1 MATTHEW R. SORENSON, PhD., APN, ANP-C Associate Professor/Associate Director School of Nursing DePaul University EDUCATION PhD. 2002 Loyola University Chicago with Distinction Major: Nursing Dissertation: Psychological Stress, Coping and Illness Uncertainty in Individuals with Multiple Sclerosis: Relationship with Cytokine Production. M.S. 1995 Northern Illinois University Major: Applied Family and Child Studies Thesis: Predicting Nonorganic Failure to Thrive from Mother Infant Interaction. M.S. 1992 Northern Illinois University Major: Nursing Concentration: Community Health B.S. 1988 Northern Illinois University Major: Nursing Minor: History A.S. 1986 Elgin Community College OTHER EDUCATION 2006 Georgetown University 12 credit hours in Molecular Genetics 2006 (Summer) Fellow, National Institutes of Health, National Institute of Nursing Research. Summer Genetics Institute 2002-2005 Edward Hines Jr. Veterans Affairs Hospital Post-Doctoral Fellow: Research and Neurology Service 2004 DePaul University Certificate: Adult Nurse Practitioner 1982 Northwest Community Hospital Certificate: Paramedical Science 2 ACADEMIC APPOINTMENTS 2011-present Associate Director of Master’s Entry to Nursing Practice Program, DePaul University 2012-present Associate Professor with Tenure, School of Nursing, DePaul University 2004-present Clinical Scholar, Northwestern University Feinberg School of Medicine, Department of Physical Medicine and Rehabilitation 2005-2012 Assistant Professor, School of Nursing, DePaul University 2004-2005 Lecturer, Department of Nursing, DePaul University 2002-2003 Part-Time Lecturer in Nursing, North Park University Provided clinical supervision to graduate nursing students completing a two-semester rotation in community health (Course Number 522: Strategic Nursing Management). 2002 Part Time Lecturer in Nursing, Loyola University Chicago Provided Clinical Instruction in Community Health Nursing to Accelerated Nursing Students (Course CMAN 379). Provided instruction in skill laboratory setting in Medical-Surgical Skills to Accelerated Nursing Students. 1998-2000 Faculty Member, Ravenswood Hospital Medical Center: Henry J. Kutsch College of Nursing Provided instruction in both clinical and classroom settings in an Associate Degree Program. Composed and edited NCA Accreditation Report with another faculty member. Also, structured and edited NLN Self-Study with another faculty member. Taught psychologic and medical-surgical content. Served as Chair of Evaluation Committee. 1993-1998 Nursing Instructor, Ravenswood Hospital Medical Center: Henry J. Kutsch School of Nursing Provided instruction in clinical skills laboratory setting; clinical instructor for psychiatric, fundamental and advanced medical surgical nursing rotations. Provided lecture content in physical rehabilitation, neurological and psychiatric nursing. In 1998 School converted to an Associate Degree program. GRANTS AND CONTRACTS Awarded 12/06/2011 to 06/30/12 Illinois Board of Higher Education. Nurse Educator Fellowship Award ($10,000). Provided funding for a project designed to incorporate genetic information into the advanced practice nursing curriculum. 3 05/1/2004 to 04/30/2006 National Institutes of Health, National Institute for Nursing Research. R03 award for the project “Stress and MRI Lesion in Multiple Sclerosis”. Two years of support to investigate the relationships among cytokine production, disease symptoms and brain lesions as detectable using magnetic resonance imaging. Study involves quantification of lesion, measurement of peripheral cytokine production and assessment of psychological variables. 