PIT: S0028-3908(99)00220-8 SUBJECT INDEX TO VOLUME 38 A Absence epilepsy 1755 Absence seizures 1691 Acetylcholine 181 Acetylcholine receptor 679 Acetylcholinesterase 181, 505, 691 Acetyl-L-carnitine 383 Acid fuchsin 1343 Acid sensing ion channels 1875 ACPD 467 Adenosine receptors 9, 1511 Adenosine transport 1009 Adrenoceptors 1175 Affinity chromatography 1641 Aggression 1851 Agonist 1811 AIDA 1607 Allopregnanolone 955 Allosteric regulation 1647 Alzheimer’s disease 349 Amino-alkyl-cyclohexane 85 1-Aminoindan-1,5-dicarboxylic acid (AIDA) 817 Amnesia 339 AMPA 935 AMPA/kainate 495 AMPA receptors 375, 505, 1243 Amphetamine 943 Amygdala 243 Amyloid 1243 Amyloid precursor protein 349 Anesthetics 843 Animal model 857 Anion transport blocker 1531 Antagonist 1493 Antidepressant drugs 597 Antidepressants 1055 Antinociception 1027 Antipsychotic drugs 1175 Antisense oligonucleotide 339 Anxiety 279 Apamin 1289 Apoptosis 1243 Arachidonic acid 87] Ascending reflex contraction 1289 ASIC 1875 Astrocytes 1477 ATP 141, 707 Atypical neuroleptic 1027 Autapses 1553 Autoradiography 1707 Auto-receptor 1805 Subject Index B Baclofen 1775 Basilen blue 1335 Basolateral amygdala 1743 BC 197 and BC 264 3, 1063 BDNF 283 Behavior 857 Behavioural despair test 1831] Benzodiazepines 1281 Bicuculline 1261] Binding 965 Biocytin 349 Biotin-avidin interaction 1641 Blockade 1235 Blood—brain barrier 1027 Body weight 893 Brain 567 Brain capillary endothelial cells 1371 Bulbar inspiratory neurone 1261 C CAI 487 Ca?* currents (R-type) 843 Ca**-gated K* channel 1893 Ca** ionophore 283 Calcineurin 1647 Calcium channels 1647 Calcium 19, 843, 1349, 1361, 1841 Calcium antagonist 879 Calcium-calmodulin dependent protein kinase (CaM-KII) 597 Cannabinoid receptors 1289 Cannabinoids 533 Ca** permeability 659 Carbamazepine 1349 Carrier-mediated release 157 Catalase 913 Catalepsy 151] CATH.a cell line 39 CBPG 1607 CCK, agonists 543, 999 CCK, receptors heterogeneity 543 CCL39 Chinese hamster lung fibroblast cells 449 Cell culture 85, 699, 793, 1631 Cell proliferation 725 Cellular transport 137] Central cholinergic system 339 Central nervous system 769 Central-type benzodiazepine receptors 725 Cerebellar granule cell 375 Cerebellum 1273 Cerebrocortical synaptosomes 477 c-fos 1775 cGMP 935 CGP 44532 1797 CGP 44533 1805 Subject Index CGP 62349 1707 CGP 36742 1789 Chelerythrine 1585 Cholecystokinin 279, 525, 1789 Cholinergic lesion 579 Cholinergic-mediated behaviour 181 Cholinoceptors 1397 CHPG 1569 Chromaffin granule ghosts 879 Cinnarizine 879 Cis-9,10-octadecenoamide 533 Clomethiazole 307 Clonidine 1861 Clotrimazole 979 Clozapine 1075 Cocaine 1797 Competitive antagonism 141, 361 Complex | 567 Conantokins 1819 Concanavalin A 375 Conditioning 587 Conflict behavior 185] Conflict tests 965, 1831 Convulsions 1281 Core temperature 555 Cortex 1699 Corticosteroid receptors 893 Corticosterone 893 Corticotrophin releasing hormone 39 Corticotropin releasing factor 433 Coupling agent 1421 CP-99,994 289 4CPG 487 [''C]Raclopride 331 [''C]SCH23390 331 Cyclic AMP 645, 991 Cyclic GMP 1307 Cyclooxygenase 1017 Cyclopiazonic acid 1585 Cyclothiazide 375 D D-2-amino-5-phosphonopentanoate 495 Dantrolene 1343 DCG-IV 73 Defensive behaviors 965 Delta activity 1755 Dementia 735 Dentate gyrus 1063 Dependence 1831 Dephosphorylation 1723 Depolarizing post-synaptic potentials 1723 Depression 415 Development Subject Index Dexfenfluramine 513 DHPG 1577 Dialysis 909 Diazepam 965 Diazepam-binding inhibitor 725 Dihydropyridines 1361 3,5-Dihydroxyphenylglycine 209 Dimerization 1485 Discrete trials 1797 Disinhibition 1851 Distribution 1553 Donepezil 181 Dopamine 943 Dopamine autoreceptor 1903 Dopamine D, and D, receptors 1397 Dopamine