BINDSLEV-JENSEN, and P. S. SKOV Multispecific Allergic Reactions ......................... 100 J. M. VARGA, G. F. KLEIN, and P. FRITSCH Loss of FceR2/CD23 Expression on T and B Lymphocytes During Rush Hyposensitization ......................... 105 J. C. PRINZ, E. P. RIEBER, and 1. RING Construction of Human Suppressor T Cell Hybridomas That Produce Glycosylation Inhibiting Factors from Peripheral Blood Mononuclear Cells of Bee Venom Sensitive Patients ......................... 109 P. THOMAS, C. CARINI, M. IWATA, and K. ISHIZAKA Anti-IgE Autoantibodies Hide Specific IgE and Are Mistaken for Specific IgG ...................... 112 E. JENSEN-JAROLIM and B. M. STADLER Mast Cells and Mediator Release In Vitro Growth of Human Mast Cells and Their Functions 117 T. ISHIZAKA, T. FURITSU, N. INAGAKI, and A.M. DVORAK Mast Cells and Fibroblasts: Partners or Neighbors? 126 F. LEVI-SCHAFFER and M. SHALIT Contents IX Factors Promoting Histamine and Leukotriene Release ..... 138 C.A. DAHINDEN, M. KRIEGER, T. BRUNNER, S. TAKAFUJI, and S. C. BISCHOFF Cyclosporin A Inhibits IgE Receptor Mediated Exocytosis from Rat Basophilic Leukemia Cells Without Inhibiting Phosphatidylinositol Hydrolysis, Ca2+ Uptake, the Rise in Cytosolic Ca2+ Actin Polymerization or Arachidonic Acid Release ............................ 143 T. HULTSCH, M. KALINER, and R.1. HOHMAN Prostaglandin D Synthetase is Localized in Antigen Presenting Cells and Mast Cells ............... 149 K. lKAI, M. UJIHARA, Y. HORIGUCHI, and Y. URADE Influence of Histamine Hj, H2, and H3 Agonists and Antagonists on IgE Mediated Histamine Release from Human Basophils ................................ 152 J. KLEINE-TEBBE, J. SCHRAMM, M. BOLZ, H. GAGNE, C. JOSTIES, R. LIpp, A. FRIESE, H. STARK, V. ZINGEL, A. BUSCHAUER, W. SCHUNACK, and G. KUNKEL Impact of Biophysical Plasma Membrane Properties on Leukocyte/Endothelium Interaction ................... 158 H.-A. LEHR, C. HUBNER, J. P. ZIMMER, A. KOHLSCHUTTER, and K. MESSMER Interleukin-3 and Granulocyte/Macrophage Colony Stimulating Factor Change the Anaphylatoxin-Induced Basophil Mediator Release Pattern. . . . . . . . . . . . . . . . . . . . . .. 161 S. C. BISCHOFF, Y. KURIMOTO, and C. A. DAHINDEN Neuropeptides and Human Mast Cells 166 M.K. CHURCH and S. EL-LATI Neuronal Interaction with Mast Cells .................... 175 1. BIENENSTOCK, M. H. PERDUE, and R. H. STEAD Atopic Eczema T Cells in Atopic Dermatitis ............................ 187 C.A.EM. BRUIJNZEEL-KoOMEN, EC. VAN REIJSEN, and G. C. MUDDE IgE Receptor Expression on Langerhans Cells 191 T. BIEBER X Contents Contact Sensitivity to Pityrosporum ovale in Patients with Atopic Dermatitis ................................. 200 H. TAGAMI, M. ROKUGO, Y. USUBA, and Y. TOMITA Irritable Skin in Atopic Eczema 207 R. GOLLHAUSEN Stigmata and Signs of Atopic Eczema 222 T. L. DIEPGEN and M. F ARTASCH Patch Test with Immediate Type Allergens in Patients with Atopic Dermatitis ................................. 230 E. VOCKS, H.-V. SEIFERT, B. SEIFERT, and M. DROSNER Chronobiological Aspects of Atopic Disease .............. 234 E. HAEN, T. LEDERER, S. BODENSTEINER, K. WOITE, R. HAUCK, and H. P. EMSLANDER Food Allergy On the Diagnosis of Food Allergy in Adults - A Comparison Between DBPCFC and Intragastric Provocations ........................... 243 C. BINDSLEv-JENSEN, A. NORGAARD, K. LADEFOGED, E. HYLLANDER, and L. K. POULSEN Gastric Reactivity to Flour Extracts and Helicobacter pylori Associated Gastritis in Patients with Flour Allergy. . . . . . . . . . . . . . . . . . . . . . . . . .. 247 M. KUREK, R. BABIC, and J. RING Immediate Contact Allergy to Foods: Skin Test Based on Contact Urticaria and IgE Tests in Children with Atopic Dermatitis ................................. 255 A. P. ORANJE, R. S. R. AARSEN, G. LIEFAARD, P. G. H. MULDER, and A. W. VAN TOORENENBERGEN The Prevalence of Food Allergy in Children with Atopic Dermatitis ................................. 259 A. TAIEB, M. DEBONS, M.H. CAVERT, M.H. MAUPOME, N. ALLOS, D. MONTAUDON, and J. MALEVILLE Computer System of Medical Information (KSIMPA) Useful for an Allergological Outpatient Clinic ............ 265 P. Z. BREWCZYNSKI, L. TOMICA, and Z. KALINA Contents XI Drug Reactions Drug Metabolism and Drug Allergy ..................... 269 H. F. MERK, D. NIEDERAU, M. HERTL, and F. JUGERT Adverse Reactions to Quinolones ........................ 281 D. VIELUF, R. RUSSWURM, B. PRZYBILLA, and J. RING Drug Induced Photosensitivity 291 E. HbLZLE Angiotensin Peptides and Anaphylaxis ................... 302 K. HERMANN, R. RITTWEGER, and 1. RING Granulocyte Mediator Release in Pseudo-allergic Reactions 311 W. CZECH, E. SCHOPF, and A. KAPP Photocontact Dermatitis and Persistent Light Reaction from Olaquindox in Piglet Feed ......................... 318 S. SCHAUDER Hyposensitization Allergoids for Hyposensitization ........................ 329 J. BOUSQUET, A. HEJJAOUI, and F.-B. MICHEL Hymenoptera Venom Allergy 335 B. PRZYBILLA and J. RING Safety of Hyposensitization ............................. 350 1. RAKOSKI, B. JESSBERGER, C. SZLISKA, and E. VOCKS Trends in the Use of Specific Immunotherapy ............. 354 A. ROSENDAHL LASSEN, L. JACOBSEN, and UG. SVENDSEN Autoimmune Diseases Autoantibodies Provide Insights into Antigens Driving Autoimmunity ................................. 363 E.M. TAN The Diagnostic Significance of Antinuclear Antibodies 372 M. MEURER The Anticardiolipin Syndrome - A Clinical Study ........ 382 P. A. REYES-LoPEZ, 1. M. CASANOVA, and M. C. AMIGO