07/01/02-06/30/05 Department of Veterans Affairs, Office of Academic Affiliations. Post-Doctoral Nursing Fellowship. An investigator initiated award of two-year’s salary support as a post-doctoral nursing fellow at Edward Hines Jr. Veterans Affairs Hospital. Awarded a third fellowship year in January 2004. Attended Resident Lectures in Department of Neurology. Audited course in Molecular and Cellular Neurobiology and received advanced instruction in the conduct of research. Project Sponsors: George Siegel, MD, Chief of Neurology Service at Hines V.A. and Linda Janusek, PhD., RN, Professor of Nursing, Loyola University Chicago. Project Director, Lauren Lawson, PhD., RN, Chief of Nursing Service for Research, Hines VA. 07/01/01-09/30/02 National Multiple Sclerosis Association. Pilot Research Grant developed in Collaboration with Herbert Mathews, Ph.D., for project “Psychological and Immunological Impact of Stress upon MS Patients” ($27,500). The project focus was on psychologic modulation of immune function in control subjects and individuals with multiple sclerosis. The project differed from the work below in that here the focus was on a select profile of cytokines and chemokines with pro-inflammatory properties that may be involved in the pathogenesis of multiple sclerosis. Variables included; cytokine production, chemokine production, perceived stress, coping profile, quality of life, appraised life events, disease symptomatology and illness uncertainty. 09/30/99-08/01/01 National Institutes of Health, National Research Service Award (Pre-doctoral). Two years of support as pre-doctoral fellowship for the project “Stress-Immune Interactions in Multiple Sclerosis” (Approx. $35,000). The relationship between psychological variables (perceived stress, coping style, life events and mood state) and immune function was examined. Immune function was measured through mitogen stimulation of peripheral blood mononuclear cells. Cell culture supernatant was assayed for the presence of a restricted number of cytokines (IL-2, IL-4, IL-6, IL-10., IL-12, IL-13, TNF-alpha, IFN-gamma, TGF-Beta1). In controls, perceived stress and other measures of psychologic distress were significantly correlated with select Th1 related cytokines. For those with MS, perceived stress and psychologic distress were correlated with select Th1 and Th2 derived cytokines. A difference was also noted to exist in the relationship between coping style and cytokine production between normative controls and those with MS. 4 07/01/1999-04/02/01 American Association of Spinal Cord Injury Nurses ($10,600). “Stress-Immune Interactions in Multiple Sclerosis.” Provided research supply funds for investigation of psychologic modulation of immune function in individuals with multiple sclerosis. Funding also provided support for the examination of plasma for the presence of catecholamines as measured by radioimmunoassay. 07/01/1999-06/30/00 Sigma Theta Tau (Alpha Beta Chapter) ($1,000). “Stress- Immune Interactions in Multiple Sclerosis." Scored, not Awarded. 2009 National Institutes of Health. ($2,464,115). Biobehavioral Research with a Psychosocial Children's Intervention. Investigators: Leonard Jason, Ben Katz, Matthew Sorenson. 2008 Robert Wood Johnson Foundation, Nurse Faculty Scholars Program ($316,962). “Immunologic and Clinical Correlates of Fatigue in Older Adults”. Named as Finalist for Award Consideration, presented, and brought to Washington, DC, by the foundation for a presentation of the proposal and interviews. 