Leica M205 A, M205 C, M165 C & M125 Experience another dimension in stereomicroscopy with the new, high performance stereomicroscopes from Leica. Living up to Life >>> >> A Step Towards Infinity Ever since their introduction by Horatio S. Greenough, stereomicroscopes have worked according to the optical principles based primarily on Ernst Abbe’s research. For over a century, ingenious optics designers and engineers have worked to push magnification, resolution and image fidelity to the limit permitted by optics. In doing so, they have always been constrained by the interrelation bet- ween three factors: the higher a microscope’s resolution, the lower the available working distance. If one increases the distance of the optical axes, the three- dimensional image seen by the observer becomes distorted a cube then becomes a tower, a flat surface curves towards the observer. Limits are made to be broken. LeicaM205 A and M205 C are the first stereomicroscopes in the world that can offer a 20.5 : 1 zoom. This accomplishment, however, was not enough for Leica’s engineers. With the new FusionOptics™, they have succeeded in taking yet another step beyond previous limits. Besides the greater magnification, they have also increased the resolution to 1050lp/mm, which corresponds to a resolved struc- ture size of 476nm. Of course, this performance increase is reflected in your daily work: Set up your specimens on the microscope table with comfortable freedom of movement and discover details that were previously unrevealed, even in stereomicroscopy. 3 The human brain is a fascinating piece of work. Using the data it receives from both eyes, it calculates a three-dimensional image of our environment in an unceas - ing stream. What is truly remarkable, however, is the brain’s ability to gauge situations with lightning speed based on the information it receives, and to react to such situations appropriately. Brain jogging with the Leica M205 A and M205 C The new Leica M205 A and M205 C stereomicroscopes with FusionOptics™ rely on the unsurpassed adaptability of the brain. The microscope assigns a different task to each of the two beam paths: the right channel contains an image with very high resolution, while the left channel provides very high depth of field. The brain then automatically gathers the best information from both sources and uses it to com- pose one image with very high richness of detail and depth of field. 4 Juggling Increases Brain Size Previous studies assumed that humans build brain mass during childhood, develop neurological networking through training in adolescence, can at best maintain this complexity during midlife, and will unavoidably experience diminished mental per- formance with increasing age. Now, a study led by Dr. Arne May * of the University of Regensburg has shown that certain regions of the adult brain have the ability to build brain matter through training. In a group of laypersons who practiced juggling over a three-month period, structural changes in the cerebral cortex were identified after the training period. Astonishingly, the new brain matter formed primarily in the two areas that are responsible for vision and touch. Obviously, the difficulty in juggling lies in visually capturing and analyzing the balls’ movements. Leica FusionOptics™ takes advantage of the flexibility of our brains, and as an added benefit improves mental performance capability. * Dr. Arne May, “Juggling boosts adult brain power”, http://www.uni-protokolle.de/nachrichten/id/28051/ The areas marked in yellow are the regions in which new brain matter was shown to have been created. Courtesy of Dr. Arne May (University Clinic Hamburg) 5 Leica M205 A: the top-of-the-line stereomicroscope for the fully automated complete system With digitally controlled zoom, focus (with the new motorized focus drive) and iris diaphragm, a Leica DFC camera, the motor- ized mechanical stage and versatile software modules of the Leica Application Suite (LAS), the Leica M205 A is capable of accepting any settings and performing any analysis expected of a stereomicroscope with a few clicks of the mouse. Of course, this directly affects your daily work: frequently used microscope settings can be restored with a few mouse clicks, time-consuming serial examinations, of relatively large speci- mens, can be programmed once in the computer and can then be allowed to run automatically whenever necessary. Leica M205 C: advance into unexplored territory with FusionOptics™ It does not matter if you need a large work surface with lots of room for handling specimens or analyzing the tiniest details, which were previously detectable only with a light microscope: with the extraordinary FusionOptics™ zoom, Leica Microsystems has set a new standard for stereomicroscopy. What was previously thought to be an optical impossibility is now reality in the Leica M205 C. The zoom range of 7.8×–160×, objec- tives from 0.63×–5×, and an enormous selection of accessories make this a system that performs superbly in any application. 6 The New Leica M-Series: A Solution for Every Task Leica M165 C: Classic stereomicroscopy of the highest order For those who wish to continue working with classic stereomi- croscopes, the Leica M165 C is equal to almost every need. The optical principle of two symmetrical channels is the same as that of the Leica MZ16, but the zoom range and numerical aperture have been increased to 16.5:1. Of course, the Leica M165 C is also compatible with the full range of cameras, objectives, tubes, bases and accessories. This means not only that you are sure to find a configuration solution for almost any task you have now, but you can also be confident that you will always be able to take advantage of the latest advances in the Leica M series in the future. Leica M125: one instrument for many tasks Supreme performance is not always the most important requirement: in many routine situations, you simply need a microscope that is exception- ally tough and reliable, and compatible with a wide range of accessories. Of course one feature cannot be compromised: the best possible optical quality. With a magnification range of 8×–100×, the Leica M125 is ideal for many applications that may be useful to you: from presorting mechani- cal components to analyzing plastics and detailed inspection of printed circuit boards, the Leica M125 provides consistently high-quality, detailed images of your specimens. 7 You Can Have It All at Once High magnification with great ergonomic benefits Conventional stereomicroscopy gives users a choice: they must choose high reso- lutions and richness of detail, or opt for a larger working distance to be able to manipulate the work specimen. The higher a microscope’s resolution, the less free room there is between specimen and objective. The Leica M205 A and M205 C uses one 1× objective to advance into magnification ranges that were previously only possible with high magnification objectives. This has a directly positive influence on your daily work: the Leica M205 A and M205 C can resolve structures of less than one micrometer. At the same time, the user has a clearance of 61.5mm manipulating specimens. Sorting and processing even for the smallest details can be carried out easily without changing objectives. APO for all To take full advantage of the performance capabilities of these new instruments, all new M-series components are corrected exclusively apochromatically. At last, color fringes can be consigned to history once and for all. 9 Up to Your Tasks. Put Us to the Test! Whenever human lives may be affected, technology must be 100% reliable. For this reason, auto- pilots in airplanes and trigger mechanisms in airbags, for example, are subjected to stringent materials testing. This testing includes a wide variety of methods used to measure the behavior and material characteristics of standardized material samples or finished parts (component testing) under thermal, mechanical and chemical stress. During the tests, a material is checked for purity, faults or load capacity. With the Leica M205 A, M205 C, M165 C and M125 stereomicroscopes, experts in the materials test laboratory can delve into even smaller structures. Thanks to the unique FusionOptics™ system on the Leica M205 A and M205 C, for the first time ever in stereomicroscopy, increased depth of field can be combined with higher resolution. With the electronic coding that is applied for all components involved in imaging, the tester can eliminate practically all sources of error associated with measurement applications, and reproduce his test settings at any time. Using the Leica Application Suite (LAS), you can read out all relevant data, store images in an image database and measure and analyze them using the computer. The two new light sources, LED5000 MCI™ (Multi Contrast Illumination) and LED5000 RL offer a wide vari - ety of adjustment and automation options. Along with the automated mechanical stage and the new M-series, they form a complete system. Not only does this help to avoid errors, it also saves time, one of the most important advantages offered by the new Leica M205 A, M205 C, M165 C and M125. Brush marks on metal section Medical implant Through-connections on printed Defective through-connection circuit board Microcrack through composite Section through soldered joint material Cutout of clockwork Cut through crimp contact 10