AUTHOR INDEX Abo V., 395 Dahlstrom A., 27 Greenfield S. A., 339 Abou-Donia M. B., 133 Dajas F., 395 Greney H., 183 Agnati L. F., 17, 39 Dally J. J., 339 Guan Z. Z., 295 Akinci M. K., 169 De Barry J., 253 Gustafsson J. A., 39 Aloyo V. J., 355 De Gennaro Colona V., 5 Altiok N., 99 De Potter W. P., 573 Hack N., 235 Amaducci L., 81 De Pouplana L. R., 327 Hamano S., 403 Amalric M., 123 DeKloet E. R., 39 Hanaoka K., 349 Anctil M., 465 Dell’ Albani P., 367 Heim C., 161 Anderson D. K., 377 Deng Y., 475 Hen R., 503 Angelucci L., 53 Desce J. M., 145 Herring P. L., 583 Annaert W. G., 573 Dodd P. R., 203 Hirayama K., 309 Arnaboldi R., 61 Domino E. F., 155 Hirouchi M., 451 Aunis D., 545 Dontenwill M., 183 Horrocks L. A., 377 Dostert P., 475 Hungund B. L., 321 Duran M., 193 Balazs R., 235 Barkai A. I., 321 Ichida T., 451 Earley B., 243, 555 Baudry M., 287 Irvin N., 287 Edlund C., 35, 295 Baunez C., 123 Ishii Y., 349 Elliott J. M., 537 Becker T., 253 Israél M., 103 Emre M., 583 Belcourt A., 183 Itano Y., 419 Enomoto R., 273 Belluardo N., 367 Ben-Ari Y., 327 Benzi G., 61 Farooqui A. A., 377 Jacob W., 573 Jarrott B., 221 Bernard A., 327 Ferhat L., 327 Biagini G., 17 Jiang X., 367 Fischer W., 47 Boeckh C., 385 Flanigan T. P., 537 Johnston J., 73 Johnston G. A. R., 169 Bonsi P., 493 Forleo P., 81 Bousquet P., 183 Frandsen A., 303 Joliot A., 103 Bricca G., 183 Frasoldati A., 17 Fredholm B. B., 99 Kabuto H., 273 Frey P., 583 Kapatos G., 309 Calvo D., 395 Friedman M., 133 Kato T., 349 Camilli F., 23 Fukuda H., 567 Keenan C., 227 Canonne-Hergaux F., 545 Fuxe K., 17, 39 Kelly P. H., 583 Carvalho A. P., 483 Khrestchatisky M., 327 Castillo-Melendez M., 221 Kitamura Y., 419 Cella S. G., 5 Garriga J., 175 Klinguer C., 433 Chadi G., 39 Gebicke-Hiarter P., 385 Kocha T., 349 Chen J. F., 355 Ghigini B., 61 Kristensson K., 35 Cheramy A., 145 Giorgi M., 493 Kuriyama K., 451 Chikuma T., 349 Giovannini M. G., 23 Cintra A., 39 Giuffrida-Stella A. M., 367 Clementi F., 69 Giulian D., 227 Lannfelt L., 73 Cocchi D., 5 Glowinski J., 145 Lawrence A. J., 221 Condorelli D. F., 367 Godeheu G., 145 Leara B., 227 Cooper J. R., 345 Gombos G., 253 Leonard B. E., 243, 555 Court J. A., 69 Gongalves P. P., 483 Lesbats B., 103 Cowburn R. F., 73 Gorini A., 61 Leslie R. A., 455, 537 Cuss6 R., 175 Grahame-Smith D. G., 455 Li J., 227 Author Index Lin L., 321 Ohta S., 475 Squitti R., 493 Lindberg J., 39 Oitzl M., 39 Standley S., 287 Llona I., 573 Oka M., 403 Strata P., 85 Locatelli V., 5 Olenik C., 385 Strosznajder J., 193 Lowe D. A., 573 Olson L., 1 Stutzmann J., 183 Lowenstein P. R., 455 Oohira A., 425 Sust M., 175 Ouagazzal A., 123 Synguelakis M., 103 MacGregor D.P., 413 Malanowski J., 583 Paggi P., 493 Takahashi T., 475 Maruyama W., 475 Palmer A. M., 441 Tanaka A., 349 Matsui F., 425 Pani A. K., 465 Theodoridu A., 385 McAllister K. H., 583 Parenti M., 5 Timmusk T., 11 McRae A., 27 Pepeu G., 23 Tinner B., 39 Medina J., 395 Peroutka S. J., 533 Toschi G., 493 Melzacka M., 161 Perry E., 69 Trifilieff E., 433 Mendelsohn F. A. O., 413 Piacentini S., 81 Metsis M., 11 Urwyler S., 583 Meyer D. K., 385 Qin Z-H., 355 Miller A., 39 Moorman J. M., 455 Villa R. F., 61 Mori A., 273 Reagan K. E., 133 Morita K., 403 Reiter C. T., 441 Watanabe E., 425 Morris C., 69 Mortilla M., 81 Reynolds D. J. M., 455 Weiner N., 161 Roberts E., 451 Weiss B., 355 Mudo G., 367 Rossi F., 85 Wells K., 377 Miiller E. E., 5 Mundula A., 23 Rubboli F., 69 Wesemann W., 161 Rtideberg C., 583 