2007 Department of Veterans Affairs ($349,100). “Clinical and Immunologic Correlates of Multiple Sclerosis related Fatigue”. SCHOLARLY ACTIVITIES Publications - Peer-Reviewed Journal Articles Sorenson, M., Witek-Janusek, L., & Mathews, H. (2013). Psychological stress and Cytokine Production in Multiple Sclerosis: Correlation with Disease Symptomatology. Biological Research for Nursing, 15, 224-231. Sorenson, M., Jason, L., Lerch, A., Porter, N., Peterson, J., Herrington, J., & Mathews, H. (2012). The production of Interluekin-8 is increased in the Peripheral Blood Mononuclear Cells of Patients with Fatigue. Neuroscience and Medicine, 3(1), 47-53. Jason, LA., Sorenson, M., Roberts, J., Sebally, J. K., Alkazemi, D., & Kubow, S. (2011). Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome. Brain, Behavior and Immunity, 25, 1544-1547. Jason, L.A., Sorenson, M., Porter, N., & Belkairous, N. (2011). An etiological model for Myalgic Encephalomyelitis/chronic fatigue syndrome. Neuroscience & Medicine, 2, 14- 27. 5 Gwin, J., Drews, N., Syed, A., Stanschror, J., Sorenson, M., & Rajah, T. (2011). Effect of Genistein on p90RSK Phosphorylation and Cell Proliferation in T47D Breast Cancer Cells. Anticancer Research, 31(1), 209-214. Porter, N., Lerch, A., Jason, L.A., Sorenson, M., & Fletcher, M.A. (2010). A comparison of immune functionality in viral versus non-viral CFS subtypes. Journal of Behavioral and Neuroscience Research, 8(2), 1-8. Jason, L.A., Sorenson, M., Porter, N., Brown, M., Lerch, A., Van der Eb, C., & Mikovits J. (2010). Possible genetic dysregulation in pediatric CFS. Psychology, 1, 247-251. Sorenson, M. (2010). Immunosenescence: An Unappreciated Risk. MedSurg Matters, 1, 6-8. Jason, L.A., Porter, N., Herrington, J., & Sorenson, M., & Kubow, S. (2009). Kindling and oxidative stress as contributors to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Journal of Behavioral and Neuroscience Research, 7, 1-17. Torres-Harding, S., Sorenson, M., Jason, L.A., Maher, K., Fletcher, M.A., Reynolds, N., & Brown, M. (2008). The associations between basal salivary cortisol levels and illness symptomatology in chronic fatigue syndrome. Journal of Applied Biobehavioral Research, 13(3), 157-180. Torres-Harding, S., Sorenson, M., Jason, L.A., Maher, K., & Fletcher, M.A. (2008). Evidence for T-helper 2 shift and association with illness parameters in chronic fatigue syndrome (CFS). Bulletin of IACFS/ME, 16(3), 19-33. Jason, L.A., Torres-Harding, S., Brown, M., Sorenson, M., Donalek, J., Corradi, K., Maher, K., & Fletcher, M.A. (2008). Predictors of change following participation in non- pharmacologic interventions for CFS. Tropical Medicine and Health, 36(1), 23-32. Jason, L.A., Torres-Harding, S., Maher, K., Reynolds, N., Brown, M., Sorenson, M., Fletcher, M.A., & Lu, T. (2007). Normal versus abnormal cortisol predict treatment outcomes in a CFS non-pharmacologic clinical trial. Journal of Chronic Fatigue Syndrome, 14, 39-59. Lyons, S., & Sorenson, M. (2007). Quality of life in spinal cord injury patients with pressure ulcers. SCI Nursing, 26(2), 13-18. Semp, M., Sorenson, M., & Holm, K. (2007). Critiquing SCI Research: Understanding Statistical Data. SCI Nursing, 24(1), Retrievable through http://www.unitedspinal.org/publications/nursing Sorenson, M., Janusek, L., & Mathews, H. (2006). Perceived Stress, Illness Uncertainty and Disease Symptomatology in Multiple Sclerosis. SCI Nursing, 23(1), retrievable through http://www.unitedspinal.org/publications/nursing/ 6 Invited Publications – Peer Reviewed Rizio, N., Tran, C., & Sorenson, M. (2012). Invited Review: Efficacy and Satisfaction of Oral Pharmacotherapies in the Treatment of Erectile Dysfunction in Men with Spinal Cord Injuries: