Alejandro F. Frangi · Julia A. Schnabel Christos Davatzikos · Carlos Alberola-López Gabor Fichtinger (Eds.) 0 Medical Image Computing 7 0 1 and Computer Assisted 1 S C Intervention – MICCAI 2018 N L 21st International Conference Granada, Spain, September 16–20, 2018 Proceedings, Part I 123 Lecture Notes in Computer Science 11070 Commenced Publication in 1973 Founding and Former Series Editors: Gerhard Goos, Juris Hartmanis, and Jan van Leeuwen Editorial Board David Hutchison Lancaster University, Lancaster, UK Takeo Kanade Carnegie Mellon University, Pittsburgh, PA, USA Josef Kittler University of Surrey, Guildford, UK Jon M. Kleinberg Cornell University, Ithaca, NY, USA Friedemann Mattern ETH Zurich, Zurich, Switzerland John C. Mitchell Stanford University, Stanford, CA, USA Moni Naor Weizmann Institute of Science, Rehovot, Israel C. Pandu Rangan Indian Institute of Technology Madras, Chennai, India Bernhard Steffen TU Dortmund University, Dortmund, Germany Demetri Terzopoulos University of California, Los Angeles, CA, USA Doug Tygar University of California, Berkeley, CA, USA Gerhard Weikum Max Planck Institute for Informatics, Saarbrücken, Germany More information about this series at http://www.springer.com/series/7412 Alejandro F. Frangi Julia A. Schnabel (cid:129) ó Christos Davatzikos Carlos Alberola-L pez (cid:129) Gabor Fichtinger (Eds.) Medical Image Computing and Computer Assisted – Intervention MICCAI 2018 21st International Conference – Granada, Spain, September 16 20, 2018 Proceedings, Part I 123 Editors Alejandro F.Frangi Carlos Alberola-López University of Leeds Universidad deValladolid Leeds Valladolid UK Spain Julia A.Schnabel Gabor Fichtinger King’sCollege London Queen’s University London Kingston, ON UK Canada Christos Davatzikos University of Pennsylvania Philadelphia, PA USA ISSN 0302-9743 ISSN 1611-3349 (electronic) Lecture Notesin Computer Science ISBN 978-3-030-00927-4 ISBN978-3-030-00928-1 (eBook) https://doi.org/10.1007/978-3-030-00928-1 LibraryofCongressControlNumber:2018909526 LNCSSublibrary:SL6–ImageProcessing,ComputerVision,PatternRecognition,andGraphics ©SpringerNatureSwitzerlandAG2018 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartofthe material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodologynow knownorhereafterdeveloped. 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ThisSpringerimprintispublishedbytheregisteredcompanySpringerNatureSwitzerlandAG Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland Preface We are very pleased to present the conference proceedings for the 21st International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI),whichwassuccessfullyheldattheGranadaConferenceCenter,September 16–20, 2018 in Granada, Spain. Theconferencealsofeatured40workshops,14tutorials,andtenchallengesheldon September 16 or 20. For the first time, we had events co-located or endorsed by other societies. The two-day Visual Computing in Biology and Medicine (VCBM) Work- shop partnered with EUROGRAPHICS1, the one-day Biomedical Workshop Biomedical Information Processing and Analysis: A Latin American perspective partnered with SIPAIM2, and the one-day MICCAI Workshop on Computational Diffusion on MRI was endorsed by ISMRM3. This year, at the time of writing this preface, the MICCAI 2018 conference had over 1,400 firm registrations for the main conference featuring the most recent work in the fields of: – Reconstruction and Image Quality – Machine Learning and Statistical Analysis – Registration and Image Guidance – Optical and Histology Applications – Cardiac, Chest and Abdominal Applications – fMRI and Diffusion Imaging – Neuroimaging – Computer-Assisted Intervention – Segmentation This was the largest MICCAI conference to date, with, for the first time, four volumes of Lecture Notes in Computer Science (LNCS) proceedings for the main conference, selected after a thorough double-blind peer-review process organized in several phases as further described below. Following the example set by the previous program chairs of MICCAI 2017, we employed the Conference Managing Toolkit (CMT)4 for paper submissions and double-blind peer-reviews, the Toronto Paper Matching System (TPMS)5 for automatic paper assignment to area chairs and reviewers, and Researcher.CC6 to handle conflicts between authors, area chairs, and reviewers. 1 https://www.eg.org. 2 http://www.sipaim.org/. 3 https://www.ismrm.org/. 