Westphalen R. I., 203 Murone C., 413 White T. G., 583 Wilmarth K. R., 133 Nacmias B., 81 Sala C., 69 Winblad B., 73 Naoi M., 475 Samochocki M., 193 Wolfman C., 395 Sasuga S., 475 Narihara R., 451 Sato H., 567 Neijt H. C., 583 Saudou F., 503 Xu X., 155 Newberry N. R., 537 Schmidt-Kastner R., 161 Nieoullon A., 123 Schousboe A., 303 Nishida A., 567 Yamawaki S., 567 Scott H. L., 203 Nishikawa K., 39 Yoneda Y., 111, 273, 263 Shimizu M., 567 Nomura Y., 419 Sieklucka M., 161 Nordberg A., 93 Silveira R., 395 Zetterstr6m T., 537 Sindelar P., 295 Zheng Z., 321 O’Connell A., 243, 555 Sdderberg M., 35, 295 Ziefer P., 385 O’ Neill C., 73 Sontag K-H., 161 Zoltay G., 345 Ogita K., 111, 263, 273 Sorbi S., 81 Zwiller J., 545 SUBJECT INDEX 1-methy1l-4-phenylpyridinium (MPP*+) - and cell death, 419 2(N)-methyl-6,7-dihydroxyisoquinolinium ions - inhibits type A MAO, 475 acetylcholine - accumulation and release, 103 - role of 16kDa protein in release, 103 acetylcholinesterase - release regulated by dopamine, 339 ACPD-sensitive glutamate binding sites, 253 acrylamide - effect on kinase-mediated phosphorylation of neurofilament, 133 adenosine A, receptors - interaction with bradykinin and interleukin receptors, 99 - in astroglioma cells, 99 adenosine transport - in a synaptosomal preparation, 221 adrenal medullary cell - tyrosine hydroxylase, 403 aged rats - effect of NGF on memory, 47 aging - effect on bFGF and steroid receptors, 39 - growth hormone neuroregulation, 5 - in hypothalamus-pituitary-adrenocortical axis, 53 - influence of isoprenoids, 35 - nicotinic receptors, 93 - plasticity, 85 Alzheimer’s disease - fatty acid composition of cardiolipin in brain, 295 - infusion of NGF, 2 - molecular genetics, 81 - processing of APP, 73 Alzheimer’s type dementia, 203 AMPA binding sites - in synaptosomal and microsomal fractions, 287 AMPA binding - in mouse forebrain, 169 - sex differences in acute swim stress, 169 AMPA receptors - gene expression, 367 AMPA receptors - involvement in epilepsy, 367 AMPA - trophic effect on granule cells, 235 amyloid precursor protein - see APP amyloidosis - in Alzheimer’s disease, 73 angiotensin converting enzyme - in post mortem brain, 413 angiotensin receptors - in post mortem brain, 413 anions - effect on uptake and release of GABA, 483 APP gene, 81 APP670/671 mutation - in Alzheimer’s disease, 73 arachidonic acid turnover - reduced by glutamate, 193 - stimulated by serotonin, 193 aspartate efflux - comparison of preaccumulated with endogenous aspartate, 441 - comparison of preaccumulated with endogenous glutamate, 441 astroblasts - expression of tropomyosin expression, 545 astrocytes - effect of deprenyl, 17 - survival regulated by cytotoxins and cytokines, 227 astroglial cells - proenkephalin gene, 385 astroglioma cells - adenosinez, receptors, 99 ATPase activities - in synaptosomes, 61 basic fibroblast growth factor - see bFGF BDNF mRNA’s - effect of kainate, 13 BDNF - gene regulation in hippocampus, 11 - MRNA, 11 benzodiazepine receptor - effect of thyroxine, 443 bFGF immunoreactivity - in aging, 39 bFGF - immunoreactivity enhanced by derenyl, 17 - regulation of tropomyosin expression, 545 bradykinin receptors - in astroglioma cells, 99 - interaction with adenosine 2, receptors, 99 brain-derived neurotrophic factor - see BDNF calcium - effect of magnesium on intracellular concentrations, 303 calcium-dependent kinase - influenced by acrylamide, 133 xi xii Subject Index calmodulin-dependent