A Literature Review. Journal of Spinal Cord Medicine, 35(4), 219-228. Publications - Books Sorenson, M., & Tichawa, U. (2013). Case Studies in Adult Health: Kendall-Hunt. Publications – Book Chapters Sorenson, M. (Under Review). Sleep Disorders. In, D. Murphy (Ed.), Psychiatric Nursing Made Incredibly Easy. Lippincott, Williams & Wilkins. Sorenson, M. (Accepted, 2013). Stress and Coping. In P. Potter, A. Perry, P. Stockert and A. Hall (Eds.), Basic Nursing (8th ed.). St. Louis: Elsevier. Sorenson, M., Witek-Janusek, L., Mathews, H. (Accepted, 2013). Stress and Health. In D. Klein, L. Quinn and K. Laurer (Eds.), Clinical Pathophysiology: Common Health Problems and Risk Factors: McGraw-Hill. Sorenson, M. (2014). Problems of Mental Health. Lippincott Manual of Nursing Practice (10th ed., pp. 1810-1840). Lippincott, Williams & Wilkins. Jason, L.A., Sorenson, M., Evans, M., Brown, A., Flores, S., Sunnquist, M., & Schafer, C. (2013). The implications of sensitization and kindling for chronic fatigue syndrome. In N. Gotsiridze-Columbus (Ed.). Encephalitis, Encephalomyelitis, Encephalopathies: Symptoms, causes and potential complications. (pp.73-94). New York: Nova Science. Sorenson, M. (2013). Bipolar Disease and Genetic Linkages. In C. Kenner and J. A. Lewis (Eds.), Genetics and Genomics for Nursing (pp. 259-269). Upper Saddle River, NJ: Pearson. Sorenson, M. (2013). In C. Kenner and J. A. Lewis (Eds.), Genetics and Genomics for Nursing (pp. 35-44). Upper Saddle River, NJ: Pearson. Sorenson, M. ( 2013). Evaluating a Program: Metrics and Stakeholders. In K. Amer (Ed.), Quality and Safety for Transformational Nursing: Core Competencies (pp. 130-147). Upper Saddle River, NJ: Pearson. Sorenson, M., & Harris, B. (2012). Personality Constructs and Coping. In V. Rice (Ed.), Handbook of Stress, Coping and Health (2nd ed., pp. 334-354). Thousand Oaks, CA: Sage. Sorenson, M. (2012). Neurological Disorders. In K. Mauk (Ed.), Rehabilitation Nursing (pp. 344-358). Jones & Bartlett. 7 Sorenson, M. (2009). Infection, Sepsis and Immune Function. In M. Foreman, K. Milisen, & T. Fulmer (Eds.), Critical Care Nursing Of Older People: Best Practices (pp. 313-338). New York: Springer. Sorenson, M. (2009). Problems of Mental Health. Lippincott Manual of Nursing Practice (9th ed., pp. 1800-1838). Lippincott, Williams & Wilkins. Sorenson, M. (2005). Problems of Mental Health. Lippincott Manual of Nursing Practice (8th ed.). Lippincott, Williams & Wilkins. Publications – Practice Guidelines Campbell, G., Higgins, P. G., Mervine, J., Radwanski, M., & Sorenson, M. (2014). Standards and Scope of Rehabilitation Nursing Practice. Chicago, IL: Association of Rehabilitation Nurses. Thompson, H. J, & Mauk, K. M. (Eds., 2011). Nursing Management of the Patient with Multiple Sclerosis. AANN, ARN, and IOMSN Clinical Practice Guideline Series. Also contributed to below webinar based on the guidelines; developed and presented a case study on relapsing-remitting multiple sclerosis. Association of Rehabilitation Nurses (01-10-2012). Putting Guidelines Into Practice: Care of the Patient with Multiple Sclerosis. To be retrievable from http://www.rehabnurse.org/education/Webcasts/index.html Publications – Contributor Sorenson, M. (2011). Assessment Made Incredibly Easy. Lippincott, Williams & Wilkins. Publications – Columns Sorenson, M. (2009). The Process of Dissemination. SCI Nursing, 26(3), 29-31. Sorenson, M. (2009). How do I find a good questionnaire? SCI Nursing 26(2), 25-26. Sorenson, M. (2009). Apples or Oranges: Is my Questionnaire congruent with my Theoretical Design? SCI Nursing, 26(1), p. 35. Sorenson, M. (2008). The Search for Funding. SCI Nursing, 25(1), p. 51-53. Sorenson, M. (2008). The Pilot Study. SCI Nursing, 25(2), p. 29-30. Sorenson, M. (2008). Is there a Place for Genetics in the Study of Spinal Cord Injury Nursing? SCI Nursing, 25(3), p. 38-40. 