4 https://cmt.research.microsoft.com. 5 http://torontopapermatching.org. 6 http://researcher.cc. VI Preface Intotal,arecord1,068fullsubmissions(ca.33%morethanthepreviousyear)were receivedandsentouttopeer-review,from1,335originalintentionstosubmit.Ofthose submissions, 80% were considered as pure Medical Image Computing (MIC), 14% as pureComputer-AssistedIntervention(CAI),and6%asMICCAIpapersthatfittedinto both MIC and CAI areas. The MICCAI 2018 Program Committee (PC) had a total of 58 area chairs,with45% from Europe, 43%from the Americas,9% from Australasia, and 3% from the Middle East. We maintained an excellent gender balance with 43% women scientists on the PC. Using TPMS scoring and CMT, each area chair was assigned between 18 and 20 manuscripts using TPMS, for each of which they suggested 9–15 potential reviewers. Subsequently, 600 invited reviewers were asked to bid for the manuscripts they had beensuggestedfor.FinalreviewerallocationsviaCMTtookPCsuggestions,reviewer bidding, and TPMS scores into account, allocating 5–6 papers perreviewer. Based on the double-blind reviews, 173 papers (16%) were directly accepted and 314 papers (30%) were directly rejected – these decisions were confirmed by the handling area chair. The remaining 579 papers (54%) were invited for rebuttal. Two further area chairs were added using CMT and TPMS scores to each of these remaining manu- scripts, whothen independentlyscored thesetoacceptorreject, based onthereviews, rebuttal, and manuscript, resulting in clear paper decisions using majority voting: 199 further manuscripts were accepted, and 380 rejected. The overall manuscript acceptance rate was 34.9%. Two PC teleconferences were held on May 14, 2018, in two different time zones to confirm the final results and collect PC feedback on the peer-review process (with over 74% PC attendance rate). For the MICCAI 2018 proceedings, the 372 accepted papers7 have been organized in four volumes as follows: – Volume LNCS 11070 includes: Image Quality and Artefacts (15 manuscripts), Image Reconstruction Methods (31), Machine Learning in Medical Imaging (22), StatisticalAnalysisforMedicalImaging(10),andImageRegistrationMethods(21) – Volume LNCS 11071 includes: Optical and Histology Applications (46); and Cardiac, Chest, and Abdominal Applications (59) – Volume LNCS 11072 includes: fMRI and Diffusion Imaging (45); Neuroimaging and Brain Segmentation (37) – Volume LNCS 11073 includes: Computer-Assisted Intervention (39) grouped into image-guided interventions and surgery; surgical planning, simulation and work flow analysis; and visualization and augmented reality; and Image Segmentation Methods (47) grouped into general segmentation methods; multi-organ segmenta- tion; abdominal, cardiac, chest, and other segmentation applications. WewouldliketothankeveryonewhocontributedgreatlytothesuccessofMICCAI 2018andthequalityofitsproceedings.TheseincludetheMICCAISociety,forsupport and insightfulcomments;and our sponsorsfor financial support and their presence on site. We are especially grateful to all members of the Program Committee for their diligentworkinthereviewerassignmentsandfinalpaperselection,aswellasthe600 7 Onepaperwaswithdrawn. Preface VII reviewersfortheirsupportduringtheentireprocess.Finally,andmostimportantly,we thank all authors, co-authors, students, and supervisors, for submitting and presenting their high-quality work which made MICCAI 2018 a greatly enjoyable, informative, and successful event. We are especially indebted to those reviewers and PC members who helped us resolve last-minute missing reviews at a very short notice. We are looking forward to seeing you in Shenzhen, China, at MICCAI 2019! August 2018 Julia A. Schnabel Christos Davatzikos Gabor Fichtinger Alejandro F. Frangi Carlos Alberola-López Alberto Gomez Herrero Spyridon Bakas Antonio R. Porras Organization Organizing Committee General Chair and Program Co-chair Alejandro F. Frangi University of Leeds, UK General Co-chair Carlos Alberola-López Universidad de Valladolid, Spain Associate to General Chairs Antonio R. Porras Children’s National Medical Center, Washington D.C., USA Program Chair Julia A. Schnabel King’s College London, UK Program Co-chairs Christos Davatzikos University of Pennsylvania, USA Gabor Fichtinger Queen’s University, Canada Associates to Program Chairs Spyridon Bakas University of Pennsylvania, USA Alberto Gomez Herrero King’s College London, UK Tutorial and Educational Chair Anne Martel University of Toronto, Canada Tutorial and Educational Co-chairs Miguel González-Ballester Universitat Pompeu Fabra, Spain Marius Linguraru Children’s National Medical Center, Washington D.C., USA Kensaku Mori Nagoya University, Japan Carl-Fredrik Westin Harvard Medical School, USA Workshop and Challenge Chair Danail Stoyanov University College London, UK X Organization Workshop and Challenge Co-chairs Hervé Delingette Inria, France Lena Maier-Hein German Cancer Research Center, Germany Zeike A. Taylor University of Leeds, UK Keynote Lecture Chair Josien Pluim TU Eindhoven, The Netherlands Keynote Lecture Co-chairs Matthias Harders ETH Zurich, Switzerland Septimiu Salcudean The University of British Columbia, Canada Corporate Affairs Chair Terry Peters Western University, Canada Corporate Affairs Co-chairs Hayit Greenspan Tel Aviv University, Israel Despina Kontos University of Pennsylvania, USA Guy Shechter Philips, USA Student Activities Facilitator Demian Wasserman Inria, France Student Activities Co-facilitator Karim Lekadir Universitat Pompeu-Fabra, Spain Communications Officer Pedro Lopes University of Leeds, UK Conference Management DEKON Group Program Committee Ali Gooya University of Sheffield, UK Amber Simpson Memorial Sloan Kettering Cancer Center, USA Andrew King King’s College London, UK Bennett Landman Vanderbilt University, USA Bernhard Kainz Imperial College London, UK Burak Acar Bogazici University, Turkey