‘Leaky Vaccines’: Misdirection or Fraud? Lee D. Merritt, M.D. The paradoxical resurgence of COVID-19 in the most to technique and interpretation. highly COVID-vaccinated countries is being blamed on Second, although the vast majority of RNA viruses mutate “leakiness” of vaccines. A vaccine is said to be “leaky” when rapidly, especially the single-strand RNA viruses (of which it no longer suppresses mutation of the virus, allowing some coronavirus is an example), coronavirus is a notable exception. “variants” to escape and become the dominant viruses in This positive-strand RNA virus has a type of proofreader in the circulation. Reviewing basic scientific logic, looking at the form of nsp 14-Exon.3 In fact, during more than a decade of actual construction of the lab-manipulated spike protein, development of vaccines against coronavirus, it was noticed and reviewing the decades-long bench science concerning that coronavirus genetic “variable” and “hypervariable” regions coronavirus (and coronavirus vaccine development) casts change (mutate) 30–60 percent more slowly than many other serious doubt on this explanation for the COVID-19 upsurge. viruses.4-6 The development of bacterial antibiotic resistance is well Third, SARS-CoV-1, the cause of severe adult respiratory understood. In a mixed population of bacteria, those most syndrome, is 97.7 percent similar to SARS CoV-2 at the spike sensitive to the effects of a given antibiotic will be preferentially domain, but only 52.5 percent similar at the N terminus and killed, leaving behind the most antibiotic-resistant subspecies. 85.5 percent at the nucleocapsid, and yet human monoclonal Metaphorically, the toughest boxer makes it to the final round, antibody to the S glycoprotein of SARS-CoV-1 neutralizes and the toughest bacteria live to fight on in the primary host, SARS-CoV-2,7 suggesting that variability outside the spike then may spread as a more deadly (antibiotic-resistant) strain protein isn’t that important. to others. During the development of COVID-19 vaccines, researchers Viruses, however, are not bacteria, and vaccines are not purposely chose to target “highly conserved” regions of the antibiotics. There is also a fundamental scientific logic that is spike protein. “Highly conserved” is geneticist patois meaning being ignored. Nature is efficient: The simplest explanation for “they don’t vary.” The researchers state specifically that they any biologic process is usually the correct one. The primary fact sought out “highly conserved” vaccine target areas to avoid the we need to explain is how, after months of declining COVID-19 problem of variant escape.8 cases, hospitalizations, and deaths, countries with the highest Was the “spike protein” lab-created or altered? The seminal vaccination rates against SARS-CoV2 are experiencing the paper by Pradhan et al. looked at all the various genetic biggest increase in all categories—during an “off season” for sequences of pathologic specimens reported to the gene data viral illness. bank.9 They discovered four “inserts” that were in every sample Simply put, increased COVID vaccination is associated collected from COVID victims. Notably, these four inserts were with increased COVID morbidity and mortality. How this not present in SARS-CoV-1 from 2002, and were never present occurs can be debated, but the simplest explanation is that in any other members of the extensive family Coronaviridae. the vaccine itself is toxic, making people ill and killing people. Furthermore, the insert sequences, when analyzed, were Everything else—including the idea of “variants”—is a more a match to areas from the human immunodeficiency virus complicated and circuitous explanation. (HIV). Most importantly for this discussion, the four inserts Looking at “variants” as the explanation, we have several were 100 percent conserved throughout all the pathological pieces of information that make this unconvincing. SARS-CoV-2 specimens, i.e., they presented with 0 percent variability. Given the ability of vaccine developers to target Reasons to Question COVID-19 Variants the most invariant areas for vaccine antibody binding, it seems unlikely that one or more of these areas would not First, variability is mathematically calculated by reported be the target. Put another way, if the developers didn’t take gene sequences, which are themselves manufactured by advantage of these invariable regions, then they purposely computer analysis. As Stefan Lanka has said in his refutation created vaccine escape. of the entire virus paradigm: “The basic insight is that these The article by Prashand et al. has been withdrawn by the manipulations, called ‘alignments,’ simply do not correspond authors, under protest, with the comment that “they intend to any ‘complete’ or known genetic material of a virus.”1 to revise it in response to comments received from the Recently, mainstream COVID-19 researchers, regarding the research community on their technical approach and their reliability of banked sequences for calculation of variability, interpretation of the results.” Additionally, why would Zero have stated: “Among the 129 sequence variations reported, Hedge—an on-line economic journal—be de-platformed for many were generated randomly by the algorithms during simply reporting on this article? It evokes the military pilot the alignment of the multiple sequences, therefore these dictum that when you are catching big “flak” you are over a should be removed or adjusted.”2 In other words, the degree big target the enemy does not want you to take out. of modeling error is unknown, and results are highly subject Fourthly, bacterial resistance develops only if the 12 Journal of American Physicians and Surgeons Volume 27 Number 1 Spring 2022 antibiotic actually kills or in other ways prevents spread of the The “variant” explanation is not competent scientific less resistant forms. No study—not even the study by Pfizer reasoning. It is at best “grasping at straws,” but is more likely that supported the original application for Emergency Use willful obfuscation and misleading the public. Consider possible Authorization (EUA)—has demonstrated that these COVID-19 motives for the promulgation of the “variant” explanation. In vaccines ever prevented transmission. So how could resistant law, motive is always considered when assessing truth, but it is “variants” arise without selective pressure? rarely considered as a possible reason for scientific data to be Fifthly, according to a table that compares the case fatality skewed. Scientists and bureaucrats paid by the pharmaceutical rates of the different “variants,” from a June 2021 technical industry—the people with the most to lose financially— briefing by Public Health England (Table 1),10 Delta is near the invoked the dreaded “Delta” and now “Omicron” variants. No bottom. So, even if it is the emerging circulating virus, it should pharmaceutical producer of these vaccines is going to admit not be increasing the rate of hospitalization and death but that the vaccines could be directly killing people. Money and decreasing it. Evolution to decreasing lethality was predicted truth do not coexist well. Now there is Omicron, next it may by researchers and is consistent with historical observations.11 be Lambda, and then Sigma. Who knows? An unverifiable It is interesting that as of Oct 4, 2021, the U.S. Centers for “table of variants” and release dates is circulating on the web. Disease Control and Prevention (CDC) was not monitoring for Whether true or not, it is certainly consistent with the actions the Delta variant.12 One must logically wonder why not. of government so far to confuse and manipulate a scientifically And finally, how do variants explain the recent experience naïve public. of the Belgian contingent at the South Pole? Sixteen of 25 “fully vaccinated” researchers who were thoroughly screened, Conclusion and presumably isolated prior to leaving for the ice cap, tested positive for Covid seven days into their stint at the facility at There have been many provable deceptions or errors Princess Elisabeth Polar Station. A few on this remote outpost about COVID-19, but the variant narrative, though scientifically are mildly symptomatic according to reports. Based only on highly improbable, will likely persist. It is too technically supposition (considering the total inability to test for variants difficult for most casual observers to dispute. Plausibility there, and most places if truth be known) this “outbreak” has is the most important characteristic of a lie, but lying about been labelled “Omicron.”13 pharmaceutical safety can be fatal. Physicians need to educate Table 1. Comparative Lethality of SARS-CoV-2 Variants of Concern10 Journal of American Physicians and Surgeons Volume 27 Number 1 Spring 2022 13 themselves on the complexities of molecular biology, err on 6. Smith EC, Denison MR. Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity. PLoS Pathog the side of healthy skepticism, and stop taking the word of 2013;9(12):e1003760. Available at: https://doi.org/10.1371/journal. “experts” on faith. ppat.1003760. Accessed Jan 29, 2022. 7. Pinto D, Park YJ, Beltramello M, et al. Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Nature 2020;583:290–295. Lee D. Merritt, M.D., practices orthopaedic surgery and anti-aging medicine Available at: https://doi.org/10.1038/s41586-020-2349-y. Accessed Jan in Omaha, Nebraska, and is a past president of AAPS. Contact schedule@ 29, 2022. drleemerritt.com. 8. Yurina V. Coronavirus epitope prediction from highly conserved region of spike protein. Clin Exp Vaccine Res 2020;9(2):169-173. doi: 10.7774/ cevr.2020.9.2.169. REFERENCES 9. Pradhan P, Pandey AK, Mishra A, et al. Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag. bioRxiv. 1. Greatreject. Dr. Stefan Lanka: ‘All claims about viruses as pathogens are Published on line Jan 31, 2020. Available at: https://www.biorxiv.org/co false.’ Greatreject; Jun 17, 2021. Available at: https://greatreject.org/dr- ntent/10.1101/2020.01.30.927871v1. Accessed Jan 29, 2022. stefan-lanka-claims-about-viruses-are-false/. Accessed Jan 29, 2022. 10. Public Health England. SARS-CoV-2 variants of concern and variants 2. Zhao Z, Li H, Wu X, et al. Moderate mutation rate in the SARS coronavirus under investigation in England. Technical Briefing 17; Jun 25, 2021. genome and its implications. BMC Evol Biol 2004;4(21). doi:10.1186/1471- Available at: https://assets.publishing.service.gov.uk/government/ 2148-4-21. Available at: https://bmcecolevol.biomedcentral.com/articl uploads/system/uploads/attachment_data/file/1001354/Variants_of_ es/10.1186/1471-2148-4-21. Accessed Jan 29, 2022. Concern_VOC_Technical_Briefing_17.pdf. Accessed Nov 30, 2021. 11. Singh J, Pandit P, McArthur AG, Banerjee A, Mossman K. Evolutionary 3. Sanjuán R, Domingo-Calap P. Mechanisms of viral mutation. Cell Mol Life trajectory of SARS-CoV-2 and emerging variants. Virol J 2021;18(1):166. Sci. 2016;73(23):4433-4448. doi:10.1007/s00018-016-2299-6. doi:10.1186/s12985-021-01633-w. 4. Kaur N, Singh R, Dar Z, et al. Genetic comparison among various 12. CDC. SARS-CoV-2 Variant Classifications and Definitions; updated Dec coronavirus strains for the identification of potential vaccine targets 1, 2021. Available at: https://www.cdc.gov/coronavirus/2019-ncov/ of SARS-CoV2. Infect Genet Evol 2021;89:104490. doi:10.1016/j. variants/variant-info.html. Accessed Jan 29, 2022. meegid.2020.104490. 13. Ellis R. COVID-19 outbreak hits research station in Antarctica. WebMD; Jan 5. Rauch J, Capoferri A, Katusiime KG, et al. PNAS USA 2020;117(40):24614- 4, 2022. Available at: https://www.webmd.com/lung/news/20220103/ 24616. Available at: https://doi.org/10.1073/pnas.2017726117. Accessed covid-19-outbreakohitsoresearchostation-in-antarctica. Accessed Feb Jan 29, 2022. 15, 2022. 14 Journal of American Physicians and Surgeons Volume 27 Number 1 Spring 2022