MTHFr, Methylation and Metals Dr. Amy A. Yasko Ph.D., ND, NHD, AMD, HHP, FAAIM “What do schizophrenia, diabetes and autism have in common? The answer is that many different factors act together to influence their development. As well as fundamentals like age and gender, other genetic and environmental factors…may play a role in the onset of multifactorial diseases. these so-called ” Multifactorial Diseases:Choose your targets BIOPEOPLE, Summer 2004 Multifactorial Disease •Environmental •Genetic DISEASE •Infectious •Stress Predisposing Factors That Increase Susceptibility to Autism MTHF & COMT Allelic Variations Number of Glutamate Receptors (total “Excitotoxin” level) Prior Underlying Streptococcal Infection Heavy Metal Burden Chronic Viral Infection Sex, Blood Type, HLA Type DPT Vaccine Viewing Order • Neurological Inflammation Tape • Putting It All Together part tape 2 • Boston DVDs Predisposing Factors That Increase Susceptibility to Autism • MTHF & COMT Allelic Variations • Number of Glutamate Receptors (total “Excitotoxin” level) Prior Underlying Streptococcal Infection Heavy Metal Burden Chronic Viral Infection Sex, Blood Type, HLA Type DPT Vaccine Methylation • Importance of methylation • Pathway • What we can do about it