Cover Page The handle http://hdl.handle.net/1887/35124 holds various files of this Leiden University dissertation. Author: Wokke, Beatrijs Henriette Aleid Title: Muscle MRI in Duchenne and Becker muscular dystrophy Issue Date: 2015-09-09 Muscle MRI in Duchenne and Becker muscular dystrophy Beatrijs Wokke Colophon PhD Thesis, Leiden University Medical Center, Leiden 2015 ISBN: 978-94-6299-137-8 Author: Beatrijs Wokke Cover design: Bilbo Schickenberg Layout: Ridderprint BV - www.ridderprint.nl Printed by: Ridderprint BV - www.ridderprint.nl Financial support for the publication of this thesis was kindly provided by Philips Healthcare Netherlands. The work in this thesis was supported by het Prinses Beatrix Spierfonds en Association Française contre les Myopathies. Copyright of the individual chapter lies with the publisher of the journal listed at the beginning of each chapter. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without prior permission of the author. Muscle MRI in Duchenne and Becker muscular dystrophy Proefschrift ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker, volgens besluit van het College voor Promoties te verdedigen op woensdag 9 september 2015 klokke 16.15 uur door Beatrijs Henriëtte Aleid Wokke geboren te Haarlem in 1983 PRoMotIeCoMMIssIe Promotor: Prof. dr. J.J.G.M. Verschuuren Co-promotores: Dr. H.E. Kan Dr. A.M Aartsma-Rus overige leden: Prof. dr. J.L. Bloem Dr. E.H. Niks Prof. dr. V. Straub (Newcastle University, Newcastle, United Kingdom) Lasciate ogne speranze, voi ch’intrate Divine Comedy, Dante Alighieri (1265-1321) Contents Chapter 1 General introduction 9 Chapter 2 Comparison of Dixon and T1-weighted MR methods to 21 assess the degree of fatty infiltration in Duchenne muscular dystrophy patients J.Magn Reson Imaging 2013 Sep 38 (3) 619-24 Chapter 3 Quantitative MRI and strength measurements in the 33 assessment of muscle quality in Duchenne muscular dystrophy Neuromusc Disord 2014 May 24 (5) 409-16 Chapter 4 Dystrophin levels and clinical severity in Becker muscular 47 dystrophy patients J. Neurol Neurosurg Psychiatry 2014 Jul 85 (7) 747-53 Chapter 5 T2 relaxation times are increased in skeletal muscle of DMD 65 but not BMD patients Muscle Nerve 2015 Apr 6 doi:10.1002/musc.24679 Chapter 6 Muscle spectroscopy detects elevated PDE/ATP ratios prior to 77 fatty infiltration in Becker muscular dystrophy patients NMR Biomed 2014 Nov 27 (11) 1371-7 Chapter 7 Discussion and conclusion 91 Chapter 8 Summary 97 Nederlandse samenvatting 101 Appendices References 107 List of abbreviations 123 List of publications 125 Curriculum vitae 129 C 1 r General introduction e t p a h C 2 r e h t p a h C 3 r e t a p a h C 4 r e p pt a h C 5 r e t t p a h C e 6 r e t p a h C r 7 r e t p a h C 8 r e t p a h 1 C 1 r e t p a h C