A AV0N/65524/S3.95 ROVL.WALFORDM.Di STARTLING NEWDISCOVERIES FROM THEWORLD'S LEADING MEDICALRESEARCH ON RETARDINGAGE-AND PROLONGINGYOUTH "Supposeyou couldlivetobe 120.and still maintainavigorous mindandbody? Dr. RoyWalfordtellsyouhowtodoit." CincinnatiEnquirer Digitized by the Internet Archive 2014 in https://archive.org/details/maximumlifespanOOroyl_iws A "RETARDATION OF THE AGING PRO- CESS MAY ALREADY BE POSSIBLE... BRILLIANT PRESENTATION OF THE EVIDENCE." Jean Dausset, Nobel Laureate in Medicine "Getting old with Dr. Roy Walford might be a lot offun .You're going to love this book." . . Los Angeles Times "Dr. Roy Walford has shown that the benefits [ofhisprogram]apparentlycanbereapedeven if one does not begin until middle age." The New York Times ROY WALFORD UCLA DR. L. heads the research laboratory for the study ofimmunol- ogy and the agingprocess. Winnerofthemajor awardsin hisfield,heis amemberoftheWhite House Conference on Aging, Chairman ofthe National Institute on Aging Task Force on Immunology, and a member of the National Academy of Sciences Committee on Aging. AvonBooksareavailableatspecialquantitydiscountsfor bulk purchases for sales promotions, premiums, fund raisingoreducationaluse.Specialbooks,orbookexcerpts, can also be created to fit specific needs. Fordetails write ortelephone the office ofthe Director of Special Markets, Avon Books, Dept. FP, 1790 Broadway, New York, New York 10019, 212-399-1357. ROY LWALPORRMiX MAXIMUM A AVON I* PUBLISHERS OF BARD, CAMELOT, DISCUS AND FLARE BOOKS Figure 3.1. Adapted from H J. Wyhe, W L. Beeaon, and J. W. Kuzma, "Is There a YoungerYou Inside?" LifeandHealth. October 1978,p 5. Figure3.2.AdaptedfromF.Bourliere,TheAssessmentofBiologicalAgeinMan,Public Health Papers, no. 37(Geneva: World Health Organization, 1970) Figure3.3. Adapted fromA. Leaf,"GettingOld,"ScientificAmerican, 229:45, 1973. Figure4.2.AdaptedfromR.HartandR.Setlow,"CorrelationbetweenDeoxyribonucleic Acid Excision..."Proc. Nat. Acad. ScL, U.S.A. 71:2169(1974). Figure5.1.(A)AdaptedfromC.L.GoodrickinScienceNews1 December1979,p.375;(B) R. Weindruch ct al, "LifeSpan..." Science 215: 1415-18(1982); (C) M.A. Rudzinska. "Overfeedingand LifeSpan...,"J. Gerontology7:544(1952). Table7.1.AdaptedfromNutritionAction,July, 1980,CenterforSciencein thePublic Interest. Figure7.3.AdaptedfromNutritionAction,September, 1981,CenterforSciencein the PublicInterest. Figure 9.1. Adapted from M. Riley, M. Johnson, A. Forer, Aging and Society: A SociologyofAgeStratification(RussellSageFoundation, 1972), p. 10. AVON BOOKS A division of The Hearst Corporation 1790 Broadway New York, New York 10019 Copyright © 1983 by Roy L. Walford Test Illustrations by Ann Morris Book design by Jacques Chazaud Published by arrangement with W. W. Norton & Company Library ofCongress Catalog Card Number: 82-12605 ISBN: 0-380-655244 - All rights reserved, which includes the right to reproduce this book or portions thereofin any form whatsoeverexcept as provided by the U. S. Copyright Law. Forinformation address W. W. Norton & Company 500 Fifth Avenue, New York, New York 10110 The W. W. Norton &Company, Inc. contains the following Library ofCongressCatalogingin Publication Data: Walford, Roy L. Maximum lifespan. Includes index. 1. Longevity. 2. Aging. 3. Lifespan. Productive. I. Title. FirstAvon Printing, April, 1984 AVON TRADEMARK REG. U. S. PAT. OFF. AND IN OTHER COUNTRIES, MARCA REGISTRADA, HECHO EN U. S. A. Printed in the U. S. A. WFH 987654321 10 This book is dedicated to my children, Lisa, Morgan, and Peter, and to Martha Walford and Susan Ritman for their love and forbearance. Contents Preface xi 1 . How to Think about Life Span / 2. The Long March of Gerontology 28 3. The Hieroglyphs of Aging 49 4. Theories of Aging I Love Best 70 5. Undernutrition Now 98 6. Keep Cool, Methuselah 114 7. Practical State of the Art of Life-Span Extension 132 8. Future Breakthrough Possibilities 161 9. Transition to the Long-living Society 176 Appendix a Nutritive Values of Foods 203 Appendix b Menus and Recipes 218 Notes 233 Index 247 Vll