FIFTH EDITION L A NGE O U TLINERE VIE W TM US MLES TEP2 Joel S. Goldberg, DO Assistant Professor of Medicine Department of Medicine Drexel University College of Medicine Philadelphia, Pennsylvania McGraw-Hill Medical Publishing Division New York Chicago San Francisco Lisbon London Madrid Mexico City Milan New Delhi San Juan Seoul Singapore Sydney Toronto Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved. Manufactured in the United States of America. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a database or retrieval system, without the prior written permission of the publisher. 0-07-148697-6. The material in this eBook also appears in the print version of this title: 0-07-145192-7. All trademarks are trademarks of their respective owners. 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If you’d like more information about this book, its author, or related books and websites, please click here. For Mickey, Daniel, and Kasey This page intentionally left blank For more information about this title, click here Contents Contributors / vii Preface / xi Acknowledgements / xiii How to Use This Book / xv 1. CARDIOVASCULAR MEDICINE / 1 2. DISORDERS OF THE SKIN AND SUBCUTANEOUS TISSUE / 39 3. ENDOCRINE AND METABOLIC DISORDERS / 69 4. GASTROENTEROLOGY / 89 5. HEMATOLOGY / 113 6. ONCOLOGY / 147 7. IMMUNOLOGY AND ALLERGY / 183 8. INJURY AND TOXICOLOGY / 203 9. INFECTIOUS AND PARASITIC DISEASES / 225 10. MUSCULOSKELETAL AND CONNECTIVE TISSUE DISEASE / 247 11. NEUROLOGY / 269 12. NORMAL GROWTH AND DEVELOPMENT AND GENERAL PRINCIPLES OF CARE / 303 13. OBSTETRICS AND GYNECOLOGY / 323 14. CONGENITAL ANOMALIES AND PERINATAL MEDICINE / 359 15. PSYCHIATRY / 395 16. PULMONARY MEDICINE / 437 17. RENAL SYSTEM AND UROLOGY / 467 v S vi T N E T N O C 18. SURGICAL PRINCIPLES / 489 19. SYMPTOMS, SIGNS, AND ILL-DEFINED CONDITIONS / 527 Index / 551 Contributors Reviewed and revised by: Siamak Barkhordarian, MD Vascular Fellow Jennifer C. Bellino, MD Section of Vascular Surgery Department of Surgery The William W. Backus Hospital Yale University School of Medicine Norwich, Connecticut New Haven, Connecticut Chapter 18, “Surgical Principles” Contributors to the previous edition: Evan Bash, MD Clinical Assistant Professor Bharat Awsare, MD Department of Orthopedic Surgery Clinical Assistant Professor of Medicine MCP–Hahnemann School of Medicine and Division of Critical Care, Pulmonary, Allergic and Temple University School of Medicine Immunologic Diseases Philadelphia, Pennsylvania Department of Medicine Attending Orthopedic Surgeon Jefferson Medical College of Thomas Jefferson Division of Orthopedic Surgery, Department University of Surgery Philadelphia, Pennsylvania Crozer–Chester Medical Center Chapter 16, “Pulmonary Medicine” Upland, Pennsylvania Chapter 10, “Musculoskeletal and Connective Tissue Arthur K. Balin, MD, PhD, FACP Disease” Clinical Senior Investigator Lankenau Institute for Medical Research Vikas Batra, MD Jefferson Health System Fellow Wynnewood, Pennsylvania Division of Critical Care, Pulmonary, Allergic and Attending Physician Immunologic Diseases Division of Dermatology Department of Medicine Department of Internal Medicine Jefferson Medical College of Thomas Jefferson Riddle Memorial Hospital University Media, Pennsylvania Philadelphia, Pennsylvania Chapter 2, “Disorders of the Skin and Subcutaneous Tissue” Chapter 16, “Pulmonary Medicine” vii Copyright © 2006 by The McGraw-Hill Companies, Inc. Click here for terms of use. S viii R O T U B RI T Jennifer C. Bellino, MD Richard Goldman, MD N O Senior Medical Resident Clinical Assistant Professor C Department of Internal Medicine Department of Internal Medicine Thomas Jefferson University Hospital MCP–Hahnemann University School of Medicine Philadelphia, Pennsylvania Philadelphia, Pennsylvania Chapter 19, “Symptoms, Signs, and Ill-Defined Conditions” Attending Physician Division of Internal Medicine Amy C. Brodkey, MD Department of Hematology/Oncology Clinical Associate Professor Crozer–Chester Medical Center Department of Psychiatry Upland, Pennsylvania University of Pennsylvania School of Medicine Chapter 5, “Hematology” Philadelphia, Pennsylvania Chapter 6, “Oncology” Chapter 15, “Psychiatry” Jeffrey I. Greenstein, MD Maria Childers, MD Chairman Instructor Department of Neurology Department of Pediatrics Graduate Hospital Jefferson Medical College of Thomas Jefferson Philadelphia, Pennsylvania University Chapter 11, “Neurology” Philadelphia, Pennsylvania Chapter 12, “Normal Growth and Development and General Victor A. Heresniak, DO Principles of Care” Chairman Chapter 14, “Congenital Anomalies and Perinatal Department of Emergency Medicine Medicine” Crozer–Chester Medical Center Christina M. Clay, MD Upland, Pennsylvania Clinical Instructor Chapter 8, “Injury and Toxicology” Department of Medicine Samuel L. Jacobs, MD Jefferson Medical College of Thomas Jefferson Associate Professor, Clinical Obstetrics and University Philadelphia, Pennsylvania Gynecology Chapter 5, “Hematology” Division of Reproductive Endocrinology and Chapter 6, “Oncology” Infertility Cooper Hospital/University Medical Center Thomas Fekete, MD UMDNJ–Robert Wood Johnson School of Medicine Professor of Medicine Camden, New Jersey Section of Infectious Diseases Chapter 13, “Obstetrics and Gynecology” Departments of Internal Medicine and Microbiology Temple University School of Medicine Ancil A. Jones, MD Philadelphia, Pennsylvania Adjunct Clinical Assistant Professor Chapter 9, “Infectious and Parasitic Diseases” Department of Medicine MCP–Hahnemann University School of Medicine Jeffrey Freeman, DO, FACOI Philadelphia, Pennsylvania Professor and Chairman Clinical Associate Professor Division of Endocrinology and Metabolism Department of Medicine Department of Medicine Temple University School of Medicine Philadelphia College of Osteopathic Medicine Philadelphia, Pennsylvania Philadelphia, Pennsylvania Invasive/Interventional and Clinical Cardiologist Chapter 3, “Endocrine and Metabolic Disorders” Department of Medicine Vivian Gahtan, MD Taylor Hospital Associate Professor Ridley Park, Pennsylvania Section of Vascular Surgery Medical Director Department of Surgery Cardiac Catheterization Laboratory Yale University School of Medicine Crozer–Chester Medical Center New Haven, Connecticut Upland, Pennsylvania Chapter 18, “Surgical Principles” Chapter 1, “Cardiovascular Medicine”