kinase - influenced by acrylamide, 133 cAMP - regulation of tropomyosin expression, 545 cardiolipin - fatty acid composition, 295 - in brain areas of Alzheimer’s patients, 295 catecholamines - synthesis in a Cnidarian, 465 cerebellum - distribution of metabotropic glutamate receptors, 253 cGMP - effect of magnesium, 303 cholecystokinin - co-stored with dopamine, 573 chromaffin granules - tyrosine hydroxylase, 403 clonidine binding, 183 coexistence - of dopamine and cholecystokinin, 573 CREB - binding to DNA, 263 3':5’cyclic nucleotide phosphodiesterases - in sympathetic ganglion, 493 cytokines - regulate survival of astrocytes and neurones, 227 - released from phagocytic microglia, 227 cytotoxins - regulate survival of astrocytes and neurones, 227 - released from phagocytic microglia, 227 D; and D2 dopamine receptor mRNAs - influence of fluphenazine-N-mustard, 355 dementia - excitotoxic mechanisms, 203 - nicotinic receptors, 93 deprenyl - activation of astrocytes, 17 - in neuroprotection, 17 - influences bFGF, 17 development - of dopamine neurones in culture, 309 DM-20 - proteolipid, 433 dopamine neurones - in culture, 309 dopamine synthesis - presynaptic control, 145 dopamine - acts presynaptically to open potassium channels, 345 - co-stored with cholecystokinin, 573 - interaction with glutamate, 123 dopaminergic fibres - regrowth caused by catecholamines, 27 dopaminergic system in nigra - regulates acetylcholinesterase release, 339 eicosanoids - involved in opening of potassium channels, 345 epilepsy - AMPA receptors, 367 epileptic mice - ionotropic glutamate receptors affected, 273 ethanol - effects phospholipase A2 activity, 321 - influence on glycogen, glucose and phosphorylated sugars, 175 excitatory amino acids - release controled by dopamine, 145 - release from striatal synaptosomes, 145 - release of endogenous and exogenous, 443 excitotoxic mechanisms - in pathogenesis of dementia, 203 excitotoxicity of glutamate, 377 fatty acid composition - of cardiolopin, 295 fluphenazine-N-mustard - differentailly regulates opioid receptor mRNAs, 355 - differentially regulates D; and D2 dopamine receptor mRNAs, 355 GABA release - effect of anions, 483 GABA uptake - effect of anions, 483 GABA - acts presynaptically to open potassium channels, 345 - uptake and release, 483 GABA = g-aminobutyric acid GABAa receptor - effect of thyroxine, 443 ganglioside GM1 - reduces ethanol induced phospholipase A2 activity, 321 glioma cells - release and accumulation of acetylcholine, 103 glucocorticoid receptors - in aging, 39 glucose and phosphorylated sugars - effect of ethanol, 175 glutamate and analogs - effect on spinal cord cultures, 377 glutamate efflux - comparison with efflux of preaccumulated aspartate, 441 glutamate receptor mRNAs, 367 glutamate receptors - in mouse forebrain, 169 - interact with serotonin receptors, 193 Subject Index xiii - ionotropic-type altered in cerebellum in epileptic mice, 273 - properties, 206 glutamate uptake, 208 glutamate - excitotoxicity, 377 - interaction with dopamine, 123 - reduces arachidonic acid turnover, 193 glutamate-associating-proteins - partial purification, 111 glutamate/AMPA receptors - in synaptosomal and microsomal fractions, 287 glycogen distribution - effect of ethanol, 175 granule cells - AMPA acts as a trophic factor, 235 G-protein-coupled 5-HT receptors, 505 hippocampus - binding of AP1 to DNA, 263 5-HT receptors - coupled to G-proteins, 505 - evolution, 533 - gated