D, receptor 223 Dopamine D, receptor 555 Dopamine D, receptors 1389 Dopamine release 1195 Dopamine transporter 157 Dorsal horn 167 Dorsal raphe 151 Down syndrome 1917 DRG neurons 1811 Drosophila melanogaster 645 Drug addiction 1381 Drug discrimination 415 965 E Ecstasy 307 EEDQ 1421 Electroconvulsive shocks 597 Electrophysiology 1667 Emesis 289 Endogenous opioid peptides 273 Endomorphin 273 Enteric nervous system 1289 Entorhinal cortex 857 Epilepsy 243 Ethanol 1273 Ethanol abstinence syndrome 1361 Ethanol withdrawal 1361 Evoked synaptic currents 645 Excitatory amino acids 243, 1519 Excitotoxicity 85 Exploration models 965 F Facilitatory autoreceptor 477 Feeding 883 Ferret 289 Fetal sleep 49 Fish somatostatin receptor 3 449 Flavonoids 965 Flumazenil 965 Subject Index Fluorowillardiine 505 Fluoxetine 893 Fos 138] Four-plate test 1831 Free radicals 307 Frontal cortex 1153 Frontocortical 513 ‘Functional switch’ 1477 Fusion protein 1035 G GABA 943, 1723 GABA, receptors 49, 1273, 1281, 1851 GABA, 725, 1667, 1691 GABA,g agonist GABA,-receptors 1647, 1657, 1675, 1789, 1723, 1730 GABA-receptors 1775 GABA release GAERS 1691 Gamma-hydroxybutyrate 1667 Gas chromatography 955 Gene knockout 253 Gene regulation 1767 GFP 785, 793 GH, cells 979 GIRK channels 467 Glial cell line-derived neurotrophic factor 913 Glial cells 825 Global ischemia 199 Glutamate 605, 1531 Glutamate and GABA release 1631 Glutamate binding 625 Glutamate ionotropic receptors 1349 Glutamate metabotropic receptor dentate gyrus 1597 Glutamate neuronal death 1631 Glutamate receptors 505 Glutamate release 477, 1273 Glutamatergic transmission 1743 Glutamate uptake 395 Glutathione 567 Glutathione peroxidase 913 Glycine 785 Glycine site antagonists 109, 233 Glycine site partial agonists 109 Golgi cell 805 G-protein coupled receptors 1657 G-proteins 403, 991, 1657, 1861 Grease-gap 805 Group-I metabotropic glutamate receptors 199, 1477 GTP-binding 403 Guanylate cyclase 1883 Guinea-pig 1409 GYKI 53655 375 H Haloperidol 567 Subject Index H ,-antihistamines 1893 Heat shock proteins 671 Heme oxygenase-| 825 Hetero-receptor 1805 High performance liquid chromatography 513, 883 Hippocampus 65, 85, 487, 579, 605, 1585, 1819 Hormone replacement therapy 65 5-HT 279, 883, 1083 5-HT receptors 403 5-HT,, receptors 279, 299, 1165 5-HT,, receptor antagonism 525, 1153, 1409 5-HT>,, receptor 1185 5-HT>,, receptors 415, 1421 1409 5-HT pip 5-HT,, receptors 1175 5-HT>. receptors 415, 1195 5-HT,p receptors 1175 5-HT receptor function 1083 5-HT, receptors 533 5-HT, receptors 1043 5-HT receptors/transporters 893 5-HT receptor subtypes 883 5-HT Releasers 1055 Human 19 Human brain 625 Human cortex 1755 Human immunodeficiency virus 273 Human neocortex 1789 Hyperalgesia 611 Hyperthermia 307 Hypoglycaemia 85, 319 Hypothalamus 433 Hypothermia 1027 Hypoxia 85 I Ifenprodil 243 IgG-saporin 579 Ileum 871 Imaging 785 Imipramine 597 Immediate—early genes 1381 Immune-stimulation 1225 Immunocytochemistry 1485 Impulsivity 185] Inducible expression (LacSwitch) 1485 Inflammation 1767 Inhibition 467 Inhibitor 319 Inositol phospholipid hydrolysis 1421 In situ hybridisation 625, 1063, 1683 Interleukin-6 1325 Interleukin-1f 1325 Interneurons 1707 Intestinal peristalsis 1289 Subject Index Intracellular calcium 39, 699, 1349 Intracellular recordings 323 Intrathecal 1317 Intrathecal injection 835 Intrinsic activity 1035 In vivo 487 In vivo microdialysis 525 In vivo occupancy 1185 In vivo release 1317 Ion channel 785 lonotropic glutamate receptor agonists 1569 IPSPs 1261 Ischemia 209 K Kainate 1349 Kainate receptors 375, 991, 1811 Kainic acid 99] KATP channel 1893 KB-R7943 319 K* channel 979 Ky 361 Kindling-induced potentiation 184] Kinetics 735 