CONTENTS Special Issue: First International Conference on Immunology and Aging Organised by the Institute for Advanced Studies in Immunology and Aging Washington, June 16-19, 1996 Immunology and the elderly: an historical perspective for future inter- national action M.E. Weksler (New York, NY) Economic and political implications of immunology and aging on tomorrow’s society R.N. Butler (New York, NY) IL-6, DHEA and the ageing process K. James, N. Premchand, A. Skibinska, G. Skibinski, M. Nicol, J.I. Mason (Edinburgh, UK) The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis C.C. Spaulding, R.L. Walford, R.B. Effros (Los Angeles, CA)... . The T cell in the ageing individual G. Pawelec, M. Adibzadeh, R. Solana, I. Beckman (Tubingen, Germany; Cordoba, Spain; Bedford Park, S. Australia, Australia) Thymocyte development in vitro: implications for studies of ageing and thymic involution E. Montecino-Rodriguez, K. Dorshkind (Los Angeles, CA) Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E A.A. Beharka, D. Wu, S.N. Han, S.N. Meydani (Boston, MA)... . Malariotherapy for HIV patients H.J. Heimlich, X.P. Chen, B.Q. Xiao, $.G. Liu, Y.H. Lu, E.G. Spletzer, J.L. Yao (Cincinnati, OH; Guangzhou, China) Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-z and IL-6 in C3BIORFI1 mice C.C. Spaulding, R.L. Walford, R.B. Effros (Los Angeles, CA)... . Age-related changes in CD4 T cells of T cell receptor transgenic mice (Mini review) L. Haynes, P.-J. Linton, S.L. Swain (Saranac Lake, NY; San Diego, CA) Effect of restraint stress on immune system and experimental B16 melanoma metastasis in aged mice J. Kanno, A. Wakikawa, M. Utsuyama, K. Hirokawa (Tokyo, Japan) 107 Contents continued on p. viti Viil Contents continued from p. vii Reversing and restoring immune functions ES eee ee eee ee 119 Peripheral blood dendritic cells reinduce proliferation in in vitro aged T cell populations M.M. Steger, C. Maczek, B. Grubeck-Loebenstein (Innsbruck, a eR ta eh eg a al eS al a ee Che ae ae ea koe 8 8 125 Impairment of signal transduction in T cells from old mice M. Utsuyama, A. Wakikawa, T. Tamura, H. Nariuchi, K. Hirokawa te es ea ek A ae be lw RR ek Bek 8 131 Accelerated onset of age-related autoimmune lesions in MRL/+ mice by ovariectomy N. Ishimaru, N. Haneji, H. Hamano, Y. Kumiko, M. Takahashi, Y. Pamyaem (TOKWGNMMR, JODOM) . ww te tee we tes 145 Regulation of cytokine production in aging: use of recombinant cytokines to upregulate mitogen-stimulated spleen cells D. Frasca, S. Pucci, C. Goso, P. Barattini, S. Barile, C. Pioli, G. Doria eh Ge es ee ee leo i Mabe ade ene 157 New developments in adjuvants Dude ME COE UU BPEPs 6 kc te ew eee we 171 Summary of a clinical trial with liposome-adjuvanted influenza A virus vaccine in elderly adults a 5kwind be. ee de eee oe “er 179 Increasing the immunogenicity of a trivalent influenza virus vaccine with adjuvant-active nonionic block copolymers for potential use in the elderly M.J. Newman, C.W. Todd, E.M. Lee, M. Balusubramanian, P.J. Didier, J.M. Katz (Norcross, GA; Covington, LA; Atlanta, GA) ....... 189 Effect of rIL-2 treatment on anti-tetanus toxoid response in the elderly U. Fagiolo, M.C. Bordin, R. Biselli, R. D’Amelio, R. Zamarchi, A. Amadori (Padova, Roma, Italy)...................2.04. 205 Long term exercise patterns and immune function in healthy older women: A report of preliminary findings S.H. Gueldner, L.W. Poon, M. La Via, G. Virella, Y. Michel, M.H. Bramlett, C.A. Noble, E. Paulling (University Park, PA; Athens, GA; ee Oke ss haw COR Re ea Oe eee 215 Author index 223 Subject index 225 Publisher’s Notice: This is the first issue containing papers presented at the First International Conference on Immunology and Aging. Further papers will be published in future issues in 1997.