8 Sorenson, M. (2007). Nogo antibodies and spinal cord regeneration. SCI Nursing, 24(2), Retrievable through http://www.unitedspinal.org/publications/nursing/ Sorenson, M. (2007). The Internet as Research Tool. SCI Nursing, 23(2), Retrievable through http://www.unitedspinal.org/publications/nursing/ Sorenson, M. (2006). The Specter of Mixed Methods Research. SCI Nursing, 23(1), Retrievable through http://www.unitedspinal.org/publications/nursing/ Scholarly Works in Progress Sorenson, M., Foreman, M., & Holm, K. (In review). A Conceptual Model for the Study of Allostasis in working with Elder Populations. Biological Research for Nursing. Sorenson, M., and Frazier, S. (Book under Contact). Pathophysiology: A case-based approach. Pearson. Sorenson, M., Jason, L., Peterson, J., & Mathews, H. Increased production of BDNF on the part of peripheral blood mononuclear cells in those with Multiple Sclerosis and Chronic Fatigue Syndrome. Sorenson, M., Saucedo, V., Siegel, G., Janusek, L., & Mathews, H. Increased plasma norepinephrine and epinephrine in individuals with Multiple Sclerosis. Journal Publications on which assistance acknowledged Sarkey, J. P., Richards, M. P., & Stubbs, E. B., jr. (2007). Lovastatin attenuates nerve injury in an animal model of gullian-barre syndrome. Journal of Neurochemistry, 100, 1265–1277 Witek-Janusek, L., Shareef, M. J., & Matthews, H. L. (2002). Reduced lymphocyte- mediated antifungal capacity in high-risk infants. Journal of Infectious Disease, 186, 129-133. PARTICIPATION IN SCHOLARLY MEETINGS, PAPERS, AND PRESENTATIONS Peer-Reviewed 2009 Paper Presentation: Quality of Life in Spinal Cord Injury Patients with a Pressure Ulcer. Congress on Spinal Cord Medicine and Rehabilitation. Dallas, TX 2008 Paper Presentation: The Disabling Nature of Fatigue. The Fourth Chronic Illness and Postsecondary Education Symposium. Chicago, IL. 2008 Poster Presentation The Disabling Nature of Fatigue. The 24th Annual Pacific Rim Conference on Disabilities. Honolulu, HI. 9 2007 Paper Presentation: A Conceptual Model for Stress Research in Individuals with SCI. Paper Presented at the American Association of Spinal Cord Injury Nurses 24th Annual Meeting. Kissimmee, FL. 2005 Paper Presentation: Biologic and Disease Modifying Agents in Multiple Sclerosis. The American Association of Spinal Cord Injury Nurses 22nd Annual Meeting. Las Vegas, NV 2004 Sorenson, M. Coping and Immune Function in Multiple Sclerosis. Paper Presented at the Midwest Nursing Research Society 28th Annual Research Conference. St. Louis, Missouri. 2004 Antonescu-Turcu, A., Collins, E., Sorenson, M., Hussain, O., Tobin, M. J., & Laghi, F. Is serum tumor necrosis factor-alpha increased in serum of unselected stable patients with COPD? Paper Presented at the American Thoracic Society 100th International Meeting. Orlando, Florida. 2004 Coping and Immune Function in Multiple Sclerosis. Poster Presented at the Consortium of Multiple Sclerosis Centers Annual Meeting. Toronto, Canada. 2004 Sorenson, M., Janusek, K., & Mathews, H. Perceived Stress in Associated with the Production of IL-6 and IL-10 in MS Patients. Paper Presented as part of the Whitaker Research Track at the Consortium of Multiple Sclerosis Centers Annual Meeting. Toronto, Canada. 2003 Sorenson, M. Psychological Stress and Cytokine Production in Multiple Sclerosis: Correlation with Disease Symptomatology. Paper Presented at the Midwest Nursing Research Society 27th Annual Research Conference. Grand Rapids, Michigan. 