Knockout l Knock-out mice 555 K ynurenine 1225 L L-AP4 1543 L-Arginine—nitric oxide—cGMP pathway 835 Larval neuromuscular junction 645 L-DOPA 1371 Learning 339 L-F,CCG-I 1531 Limbic 1343 Lipid peroxidation 307 Locomotion 109 Locomotor activity 555 Locus coeruleus 39 Long-term depression (LTD) 73, 495, 605, 1585, 1597 Long-term potentiation (LTP) 65, 487, 1253, 1917 LY 354740 73 LY 367385 199 LY 367366 1505 LY 367385 1505 LY 393053 1577 LY 367385 1577 LY 341495 1519 LY 354740 1831 M MAM 857 MAP kinase 283 Mass spectroscopy 955 MCPG 487 Subject Index MDL 73005EF 299 MDMA 307 Mechanism 1553 Medial prefrontal cortex 121 Median raphe 151 Memantine 735 Memory 339 Meninges 1043 Mental retardation 1917 MES-convulsions 85 Metabotropic 143] Metabotropic glutamate (mGlu) receptors 73, 129, 361, 477, 487, 495, 605, 645, 805, 917, 927, 1431, 1485, 1493, 1505, 1543, 1569, 1577, 1569, 1607, 1631, 1831 Metabotropic glutamate receptor agonists 1569 Metabotropic glutamate receptor antagonist 1505 Met-enkephalin 1317 Methanandamide 1289 5-Methoxy-6-methyl-2-aminoindan 1055 3,4-Methylenedioxymethamphetamine 307 Methyllycaconitine 679 Methylnaltrexone 425 1-Methyl-4-phenylpyridinium 913 4-Methylthioamphetamine 1055 Met-LI CCK-LI release 999 Mg?* 1253 Microdialysis 85 Microglia 1017 Microiontophoresis 1903 Midazolam 1775 Migraine 1043 Miniature synaptic currents 645 MK-801 , 1253 mKvl.1 1893 mNBA 1225 Modulation 1553 Monkey 331 Monoamines 909 Monoamino oxidase 1055 Monoarthritis Morphine 1851 Morphine withdrawal 1831 Motor behaviour 1683 MPEP 1493 M, receptors 339 mRNA 433 MSOPPE 73 Muscarinic receptors 1903 N Na* /Ca?*+ exchanger Na* —dependent transporters NADPH-d [Na*], Naloxone Subject Index Naltrexone 185] Neonatal 1299 Neural cells 991 Neuroactive steroids 843 Neuroblastoma 1009 Neurodegeneration 1477 Neurodevelopmental 1299 Neurogenic inflammation 1043 Neuroimmunomodulation 273 Neuroleptic 567 Neuronal cell cultures 395 Neuronal death 1243 Neuronal development 505 Neuronal nicotinic 679 Neurones 793, 1875 Neuropathic pain 167, 611 Neuropeptide FF 1317 Neuroprotection 1477 Neurosteroids 267 Neurotensin 1027 Neurotoxicity 1883 Neurotrophic factor 1075 NF023 141 NGF 857 Nicardipine 1841 Nicotine 587 Nicotine addiction 769 Nicotinic receptor subtypes 769 Nimodipine 1361 Nitric oxide 1307 Nitrobenzylthioinosine 1009 7-Nitroindazole 935 N-linked glycosylation 1485 NMDA 935 NMDA channels 1235 NMDA NRI subunit 625 NMDA receptors 223, 495, 659, 735, 1243, 1819 N-methyl-D-aspartate toxicity 199 Nociception 1569 Non-competitive 1493 Non-NMDA receptor 825 Noradrenaline 1153 Noradrenaline transporter 157 NRAO00045 1185 NR2B antagonists 611 NR2C subunit 1477 NRI1 subunit 233 NSAIDs 1325 NT-3 283 NTS 935 Nucleoside transport 1009 Nucleus accumbens 121, 1397 Nucleus tractus solitarius 425 NXX-066 181 Subject Index O Octadecaneuropeptide ODQ Oestradiol 7-OH-DPAT Oleamide 3-O-Methyl-L-DOPA Ondansetron Opiates 0 Opioid antagonists ut Opioid antagonists Opioid receptors 273, 425, 871, 991, Opioids Ornithine transcarbamylase Orphenadrine (— )-OSU6162 Oxidative stress Oxygen-—glucose deprivation P pA, Pain Paired-pulse depression Paired pulse facilitation Parkinson’s disease Partial agonist Patch clamp 85, 1235, PD 128907 PDE IV Pentobarbital Peripheral-type benzodiazepine-receptor Pertussis toxin Pharmacology Pharmacophore model Phenylmethylsulfonyl fluoride pH modulation Phosphodiesterase Phosphodiesterase inhibitors Phosphoinositide turnover Photoaffinity labeling PICK] Picrotoxin PI3 kinase ( — )-Pindolol Pirenzepine binding Pituitary Plasticity Play behavior PNU 99194A Polyamines Positron emission tomography Postnatal development Pregnane steroids Pregnanolone Prenatal exposure