Nanoengineered Biomaterials for Advanced Drug Delivery Woodhead Publishing Series in Biomaterials Nanoengineered Biomaterials for Advanced Drug Delivery Edited by Masoud Mozafari Elsevier Radarweg 29, PO Box 211, 1000 AE Amsterdam, Netherlands The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States © 2020 Elsevier Ltd. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/ permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library ISBN: 978-0-08-102985-5 For information on all Elsevier publications visit our website at https://www.elsevier.com/books-and-journals Publisher: Matthew Deans Acquisitions Editor: Sabrina Webber Editorial Project Manager: Charlotte Rowley Production Project Manager: Surya Narayanan Jayachandran Cover Designer: Mark Rogers Typeset by SPi Global, India Contributors Basel A. Abdel-Wahab Department of Pharmacology, College of Medicine, Assiut University, Assiut, Egypt; Department of Pharmacology, College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia Adewale Adewuyi Department of Chemical Sciences, Redeemer’s University, Ede, Osun, Nigeria Anne Adebukola Adeyanju  Department of Biological Sciences, McPherson University, Seriki-Sotayo, Ogun, Nigeria Oluyomi Stephen Adeyemi Medicinal Biochemistry, Nanomedicine and Toxicology Laboratory, Department of Biochemistry, Landmark University, Omu-Aran, Kwara, Nigeria Abbas Afkhami Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran Javed Ahmad Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia Mohammad Zaki Ahmad Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia Mazaher Ahmadi Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran Sohail Akhter  Center for Molecular Biophysics (CBM), CNRS UPR4301; LE STUDIUM Loire Valley Institute for Advanced Studies, Orleans, France; Nanomedicine Research Lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India Rafieh Alizadeh ENT and Head & Neck Research Center and Department, The Five Senses Institute, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran xiv Contributors José L. Arias Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy; Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM); Biosanitary Research Institute of Granada (ibs. GRANADA), Andalusian Health Service (SAS)—University of Granada, Granada, Spain Sajjad Ashraf Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada Sara Aly Attia  Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, United States Oluwakemi Josephine Awakan  Medicinal Biochemistry, Nanomedicine and Toxicology Laboratory, Department of Biochemistry, Landmark University, Omu- Aran, Kwara, Nigeria Babak Bagheri Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea Amir Hossein Bahmanpour Biomaterial Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, Tehran, Iran Shuang Bai School of Materials and Energy, Southwest University, Chongqing, People’s Republic of China Satheeswaran Balasubramanian Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, India Liliana Bernardino Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Covilhã, Portugal D. Cristea Transilvania University of Brasov, Material Science Department, Brasov, Romania Mazen M. El-Hammadi Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain Mehdi Farokhi National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran Marziyeh Fathi  Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran Raquel Ferreira Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Covilhã, Portugal Contributors xv Nina Filipczak  Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, United States; Laboratory of Lipids and Liposomes, Department of Biotechnology, University of Wroclaw, Wroclaw, Poland Camilla Foged Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Mohammad Reza Ganjali Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran; Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Yong-E Gao School of Materials and Energy, Southwest University, Chongqing, People’s Republic of China Yuan Gao  School of Materials and Energy, Southwest University, Chongqing, People’s Republic of China Laxmikant Gautam  Drug Delivery and Research Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, M.P., India Maryam Ghaffari Biomaterial Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, Tehran, Iran Maryam Ghavami  Department of pharmacy, Faculty of pharmacy, Eastern Mediterranean University, Famagusta, Turkey I. Ghiuță Transilvania University of Brasov, Material Science Department, Brasov, Romania Arash Ghoorchian Department of Analytical Chemistry, Faculty of Chemistry, Bu- Ali Sina University, Hamedan, Iran Jouni Hirvonen  Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland Yuan Hu State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, People’s Republic of China Anamika Jain Drug Delivery and Research Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, M.P., India Fatemeh Kabirian Bioengineering Research Group, Nanotechnology & Advanced Materials Department, Materials & Energy Research Center (MERC), Tehran, Iran xvi Contributors Mahdie Kamalabadi Department of Analytical Chemistry, Faculty of Chemistry, Bu- Ali Sina University, Hamedan, Iran Yeu Chun Kim Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea Maryam Koopaie  Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Kit S. Lam Department of Biochemistry and Molecular Medicine, UC Davis NCI- designated Comprehensive Cancer Center, University of California Davis, Sacramento, CA, United States Ling Li State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China Yuanpei Li Department of Biochemistry and Molecular Medicine, UC Davis NCI- designated Comprehensive Cancer Center, University of California Davis, Sacramento, CA, United States Xiaoqian Ma School of Materials and Energy, Southwest University, Chongqing, People’s Republic of China Tayyebeh Madrakian Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran Akhilesh Kumar Maurya Applied Science Division, Indian Institute of Information Technology, Allahabad, Uttar Pradesh, India Anamika Mishra  Applied Science Division, Indian Institute of Information Technology, Allahabad, Uttar Pradesh, India Nidhi Mishra Applied Science Division, Indian Institute of Information Technology, Allahabad, Uttar Pradesh, India Nishi Mody Drug Delivery and Research Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, M.P., India Fatemeh Mottaghitalab Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Masoud Mozafari Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada Contributors xvii Hafezeh Nabipour State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, People’s Republic of China Parisa Norouzi Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Yadollah Omidi  Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran David Adeiza Otohinoyi All Saints University, College of Medicine, Belair, Saint Vincent and the Grenadines Chiagoziem Anariochi Otuechere  Department of Biochemistry, Redeemer’s University, Ede, Osun, Nigeria Yousef Pakzad Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran; Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran Jiayi Pan Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, United States Satyanarayan Pattnaik Talla Padmavathi College of Pharmacy, Warangal, India Leena Peltonen  Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland Ekambaram Perumal  Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, India Azhwar Raghunath Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, India Joshua D. Ramsey School of Chemical Engineering, Oklahoma State University, Stillwater, OK, United States J. Venkateshwar Rao Talla Padmavathi College of Pharmacy, Warangal, India Ali Rastegari Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Jessica M. Rosenholm Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland xviii Contributors Mohammad Reza Saeb Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran Rajeev Sharma  Drug Delivery and Research Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, M.P., India Priya Shrivastava  Drug Delivery and Research Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, M.P., India Satya Prakash Singh Faculty of Pharmacy, Integral University, Lucknow, India Mayank Singhal Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland Anup Kumar Sirbaiya Faculty of Pharmacy, Integral University, Lucknow, India Y. Surendra Talla Padmavathi College of Pharmacy, Warangal, India Kalpana Swain Talla Padmavathi College of Pharmacy, Warangal, India Aneesh Thakur Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Vladimir P. Torchilin Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, United States Nila Mary Varghese Department of Pharmaceutics, JSS College of Pharmacy, Ooty; St. Johns College of Pharmaceutical Sciences and Research, Idukki, India Senthil Venkatachalam Department of Pharmaceutics, JSS College of Pharmacy, Ooty, India Nikhar Vishwakarma Drug Delivery and Research Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, M.P., India Sonal Vyas Department of Pathology, Index Medical College, Hospital and Research Centre, Indore, M.P., India Suresh P. Vyas Drug Delivery and Research Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, M.P., India Yajun Wang School of Materials and Energy, Southwest University, Chongqing, People’s Republic of China