2002 Sorenson, M., Janusek, L., & Mathews, H. Psychological Stress and Cytokine Production in Multiple Sclerosis: Correlation with Disease Symptomatology. Poster Presentation at the PsychoNeuroImmunology Research Society: 9th International Annual Meeting. Madison, Wisconsin. 2002 Sorenson, M., Janusek, L., & Mathews, H. Coping Style and Cytokine Production in Individuals with Multiple Sclerosis and Normative Controls: An Unexpected Relationship. Poster Presentation at the PsychoNeuroImmunology Research Society: 9th International Annual Meeting. Madison, Wisconsin. 2002 Sorenson, M., Janusek, L., & Mathews, H. Psychological Stress and Illness Uncertainty in Individuals with Multiple Sclerosis: Relationship with Disease Symptomatology. Paper Presented to the Midwest Nursing Research Society: 26th Annual Research Conference. Chicago, Illinois. 2001 Sorenson, M., Janusek, L., & Mathews, H. Psychological Stress is Correlated with the Presence of Disease Symptoms in Individuals with Multiple Sclerosis. Poster Presentation at the Ruth K. Palmer Research Symposium. Maywood, IL. 10 2001 Sorenson, M. Stress-Immune Interactions in Multiple Sclerosis. Paper Presented to the American Association of Spinal Cord Injury Nurses: 18th Annual Conference. Las Vegas, NV. 1999 Janusek, L., Cusack, C., Sorenson, M., & Mathews, H. Reduced capacity of neonatal lymphocytes to inhibit growth of Candida Albicans: Relationship to age and severity of illness. Poster Presentation at the Loyola University Research Colloquium. Maywood, IL. 1999 Sorenson, M., & Watland, K. Program Evaluation in Nursing. Poster Presentation at the Assessing Program Outcomes: 4th National Conference for Nurse Educators. Indianapolis, IN. 1995 Sorenson, M. Non-Organic Failure to Thrive. Paper presented to the Northern Illinois University: Thirteenth Annual Research Day: Nursing Scholars in Action. Dekalb, IL. Invited 2002 Sorenson, M., & de Leon, P. (May). Emerging Trends in Adolescent Health and Healthy People 2010. Panel discussion at the Heath Issues for Youth at Risk: Fifth Annual Conference. Chicago, Illinois. Other 2012 Psychosocial Healthcare Patterns & Nursing Interventions. Lecture given as part of: Rehabilitation Nursing Practice: Review of Principles, Concepts & Interventions (A review course for the CRRN Exam). Rehabilitation Institute of Chicago. 2011 Psychosocial Healthcare Patterns & Nursing Interventions. Lecture given as part of: Rehabilitation Nursing Practice: Review of Principles, Concepts & Interventions (A review course for the CRRN Exam). Rehabilitation Institute of Chicago. 2010 Acute and Chronic Pain. Lecture given as part of: Rehabilitation Nursing Practice: Review of Principles, Concepts & Interventions (A review course for the CRRN Exam). Rehabilitation Institute of Chicago. 2010 Psychosocial Healthcare Patterns & Nursing Interventions. Lecture given as part of: Rehabilitation Nursing Practice: Review of Principles, Concepts & Interventions (A review course for the CRRN Exam). Rehabilitation Institute of Chicago. 2009 Psychosocial Healthcare Patterns & Nursing Interventions. Lecture given as part of: Rehabilitation Nursing Practice: Review of Principles, Concepts & Interventions (A review course for the CRRN Exam). Rehabilitation Institute of Chicago. 2008 Psychosocial Healthcare Patterns & Nursing Interventions. Lecture given as part of: Rehabilitation Nursing Practice: Review of Principles, Concepts & Interventions (A review course for the CRRN Exam). Rehabilitation Institute of Chicago.