to ion channels, 522 - regulation and function, 537 - role in man, 539 human brain - distribution of nicotinic receptor subunits, 69 hybrid NG108-15 cells - release and accumulation of acetylcholine, 103 5-hydroxytryptamine receptors, 533 5-hydroxytryptamine - receptor subtypes in vertebrates and invertebrates, 503 5-hydroxytryptamine = serotonin = 5-HT hypothalamus - development of dopamine neurones in culture, 309 hypothalamus-pituitary-adrenocortical axis - in aging and involvement of NGF, 53 hypoxia - age-related changes in synaptosomal ATPase activities, 61 - influence on synaptosomal ATPase activities, 61 - oligemic hypoxia, 161 idazoxan binding, 183 imidazoline binding sites - human brain, 183 imidozoline binding protein(s) - solubilisation with CHAPS, 183 imipramine - stimulates phospholipase C, 567 immunological identification - of proteoglycan fragemts of neurocan, 425 indoleamines - synthesis in a Cnidarian, 465 interleukin receptors - in astroglioma cells, 99 - interaction with adenosine 2, receptors, 99 invertebrates - serotonin receptors, 503 ionic factors - tyrosine hydroxylase, 403 ionotropic glutamate receptors - affected in epileptic mice, 273 isoprenoids - in aging and neurodegeneration, 35 isoquinolines - effect on type A MAO, 475 kainate binding - in mouse forebrain, 169 - sex differences in acute swim stress, 169 kainate - effect on BDNF mRNA’s, 13 lipid peroxidation - in oligemic hypoxia, 161 locomotory activity - influenced by phencylidine and MK-801, 155 magnesium - effect on intracellular calcium, 303 - effect on cGMP, 303 - effect on NMDA mediated toxicity, 303 MAP2d - a MAP2 splice variant, 327 - regional and developmental expression, 329 MAPs = microtubule-associated proteins membrane anisotropy - in oligemic hypoxia, 161 memory impairments - reversed in aged rats by NGF, 47 mesencephalon - development of dopamine neurones in culture, 309 metabotropic glutamate receptors - in developing cerebellum, 253 microglia - release cytokines and cytotoxins, 227 microsomes - binding of 3H-AMPA, 287 MK-801 - locomotor stimulant, 155 monoamine oxidase - efffect of isoquinolines, 475 Subject Index - inhibition by 2(N)-methyl-6,7-dihydroxyisoquinolinium ions, 475 monoamines - synthesis in a Cnidarian, 465 mRNAs - for AMPA receptors, 367 muscarinic M, receptors - located presynaptically in vagal afferents, 455 muscarinic receptors - effect of trimethyltin, 555 - in ferret brainstem vagal nuclei, 455 - influenced by trimethyltin intoxication, 243 mutations - in Alzheimer’s disease, 73 Myc - binding to DNA, 263 nerve growth factor - see NGF neuroblastoma cells - release and accumulation of acteylcholine, 103 neurocan - brain chondroitin sulphate proteoglycan, 425 neurodegeneration - influence of isoprenoids, 35 neuroendocrine aging, 5 neurofilament proteins - influence of acrylamide, 133 neurones - survival regulated by cytokines and cytotoxins, 227 neuroprotection - caused by deprenyl, 17 - caused by tacrine, 555 neurotoxin DSP4 - effect on noradrenergic neurones, 395 neurotrophins - in clinical disease, 1 NGF - in aging of hypothalamus-pituitary-adrenocortical axis, 53 - in Alzheimer’s disease, 2 - medullary graphs in parkinsonism, 1 - reverses memory impairments in aged rats, 47 nicotinic receptor - subunits in human brain, 69 - in aging and dementia, 93 NMDA anatagonist - SDZ EAA 494, 583 NMDA mediated toxicity - influence of magnesium, 303 NMDA receptor - influenced by modulators, 303 NMDA - displaces 3H-glutamate from associating proteins, 111 NMDA - enhances binding of AP1 to DNA in hippocampus, 263 noradrenergic neurones - recovery following treatment with neurotoxin DSP4, 395 N-methyl-D-aspartate - see NNDA oligemic hypoxia - membrane anisotropy and lipid peroxidation, 161 olivocerebellar system - plasticity, 85 opioid receptors - influence of fluphenazine-N-mustard, 355 parkinsonism - influence of NGF on medullary graphs, 1 PC12 cells - inhibition of cell death caused by MPP+, 419 peptidylglycine-a-amidating monooxygenase - in hypothalamus, 349 peroxidation of lipids, 161 phagocytic microglia, 227 phencyclidine receptors - influenced by trimethyltin intoxication, 243 phencyclidine - locomotor stimulant, 155 phosphodiesterases - in sympathetic ganglion, 493 phospholipase A2 activity - ethanol induced effects are reduced by ganglioside GM1, 321 - induced by ethanol, 321 phospholipase C - stimulated by imipramine, 567 phosphorylation - increased by acrylamide, 133 PKA - interaction with PKC, 385 PKC - interaction with PKA, 385 plasticity - in adulthood and aging, 85 PLP - proteolipid, 433 polyclonal immune response - to purified proteolipds, 433 post mortem brain - angiotensin receptors and converting enzyme, 413 potassium channel - opened in synaptosomes by dopamine and GABA, 345 potassium channels in synaptosomes - involvement of eicosanoids, 345 presynaptic - control of dopamine synthesis, 145 proenkephalin gene - in astroglial cells, 385 - interactions of protein kinase A and C, 385 protein kinase A and C - effects on proenkephalin gene, 385 proteoglycan fragments of neurocan - immunological identification, 425 Subject Index proteoglycan fragments - of neurocan, 425 proteolipids - polyclonal immune response to purified PLP and DM-20, 433 Purkinje cell synapse - plasticity, 85 rauwolscine binding, 183 regrowth of dopaminergic fibres - implantation of transmitter-loaded microspheres, 27 release - of acetylcholinesterase, 339 SDZ EAA 494 - a competitive NMDA antagonist, 583 serotonin receptors in invertebrates, 520 serotonin receptors - interact with glutamate receptors, 193 serotonin - stimulates arachidonic acid turnover, 193 somatotrophic function - in neuroendocrine aging, 5 steroid receptors - in aging, 39 Striatum - interaction between dopamine and glutamate, 123 substantia nigra - release of acetylcholinesterase regulated by dopamine, 339 sympathetic ganglion - phosphodiesterases, 493 synaptic plasma membranes - uptake and release of GABA, 483 synaptosomal ATPase activities, 61 synaptosomes - binding of 3H-AMPA, 287 - release of excitatory amino acids, 145 synaptosomal ATPase activities - hypoxia effects are age-related, 61 tacrine - neuroprotective effect, 555 thyroxine - effect on GABA receptors, 443 - inhibitory action on benzodiazepine site, 443 transcription factor activator protein-1 (AP1) - binding enhanced by NMDA, 263 transmitter-loaded microspheres - implantation causes regrowth of dopamine fibres, 27 trimethyltin intoxication - influences muscarinic and phencyclidine receptors, 243 trimethyltin - action on memory and muscarinic receptors, 555 - effects antagonised by tacrine, 555 tropomyosin expression - in astroblasts, 545 - regulated by bFGF and cAMP, 545 tyrosine hydroxylase - adrenal medullary cell, 403 - in chromaffin granules, 403 - ionic factors, 403 vagal afferents - localisation of cholinergic receptors, 455 vagal nuclei - muscarinic receptors, 455